Methotrexate Sodium

Product NDC
64850-330
11-digit product format
648500330
Labeler code
64850
Product ID
64850-330_030a6bcf-d482-4c98-9d27-423235cdb930
Type
HUMAN PRESCRIPTION DRUG
Nonproprietary name
Methotrexate Sodium
Dosage form
TABLET
Route
ORAL
Labeler
Elite Laboratories, Inc.
Application
ANDA216453
Marketing category
ANDA
Marketing start
2024-05-16
Substance
METHOTREXATE SODIUM
Active strength
2.5 mg/1
Pharmacologic classes
Folate Analog Metabolic Inhibitor [EPC], Folic Acid Metabolism Inhibitors [MoA]
NDC exclude flag
No
Listing certified through
2027-12-31
Current FDA listing
Yes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 42.

Orange Book products#

Current product rows page 1 of 1 · 1 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
A216453-001METHOTREXATE SODIUMMETHOTREXATE SODIUMEQ 2.5MG BASETABLET / ORALAB2024-05-16

Therapeutic equivalence codes#

Current TE-code rows page 1 of 1 · 1 matching rows.

Application-product, TE code table
Application-productTE code
A216453-001AB

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-08-18 06:07:402026-07A216453-001METHOTREXATE SODIUMEQ 2.5MG BASETABLET / ORALAB2024-05-16caaa826d4ba7…
2026-02-19 14:30 UTC2026-02A216453-001METHOTREXATE SODIUMEQ 2.5MG BASETABLET / ORALAB2024-05-16011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A216453-001METHOTREXATE SODIUMEQ 2.5MG BASETABLET / ORALAB2024-05-1631067a03dcf5…
2025-08-23 18:47 UTC2025-08A216453-001METHOTREXATE SODIUMEQ 2.5MG BASETABLET / ORALAB2024-05-166a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A216453-001METHOTREXATE SODIUMEQ 2.5MG BASETABLET / ORALAB2024-05-16fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A216453-001METHOTREXATE SODIUMEQ 2.5MG BASETABLET / ORALAB2024-05-16b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A216453-001METHOTREXATE SODIUMEQ 2.5MG BASETABLET / ORALAB2024-05-1603ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A216453-001METHOTREXATE SODIUMEQ 2.5MG BASETABLET / ORALAB2024-05-162680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A216453-001METHOTREXATE SODIUMEQ 2.5MG BASETABLET / ORALAB2024-05-165bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A216453-001METHOTREXATE SODIUMEQ 2.5MG BASETABLET / ORALAB2024-05-16d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A216453-001METHOTREXATE SODIUMEQ 2.5MG BASETABLET / ORALAB2024-05-16d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A216453-001METHOTREXATE SODIUMEQ 2.5MG BASETABLET / ORALAB2024-05-1679d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A216453-001METHOTREXATE SODIUMEQ 2.5MG BASETABLET / ORALAB2024-05-16301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A216453-001METHOTREXATE SODIUMEQ 2.5MG BASETABLET / ORALAB2024-05-161e350fbaab3a…
2026-07-26 02:55 UTC · 3 captures of this ZIP2026-06A216453-001METHOTREXATE SODIUMEQ 2.5MG BASETABLET / ORALAB2024-05-16a50c72e98297…

Observed Orange Book normalized TE history#

Captured, Edition, Application-product table
CapturedEditionApplication-productTE codeOrderSource SHA-256
2026-08-18 06:07:402026-07A216453-001AB1caaa826d4ba7…
2026-02-19 14:30 UTC2026-02A216453-001AB1011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A216453-001AB131067a03dcf5…
2025-08-23 18:47 UTC2025-08A216453-001AB16a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A216453-001AB1fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A216453-001AB1b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A216453-001AB103ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A216453-001AB12680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A216453-001AB15bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A216453-001AB1d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A216453-001AB1d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A216453-001AB179d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A216453-001AB1301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A216453-001AB11e350fbaab3a…
2026-07-26 02:55 UTC · 3 captures of this ZIP2026-06A216453-001AB1a50c72e98297…

Additional Listing Data#

Finished product
Yes
Brand name base
Methotrexate Sodium
Listing expiration
2027-12-31

Active Ingredients#

Ingredient, Strength table
IngredientStrength
METHOTREXATE SODIUM2.5 mg/1

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
3IG1E710ZNInternal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
105585Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
89c05ea3-3be1-46dd-b112-29c436fd7289Available on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product conceptRelationVersionEffective
2eb9a854-4fbc-9bbe-3199-41fc1018a1f0Product name920250224
3082de91-569a-4d57-b379-acbf37f1d5c3Product name120210312
f76135bc-a210-42d9-851b-1b73cbaccdb3Product name120200511
423544b2-e325-49ee-8910-4c5dfe41906fProduct name120181120
c9fd924b-0a8d-4d53-bf70-11070e24e4ddProduct name220181120
ce1e7cc6-4850-4cb1-8dde-8010b2fbc359Product name120181120
eb454f54-2806-4c31-a08b-8dcb08261099Product name220181120
d9cebc09-c68d-46f5-bdcd-fd82e945cc27Product name120170705
16ba0c1e-2371-48a4-8b4c-a9a338dfe1f3Product name220160504
88514aea-9d58-4ed2-b135-9811fb14c8fbProduct name120141209
0eba90a2-1cca-7e7b-28a5-85a09e2bc9a4Product name120140508

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDCProductDescriptionFormQuantityStrengthSPL version
64850-330-01Methotrexate Sodium100 in 1 BOTTLE, PLASTICTABLET1006

DailyMed Billing Units#

Package NDC, Billing unit, Product NDC table
Package NDCBilling unitProduct NDCDailyMed indexing SPLSPL versionEffective
64850-330-01EA - Each64850-330cd9caee3-d6d3-4260-8114-ae42a934135312024-08-12

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDCDashboard titleSPL versionValidationDashboard ZIP
64850-330METHOTREXATE SODIUM TABLET [ELITE LABORATORIES, INC.]2Current NDC, 1 package rows20240524_89c05ea3-3be1-46dd-b112-29c436fd7289.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 1 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
Methotrexate SodiumMETHOTREXATE SODIUMElite Laboratories, Inc.89c05ea3-3be1-46dd-b112-29c436fd72892026-05-22Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 216453
application number: ANDA216453
ndc (product): 64850-330

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUIRxNorm stringTTYDailyMedSPL version
105585methotrexate 2.5 MG Oral TabletPSN89c05ea3-3be1-46dd-b112-29c436fd72896
105585methotrexate 2.5 MG Oral TabletSCD89c05ea3-3be1-46dd-b112-29c436fd72896
105585methotrexate 2.5 MG (as methotrexate sodium) Oral TabletSY89c05ea3-3be1-46dd-b112-29c436fd72896

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionUnitsMarketing startSampleExclude flagStatus
64850-330-0164850033001100 TABLET in 1 BOTTLE, PLASTIC (64850-330-01) 100 tablet2024-05-16NoNoCurrent