Alka-Seltzer Plus Cold and Flu, CVP
- Product NDC
- 66715-6531
- 11-digit product format
- 667156531
- Labeler code
- 66715
- Product ID
- 66715-6531_27c33a7d-6d48-b04c-e063-6294a90a77e2
- Type
- HUMAN OTC DRUG
- Nonproprietary name
- chlorpheniramine maleate, acetaminophen, phenylephrine hydrochloride, dextromethorphan hydrobromide tablet
- Dosage form
- TABLET, EFFERVESCENT
- Route
- ORAL
- Labeler
- Lil' Drug Store Products, Inc.
- Application
- M012
- Marketing category
- OTC MONOGRAPH DRUG
- Marketing start
- 2022-04-25
- Substance
- ACETAMINOPHEN; DEXTROMETHORPHAN HYDROBROMIDE; PHENYLEPHRINE HYDROCHLORIDE; CHLORPHENIRAMINE MALEATE
- Active strength
- 250; 10; 5; 2 mg/1; mg/1; mg/1; mg/1
- Pharmacologic classes
- Adrenergic alpha1-Agonists [MoA], Histamine H1 Receptor Antagonists [MoA], Histamine-1 Receptor Antagonist [EPC], Sigma-1 Agonist [EPC], Sigma-1 Receptor Agonists [MoA], Uncompetitive N-methyl-D-aspartate Receptor Antagonist [EPC], Uncompetitive NMDA Receptor Antagonists [MoA], alpha-1 Adrenergic Agonist [EPC]
- NDC exclude flag
- No
- Listing certified through
- 2026-12-31
- Current FDA listing
- Yes
Reported adverse events (FAERS/openFDA)#
Adverse event summaries are temporarily unavailable. Other product information remains available.
Additional Listing Data#
- Finished product
- Yes
- Brand name base
- Alka-Seltzer Plus Cold and Flu, CVP
- Listing expiration
- 2026-12-31
Active Ingredients#
| Ingredient | Strength |
|---|---|
| ACETAMINOPHEN | 250 mg/1 |
| DEXTROMETHORPHAN HYDROBROMIDE | 10 mg/1 |
| PHENYLEPHRINE HYDROCHLORIDE | 5 mg/1 |
| CHLORPHENIRAMINE MALEATE | 2 mg/1 |
Harmonized UNII identifiers#
| Identifier | FDA.report destination |
|---|---|
| 9D2RTI9KYH | Internal UNII lookup |
| 362O9ITL9D | Internal UNII lookup |
| 04JA59TNSJ | Internal UNII lookup |
| V1Q0O9OJ9Z | Internal UNII lookup |
Harmonized RxCUI identifiers#
| Identifier | FDA.report destination |
|---|---|
| 1536477 | Internal RxNorm lookup |
Harmonized SPL set identifiers#
| Identifier | FDA.report destination |
|---|---|
| e7a27773-69d6-9e07-e053-2a95a90af8ea | Available on FDA.report |
DailyMed Product Concepts#
| Product concept | Relation | Version | Effective |
|---|---|---|---|
| d17a97fa-387f-690e-d2be-0083ab044a03 | Product name | 3 | 20170725 |
| 0fdb98e2-b951-a1ce-5715-2b187ba500ef | Product name | 4 | 20170718 |
| c6fba691-a132-4ede-95c6-f8c6bd696636 | Product name | 1 | 20150902 |
| c0200ab5-4954-454e-9676-30b741b245bd | Product name | 1 | 20150730 |
DailyMed Package Descriptions#
| Package NDC | Product | Description | Form | Quantity | Strength | SPL version |
|---|---|---|---|---|---|---|
