Migraine Relief

Product NDC: 63868-316
11-digit product format: 638680316
Labeler code: 63868
Product ID: 63868-316_ee299f62-f505-5e30-e053-2995a90a3c41
Type: HUMAN OTC DRUG
Nonproprietary name: ACETAMINOPHEN, ASPIRIN and CAFFEINE
Dosage form: TABLET
Route: ORAL
Labeler: CHAIN DRUG MARKETING ASSOCIATION INC
Application: ANDA214039
Marketing category: ANDA
Marketing start: 2022-05-05
Marketing end: 0000-00-00
Substance: ACETAMINOPHEN; ASPIRIN; CAFFEINE
Active strength: 250 mg/1; mg/1; mg/1
Pharmacologic classes: Anti-Inflammatory Agents, Non-Steroidal [CS], Central Nervous System Stimulant [EPC], Central Nervous System Stimulation [PE], Cyclooxygenase Inhibitors [MoA], Decreased Platelet Aggregation [PE], Decreased Prostaglandin Production [PE], Methylxanthine [EPC], Nonsteroidal Anti-inflammatory Drug [EPC], Platelet Aggregation Inhibitor [EPC], Xanthines [CS]
NDC exclude flag: No
Listing certified through: 2023-12-31
Current FDA listing: Historical FDA.report record

NDC auxiliary status#

These records are reproduced from FDA’s unfinished, excluded, and compounder listings. They describe what appeared in the source files; a missing record does not establish a regulatory status. View all current auxiliary records, including entries without an NDC. · View the auxiliary file history.

Current NDC status page 1 of 1 · 2 matching rows.

Dataset, Scope, Product NDC table
Dataset	Scope	Product NDC	Package NDC	Code	Status	Reporting period	Source date
excluded product	product	63868-316		D	Discontinued by firm		2026-08-17
excluded package	package	63868-316	63868-316-24	D	Discontinued by firm		2026-08-17

Observed NDC auxiliary status history#

This history shows the information present in each captured FDA auxiliary file. It is not a continuous regulatory timeline, and a missing record does not establish a status.

Historic NDC status page 1 of 1 · 2 matching rows.

View current auxiliary records. · View the auxiliary file history.

Captured / source date, Dataset, Scope table
Captured / source date	Dataset	Scope	Product NDC	Package NDC	Code	Status	Reporting period	Archive	Snapshot	Source SHA-256
2025-12-14 17:58 UTC · source 2025-12-05	excluded product	product	63868-316		D	Discontinued by firm		excluded / ndc_excluded.zip	`d630ba8d3edf…`	`732f749b63fb…`
2025-12-14 17:58 UTC · source 2025-12-05	excluded package	package	63868-316	63868-316-24	D	Discontinued by firm		excluded / ndc_excluded.zip	`d630ba8d3edf…`	`732f749b63fb…`

Source provenance: Browse the complete Orange Book source catalog · source snapshot 42.

Orange Book products#

Current product rows page 1 of 1 · 1 matching rows.

Application-product, Trade name, Ingredient table
Application-product	Trade name	Ingredient	Strength	Dosage form / route	TE codes	RLD / RS	Approval date
A214039-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	ACETAMINOPHEN; ASPIRIN; CAFFEINE	250MG;250MG;65MG	TABLET / ORAL			2021-02-23

