FDA.reportPublic FDA data

Valsartan and Hydrochlorothiazide

Product NDC
65162-849
Requested package NDC
65162-849-11
11-digit product format
651620849
Labeler code
65162
Product ID
65162-849_e40f4475-c8d3-48a6-913f-cf7c8c7b119b
Type
HUMAN PRESCRIPTION DRUG
Nonproprietary name
Valsartan and Hydrochlorothiazide
Dosage form
TABLET, FILM COATED
Route
ORAL
Labeler
Amneal Pharmaceuticals LLC
Application
ANDA204382
Marketing category
ANDA
Marketing start
2023-08-14
Substance
VALSARTAN; HYDROCHLOROTHIAZIDE
Active strength
320; 25 mg/1; mg/1
Pharmacologic classes
Angiotensin 2 Receptor Antagonists [MoA], Angiotensin 2 Receptor Blocker [EPC], Increased Diuresis [PE], Thiazide Diuretic [EPC], Thiazides [CS]
NDC exclude flag
No
Listing certified through
2026-12-31
Current FDA listing
Yes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 43.

Orange Book products#

Current product rows page 1 of 1 · 5 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
A204382-001VALSARTAN AND HYDROCHLOROTHIAZIDEHYDROCHLOROTHIAZIDE; VALSARTAN12.5MG;80MGTABLET / ORALAB2023-08-11
A204382-002VALSARTAN AND HYDROCHLOROTHIAZIDEHYDROCHLOROTHIAZIDE; VALSARTAN12.5MG;160MGTABLET / ORALAB2023-08-11
A204382-003VALSARTAN AND HYDROCHLOROTHIAZIDEHYDROCHLOROTHIAZIDE; VALSARTAN25MG;160MGTABLET / ORALAB2023-08-11
A204382-004VALSARTAN AND HYDROCHLOROTHIAZIDEHYDROCHLOROTHIAZIDE; VALSARTAN12.5MG;320MGTABLET / ORALAB2023-08-11
A204382-005VALSARTAN AND HYDROCHLOROTHIAZIDEHYDROCHLOROTHIAZIDE; VALSARTAN25MG;320MGTABLET / ORALAB2023-08-11

Therapeutic equivalence codes#

Current TE-code rows page 1 of 1 · 5 matching rows.

Application-product, TE code table
Application-productTE code
A204382-001AB
A204382-002AB
A204382-003AB
A204382-004AB
A204382-005AB

