PRO-RED

Product NDC: 66594-499
11-digit product format: 665940499
Labeler code: 66594
Product ID: 66594-499_cc958709-6208-4ae0-8d57-2361bf78d826
Type: HUMAN OTC DRUG
Nonproprietary name: Codeine Phosphate, Dexchorpheniramine Maleate, Phenylephrine Hydrochloride
Dosage form: SYRUP
Route: ORAL
Labeler: Pro-Pharma, LLC
Application: part341
Marketing category: OTC MONOGRAPH FINAL
Marketing start: 2013-09-30
Marketing end: 0000-00-00
Substance: CODEINE PHOSPHATE; DEXCHLORPHENIRAMINE MALEATE; PHENYLEPHRINE HYDROCHLORIDE
Active strength: 9 mg/5mL; mg/5mL; mg/5mL
DEA schedule: CV
NDC exclude flag: E
Listing certified through: 2017-12-31
Current FDA listing: Historical FDA.report record

NDC auxiliary status#

These records are reproduced from FDA’s unfinished, excluded, and compounder listings. They describe what appeared in the source files; a missing record does not establish a regulatory status. View all current auxiliary records, including entries without an NDC. · View the auxiliary file history.

Current NDC status page 1 of 1 · 3 matching rows.

Dataset, Scope, Product NDC table
Dataset	Scope	Product NDC	Package NDC	Code	Status	Source date
excluded product	product	66594-499		I	Inactivated by FDA	2026-10-05
excluded package	package	66594-499	66594-499-01	I	Inactivated by FDA	2026-10-05
excluded package	package	66594-499	66594-499-16	I	Inactivated by FDA	2026-10-05

Observed NDC auxiliary status history#

This history shows the information present in each captured FDA auxiliary file. It is not a continuous regulatory timeline, and a missing record does not establish a status.

Historic NDC status page 1 of 2 · 66 matching rows.

View current auxiliary records. · View the auxiliary file history.

