Gadobutrol

Product NDC
65219-281
11-digit product format
652190281
Labeler code
65219
Product ID
65219-281_490c8c3e-3195-40af-8f34-40d8df2719c3
Type
HUMAN PRESCRIPTION DRUG
Nonproprietary name
Gadobutrol
Dosage form
INJECTION
Route
INTRAVENOUS
Labeler
Fresenius Kabi USA, LLC
Application
ANDA215061
Marketing category
ANDA
Marketing start
2023-04-14
Substance
GADOBUTROL
Active strength
604.72 mg/mL
Pharmacologic classes
Gadolinium-based Contrast Agent [EPC], Magnetic Resonance Contrast Activity [MoA]
NDC exclude flag
No
Listing certified through
2026-12-31
Current FDA listing
Yes

Source provenance: Browse the complete Orange Book source catalog.

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Product history page 1 of 2 · 48 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A215061-001GADOBUTROL1.20944GM/2ML (604.72MG/ML)SOLUTION / INTRAVENOUSAP2022-11-17301d65b070ca…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A215061-002GADOBUTROL4.5354GM/7.5ML (604.72MG/ML)SOLUTION / INTRAVENOUSAP2022-11-17301d65b070ca…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A215061-003GADOBUTROL6.0472GM/10ML (604.72MG/ML)SOLUTION / INTRAVENOUSAP2022-11-17301d65b070ca…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A215061-004GADOBUTROL9.0708GM/15ML (604.72MG/ML)SOLUTION / INTRAVENOUSAP2022-11-17301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A215061-001GADOBUTROL1.20944GM/2ML (604.72MG/ML)SOLUTION / INTRAVENOUSAP2022-11-171e350fbaab3a…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A215061-002GADOBUTROL4.5354GM/7.5ML (604.72MG/ML)SOLUTION / INTRAVENOUSAP2022-11-171e350fbaab3a…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A215061-003GADOBUTROL6.0472GM/10ML (604.72MG/ML)SOLUTION / INTRAVENOUSAP2022-11-171e350fbaab3a…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A215061-004GADOBUTROL9.0708GM/15ML (604.72MG/ML)SOLUTION / INTRAVENOUSAP2022-11-171e350fbaab3a…
2024-05-31 18:47 UTC2024-05A215061-001GADOBUTROL1.20944GM/2ML (604.72MG/ML)SOLUTION / INTRAVENOUSAP2022-11-178072bd15b7f6…
2024-05-31 18:47 UTC2024-05A215061-002GADOBUTROL4.5354GM/7.5ML (604.72MG/ML)SOLUTION / INTRAVENOUSAP2022-11-178072bd15b7f6…
2024-05-31 18:47 UTC2024-05A215061-003GADOBUTROL6.0472GM/10ML (604.72MG/ML)SOLUTION / INTRAVENOUSAP2022-11-178072bd15b7f6…
2024-05-31 18:47 UTC2024-05A215061-004GADOBUTROL9.0708GM/15ML (604.72MG/ML)SOLUTION / INTRAVENOUSAP2022-11-178072bd15b7f6…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A215061-001GADOBUTROL1.20944GM/2ML (604.72MG/ML)SOLUTION / INTRAVENOUSAP2022-11-176a51e52b5d6a…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A215061-002GADOBUTROL4.5354GM/7.5ML (604.72MG/ML)SOLUTION / INTRAVENOUSAP2022-11-176a51e52b5d6a…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A215061-003GADOBUTROL6.0472GM/10ML (604.72MG/ML)SOLUTION / INTRAVENOUSAP2022-11-176a51e52b5d6a…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A215061-004GADOBUTROL9.0708GM/15ML (604.72MG/ML)SOLUTION / INTRAVENOUSAP2022-11-176a51e52b5d6a…
2024-02-18 07:12 UTC2024-02A215061-001GADOBUTROL1.20944GM/2ML (604.72MG/ML)SOLUTION / INTRAVENOUSAP2022-11-171c564ffb4f44…