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Product history page 1 of 3 · 110 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-09-14 22:38:342026-08A204382-001VALSARTAN AND HYDROCHLOROTHIAZIDE12.5MG;80MGTABLET / ORALAB2023-08-1184e616aacf4f…
2026-09-14 22:38:342026-08A204382-002VALSARTAN AND HYDROCHLOROTHIAZIDE12.5MG;160MGTABLET / ORALAB2023-08-1184e616aacf4f…
2026-09-14 22:38:342026-08A204382-003VALSARTAN AND HYDROCHLOROTHIAZIDE25MG;160MGTABLET / ORALAB2023-08-1184e616aacf4f…
2026-09-14 22:38:342026-08A204382-004VALSARTAN AND HYDROCHLOROTHIAZIDE12.5MG;320MGTABLET / ORALAB2023-08-1184e616aacf4f…
2026-09-14 22:38:342026-08A204382-005VALSARTAN AND HYDROCHLOROTHIAZIDE25MG;320MGTABLET / ORALAB2023-08-1184e616aacf4f…
2026-08-18 06:07:402026-07A204382-001VALSARTAN AND HYDROCHLOROTHIAZIDE12.5MG;80MGTABLET / ORALAB2023-08-11caaa826d4ba7…
2026-08-18 06:07:402026-07A204382-002VALSARTAN AND HYDROCHLOROTHIAZIDE12.5MG;160MGTABLET / ORALAB2023-08-11caaa826d4ba7…
2026-08-18 06:07:402026-07A204382-003VALSARTAN AND HYDROCHLOROTHIAZIDE25MG;160MGTABLET / ORALAB2023-08-11caaa826d4ba7…
2026-08-18 06:07:402026-07A204382-004VALSARTAN AND HYDROCHLOROTHIAZIDE12.5MG;320MGTABLET / ORALAB2023-08-11caaa826d4ba7…
2026-08-18 06:07:402026-07A204382-005VALSARTAN AND HYDROCHLOROTHIAZIDE25MG;320MGTABLET / ORALAB2023-08-11caaa826d4ba7…
2026-02-19 14:30 UTC2026-02A204382-001VALSARTAN AND HYDROCHLOROTHIAZIDE12.5MG;80MGTABLET / ORALAB2023-08-11011fe1cb6892…
2026-02-19 14:30 UTC2026-02A204382-002VALSARTAN AND HYDROCHLOROTHIAZIDE12.5MG;160MGTABLET / ORALAB2023-08-11011fe1cb6892…
2026-02-19 14:30 UTC2026-02A204382-003VALSARTAN AND HYDROCHLOROTHIAZIDE25MG;160MGTABLET / ORALAB2023-08-11011fe1cb6892…
2026-02-19 14:30 UTC2026-02A204382-004VALSARTAN AND HYDROCHLOROTHIAZIDE12.5MG;320MGTABLET / ORALAB2023-08-11011fe1cb6892…
2026-02-19 14:30 UTC2026-02A204382-005VALSARTAN AND HYDROCHLOROTHIAZIDE25MG;320MGTABLET / ORALAB2023-08-11011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A204382-001VALSARTAN AND HYDROCHLOROTHIAZIDE12.5MG;80MGTABLET / ORALAB2023-08-1131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A204382-002VALSARTAN AND HYDROCHLOROTHIAZIDE12.5MG;160MGTABLET / ORALAB2023-08-1131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A204382-003VALSARTAN AND HYDROCHLOROTHIAZIDE25MG;160MGTABLET / ORALAB2023-08-1131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A204382-004VALSARTAN AND HYDROCHLOROTHIAZIDE12.5MG;320MGTABLET / ORALAB2023-08-1131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A204382-005VALSARTAN AND HYDROCHLOROTHIAZIDE25MG;320MGTABLET / ORALAB2023-08-1131067a03dcf5…
2025-08-23 18:47 UTC2025-08A204382-001VALSARTAN AND HYDROCHLOROTHIAZIDE12.5MG;80MGTABLET / ORALAB2023-08-116a471c1ec25d…
2025-08-23 18:47 UTC2025-08A204382-002VALSARTAN AND HYDROCHLOROTHIAZIDE12.5MG;160MGTABLET / ORALAB2023-08-116a471c1ec25d…
2025-08-23 18:47 UTC2025-08A204382-003VALSARTAN AND HYDROCHLOROTHIAZIDE25MG;160MGTABLET / ORALAB2023-08-116a471c1ec25d…
2025-08-23 18:47 UTC2025-08A204382-004VALSARTAN AND HYDROCHLOROTHIAZIDE12.5MG;320MGTABLET / ORALAB2023-08-116a471c1ec25d…
2025-08-23 18:47 UTC2025-08A204382-005VALSARTAN AND HYDROCHLOROTHIAZIDE25MG;320MGTABLET / ORALAB2023-08-116a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A204382-001VALSARTAN AND HYDROCHLOROTHIAZIDE12.5MG;80MGTABLET / ORALAB2023-08-11fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A204382-002VALSARTAN AND HYDROCHLOROTHIAZIDE12.5MG;160MGTABLET / ORALAB2023-08-11fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A204382-003VALSARTAN AND HYDROCHLOROTHIAZIDE25MG;160MGTABLET / ORALAB2023-08-11fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A204382-004VALSARTAN AND HYDROCHLOROTHIAZIDE12.5MG;320MGTABLET / ORALAB2023-08-11fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A204382-005VALSARTAN AND HYDROCHLOROTHIAZIDE25MG;320MGTABLET / ORALAB2023-08-11fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A204382-001VALSARTAN AND HYDROCHLOROTHIAZIDE12.5MG;80MGTABLET / ORALAB2023-08-11b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A204382-002VALSARTAN AND HYDROCHLOROTHIAZIDE12.5MG;160MGTABLET / ORALAB2023-08-11b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A204382-003VALSARTAN AND HYDROCHLOROTHIAZIDE25MG;160MGTABLET / ORALAB2023-08-11b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A204382-004VALSARTAN AND HYDROCHLOROTHIAZIDE12.5MG;320MGTABLET / ORALAB2023-08-11b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A204382-005VALSARTAN AND HYDROCHLOROTHIAZIDE25MG;320MGTABLET / ORALAB2023-08-11b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A204382-001VALSARTAN AND HYDROCHLOROTHIAZIDE12.5MG;80MGTABLET / ORALAB2023-08-1103ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A204382-002VALSARTAN AND HYDROCHLOROTHIAZIDE12.5MG;160MGTABLET / ORALAB2023-08-1103ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A204382-003VALSARTAN AND HYDROCHLOROTHIAZIDE25MG;160MGTABLET / ORALAB2023-08-1103ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A204382-004VALSARTAN AND HYDROCHLOROTHIAZIDE12.5MG;320MGTABLET / ORALAB2023-08-1103ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A204382-005VALSARTAN AND HYDROCHLOROTHIAZIDE25MG;320MGTABLET / ORALAB2023-08-1103ed91905a0d…

