Leucovorin calcium

Product NDC
63323-631
11-digit product format
633230631
Labeler code
63323
Product ID
63323-631_a0d41f71-6197-4c9a-8cd2-217945cb722b
Type
HUMAN PRESCRIPTION DRUG
Nonproprietary name
Leucovorin calcium
Dosage form
INJECTION
Route
INTRAMUSCULAR; INTRAVENOUS
Labeler
Fresenius Kabi USA, LLC
Application
ANDA207226
Marketing category
ANDA
Marketing start
2018-07-27
Substance
LEUCOVORIN CALCIUM
Active strength
10 mg/mL
Pharmacologic classes
Folate Analog [EPC], Folic Acid [CS]
NDC exclude flag
No
Listing certified through
2026-12-31
Current FDA listing
Yes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 1.

Orange Book products#

Current product rows page 1 of 1 · 1 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
A207226-001LEUCOVORIN CALCIUMLEUCOVORIN CALCIUMEQ 500MG BASE/50ML (EQ 10MG BASE/ML)SOLUTION / INTRAMUSCULAR, INTRAVENOUSRS2018-07-27

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Product history page 1 of 2 · 41 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-02-19 14:30 UTC2026-02A207226-001LEUCOVORIN CALCIUMEQ 500MG BASE/50ML (EQ 10MG BASE/ML)SOLUTION / INTRAMUSCULAR, INTRAVENOUSRS2018-07-27011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A207226-001LEUCOVORIN CALCIUMEQ 500MG BASE/50ML (EQ 10MG BASE/ML)SOLUTION / INTRAMUSCULAR, INTRAVENOUSRS2018-07-2731067a03dcf5…
2025-08-23 18:47 UTC2025-08A207226-001LEUCOVORIN CALCIUMEQ 500MG BASE/50ML (EQ 10MG BASE/ML)SOLUTION / INTRAMUSCULAR, INTRAVENOUSRS2018-07-276a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A207226-001LEUCOVORIN CALCIUMEQ 500MG BASE/50ML (EQ 10MG BASE/ML)SOLUTION / INTRAMUSCULAR, INTRAVENOUSRS2018-07-27fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A207226-001LEUCOVORIN CALCIUMEQ 500MG BASE/50ML (EQ 10MG BASE/ML)SOLUTION / INTRAMUSCULAR, INTRAVENOUSRS2018-07-27b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A207226-001LEUCOVORIN CALCIUMEQ 500MG BASE/50ML (EQ 10MG BASE/ML)SOLUTION / INTRAMUSCULAR, INTRAVENOUSRS2018-07-2703ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A207226-001LEUCOVORIN CALCIUMEQ 500MG BASE/50ML (EQ 10MG BASE/ML)SOLUTION / INTRAMUSCULAR, INTRAVENOUSRS2018-07-272680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A207226-001LEUCOVORIN CALCIUMEQ 10MG BASE/MLINJECTABLE / INJECTIONRS2018-07-275bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A207226-001LEUCOVORIN CALCIUMEQ 500MG BASE/50ML (EQ 10MG BASE/ML)SOLUTION / INTRAMUSCULAR, INTRAVENOUSRS2018-07-27d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A207226-001LEUCOVORIN CALCIUMEQ 500MG BASE/50ML (EQ 10MG BASE/ML)SOLUTION / INTRAMUSCULAR, INTRAVENOUSRS2018-07-27d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A207226-001LEUCOVORIN CALCIUMEQ 10MG BASE/MLINJECTABLE / INJECTIONRS2018-07-2779d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A207226-001LEUCOVORIN CALCIUMEQ 10MG BASE/MLINJECTABLE / INJECTIONRS2018-07-27301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A207226-001LEUCOVORIN CALCIUMEQ 10MG BASE/MLINJECTABLE / INJECTIONRS2018-07-271e350fbaab3a…
2024-05-31 18:47 UTC2024-05A207226-001LEUCOVORIN CALCIUMEQ 10MG BASE/MLINJECTABLE / INJECTIONRS2018-07-278072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06A207226-001LEUCOVORIN CALCIUMEQ 10MG BASE/MLINJECTABLE / INJECTIONAP2018-07-275c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04A207226-001LEUCOVORIN CALCIUMEQ 10MG BASE/MLINJECTABLE / INJECTIONAP2018-07-275d02ea3f76ae…
