OPSYNVI

Product NDC
66215-814
11-digit product format
662150814
Labeler code
66215
Product ID
66215-814_32840e17-39b6-50b2-e063-6394a90a7a37
Type
HUMAN PRESCRIPTION DRUG
Nonproprietary name
macitentan and tadalafil
Dosage form
TABLET, FILM COATED
Route
ORAL
Labeler
Actelion Pharmaceuticals US, Inc.
Application
NDA218490
Marketing category
NDA
Marketing start
2024-03-22
Substance
MACITENTAN; TADALAFIL
Active strength
10; 40 mg/1; mg/1
Pharmacologic classes
Endothelin Receptor Antagonist [EPC], Endothelin Receptor Antagonists [MoA], Phosphodiesterase 5 Inhibitor [EPC], Phosphodiesterase 5 Inhibitors [MoA]
NDC exclude flag
No
Listing certified through
2026-12-31
Current FDA listing
Yes

Additional Listing Data#

Finished product
Yes
Brand name base
OPSYNVI
Listing expiration
2026-12-31

Active Ingredients#

Ingredient, Strength table
IngredientStrength
MACITENTAN10 mg/1
TADALAFIL40 mg/1

Harmonized Identifiers#

Field, Values table
FieldValues
Unii742SXX0ICT, Z9K9Y9WMVL
Rxcui2677765, 2677771, 2677773, 2677775

DailyMed Product Concepts#

Product concept, Relation, Version table
Product conceptRelationVersionEffective
b90b74cb-f6c8-3798-d11c-73b8768b278aProduct name820250317
0fe0157c-95a7-4870-ae64-de9f3fa874aeProduct name120250227
20ae0006-d78c-4dba-9e3e-6ae424841903Product name120250127
b86a08b7-54cc-440b-ad4a-3e530ccd8324Product name620230421
7a02e74a-2844-42af-84a8-96bae57351cfProduct name120230313
928d249c-35c3-4d88-a9ef-cf2f2e31b96fProduct name120220706
213da918-5ef0-42e4-b7f0-17d9bae8699aProduct name120151210

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDCProductDescriptionFormQuantityStrengthSPL version
66215-814-01OPSYNVI10 in 1 BLISTER PACKTABLET, FILM COATED103
66215-814-10OPSYNVI1 in 1 CARTONTABLET, FILM COATED13
66215-814-30OPSYNVI1 in 1 CARTONTABLET, FILM COATED13
66215-814-30OPSYNVI30 in 1 BOTTLETABLET, FILM COATED303

DailyMed Billing Units#

Package NDC, Billing unit, Product NDC table
Package NDCBilling unitProduct NDCDailyMed indexing SPLSPL versionEffective
66215-814-01EA - Each66215-81430ebed53-dfbd-4151-b025-10436232f85712024-04-05
66215-814-10EA - Each66215-814ce21938d-7abd-4664-a686-3ea9f7d8b08412024-04-05
66215-814-30EA - Each66215-814edf36104-5223-4bb4-8e54-6c479d3b876c12024-04-05

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDCDashboard titleSPL versionValidationDashboard ZIP
66215-814OPSYNVI (MACITENTAN AND TADALAFIL) TABLET, FILM COATED [ACTELION PHARMACEUTICALS US, INC.]3Current NDC, 4 package rows20250413_6945b183-18d3-40de-afd1-c88e33cc1a63.zip

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUIRxNorm stringTTYDailyMedSPL version
2677765macitentan 10 MG / tadalafil 20 MG Oral TabletPSN6945b183-18d3-40de-afd1-c88e33cc1a633
2677773macitentan 10 MG / tadalafil 40 MG Oral TabletPSN6945b183-18d3-40de-afd1-c88e33cc1a633
2677771Opsynvi 10 MG / 20 MG Oral TabletPSN6945b183-18d3-40de-afd1-c88e33cc1a633
2677775Opsynvi 10 MG / 40 MG Oral TabletPSN6945b183-18d3-40de-afd1-c88e33cc1a633
2677771macitentan 10 MG / tadalafil 20 MG Oral Tablet [Opsynvi]SBD6945b183-18d3-40de-afd1-c88e33cc1a633
2677775macitentan 10 MG / tadalafil 40 MG Oral Tablet [Opsynvi]SBD6945b183-18d3-40de-afd1-c88e33cc1a633
2677765macitentan 10 MG / tadalafil 20 MG Oral TabletSCD6945b183-18d3-40de-afd1-c88e33cc1a633
2677773macitentan 10 MG / tadalafil 40 MG Oral TabletSCD6945b183-18d3-40de-afd1-c88e33cc1a633
2677765macitentan 10 MG / tadalafil 20 MG Oral TabletSY6945b183-18d3-40de-afd1-c88e33cc1a633
2677773macitentan 10 MG / tadalafil 40 MG Oral TabletSY6945b183-18d3-40de-afd1-c88e33cc1a633
2677771Opsynvi (macitentan 10 MG / tadalafil 20 MG) Oral TabletSY6945b183-18d3-40de-afd1-c88e33cc1a633
2677775Opsynvi (macitentan 10 MG / tadalafil 40 MG) Oral TabletSY6945b183-18d3-40de-afd1-c88e33cc1a633

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionUnitsMarketing startSampleExclude flagStatus
66215-814-016621508140110 in 1 BLISTER PACKHistorical
66215-814-10662150814101 BLISTER PACK in 1 CARTON (66215-814-10) / 10 TABLET, FILM COATED in 1 BLISTER PACK (66215-814-01) 1 blister pack2024-03-22NoNoHistorical
66215-814-30662150814301 BOTTLE in 1 CARTON (66215-814-30) / 30 TABLET, FILM COATED in 1 BOTTLE1 bottle2024-03-22NoNoHistorical