Observed Orange Book normalized TE history#

Normalized TE history page 1 of 3 · 110 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTE codeOrderSource SHA-256
2026-09-14 22:38:342026-08A204382-001AB184e616aacf4f…
2026-09-14 22:38:342026-08A204382-002AB184e616aacf4f…
2026-09-14 22:38:342026-08A204382-003AB184e616aacf4f…
2026-09-14 22:38:342026-08A204382-004AB184e616aacf4f…
2026-09-14 22:38:342026-08A204382-005AB184e616aacf4f…
2026-08-18 06:07:402026-07A204382-001AB1caaa826d4ba7…
2026-08-18 06:07:402026-07A204382-002AB1caaa826d4ba7…
2026-08-18 06:07:402026-07A204382-003AB1caaa826d4ba7…
2026-08-18 06:07:402026-07A204382-004AB1caaa826d4ba7…
2026-08-18 06:07:402026-07A204382-005AB1caaa826d4ba7…
2026-02-19 14:30 UTC2026-02A204382-001AB1011fe1cb6892…
2026-02-19 14:30 UTC2026-02A204382-002AB1011fe1cb6892…
2026-02-19 14:30 UTC2026-02A204382-003AB1011fe1cb6892…
2026-02-19 14:30 UTC2026-02A204382-004AB1011fe1cb6892…
2026-02-19 14:30 UTC2026-02A204382-005AB1011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A204382-001AB131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A204382-002AB131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A204382-003AB131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A204382-004AB131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A204382-005AB131067a03dcf5…
2025-08-23 18:47 UTC2025-08A204382-001AB16a471c1ec25d…
2025-08-23 18:47 UTC2025-08A204382-002AB16a471c1ec25d…
2025-08-23 18:47 UTC2025-08A204382-003AB16a471c1ec25d…
2025-08-23 18:47 UTC2025-08A204382-004AB16a471c1ec25d…
2025-08-23 18:47 UTC2025-08A204382-005AB16a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A204382-001AB1fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A204382-002AB1fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A204382-003AB1fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A204382-004AB1fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A204382-005AB1fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A204382-001AB1b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A204382-002AB1b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A204382-003AB1b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A204382-004AB1b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A204382-005AB1b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A204382-001AB103ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A204382-002AB103ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A204382-003AB103ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A204382-004AB103ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A204382-005AB103ed91905a0d…

Reported adverse events (FAERS/openFDA)#

Adverse event summaries are temporarily unavailable. Other product information remains available.