2024-02-18 07:12 UTC2024-02A215061-002GADOBUTROL4.5354GM/7.5ML (604.72MG/ML)SOLUTION / INTRAVENOUSAP2022-11-171c564ffb4f44…
2024-02-18 07:12 UTC2024-02A215061-003GADOBUTROL6.0472GM/10ML (604.72MG/ML)SOLUTION / INTRAVENOUSAP2022-11-171c564ffb4f44…
2024-02-18 07:12 UTC2024-02A215061-004GADOBUTROL9.0708GM/15ML (604.72MG/ML)SOLUTION / INTRAVENOUSAP2022-11-171c564ffb4f44…
2023-12-20 04:57 UTC2023-12A215061-001GADOBUTROL1.20944GM/2ML (604.72MG/ML)SOLUTION / INTRAVENOUSAP2022-11-17ea1830bbd6c7…
2023-12-20 04:57 UTC2023-12A215061-002GADOBUTROL4.5354GM/7.5ML (604.72MG/ML)SOLUTION / INTRAVENOUSAP2022-11-17ea1830bbd6c7…
2023-12-20 04:57 UTC2023-12A215061-003GADOBUTROL6.0472GM/10ML (604.72MG/ML)SOLUTION / INTRAVENOUSAP2022-11-17ea1830bbd6c7…
2023-12-20 04:57 UTC2023-12A215061-004GADOBUTROL9.0708GM/15ML (604.72MG/ML)SOLUTION / INTRAVENOUSAP2022-11-17ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11A215061-001GADOBUTROL1.20944GM/2ML (604.72MG/ML)SOLUTION / INTRAVENOUSAP2022-11-17a72a2bbeb626…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11A215061-002GADOBUTROL4.5354GM/7.5ML (604.72MG/ML)SOLUTION / INTRAVENOUSAP2022-11-17a72a2bbeb626…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11A215061-003GADOBUTROL6.0472GM/10ML (604.72MG/ML)SOLUTION / INTRAVENOUSAP2022-11-17a72a2bbeb626…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11A215061-004GADOBUTROL9.0708GM/15ML (604.72MG/ML)SOLUTION / INTRAVENOUSAP2022-11-17a72a2bbeb626…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10A215061-001GADOBUTROL1.20944GM/2ML (604.72MG/ML)SOLUTION / INTRAVENOUSAP2022-11-179b2671bbb829…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10A215061-002GADOBUTROL4.5354GM/7.5ML (604.72MG/ML)SOLUTION / INTRAVENOUSAP2022-11-179b2671bbb829…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10A215061-003GADOBUTROL6.0472GM/10ML (604.72MG/ML)SOLUTION / INTRAVENOUSAP2022-11-179b2671bbb829…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10A215061-004GADOBUTROL9.0708GM/15ML (604.72MG/ML)SOLUTION / INTRAVENOUSAP2022-11-179b2671bbb829…
2023-07-15 15:27 UTC · 2 captures of this ZIP2023-07A215061-001GADOBUTROL1.20944GM/2ML (604.72MG/ML)SOLUTION / INTRAVENOUSAP2022-11-17a67488948f0b…
2023-07-15 15:27 UTC · 2 captures of this ZIP2023-07A215061-002GADOBUTROL4.5354GM/7.5ML (604.72MG/ML)SOLUTION / INTRAVENOUSAP2022-11-17a67488948f0b…
2023-07-15 15:27 UTC · 2 captures of this ZIP2023-07A215061-003GADOBUTROL6.0472GM/10ML (604.72MG/ML)SOLUTION / INTRAVENOUSAP2022-11-17a67488948f0b…
2023-07-15 15:27 UTC · 2 captures of this ZIP2023-07A215061-004GADOBUTROL9.0708GM/15ML (604.72MG/ML)SOLUTION / INTRAVENOUSAP2022-11-17a67488948f0b…
2023-06-13 01:57 UTC · 3 captures of this ZIP2023-06A215061-001GADOBUTROL1.20944GM/2ML (604.72MG/ML)SOLUTION / INTRAVENOUSAP2022-11-173f0d92c62455…
2023-06-13 01:57 UTC · 3 captures of this ZIP2023-06A215061-002GADOBUTROL4.5354GM/7.5ML (604.72MG/ML)SOLUTION / INTRAVENOUSAP2022-11-173f0d92c62455…
2023-06-13 01:57 UTC · 3 captures of this ZIP2023-06A215061-003GADOBUTROL6.0472GM/10ML (604.72MG/ML)SOLUTION / INTRAVENOUSAP2022-11-173f0d92c62455…
2023-06-13 01:57 UTC · 3 captures of this ZIP2023-06A215061-004GADOBUTROL9.0708GM/15ML (604.72MG/ML)SOLUTION / INTRAVENOUSAP2022-11-173f0d92c62455…

