Indications and uses
Uses temporarily relieves these symptoms due to a cold or flu: minor aches and pains headache cough sore throat runny nose sneezing nasal and sinus congestion temporarily reduces fever
Alka-Seltzer Plus Cold and Flu
- Manufacturer
- Lil' Drug Store Products, Inc.
- Effective date
- 2024-11-25
- Label type
- HUMAN OTC DRUG LABEL
- Version
- 4
- Source
- full-release
- Hydrated at
- 2026-06-01 00:39:30
Label at a glance#
ProductAlka-Seltzer Plus Cold and Flu, CVP
Active ingredientACETAMINOPHEN, DEXTROMETHORPHAN HYDROBROMIDE, PHENYLEPHRINE HYDROCHLORIDE, CHLORPHENIRAMINE MALEATE
Label structure14 sections
Dosage and administration
Directions do not take more than the recommended dose adults and children 12 years and over: take 2 tablets fully dissolved in 4 oz of water every 4 hours. Do not exceed 8 tablets in 24 hours or as directed by a doctor. children under 12 years: do not use
Storage and handling
Other information each tablet contains : potassium 80 mg; sodium 356 mg store at room temperature. Avoid excessive heat.
Contacts and useful links#
Label contents#
Full prescribing information#
Active ingredients
Active ingredients (in each tablet)
Acetaminophen 250 mg
Chlorpheniramine maleate 2 mg
Dextromethorphan hydrobromide 10 mg
Phenylephrine hydrochloride 5 mg
Purposes
Purposes
Pain reliever/fever reducer
Antihistamine
Cough suppressant
Nasal decongestant
Uses
Uses
- temporarily relieves these symptoms due to a cold or flu:
- minor aches and pains
- headache
- cough
- sore throat
- runny nose
- sneezing
- nasal and sinus congestion
- temporarily reduces fever
Warnings
Liver warning
Liver warning: This product contains acetaminophen. Severe liver damage may occur if you take
- more than 4,000 mg of acetaminophen in 24 hours
- with other drugs containing acetaminophen
- 3 or more alcoholic drinks every day while using this product
Allergy alert
Allergy alert: Acetaminophen may cause severe skin or severe allergic reactions. Symptoms may include:
- skin reddening
- blisters
- rash
- hives
- facial swelling
- asthma (wheezing)
- shock
If a skin or general allergic reaction occurs, stop use and seek medical help right away.
Sore throat warning
Sore throat warning: If sore throat is severe, persists for more than 2 days, is accompanied or followed by fever, headache, rash, nausea, or vomiting, consult a doctor promptly.
SPL UNCLASSIFIED SECTION
Do not use to sedate children
Do not use
Do not use
- with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist.
- if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product.
- if you have ever had an allergic reaction to this product or any of its ingredients
- in children under 12 years of age
Ask a doctor
Ask a doctor before use if you have
- liver disease
- heart disease
- high blood pressure
- thyroid disease
- diabetes
- glaucoma
- cough with excessive phlegm (mucus)
- a breathing problem such as emphysema or chronic bronchitis
- difficulty in urination due to enlargement of the prostate gland
- persistent or chronic cough such as occurs with smoking, asthma, or emphysema
- a sodium restricted diet
OTC - ASK DOCTOR/PHARMACIST SECTION
Ask a doctor or pharmacist before use if you are
- taking the blood thinning drug warfarin
- taking sedatives or tranquilizers
OTC - WHEN USING SECTION
When using this product
- do not exceed recommended dosage
- may cause marked drowsiness
- avoid alcoholic drinks
- alcohol, sedatives, and tranquilizers may increase drowsiness
- be careful when driving a motor vehicle or operating machinery
- excitability may occur, especially in children
OTC - STOP USE SECTION
Stop use and ask a doctor if
- pain, cough, or nasal congestion gets worse or lasts more than 7 days
- fever gets worse or lasts more than 3 days
- redness or swelling is present
- new symptoms occur
- cough comes back or occurs with rash or headache that lasts. These could be signs of a serious condition.