| 66715-6531-2 | Alka-Seltzer Plus Cold and Flu, CVP | 2 in 1 POUCH | TABLET, EFFERVESCENT | 2 | 4 | |
| 66715-6531-2 | Alka-Seltzer Plus Cold and Flu, CVP | 2 in 1 CARTON | TABLET, EFFERVESCENT | 2 | 4 |
DailyMed Dashboard NDC Coverage#
| NDC | Dashboard title | SPL version | Validation | Dashboard ZIP |
|---|---|---|---|---|
| 66715-6531 | ALKA-SELTZER PLUS COLD AND FLU, CVP (CHLORPHENIRAMINE MALEATE, ACETAMINOPHEN, PHENYLEPHRINE HYDROCHLORIDE, DEXTROMETHORPHAN HYDROBROMIDE TABLET) TABLET, EFFERVESCENT ALKA-SELTZER PLUS COLD AND FLU, BASIX (CHLORPHENIRAMINE MALEATE, ACETAMINOPHEN, PHENYLEPHRINE HYDROCHLORIDE, DEXTROMETHORPHAN HYDROBROMIDE TABLET) TABLET, EFFERVESCENT ALKA-SELTZER PLUS COLD AND FLU (CHLORPHENIRAMINE MALEATE, ACETAMINOPHEN, PHENYLEPHRINE HYDROCHLORIDE, DEXTROMETHORPHAN HYDROBROMIDE TABLET) TABLET, EFFERVESCENT [LIL' DRUG STORE PRODUCTS, INC.] | 4 | Current NDC, 2 package rows | 20241127_e7a27773-69d6-9e07-e053-2a95a90af8ea.zip |
openFDA label cross-check#
OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.
| Brand | Generic | Manufacturer | SPL set ID | Effective date | Available safety fields | Join |
|---|---|---|---|---|---|---|
| Diphenhydramine Hydrochloride | DIPHENHYDRAMINE HYDROCHLORIDE | Major Pharmaceuticals | 04e70311-6412-4a20-84e3-f6e26d5f19ab | 2026-02-20 | Warnings | M012 |
| Banophen | DIPHENHYDRAMINE HCL | Major Pharmaceuticals | 7f2b72cc-d4f7-431f-be61-c103cf8c489e | 2026-02-20 | Warnings | M012 |
| Diphenhydramine Hydrochloride | DIPHENHYDRAMINE HYDROCHLORIDE | Major Pharmaceuticals | dca04d80-e781-40b1-e053-2995a90a7010 | 2026-02-20 | Warnings | M012 |
| Diphenhydramine Hydrochloride | DIPHENHYDRAMINE HYDROCHLORIDE | LEADER/ Cardinal Health 110, Inc. | e33cbd1d-1848-145a-e053-2995a90aeb50 | 2026-02-20 | Warnings | M012 |
| Head Congestion and Flu Severe Relief | ACETAMINOPHEN, DEXTROMETHORPHAN HBR, GUAIFENESIN, PHENYLEPHRINE HCL | Rite Aid Corporation | 416080a9-e817-485b-a4ae-6c9d0152c165 | 2026-02-20 | Warnings | M012 |
| Walmart Dye Free Chidrens Allergy Chews | DIPHENHYDRAMINE HCL | WALMART STORES INC | 18436026-b0e4-4481-a647-d735a27d0b00 | 2026-02-19 | Warnings | M012 |
| Vaporizing | CAMPHOR | Meijer, Inc. | 7afc98d7-f64f-42d5-9022-28ad6b01db8a | 2026-02-19 | Warnings, Adverse reactions | M012 |
| CHILDRENS COLD AND COUGH | BROMPHENIRAMINE MALEATE, DEXTROMETHORPHAN HYDROBROMIDE | Kroger Company | 8196b482-070e-4d7d-8943-129141f926ee | 2026-02-19 | Warnings | M012 |
| Walmart Dye Free Chidrens Allergy Chews Bubblegum | DIPHENHYDRAMINE HCL | WALMART STORES INC | 9f83d2f0-9718-4f2b-bc7f-e29ba2917412 | 2026-02-19 | Warnings | M012 |