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Captured, Edition, Application-product table
Captured	Edition	Application-product	Trade name	Strength	Dosage form / route	Approval date	Source SHA-256
2026-08-18 06:07:40	2026-07	A214039-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2021-02-23	`caaa826d4ba7…`
2026-02-19 14:30 UTC	2026-02	A214039-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2021-02-23	`011fe1cb6892…`
2025-12-14 10:44 UTC · 2 captures of this ZIP	2025-12	A214039-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2021-02-23	`31067a03dcf5…`
2025-08-23 18:47 UTC	2025-08	A214039-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2021-02-23	`6a471c1ec25d…`
2025-03-22 03:13 UTC · 3 captures of this ZIP	2025-03	A214039-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2021-02-23	`fd3edfee7708…`
2025-02-26 10:13 UTC · 3 captures of this ZIP	2025-02	A214039-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2021-02-23	`b8a1b40f171c…`
2025-01-19 17:59 UTC · 7 captures of this ZIP	2025-01	A214039-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2021-02-23	`03ed91905a0d…`
2024-12-13 21:23 UTC · 2 captures of this ZIP	2024-12	A214039-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2021-02-23	`2680178bc6a6…`
2024-09-14 05:58 UTC · 2 captures of this ZIP	2024-09	A214039-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2021-02-23	`5bbf6a4d5a75…`
2024-11-08 22:44 UTC · 3 captures of this ZIP	2024-11	A214039-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2021-02-23	`d8e5a09893c0…`
2024-10-29 15:01 UTC	2024-10	A214039-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2021-02-23	`d06236e962d9…`
2024-08-13 05:28 UTC · 3 captures of this ZIP	2024-08	A214039-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2021-02-23	`79d66fd596c7…`
2024-07-13 05:37 UTC · 2 captures of this ZIP	2024-07	A214039-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2021-02-23	`301d65b070ca…`
2024-06-18 03:08 UTC · 5 captures of this ZIP	2024-06	A214039-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2021-02-23	`1e350fbaab3a…`
2024-05-31 18:47 UTC	2024-05	A214039-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2021-02-23	`8072bd15b7f6…`
2022-06-29 02:47 UTC · 2 captures of this ZIP	2022-06	A214039-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2021-02-23	`5c6f7cd8ea54…`
2022-04-08 23:34 UTC	2022-04	A214039-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2021-02-23	`5d02ea3f76ae…`
2022-04-04 05:41 UTC	2022-04	A214039-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2021-02-23	`4b0b4de00fa7…`
2022-03-09 01:35 UTC	2022-03	A214039-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2021-02-23	`bb7c543d1eb4…`
2021-12-28 21:50 UTC	2021-12	A214039-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2021-02-23	`782e0a99824c…`
2021-05-05 16:15 UTC · 3 captures of this ZIP	2021-05	A214039-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2021-02-23	`87673890dc5c…`
2024-03-16 18:09 UTC · 4 captures of this ZIP	2024-03	A214039-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2021-02-23	`6a51e52b5d6a…`
2024-02-18 07:12 UTC	2024-02	A214039-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2021-02-23	`1c564ffb4f44…`
2023-12-20 04:57 UTC	2023-12	A214039-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2021-02-23	`ea1830bbd6c7…`
2023-11-28 05:40 UTC · 2 captures of this ZIP	2023-11	A214039-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2021-02-23	`a72a2bbeb626…`
2023-10-25 00:34 UTC · 2 captures of this ZIP	2023-10	A214039-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2021-02-23	`9b2671bbb829…`
2023-07-15 15:27 UTC · 2 captures of this ZIP	2023-07	A214039-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2021-02-23	`a67488948f0b…`
2023-06-13 01:57 UTC · 3 captures of this ZIP	2023-06	A214039-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2021-02-23	`3f0d92c62455…`
2023-05-13 08:27 UTC	2023-05	A214039-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2021-02-23	`053a50430f4f…`
2023-01-26 05:58 UTC	2023-01	A214039-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2021-02-23	`3bdfa0b2c4d7…`
2022-11-12 20:34 UTC · 5 captures of this ZIP	2022-11	A214039-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2021-02-23	`3a93d1ddd44b…`
2022-10-28 04:53 UTC	2022-10	A214039-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2021-02-23	`f41ea6bd6efb…`
2022-09-29 23:25 UTC	2022-09	A214039-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2021-02-23	`e64feba35796…`
2022-07-09 03:26 UTC · 3 captures of this ZIP	2022-07	A214039-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2021-02-23	`cb3db0bc1861…`
2026-07-26 02:55 UTC · 3 captures of this ZIP	2026-06	A214039-001	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	250MG;250MG;65MG	TABLET / ORAL	2021-02-23	`a50c72e98297…`

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDC	Dashboard title	SPL version	Validation	Dashboard ZIP
63868-316	MIGRAINE RELIEF (ACETAMINOPHEN, ASPIRIN AND CAFFEINE) TABLET [CHAIN DRUG MARKETING ASSOCIATION INC]	3	Legacy NDC	20241013_4ec0f9e7-a533-4084-a03a-24c25132435a.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 13 matching rows.