- nervousness, dizziness, or sleeplessness occurs
OTC - PREGNANCY OR BREAST FEEDING SECTION
If pregnant or breast-feeding, ask a health professional before use.
OTC - KEEP OUT OF REACH OF CHILDREN SECTION
Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away. Quick medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms.
Directions
Directions
- do not take more than the recommended dose
- adults and children 12 years and over: take 2 tablets fully dissolved in 4 oz of water every 4 hours. Do not exceed 8 tablets in 24 hours or as directed by a doctor.
- children under 12 years: do not use
Other information
Other information
- each tablet contains: potassium 80 mg; sodium 356 mg
- store at room temperature. Avoid excessive heat.
Inactive ingredients
Inactive ingredients
anhydrous citric acid, calcium silicate, dimethicone, FD&C red #40, FD&C yellow #6, flavors, magnesium stearate, maltodextrin,
mannitol, potassium bicarbonate, povidone, sodium bicarbonate, sucralose
Questions or comments?
Questions or comments?
1-800-986-0369 (Mon-Fri 9AM - 5PM EST)
SPL UNCLASSIFIED SECTION
DO NOT USE IF INNER POUCH OR CARTON IS OPEN OR DAMAGED!
PACKAGE NOT CHILD RESISTANT!
PDP/Package - Lil Drug Store
Alka-
Seltzer
Plus ®
CITRUS
FLAVOR
SEVERE Cold & Flu
POWERFAST FIZZ™
ACETAMINOPHEN/Pain Reliever-Fever Reducer
Chlorpheniramine Maleate/Antihistamine
Dextromethorphan HBr/Cough Suppressant
Phenylephrine Hydrochloride/Nasal Decongestant
- Fever & Body Ache
- Cough
- Nasal Congestion
- Runny Nose
- Sore Throat
4
Effervescent Tablets
[Lil' Drug Store logo]
PDP/Package - BASIX
Alka-
Seltzer
Plus ®
CITRUS
FLAVOR
SEVERE Cold & Flu
POWERFAST FIZZ™
ACETAMINOPHEN/Pain Reliever-Fever Reducer
Chlorpheniramine Maleate/Antihistamine
Dextromethorphan HBr/Cough Suppressant
Phenylephrine Hydrochloride/Nasal Decongestant
- Fever & Body Ache
- Cough
- Nasal Congestion
- Runny Nose
- Sore Throat
4
Effervescent Tablets
[TRAVEL
BASIX logo]
PDP/Package - Alka-Selter Plus Cold & Flu, CVP
Alka-
Seltzer
Plus ®
CITRUS
FLAVOR
SEVERE Cold & Flu
POWERFAST FIZZ™
ACETAMINOPHEN/Pain Reliever-Fever Reducer
Chlorpheniramine Maleate/Antihistamine
Dextromethorphan HBr/Cough Suppressant
Phenylephrine Hydrochloride/Nasal Decongestant
- Fever & Body Ache
- Cough
- Nasal Congestion
- Runny Nose
- Sore Throat
4
Effervescent Tablets
[CVP HEALTH logo]
Alka-Seltzer Plus Cold & Flu, 25ct Unit Dose Box
Alka-
Seltzer
PLUS ®
CITRUS
FLAVOR
SEVERE COLD & FLU
POWERFAST FIZZ™
ACETAMINOPHEN/Pain Reliever-Fever Reducer
Chlorpheniramine Maleate/Antihistamine
Dextromethorphan HBr/Cough Suppressant
Phenylephrine Hydrochloride/Nasal Decongestant
- Fever & Body Ache
- Cough
- Nasal Congestion
- Runny Nose
- Sore Throat