Additional Listing Data#

Finished product
Yes
Brand name base
Valsartan and Hydrochlorothiazide
Listing expiration
2026-12-31

Active Ingredients#

Ingredient, Strength table
IngredientStrength
VALSARTAN320 mg/1
HYDROCHLOROTHIAZIDE25 mg/1

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 2 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
80M03YXJ7IInternal UNII lookup
0J48LPH2THInternal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 5 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
200284Internal RxNorm lookup
200285Internal RxNorm lookup
349353Internal RxNorm lookup
636042Internal RxNorm lookup
636045Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
c9acbc95-3629-4276-842b-5c074844dba7Available on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product conceptRelationVersionEffective
692a3434-fece-49c6-9b7d-ed7aefc52b50Product name320260317
c19ec24d-2c40-4b8d-7c20-500ffa3660a1Product name320260303
1199f4b7-b537-466c-9a1c-cb09131e9f8bProduct name120251117
e1a63b6e-1877-c2c1-01a3-03ea2817aa6fProduct name320251027
b15e9aa6-d523-ca97-480e-570e0543a342Product name420251024
265792b3-b999-c010-7364-a7db20b9d4d9Product name520250515
96816964-c075-ffa7-b7b8-d8570411a3b9Product name720250305
e7dfdaab-7cf9-4f89-804c-eff5108d94d1Product name920250305
b6abae2f-ee27-47bc-b150-54dc8d969483Product name220250221
52311e76-a520-4bd2-9d5b-e0b6d6f44519Product name220231208
162cbc9d-ecc3-72ba-af9f-c76e2756ef54Product name320221207
9b303cd4-3186-2454-5706-3137e8b2dfd2Product name420221110
47fc2fe9-7afb-4be9-989d-787aaa6ad0eaProduct name120200505
a8e65197-7914-7acf-c7ec-914d53819b34Product name320190624
8b67f333-47d1-8464-7ce4-406d3dbb295fProduct name720190618
89a57420-ab44-5323-14f9-595159145f9bProduct name220190612
c27b049d-3258-48cf-ebe5-08c236ae78e2Product name320190610
00fc2cf9-672f-3e0b-6afa-43cbc864d058Product name420180613
15b375b1-89c7-9594-80df-5a8c8864aee0Product name320180108
a7349398-661d-d9fc-46df-7e128bbd61d9Product name520171113
1bdb87cf-9b1f-6a51-5eb7-d182aaffaa3dProduct name220170719
e0eeb018-194e-4b70-a57d-bac47a97b8eaProduct name120160825
55bffd21-17e1-ff02-2e8f-1f9a532b9502Product name220150320
ea069444-e874-4c28-833f-d2f52734ef4dProduct name120150206
041df61b-f8b6-48a6-7b67-411e1412678bProduct name120140508
0ad8bdca-888e-00da-648b-6a4de854a167Product name120140508
433a3439-b8f3-d13a-d2c8-9b221d628d60Product name120140508
59212689-39e5-a976-6d21-882d76d8079aProduct name120140508
7613b1a5-acb6-4e5e-6048-c44deeeb1212Product name120140508
78637fb0-95c8-441f-e4b4-db1274b6f956Product name120140508
df89bd47-2db4-d593-ab37-d11953fd5536Product name120140508
f151007d-265d-9fbe-857d-1d44f1cb76baProduct name120140508
f5231d08-c52b-a5a0-ba93-675895c292beProduct name120140508

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDCProductDescriptionFormQuantityStrengthSPL version
65162-849-03Valsartan and Hydrochlorothiazide30 in 1 BOTTLETABLET, FILM COATED3012
65162-849-09Valsartan and Hydrochlorothiazide90 in 1 BOTTLETABLET, FILM COATED9012
65162-849-11Valsartan and Hydrochlorothiazide1000 in 1 BOTTLETABLET, FILM COATED100012
65162-849-50Valsartan and Hydrochlorothiazide500 in 1 BOTTLETABLET, FILM COATED50012