Captured / source date, Dataset, Scope table
Captured / source date	Dataset	Scope	Package NDC	Snapshot	Source SHA-256
2025-12-14 17:58 UTC · source 2025-12-05	excluded product	product		`d630ba8d3edf…`	`732f749b63fb…`
2025-12-14 17:58 UTC · source 2025-12-05	excluded package	package	66594-499-16	`d630ba8d3edf…`	`732f749b63fb…`
2025-12-14 17:58 UTC · source 2025-12-05	excluded package	package	66594-499-01	`d630ba8d3edf…`	`732f749b63fb…`
2025-08-27 00:01 UTC · source 2025-08-26	excluded product	product		`f5e01cc5f278…`	`a2eaf40c39c3…`
2025-08-27 00:01 UTC · source 2025-08-26	excluded package	package	66594-499-16	`f5e01cc5f278…`	`a2eaf40c39c3…`
2025-08-27 00:01 UTC · source 2025-08-26	excluded package	package	66594-499-01	`f5e01cc5f278…`	`a2eaf40c39c3…`
2025-04-01 02:39 UTC · source 2025-03-31	excluded product	product		`2ef7874e63bc…`	`57b86245f4fa…`
2025-04-01 02:39 UTC · source 2025-03-31	excluded package	package	66594-499-16	`2ef7874e63bc…`	`57b86245f4fa…`
2025-04-01 02:39 UTC · source 2025-03-31	excluded package	package	66594-499-01	`2ef7874e63bc…`	`57b86245f4fa…`
2025-03-28 20:22 UTC · source 2025-03-28	excluded product	product		`a1b67e2a42f9…`	`c4cf2c586c0d…`
2025-03-28 20:22 UTC · source 2025-03-28	excluded package	package	66594-499-16	`a1b67e2a42f9…`	`c4cf2c586c0d…`
2025-03-28 20:22 UTC · source 2025-03-28	excluded package	package	66594-499-01	`a1b67e2a42f9…`	`c4cf2c586c0d…`
2025-03-22 03:12 UTC · source 2025-03-21	excluded product	product		`cfe11265f3b6…`	`090c488252e2…`
2025-03-22 03:12 UTC · source 2025-03-21	excluded package	package	66594-499-16	`cfe11265f3b6…`	`090c488252e2…`
2025-03-22 03:12 UTC · source 2025-03-21	excluded package	package	66594-499-01	`cfe11265f3b6…`	`090c488252e2…`
2025-03-10 12:48 UTC · source 2025-03-10	excluded product	product		`cdf11ea48f46…`	`ba0047e9e063…`
2025-03-10 12:48 UTC · source 2025-03-10	excluded package	package	66594-499-16	`cdf11ea48f46…`	`ba0047e9e063…`
2025-03-10 12:48 UTC · source 2025-03-10	excluded package	package	66594-499-01	`cdf11ea48f46…`	`ba0047e9e063…`
2025-02-02 03:52 UTC · source 2025-01-31	excluded product	product		`302b2466d912…`	`e7b80fea0513…`
2025-02-02 03:52 UTC · source 2025-01-31	excluded package	package	66594-499-16	`302b2466d912…`	`e7b80fea0513…`
2025-02-02 03:52 UTC · source 2025-01-31	excluded package	package	66594-499-01	`302b2466d912…`	`e7b80fea0513…`
2025-01-20 13:05 UTC · source 2025-01-20	excluded product	product		`ed331223b511…`	`672a5bd82f5f…`
2025-01-20 13:05 UTC · source 2025-01-20	excluded package	package	66594-499-16	`ed331223b511…`	`672a5bd82f5f…`
2025-01-20 13:05 UTC · source 2025-01-20	excluded package	package	66594-499-01	`ed331223b511…`	`672a5bd82f5f…`
2025-01-11 03:41 UTC · source 2025-01-10	excluded product	product		`0efc9e666f02…`	`f202fb6c5f17…`
2025-01-11 03:41 UTC · source 2025-01-10	excluded package	package	66594-499-16	`0efc9e666f02…`	`f202fb6c5f17…`
2025-01-11 03:41 UTC · source 2025-01-10	excluded package	package	66594-499-01	`0efc9e666f02…`	`f202fb6c5f17…`
2024-11-09 02:27 UTC · source 2024-11-08	excluded product	product		`ad56d346431e…`	`cc804d4bbf1e…`
2024-11-09 02:27 UTC · source 2024-11-08	excluded package	package	66594-499-16	`ad56d346431e…`	`cc804d4bbf1e…`
2024-11-09 02:27 UTC · source 2024-11-08	excluded package	package	66594-499-01	`ad56d346431e…`	`cc804d4bbf1e…`
2024-10-04 04:10 UTC · source 2024-10-03	excluded product	product		`367a005e9d99…`	`383a685ebd0f…`
2024-10-04 04:10 UTC · source 2024-10-03	excluded package	package	66594-499-16	`367a005e9d99…`	`383a685ebd0f…`
2024-10-04 04:10 UTC · source 2024-10-03	excluded package	package	66594-499-01	`367a005e9d99…`	`383a685ebd0f…`
2024-07-10 04:00 UTC · source 2024-07-09	excluded product	product		`557ba5c1ecfa…`	`9c80585c8c6e…`
2024-07-10 04:00 UTC · source 2024-07-09	excluded package	package	66594-499-16	`557ba5c1ecfa…`	`9c80585c8c6e…`
2024-07-10 04:00 UTC · source 2024-07-09	excluded package	package	66594-499-01	`557ba5c1ecfa…`	`9c80585c8c6e…`
2024-05-28 21:12 UTC · source 2024-05-28	excluded product	product		`8af77b9d5b6f…`	`d9bbb34c5368…`
2024-05-28 21:12 UTC · source 2024-05-28	excluded package	package	66594-499-16	`8af77b9d5b6f…`	`d9bbb34c5368…`
2024-05-28 21:12 UTC · source 2024-05-28	excluded package	package	66594-499-01	`8af77b9d5b6f…`	`d9bbb34c5368…`
2024-05-15 03:39 UTC · source 2024-05-14	excluded product	product		`834df4deac94…`	`adcc014656a3…`
2024-05-15 03:39 UTC · source 2024-05-14	excluded package	package	66594-499-16	`834df4deac94…`	`adcc014656a3…`
2024-05-15 03:39 UTC · source 2024-05-14	excluded package	package	66594-499-01	`834df4deac94…`	`adcc014656a3…`
2024-03-11 06:39 UTC · source 2024-03-08	excluded product	product		`1332a3947898…`	`d4bfe170f9cd…`
2024-03-11 06:39 UTC · source 2024-03-08	excluded package	package	66594-499-16	`1332a3947898…`	`d4bfe170f9cd…`
2024-03-11 06:39 UTC · source 2024-03-08	excluded package	package	66594-499-01	`1332a3947898…`	`d4bfe170f9cd…`
2022-08-30 03:57 UTC · source 2022-08-29	excluded product	product		`fb8cb913e6d1…`	`eb8c232b6be0…`
2022-08-30 03:57 UTC · source 2022-08-29	excluded package	package	66594-499-16	`fb8cb913e6d1…`	`eb8c232b6be0…`
2022-08-30 03:57 UTC · source 2022-08-29	excluded package	package	66594-499-01	`fb8cb913e6d1…`	`eb8c232b6be0…`
2022-04-09 23:13 UTC · source 2022-04-08	excluded product	product		`86f5da6cb304…`	`a595104c45d7…`
2022-04-09 23:13 UTC · source 2022-04-08	excluded package	package	66594-499-16	`86f5da6cb304…`	`a595104c45d7…`
2022-04-09 23:13 UTC · source 2022-04-08	excluded package	package	66594-499-01	`86f5da6cb304…`	`a595104c45d7…`
2022-04-04 05:40 UTC · source 2022-04-01	excluded product	product		`bd6a592717d7…`	`303034d00443…`
2022-04-04 05:40 UTC · source 2022-04-01	excluded package	package	66594-499-16	`bd6a592717d7…`	`303034d00443…`
2022-04-04 05:40 UTC · source 2022-04-01	excluded package	package	66594-499-01	`bd6a592717d7…`	`303034d00443…`
2021-12-27 23:28 UTC · source 2021-12-27	excluded product	product		`8dfbde2a14a4…`	`c9ff85d89658…`
2021-12-27 23:28 UTC · source 2021-12-27	excluded package	package	66594-499-16	`8dfbde2a14a4…`	`c9ff85d89658…`
2021-12-27 23:28 UTC · source 2021-12-27	excluded package	package	66594-499-01	`8dfbde2a14a4…`	`c9ff85d89658…`
2020-12-18 03:04 UTC · source 2020-12-17	excluded product	product		`e2bbac7714bc…`	`27bdfed8d636…`
2020-12-18 03:04 UTC · source 2020-12-17	excluded package	package	66594-499-16	`e2bbac7714bc…`	`27bdfed8d636…`
2020-12-18 03:04 UTC · source 2020-12-17	excluded package	package	66594-499-01	`e2bbac7714bc…`	`27bdfed8d636…`