2 EFFERVESCENT TABLETS PER POUCH
Alka-Seltzer Plus Cold & Flu, 30ct Unit Dose Box
Alka-
Seltzer
PLUS ®
CITRUS
FLAVOR
SEVERE COLD & FLU
POWERFAST FIZZ™
ACETAMINOPHEN/Pain Reliever-Fever Reducer
Chlorpheniramine Maleate/Antihistamine
Dextromethorphan HBr/Cough Suppressant
Phenylephrine Hydrochloride/Nasal Decongestant
- Fever & Body Ache
- Cough
- Nasal Congestion
- Runny Nose
- Sore Throat
2 EFFERVESCENT TABLETS PER POUCH
DailyMed RxNorm Mappings#
| RxCUI | RxNorm string | TTY | SPL version |
|---|---|---|---|
| 1536477 | acetaminophen 250 MG / chlorpheniramine maleate 2 MG / dextromethorphan HBr 10 MG / phenylephrine HCl 5 MG Effervescent Oral Tablet | PSN | 4 |
| 1536477 | acetaminophen 250 MG / chlorpheniramine maleate 2 MG / dextromethorphan hydrobromide 10 MG / phenylephrine hydrochloride 5 MG Effervescent Oral Tablet | SCD | 4 |
| 1536477 | APAP 250 MG / Chlorpheniramine Maleate 2 MG / Dextromethorphan Hydrobromide 10 MG / Phenylephrine Hydrochloride 5 MG Effervescent Oral Tablet | SY | 4 |
DailyMed Pharmacologic Classes#
| Class | Version | Type | Effective |
|---|---|---|---|
| CHLORPHENIRAMINE Pharmacologic Class Indexing | 3 | Indexing - Pharmacologic Class | 20180813 |
| DEXTROMETHORPHAN Pharmacologic Class Indexing | 2 | Indexing - Pharmacologic Class | 20180813 |
| PHENYLEPHRINE Pharmacologic Class Indexing | 2 | Indexing - Pharmacologic Class | 20180813 |
DailyMed Product Concepts#
| Product concept | Relation | Version | Effective |
|---|---|---|---|
| d17a97fa-387f-690e-d2be-0083ab044a03 | Product name | 3 | 20170725 |
| 0fdb98e2-b951-a1ce-5715-2b187ba500ef | Product name | 4 | 20170718 |
| c6fba691-a132-4ede-95c6-f8c6bd696636 | Product name | 1 | 20150902 |
| c0200ab5-4954-454e-9676-30b741b245bd | Product name | 1 | 20150730 |
DailyMed Package Descriptions#
| Package NDC | Product | Description | Form | Quantity | Strength | SPL version |
|---|---|---|---|---|---|---|
| 66715-6531-2 | Alka-Seltzer Plus Cold and Flu, CVP | 2 in 1 POUCH | TABLET, EFFERVESCENT | 2 | 4 | |
| 66715-6531-2 | Alka-Seltzer Plus Cold and Flu, CVP | 2 in 1 CARTON | TABLET, EFFERVESCENT | 2 | 4 | |
| 66715-7831-2 | Alka-Seltzer Plus Cold and Flu, BASIX | 2 in 1 CARTON | TABLET, EFFERVESCENT | 2 | 4 | |
| 66715-7831-2 | Alka-Seltzer Plus Cold and Flu, BASIX | 2 in 1 POUCH | TABLET, EFFERVESCENT | 2 | 4 | |
| 66715-9831-2 | Alka-Seltzer Plus Cold and Flu | 2 in 1 CARTON | TABLET, EFFERVESCENT | 2 | 4 | |
| 66715-9831-2 | Alka-Seltzer Plus Cold and Flu | 2 in 1 POUCH | TABLET, EFFERVESCENT | 2 | 4 | |
| 66715-9831-8 | Alka-Seltzer Plus Cold and Flu | 25 in 1 BOX, UNIT-DOSE | TABLET, EFFERVESCENT | 25 | 4 | |