Brand, Generic, Manufacturer table
Brand	Generic	Manufacturer	SPL set ID	Effective date	Available safety fields	Join
Migraine Relief	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	HARRIS TEETER	ff32572c-393b-0b49-e053-6394a90a83da	2026-08-05	Warnings	Exact identifier application applno (ANDA): 214039 application number: ANDA214039
Migraine Relief	ACETAMINOPHEN, ASPIRIN, CAFFEINE	Family Dollar (FAMILY WELLNESS)	bfcffa70-94a9-43de-9f22-4ed6a71c0a8d	2026-01-29	Warnings	Exact identifier application applno (ANDA): 214039 application number: ANDA214039
Acetaminophen, Aspirin and Caffeine	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	Safeway, Inc	f2a2cbb5-5a63-7514-e053-2995a90a572c	2025-12-19	Warnings	Exact identifier application applno (ANDA): 214039 application number: ANDA214039
Acetaminophen Aspirin Caffeine	ACETAMINOPHEN ASPIRIN CAFFEINE	CVS PHARMACY, INC	c340c5ef-e15d-53ce-e053-2995a90a73e7	2025-12-19	Warnings	Exact identifier application applno (ANDA): 214039 application number: ANDA214039
Acetaminophen Aspirin Caffeine	ACETAMINOPHEN ASPIRIN CAFFEINE	WALGREEN CO	c32c8cbd-5775-afe3-e053-2995a90a81cb	2025-12-19	Warnings	Exact identifier application applno (ANDA): 214039 application number: ANDA214039
Acetaminophen, Aspirin and Caffeine	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	FAMILY DOLLAR	f837e190-6fb3-e22e-e053-6394a90a12e6	2025-12-19	Warnings	Exact identifier application applno (ANDA): 214039 application number: ANDA214039
Acetaminophen, Aspirin and Caffeine	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	Granules India Ltd	e9534a13-ee8f-470f-8dd1-8ef0ce68526a	2025-12-01	Warnings	Exact identifier application applno (ANDA): 214039 application number: ANDA214039
PUBLIX SUPER MARKETS INC	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	PUBLIX SUPER MARKETS INC	08a46808-2bb2-0b40-e063-6394a90af80e	2025-01-02	Warnings	Exact identifier application applno (ANDA): 214039 application number: ANDA214039
Migraine Relief	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	CHAIN DRUG MARKETING ASSOCIATION, INC.	a6a07615-3108-436f-bbce-be7cb89ce456	2024-06-13	Warnings	Exact identifier application applno (ANDA): 214039 application number: ANDA214039
Migraine Relief	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	DISCOUNT DRUG MART	0ac12ced-70b3-7bbe-e063-6394a90aad52	2024-06-13	Warnings	Exact identifier application applno (ANDA): 214039 application number: ANDA214039
Acetaminophen, Aspirin and Caffeine	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	Safrel Pharmaceuticals, LLC.	0ac07846-5f04-dc4b-e063-6394a90ac8ca	2023-11-22	Warnings	Exact identifier application applno (ANDA): 214039 application number: ANDA214039
Migraine Relief	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	AAA PHARMACEUTICAL, INC.	f9c9a0b4-dbfe-7da9-e053-6294a90a7e09	2023-05-03	Warnings	Exact identifier application applno (ANDA): 214039 application number: ANDA214039
Migraine Relief	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	FSA STORE INC.	ec6b7017-cf12-09a7-e053-2995a90a2db9	2023-01-12	Warnings	Exact identifier application applno (ANDA): 214039 application number: ANDA214039

UNII, Preferred term, Registry number table
UNII	Preferred term	Registry number	Matched term
362O9ITL9D	ACETAMINOPHEN	103-90-2	ACETAMINOPHEN
R16CO5Y76E	ASPIRIN	50-78-2	ASPIRIN
3G6A5W338E	CAFFEINE	58-08-2	CAFFEINE

Packages#

Package NDC, 11-digit format, Description table
Package NDC	11-digit format	Description	Marketing start	Marketing end	Sample	Exclude flag	Status
63868-316-24	63868031624	1 BOTTLE, PLASTIC in 1 CARTON (63868-316-24) > 24 TABLET in 1 BOTTLE, PLASTIC	2022-05-05	0000-00-00	No	No	Current