Reported adverse events (FAERS/openFDA)#

Adverse event summaries are temporarily unavailable. Other product information remains available.

DailyMed Product Concepts#

Product concept, Relation, Version table
Product concept	Relation	Version	Effective
e4e263da-1c53-440f-bb80-b7a575843b5a	Product name	1	20260313
d2168cac-a261-415a-9c78-3522859fa720	Product name	3	20251124
05a8cdd1-eeb8-409e-b938-0778225eca7d	Product name	4	20250221
e5b5c132-b15d-435b-9faa-2f74e5cadcf9	Product name	8	20250220
f489e8f3-5c9e-4818-b539-a73587edcfc7	Product name	2	20240229
0f7ae452-206d-4fc4-868d-56fc47074084	Product name	1	20231011
41b814f3-0166-1c53-c9ef-a0794c7daf9d	Product name	3	20221110
a590be26-846c-8659-a5a1-fb25907965dc	Product name	2	20221110
09d8330d-4fec-be98-3a66-f985140646b2	Product name	2	20210513
20c8cafe-5cfc-44f8-a9be-a664f437f780	Product name	2	20200225
b5abe2e3-39a1-43eb-9bff-f3c1653fe3df	Product name	2	20190930
44893bf2-1be4-4e68-8bc4-bbb0f543085e	Product name	1	20180830
182f9ab4-4ab5-c449-200f-87ce2ce8e550	Product name	2	20151105
e0b6c8be-f2bd-9f86-a9fc-3ed56ffaa814	Product name	3	20150910
c6fba691-a132-4ede-95c6-f8c6bd696636	Product name	1	20150902
d5e51f11-ad28-caa4-4b49-4143974782ad	Product name	1	20150831
c0200ab5-4954-454e-9676-30b741b245bd	Product name	1	20150730
e9576821-a971-5261-628e-82ad9e10acdb	Product name	2	20150121
2a21311a-89e2-0e83-2ebd-117f9798b2b2	Product name	1	20140508
30c51294-7ae9-8007-7de6-58222684a0be	Product name	1	20140508
42f3c020-f1b3-89bc-7bdc-e1f10e680485	Product name	1	20140508
47fd879b-91c5-e1e5-130f-29d082a871ec	Product name	1	20140508
c35d1ac8-8885-2ee1-6c52-5a715b242c00	Product name	1	20140508
ce055423-1d7f-3c41-dff1-83660fa8cd96	Product name	1	20140508
e949165d-714d-e548-2b76-0cb5def16f30	Product name	1	20140508