| tussin dm max | DEXTROMETHORPHAN HBR, GUAIFENESIN | Kroger Company | be9aaf66-6c59-4042-88e2-acd920dcf992 | 2026-02-19 | Warnings | M012 |
| Allergy Relief Dye-Free | DIPHENHYDRAMINE HCL | CVS Pharmacy | 08459cf4-feb3-4283-88e1-d61e030c57f9 | 2026-02-19 | Warnings | M012 |
| allergy relief | CHLORPHENIRAMINE MALEATE | Rite Aid Corporation | b0d70488-ea1d-4c1d-bd07-53dfb0e4d03c | 2026-02-18 | Warnings | M012 |
| Walgreens Wild Cherry Pectin Throat Drops | PECTIN | Walgreens | 424fda2d-c1e5-0ed9-e063-6394a90a06ea | 2026-02-18 | Warnings | M012 |
| cough suppressant and topical analgesic | CAMPHOR, EUCALYPTUS OIL, MENTHOL | Target Corporation | df21d9d6-36a9-49cf-a29c-c4a573899bd5 | 2026-02-18 | Warnings, Adverse reactions | M012 |
| Allergy Relief | CHLORPHENIRAMINE MALEATE | Amerisource Bergen | eeda80ff-212d-428e-a0c6-782f271357b4 | 2026-02-18 | Warnings | M012 |
| good sense night time | ACETAMINOPHEN, DEXTROMETHORPHAN HBR, DOXYLAMINE SUCCINATE | L. Perrigo Company | e47dffdf-5778-4804-8ce2-54c5a72bba3a | 2026-02-18 | Warnings | M012 |
| Chest Rub | CAMPHOR, EUCALYPTUS OIL, MENTHOL | United Natural Foods, Inc. dba UNFI | b139e7d6-bf4d-45b9-b7cf-d34e5352095c | 2026-02-17 | Warnings, Adverse reactions | M012 |
| Chest Rub | CAMPHOR, EUCALYPTUS OIL, MENTHOL | Strategic Sourcing Services LLC | bd54bf7a-2304-4c3f-9cd2-bafea217466e | 2026-02-17 | Warnings, Adverse reactions | M012 |
| Creomulsion For Children | DEXTROMETHORPHAN HYDROBROMIDE | Socius Care, LLC | 39d0e96c-1cc3-4961-e054-00144ff88e88 | 2026-02-17 | Warnings | M012 |
| Creomulsion Cough Medicine Adult Formula | DEXTROMETHORPHAN HYDROBROMIDE | Socius Care, LLC | 39d07486-99b7-5c06-e054-00144ff8d46c | 2026-02-17 | Warnings | M012 |
DailyMed RxNorm Mappings#
| RxCUI | RxNorm string | TTY | DailyMed | SPL version |
|---|---|---|---|---|
| 1536477 | acetaminophen 250 MG / chlorpheniramine maleate 2 MG / dextromethorphan HBr 10 MG / phenylephrine HCl 5 MG Effervescent Oral Tablet | PSN | e7a27773-69d6-9e07-e053-2a95a90af8ea | 4 |
| 1536477 | acetaminophen 250 MG / chlorpheniramine maleate 2 MG / dextromethorphan hydrobromide 10 MG / phenylephrine hydrochloride 5 MG Effervescent Oral Tablet | SCD | e7a27773-69d6-9e07-e053-2a95a90af8ea | 4 |
| 1536477 | APAP 250 MG / Chlorpheniramine Maleate 2 MG / Dextromethorphan Hydrobromide 10 MG / Phenylephrine Hydrochloride 5 MG Effervescent Oral Tablet | SY | e7a27773-69d6-9e07-e053-2a95a90af8ea | 4 |
Packages#
| Package NDC | 11-digit format | Description | Units | Marketing start | Sample | Exclude flag | Status |
|---|---|---|---|---|---|---|---|
| 66715-6531-2 | 66715653102 | 2 POUCH in 1 CARTON (66715-6531-2) / 2 TABLET, EFFERVESCENT in 1 POUCH | 2 pouch | 2022-08-01 | No | No | Current |