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDCDashboard titleSPL versionValidationDashboard ZIP
65162-849VALSARTAN AND HYDROCHLOROTHIAZIDE TABLET, FILM COATED [AMNEAL PHARMACEUTICALS LLC]12Current NDC, 4 package rows20241031_c9acbc95-3629-4276-842b-5c074844dba7.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 3 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
Valsartan and HydrochlorothiazideVALSARTAN AND HYDROCHLOROTHIAZIDEAvKARE05ba1369-6484-75d4-e063-6294a90a63e42026-01-19Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 204382
application number: ANDA204382
Valsartan and HydrochlorothiazideVALSARTAN AND HYDROCHLOROTHIAZIDEAmneal Pharmaceuticals of New York LLCd5a1db33-3046-407c-a557-6b41642164a92023-05-08Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 204382
application number: ANDA204382
Valsartan and HydrochlorothiazideVALSARTAN AND HYDROCHLOROTHIAZIDEAmneal Pharmaceuticals LLCc9acbc95-3629-4276-842b-5c074844dba72019-02-02Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 204382
application number: ANDA204382
ndc (package): 65162-849-11
ndc (product): 65162-849
ndc11 (package): 65162084911

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUIRxNorm stringTTYDailyMedSPL version
200284HCTZ 12.5 MG / valsartan 80 MG Oral TabletPSNc9acbc95-3629-4276-842b-5c074844dba712
200285valsartan 160 MG / hydroCHLOROthiazide 12.5 MG Oral TabletPSNc9acbc95-3629-4276-842b-5c074844dba712
349353valsartan 160 MG / hydroCHLOROthiazide 25 MG Oral TabletPSNc9acbc95-3629-4276-842b-5c074844dba712
636042valsartan 320 MG / hydroCHLOROthiazide 12.5 MG Oral TabletPSNc9acbc95-3629-4276-842b-5c074844dba712
636045valsartan 320 MG / hydroCHLOROthiazide 25 MG Oral TabletPSNc9acbc95-3629-4276-842b-5c074844dba712
200285hydrochlorothiazide 12.5 MG / valsartan 160 MG Oral TabletSCDc9acbc95-3629-4276-842b-5c074844dba712
636042hydrochlorothiazide 12.5 MG / valsartan 320 MG Oral TabletSCDc9acbc95-3629-4276-842b-5c074844dba712
200284hydrochlorothiazide 12.5 MG / valsartan 80 MG Oral TabletSCDc9acbc95-3629-4276-842b-5c074844dba712
349353hydrochlorothiazide 25 MG / valsartan 160 MG Oral TabletSCDc9acbc95-3629-4276-842b-5c074844dba712
636045hydrochlorothiazide 25 MG / valsartan 320 MG Oral TabletSCDc9acbc95-3629-4276-842b-5c074844dba712
200285HCTZ 12.5 MG / valsartan 160 MG Oral TabletSYc9acbc95-3629-4276-842b-5c074844dba712
636042HCTZ 12.5 MG / valsartan 320 MG Oral TabletSYc9acbc95-3629-4276-842b-5c074844dba712
200284HCTZ 12.5 MG / valsartan 80 MG Oral TabletSYc9acbc95-3629-4276-842b-5c074844dba712
349353HCTZ 25 MG / valsartan 160 MG Oral TabletSYc9acbc95-3629-4276-842b-5c074844dba712
636045HCTZ 25 MG / valsartan 320 MG Oral TabletSYc9acbc95-3629-4276-842b-5c074844dba712

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionMarketing startSampleExclude flagStatus
65162-849-11651620849111000 TABLET, FILM COATED in 1 BOTTLE (65162-849-11) 2023-08-14NoNoCurrent