FDA-Initiated Inactive NDC Indexing#

NDC, Effective, Action table
NDC	Effective	Action	Document	Indexing SPL	Related label
66594-499-01	2019-11-27	C162847	48780-1	9855e2a2-393f-60a7-e053-dbdaa90a05bd	PRO-RED AC SYRUP
66594-499-16	2019-11-27	C162847	48780-1	9855e2a2-393f-60a7-e053-dbdaa90a05bd	PRO-RED AC SYRUP

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDC	Product	Description	Form	Quantity	Strength	SPL version
66594-499-01	PRO-REDAC	30 mL in 1 BOTTLE	SYRUP	30		1
66594-499-16	PRO-REDAC	473 mL in 1 BOTTLE	SYRUP	473		1

DailyMed Billing Units#

Package NDC, Billing unit, Product NDC table
Package NDC	Billing unit	Product NDC	DailyMed indexing SPL	SPL version	Effective
66594-499-16	ML - Milliliter	66594-499	ed62d2a7-f1a7-4bd3-acdb-b29178e4ca44	1	2014-01-04

DailyMed Socrata Ingredients#

Ingredient, Type, UNII table
Ingredient	Type	UNII	DailyMed label	SPL version
Codeine Phosphate	ACTIVE INGREDIENT	GSL05Y1MN6	PRO-RED AC (CODEINE PHOSPHATE, DEXCHORPHENIRAMINE MALEATE, PHENYLEPHRINE HYDROCHLORIDE) SYRUP [PRO-PHARMA, LLC]	1
DEXCHLORPHENIRAMINE MALEATE	ACTIVE INGREDIENT	B10YD955QW	PRO-RED AC (CODEINE PHOSPHATE, DEXCHORPHENIRAMINE MALEATE, PHENYLEPHRINE HYDROCHLORIDE) SYRUP [PRO-PHARMA, LLC]	1
PHENYLEPHRINE HYDROCHLORIDE	ACTIVE INGREDIENT	04JA59TNSJ	PRO-RED AC (CODEINE PHOSPHATE, DEXCHORPHENIRAMINE MALEATE, PHENYLEPHRINE HYDROCHLORIDE) SYRUP [PRO-PHARMA, LLC]	1
CODEINE ANHYDROUS	ACTIVE MOIETY	UX6OWY2V7J	PRO-RED AC (CODEINE PHOSPHATE, DEXCHORPHENIRAMINE MALEATE, PHENYLEPHRINE HYDROCHLORIDE) SYRUP [PRO-PHARMA, LLC]	1
DEXCHLORPHENIRAMINE	ACTIVE MOIETY	3Q9Q0B929N	PRO-RED AC (CODEINE PHOSPHATE, DEXCHORPHENIRAMINE MALEATE, PHENYLEPHRINE HYDROCHLORIDE) SYRUP [PRO-PHARMA, LLC]	1
PHENYLEPHRINE	ACTIVE MOIETY	1WS297W6MV	PRO-RED AC (CODEINE PHOSPHATE, DEXCHORPHENIRAMINE MALEATE, PHENYLEPHRINE HYDROCHLORIDE) SYRUP [PRO-PHARMA, LLC]	1
CITRIC ACID MONOHYDRATE	INACTIVE INGREDIENT	2968PHW8QP	PRO-RED AC (CODEINE PHOSPHATE, DEXCHORPHENIRAMINE MALEATE, PHENYLEPHRINE HYDROCHLORIDE) SYRUP [PRO-PHARMA, LLC]	1
Glycerin	INACTIVE INGREDIENT	PDC6A3C0OX	PRO-RED AC (CODEINE PHOSPHATE, DEXCHORPHENIRAMINE MALEATE, PHENYLEPHRINE HYDROCHLORIDE) SYRUP [PRO-PHARMA, LLC]	1
Propylene Glycol	INACTIVE INGREDIENT	6DC9Q167V3	PRO-RED AC (CODEINE PHOSPHATE, DEXCHORPHENIRAMINE MALEATE, PHENYLEPHRINE HYDROCHLORIDE) SYRUP [PRO-PHARMA, LLC]	1
Saccharin Sodium	INACTIVE INGREDIENT	SB8ZUX40TY	PRO-RED AC (CODEINE PHOSPHATE, DEXCHORPHENIRAMINE MALEATE, PHENYLEPHRINE HYDROCHLORIDE) SYRUP [PRO-PHARMA, LLC]	1
Sodium Citrate	INACTIVE INGREDIENT	1Q73Q2JULR	PRO-RED AC (CODEINE PHOSPHATE, DEXCHORPHENIRAMINE MALEATE, PHENYLEPHRINE HYDROCHLORIDE) SYRUP [PRO-PHARMA, LLC]	1
Sorbitol	INACTIVE INGREDIENT	506T60A25R	PRO-RED AC (CODEINE PHOSPHATE, DEXCHORPHENIRAMINE MALEATE, PHENYLEPHRINE HYDROCHLORIDE) SYRUP [PRO-PHARMA, LLC]	1
Water	INACTIVE INGREDIENT	059QF0KO0R	PRO-RED AC (CODEINE PHOSPHATE, DEXCHORPHENIRAMINE MALEATE, PHENYLEPHRINE HYDROCHLORIDE) SYRUP [PRO-PHARMA, LLC]	1