2022-04-04 05:41 UTC2022-04A207226-001LEUCOVORIN CALCIUMEQ 10MG BASE/MLINJECTABLE / INJECTIONAP2018-07-274b0b4de00fa7…
2019-12-13 00:20 UTC2019-12A207226-001LEUCOVORIN CALCIUMEQ 10MG BASE/MLINJECTABLE / INJECTIONAP2018-07-2774a2ff9319b5…
2022-03-09 01:35 UTC2022-03A207226-001LEUCOVORIN CALCIUMEQ 10MG BASE/MLINJECTABLE / INJECTIONAP2018-07-27bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12A207226-001LEUCOVORIN CALCIUMEQ 10MG BASE/MLINJECTABLE / INJECTIONAP2018-07-27782e0a99824c…
2021-05-05 16:15 UTC · 3 captures of this ZIP2021-05A207226-001LEUCOVORIN CALCIUMEQ 10MG BASE/MLINJECTABLE / INJECTIONAP2018-07-2787673890dc5c…
2021-03-12 10:30 UTC2021-03A207226-001LEUCOVORIN CALCIUMEQ 10MG BASE/MLINJECTABLE / INJECTIONAP2018-07-275aa47cf7b7d7…
2020-12-22 03:56 UTC2020-12A207226-001LEUCOVORIN CALCIUMEQ 10MG BASE/MLINJECTABLE / INJECTIONAP2018-07-278869cabd3fbd…
2020-11-12 02:37 UTC2020-11A207226-001LEUCOVORIN CALCIUMEQ 10MG BASE/MLINJECTABLE / INJECTIONAP2018-07-27c0c555d07b60…
2019-12-14 00:12 UTC2019-12A207226-001LEUCOVORIN CALCIUMEQ 10MG BASE/MLINJECTABLE / INJECTIONAP2018-07-273f01610625f2…
2019-09-15 20:21 UTC2019-09A207226-001LEUCOVORIN CALCIUMEQ 10MG BASE/MLINJECTABLE / INJECTIONAP2018-07-27b00525d2431f…
2019-07-19 19:46 UTC2019-07A207226-001LEUCOVORIN CALCIUMEQ 10MG BASE/MLINJECTABLE / INJECTIONAP2018-07-27ea99ee380514…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A207226-001LEUCOVORIN CALCIUMEQ 10MG BASE/MLINJECTABLE / INJECTIONRS2018-07-276a51e52b5d6a…
2024-02-18 07:12 UTC2024-02A207226-001LEUCOVORIN CALCIUMEQ 10MG BASE/MLINJECTABLE / INJECTIONRS2018-07-271c564ffb4f44…
2023-12-20 04:57 UTC2023-12A207226-001LEUCOVORIN CALCIUMEQ 10MG BASE/MLINJECTABLE / INJECTIONRS2018-07-27ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11A207226-001LEUCOVORIN CALCIUMEQ 10MG BASE/MLINJECTABLE / INJECTIONRS2018-07-27a72a2bbeb626…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10A207226-001LEUCOVORIN CALCIUMEQ 10MG BASE/MLINJECTABLE / INJECTIONRS2018-07-279b2671bbb829…
2023-07-15 15:27 UTC · 2 captures of this ZIP2023-07A207226-001LEUCOVORIN CALCIUMEQ 10MG BASE/MLINJECTABLE / INJECTIONRS2018-07-27a67488948f0b…
2023-06-13 01:57 UTC · 3 captures of this ZIP2023-06A207226-001LEUCOVORIN CALCIUMEQ 10MG BASE/MLINJECTABLE / INJECTIONRS2018-07-273f0d92c62455…
2023-05-13 08:27 UTC2023-05A207226-001LEUCOVORIN CALCIUMEQ 10MG BASE/MLINJECTABLE / INJECTIONAP2018-07-27053a50430f4f…
2023-01-26 05:58 UTC2023-01A207226-001LEUCOVORIN CALCIUMEQ 10MG BASE/MLINJECTABLE / INJECTIONAP2018-07-273bdfa0b2c4d7…
2022-11-12 20:34 UTC · 5 captures of this ZIP2022-11A207226-001LEUCOVORIN CALCIUMEQ 10MG BASE/MLINJECTABLE / INJECTIONAP2018-07-273a93d1ddd44b…
2022-10-28 04:53 UTC2022-10A207226-001LEUCOVORIN CALCIUMEQ 10MG BASE/MLINJECTABLE / INJECTIONAP2018-07-27f41ea6bd6efb…
2022-09-29 23:25 UTC2022-09A207226-001LEUCOVORIN CALCIUMEQ 10MG BASE/MLINJECTABLE / INJECTIONAP2018-07-27e64feba35796…
2022-07-09 03:26 UTC · 3 captures of this ZIP2022-07A207226-001LEUCOVORIN CALCIUMEQ 10MG BASE/MLINJECTABLE / INJECTIONAP2018-07-27cb3db0bc1861…