Observed Orange Book normalized TE history#

Normalized TE history page 1 of 2 · 48 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTE codeOrderSource SHA-256
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A215061-001AP1301d65b070ca…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A215061-002AP1301d65b070ca…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A215061-003AP1301d65b070ca…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A215061-004AP1301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A215061-001AP11e350fbaab3a…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A215061-002AP11e350fbaab3a…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A215061-003AP11e350fbaab3a…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A215061-004AP11e350fbaab3a…
2024-05-31 18:47 UTC2024-05A215061-001AP18072bd15b7f6…
2024-05-31 18:47 UTC2024-05A215061-002AP18072bd15b7f6…
2024-05-31 18:47 UTC2024-05A215061-003AP18072bd15b7f6…
2024-05-31 18:47 UTC2024-05A215061-004AP18072bd15b7f6…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A215061-001AP16a51e52b5d6a…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A215061-002AP16a51e52b5d6a…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A215061-003AP16a51e52b5d6a…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A215061-004AP16a51e52b5d6a…
2024-02-18 07:12 UTC2024-02A215061-001AP11c564ffb4f44…
2024-02-18 07:12 UTC2024-02A215061-002AP11c564ffb4f44…
2024-02-18 07:12 UTC2024-02A215061-003AP11c564ffb4f44…
2024-02-18 07:12 UTC2024-02A215061-004AP11c564ffb4f44…
2023-12-20 04:57 UTC2023-12A215061-001AP1ea1830bbd6c7…
2023-12-20 04:57 UTC2023-12A215061-002AP1ea1830bbd6c7…
2023-12-20 04:57 UTC2023-12A215061-003AP1ea1830bbd6c7…
2023-12-20 04:57 UTC2023-12A215061-004AP1ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11A215061-001AP1a72a2bbeb626…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11A215061-002AP1a72a2bbeb626…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11A215061-003AP1a72a2bbeb626…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11A215061-004AP1a72a2bbeb626…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10A215061-001AP19b2671bbb829…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10A215061-002AP19b2671bbb829…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10A215061-003AP19b2671bbb829…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10A215061-004AP19b2671bbb829…
2023-07-15 15:27 UTC · 2 captures of this ZIP2023-07A215061-001AP1a67488948f0b…
2023-07-15 15:27 UTC · 2 captures of this ZIP2023-07A215061-002AP1a67488948f0b…
2023-07-15 15:27 UTC · 2 captures of this ZIP2023-07A215061-003AP1a67488948f0b…
2023-07-15 15:27 UTC · 2 captures of this ZIP2023-07A215061-004AP1a67488948f0b…
2023-06-13 01:57 UTC · 3 captures of this ZIP2023-06A215061-001AP13f0d92c62455…
2023-06-13 01:57 UTC · 3 captures of this ZIP2023-06A215061-002AP13f0d92c62455…
2023-06-13 01:57 UTC · 3 captures of this ZIP2023-06A215061-003AP13f0d92c62455…
2023-06-13 01:57 UTC · 3 captures of this ZIP2023-06A215061-004AP13f0d92c62455…

Additional Listing Data#

Finished product
Yes
Brand name base
Gadobutrol
Listing expiration
2026-12-31

Active Ingredients#

Ingredient, Strength table
IngredientStrength
GADOBUTROL604.72 mg/mL

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
1BJ477IO2LInternal UNII lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
007696d0-4b62-4937-9640-4ad619504df4Available on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product conceptRelationVersionEffective
77dc03a4-fbfc-e6a3-fe95-285bbae40d75Product name220250814
5b2d15dc-225b-aca9-f9ef-b38666fe1e57Product name420250620
c34d3757-8380-f2a9-d77b-04fccc1c986eProduct name420250226
3c386306-c48a-413e-bb69-70cb268496f3Product name120210727
3c495eba-e7eb-cf97-a376-25ae31b0cc54Product name120140508
51162ac0-9a99-d9a1-b417-523615d04171Product name120140508