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDC	Dashboard title	SPL version	Validation	Dashboard ZIP
66594-499	PRO-RED AC (CODEINE PHOSPHATE, DEXCHORPHENIRAMINE MALEATE, PHENYLEPHRINE HYDROCHLORIDE) SYRUP [PRO-PHARMA, LLC]	1	Legacy NDC, 2 package rows	20131008_72355a55-e1b9-4004-9d2d-e215f947946e.zip

UNII, Preferred term, Registry number table
UNII	Preferred term	Registry number	Matched term
GSL05Y1MN6	CODEINE PHOSPHATE	41444-62-6	CODEINE PHOSPHATE
B10YD955QW	DEXCHLORPHENIRAMINE MALEATE	2438-32-6	DEXCHLORPHENIRAMINE MALEATE
04JA59TNSJ	PHENYLEPHRINE HYDROCHLORIDE	61-76-7	PHENYLEPHRINE HYDROCHLORIDE

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUI	RxNorm string	TTY	DailyMed	SPL version
1440003	codeine phosphate 9 MG / dexchlorpheniramine maleate 1 MG / phenylephrine HCl 5 MG in 5 mL Oral Solution	PSN	72355a55-e1b9-4004-9d2d-e215f947946e	1
1440003	codeine phosphate 1.8 MG/ML / dexchlorpheniramine maleate 0.2 MG/ML / phenylephrine hydrochloride 1 MG/ML Oral Solution	SCD	72355a55-e1b9-4004-9d2d-e215f947946e	1
1440003	codeine phosphate 9 MG / dexchlorpheniramine maleate 1 MG / phenylephrine hydrochloride 5 MG per 5 ML Oral Solution	SY	72355a55-e1b9-4004-9d2d-e215f947946e	1

Packages#

Package NDC, 11-digit format, Description table
Package NDC	11-digit format	Description	Units	Status
66594-499-01	66594049901	30 mL in 1 BOTTLE	30 ml	Historical
66594-499-16	66594049916	473 mL in 1 BOTTLE	473 ml	Historical

Title, Manufacturer, Effective date table
Title	Manufacturer	Effective date	Type	Version
PRO-RED AC SYRUP	Pro-Pharma, LLC \| Pernix Manufacturing, LLC \| Pernix Manufacturing, LLC dba Great Southern Laboratories	2013-10-07	HUMAN OTC DRUG LABEL	1