Observed Orange Book normalized TE history#

Captured, Edition, Application-product table
CapturedEditionApplication-productTE codeOrderSource SHA-256
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06A207226-001AP15c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04A207226-001AP15d02ea3f76ae…
2022-04-04 05:41 UTC2022-04A207226-001AP14b0b4de00fa7…
2019-12-13 00:20 UTC2019-12A207226-001AP174a2ff9319b5…
2022-03-09 01:35 UTC2022-03A207226-001AP1bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12A207226-001AP1782e0a99824c…
2021-05-05 16:15 UTC · 3 captures of this ZIP2021-05A207226-001AP187673890dc5c…
2021-03-12 10:30 UTC2021-03A207226-001AP15aa47cf7b7d7…
2020-12-22 03:56 UTC2020-12A207226-001AP18869cabd3fbd…
2020-11-12 02:37 UTC2020-11A207226-001AP1c0c555d07b60…
2019-12-14 00:12 UTC2019-12A207226-001AP13f01610625f2…
2019-09-15 20:21 UTC2019-09A207226-001AP1b00525d2431f…
2019-07-19 19:46 UTC2019-07A207226-001AP1ea99ee380514…
2023-05-13 08:27 UTC2023-05A207226-001AP1053a50430f4f…
2023-01-26 05:58 UTC2023-01A207226-001AP13bdfa0b2c4d7…
2022-11-12 20:34 UTC · 5 captures of this ZIP2022-11A207226-001AP13a93d1ddd44b…
2022-10-28 04:53 UTC2022-10A207226-001AP1f41ea6bd6efb…
2022-09-29 23:25 UTC2022-09A207226-001AP1e64feba35796…
2022-07-09 03:26 UTC · 3 captures of this ZIP2022-07A207226-001AP1cb3db0bc1861…

Additional Listing Data#

Finished product
Yes
Brand name base
Leucovorin calcium
Listing expiration
2026-12-31

Active Ingredients#

Ingredient, Strength table
IngredientStrength
LEUCOVORIN CALCIUM10 mg/mL

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
RPR1R4C0P4Internal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 2 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
2099993Internal RxNorm lookup
2104714Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
4b72d1fd-f389-45d9-b43b-510b45c92263Available on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product conceptRelationVersionEffective
31adef49-84cb-4c51-b122-69e924e10ea3Product name420240827
df40773e-fe5a-474c-8d32-d19c7094e396Product name220240813
cd1aa5b9-18a7-4dc4-8a13-b5c677c859a2Product name120231116
38866763-6a8e-4096-95c3-082a000c243dProduct name120230809
7ce39568-aceb-b33a-23ed-c4964cdcf486Product name220210211
6c712ad1-eecf-448f-84d9-5c0c307a7112Product name120161130

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDCProductDescriptionFormQuantityStrengthSPL version
63323-631-10Leucovorin calcium10 mL in 1 VIAL, SINGLE-USEINJECTION107
63323-631-10Leucovorin calcium1 in 1 CARTONINJECTION17
63323-631-50Leucovorin calcium50 mL in 1 VIAL, SINGLE-USEINJECTION507
63323-631-50Leucovorin calcium1 in 1 CARTONINJECTION17