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDCProductDescriptionFormQuantityStrengthSPL version
65219-281-00Gadobutrol2 mL in 1 VIAL, SINGLE-DOSEINJECTION23
65219-281-02Gadobutrol3 in 1 CARTONINJECTION33
65219-281-02Gadobutrol5 in 1 BOXINJECTION53
65219-281-03Gadobutrol7.5 mL in 1 VIAL, SINGLE-DOSEINJECTION7.53
65219-281-05Gadobutrol15 mL in 1 VIAL, SINGLE-DOSEINJECTION153
65219-281-07Gadobutrol10 in 1 CARTONINJECTION103
65219-281-07Gadobutrol2 in 1 BOXINJECTION23
65219-281-08Gadobutrol10 mL in 1 VIAL, SINGLE-DOSEINJECTION103
65219-281-10Gadobutrol10 in 1 CARTONINJECTION103
65219-281-10Gadobutrol2 in 1 BOXINJECTION23
65219-281-15Gadobutrol10 in 1 CARTONINJECTION103
65219-281-15Gadobutrol2 in 1 BOXINJECTION23

DailyMed Billing Units#

Package NDC, Billing unit, Product NDC table
Package NDCBilling unitProduct NDCDailyMed indexing SPLSPL versionEffective
65219-281-00ML - Milliliter65219-281273c0413-88f9-4927-970f-5828015629a212023-08-08
65219-281-02ML - Milliliter65219-281940a2b60-1fab-41ce-82d4-15220f38969112023-08-08
65219-281-03ML - Milliliter65219-281a4279d8f-cf98-4527-b747-9e196c1844a412023-08-08
65219-281-05ML - Milliliter65219-28117da6f10-18c3-4d3d-bbae-3f715f703eb112023-08-08
65219-281-07ML - Milliliter65219-281b7d8a359-61db-4ded-a1e2-3c40eea22a5d12023-08-08
65219-281-08ML - Milliliter65219-2811d458f43-36a1-4389-b635-1a91762ba07812023-08-08
65219-281-10ML - Milliliter65219-28199027c20-79d7-4c70-bfa9-78ad46fc19ca12023-08-08
65219-281-15ML - Milliliter65219-2818980610e-44fb-43a8-8815-31a9866d08f012023-08-08

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDCDashboard titleSPL versionValidationDashboard ZIP
65219-281GADOBUTROL INJECTION [FRESENIUS KABI USA, LLC]2Current NDC, 12 package rows20250119_007696d0-4b62-4937-9640-4ad619504df4.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 1 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
GadobutrolGADOBUTROLFresenius Kabi USA, LLC007696d0-4b62-4937-9640-4ad619504df42025-07-15Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 215061
application number: ANDA215061
ndc (product): 65219-281

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionUnitsMarketing startSampleExclude flagStatus
65219-281-00652190281002 mL in 1 VIAL, SINGLE-DOSE2 mlHistorical
65219-281-02652190281025 CARTON in 1 BOX (65219-281-02) / 3 VIAL, SINGLE-DOSE in 1 CARTON / 2 mL in 1 VIAL, SINGLE-DOSE (65219-281-00) 5 carton2023-04-14NoNoCurrent
65219-281-03652190281037.5 mL in 1 VIAL, SINGLE-DOSE7.5 mlHistorical
65219-281-056521902810515 mL in 1 VIAL, SINGLE-DOSE15 mlHistorical
65219-281-07652190281072 CARTON in 1 BOX (65219-281-07) / 10 VIAL, SINGLE-DOSE in 1 CARTON / 7.5 mL in 1 VIAL, SINGLE-DOSE (65219-281-03) 2 carton2023-04-14NoNoCurrent
65219-281-086521902810810 mL in 1 VIAL, SINGLE-DOSE10 mlHistorical
65219-281-10652190281102 CARTON in 1 BOX (65219-281-10) / 10 VIAL, SINGLE-DOSE in 1 CARTON / 10 mL in 1 VIAL, SINGLE-DOSE (65219-281-08) 2 carton2023-04-14NoNoCurrent
65219-281-15652190281152 CARTON in 1 BOX (65219-281-15) / 10 VIAL, SINGLE-DOSE in 1 CARTON / 15 mL in 1 VIAL, SINGLE-DOSE (65219-281-05) 2 carton2023-04-14NoNoCurrent