DailyMed Billing Units#

Package NDC, Billing unit, Product NDC table
Package NDCBilling unitProduct NDCDailyMed indexing SPLSPL versionEffective
63323-631-10ML - Milliliter63323-6310e3ba9d7-99dc-4a7d-afa7-6830472d301412018-12-13
63323-631-50ML - Milliliter63323-6316e44d0cb-ecb4-4da0-92c2-b6a2849d61a212018-12-13

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDCDashboard titleSPL versionValidationDashboard ZIP
63323-631LEUCOVORIN CALCIUM INJECTION [FRESENIUS KABI USA, LLC]7Current NDC, Legacy NDC, 2 package rows20241019_4b72d1fd-f389-45d9-b43b-510b45c92263.zip
63323-631LEUCOVORIN CALCIUM INJECTION [FRESENIUS KABI USA, LLC]7Current NDC, Legacy NDC, 2 package rows20241031_d5d4f0fd-7520-43a9-9acc-f7e117e1f6ee.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 2 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
Leucovorin calciumLEUCOVORIN CALCIUMFresenius Kabi USA, LLC4b72d1fd-f389-45d9-b43b-510b45c922632024-10-14Warnings, Adverse reactionsExact identifier
application applno (ANDA): 207226
application number: ANDA207226
ndc (product): 63323-631
Leucovorin calciumLEUCOVORIN CALCIUMFresenius Kabi USA, LLCd5d4f0fd-7520-43a9-9acc-f7e117e1f6ee2024-10-14Warnings, Adverse reactionsExact identifier
ndc (product): 63323-631

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUIRxNorm stringTTYDailyMedSPL version
2099993leucovorin 100 MG in 10 ML InjectionPSN4b72d1fd-f389-45d9-b43b-510b45c922637
2099993leucovorin 100 MG in 10 ML InjectionPSNd5d4f0fd-7520-43a9-9acc-f7e117e1f6ee7
2104714leucovorin 500 MG in 50 ML InjectionPSN4b72d1fd-f389-45d9-b43b-510b45c922637
2104714leucovorin 500 MG in 50 ML InjectionPSNd5d4f0fd-7520-43a9-9acc-f7e117e1f6ee7
209999310 ML leucovorin 10 MG/ML InjectionSCD4b72d1fd-f389-45d9-b43b-510b45c922637
209999310 ML leucovorin 10 MG/ML InjectionSCDd5d4f0fd-7520-43a9-9acc-f7e117e1f6ee7
210471450 ML leucovorin 10 MG/ML InjectionSCD4b72d1fd-f389-45d9-b43b-510b45c922637
210471450 ML leucovorin 10 MG/ML InjectionSCDd5d4f0fd-7520-43a9-9acc-f7e117e1f6ee7
2099993leucovorin (as leucovorin calcium) 100 MG per 10 ML InjectionSY4b72d1fd-f389-45d9-b43b-510b45c922637
2099993leucovorin (as leucovorin calcium) 100 MG per 10 ML InjectionSYd5d4f0fd-7520-43a9-9acc-f7e117e1f6ee7
2104714leucovorin (as leucovorin calcium) 500 MG per 50 ML InjectionSY4b72d1fd-f389-45d9-b43b-510b45c922637
2104714leucovorin (as leucovorin calcium) 500 MG per 50 ML InjectionSYd5d4f0fd-7520-43a9-9acc-f7e117e1f6ee7
2099993leucovorin 100 MG per 10 ML InjectionSY4b72d1fd-f389-45d9-b43b-510b45c922637
2099993leucovorin 100 MG per 10 ML InjectionSYd5d4f0fd-7520-43a9-9acc-f7e117e1f6ee7
2104714leucovorin 500 MG per 50 ML InjectionSY4b72d1fd-f389-45d9-b43b-510b45c922637
2104714leucovorin 500 MG per 50 ML InjectionSYd5d4f0fd-7520-43a9-9acc-f7e117e1f6ee7

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionMarketing startMarketing endSampleExclude flagStatus
63323-631-10633230631101 VIAL, SINGLE-USE in 1 CARTON (63323-631-10) / 10 mL in 1 VIAL, SINGLE-USE2017-01-310000-00-00NoNoCurrent
63323-631-50633230631501 VIAL, SINGLE-USE in 1 CARTON (63323-631-50) / 50 mL in 1 VIAL, SINGLE-USE2018-07-270000-00-00NoNoCurrent