| 66715-9831-9 | Alka-Seltzer Plus Cold and Flu | 30 in 1 BOX, UNIT-DOSE | TABLET, EFFERVESCENT | 30 | 4 |
DailyMed Dashboard NDC Coverage#
| NDC | Dashboard title | SPL version | Validation | Dashboard ZIP |
|---|---|---|---|---|
| 66715-6531 | ALKA-SELTZER PLUS COLD AND FLU, CVP (CHLORPHENIRAMINE MALEATE, ACETAMINOPHEN, PHENYLEPHRINE HYDROCHLORIDE, DEXTROMETHORPHAN HYDROBROMIDE TABLET) TABLET, EFFERVESCENT ALKA-SELTZER PLUS COLD AND FLU, BASIX (CHLORPHENIRAMINE MALEATE, ACETAMINOPHEN, PHENYLEPHRINE HYDROCHLORIDE, DEXTROMETHORPHAN HYDROBROMIDE TABLET) TABLET, EFFERVESCENT ALKA-SELTZER PLUS COLD AND FLU (CHLORPHENIRAMINE MALEATE, ACETAMINOPHEN, PHENYLEPHRINE HYDROCHLORIDE, DEXTROMETHORPHAN HYDROBROMIDE TABLET) TABLET, EFFERVESCENT [LIL' DRUG STORE PRODUCTS, INC.] | 4 | Current NDC, 2 package rows | 20241127_e7a27773-69d6-9e07-e053-2a95a90af8ea.zip |
| 66715-7831 | ALKA-SELTZER PLUS COLD AND FLU, CVP (CHLORPHENIRAMINE MALEATE, ACETAMINOPHEN, PHENYLEPHRINE HYDROCHLORIDE, DEXTROMETHORPHAN HYDROBROMIDE TABLET) TABLET, EFFERVESCENT ALKA-SELTZER PLUS COLD AND FLU, BASIX (CHLORPHENIRAMINE MALEATE, ACETAMINOPHEN, PHENYLEPHRINE HYDROCHLORIDE, DEXTROMETHORPHAN HYDROBROMIDE TABLET) TABLET, EFFERVESCENT ALKA-SELTZER PLUS COLD AND FLU (CHLORPHENIRAMINE MALEATE, ACETAMINOPHEN, PHENYLEPHRINE HYDROCHLORIDE, DEXTROMETHORPHAN HYDROBROMIDE TABLET) TABLET, EFFERVESCENT [LIL' DRUG STORE PRODUCTS, INC.] | 4 | Current NDC, 2 package rows | 20241127_e7a27773-69d6-9e07-e053-2a95a90af8ea.zip |
| 66715-9831 | ALKA-SELTZER PLUS COLD AND FLU, CVP (CHLORPHENIRAMINE MALEATE, ACETAMINOPHEN, PHENYLEPHRINE HYDROCHLORIDE, DEXTROMETHORPHAN HYDROBROMIDE TABLET) TABLET, EFFERVESCENT ALKA-SELTZER PLUS COLD AND FLU, BASIX (CHLORPHENIRAMINE MALEATE, ACETAMINOPHEN, PHENYLEPHRINE HYDROCHLORIDE, DEXTROMETHORPHAN HYDROBROMIDE TABLET) TABLET, EFFERVESCENT ALKA-SELTZER PLUS COLD AND FLU (CHLORPHENIRAMINE MALEATE, ACETAMINOPHEN, PHENYLEPHRINE HYDROCHLORIDE, DEXTROMETHORPHAN HYDROBROMIDE TABLET) TABLET, EFFERVESCENT [LIL' DRUG STORE PRODUCTS, INC.] | 4 | Current NDC, Legacy NDC, 4 package rows | 20241127_e7a27773-69d6-9e07-e053-2a95a90af8ea.zip |
Products#
Every source-derived product name is available through these pages.
- Alka-Seltzer Plus Cold and Flu, CVP
- chlorpheniramine maleate, acetaminophen, phenylephrine hydrochloride, dextromethorphan hydrobromide tablet
- POTASSIUM BICARBONATE
- POVIDONE, UNSPECIFIED
- SODIUM BICARBONATE
- ANHYDROUS CITRIC ACID
- DIMETHICONE
- MAGNESIUM STEARATE
- MALTODEXTRIN
- SUCRALOSE
- CALCIUM SILICATE
- FD&C RED NO. 40
- ACETAMINOPHEN
- DEXTROMETHORPHAN HYDROBROMIDE
- DEXTROMETHORPHAN
- PHENYLEPHRINE HYDROCHLORIDE
- PHENYLEPHRINE
- CHLORPHENIRAMINE MALEATE
- CHLORPHENIRAMINE
- FD&C YELLOW NO. 6
- MANNITOL
- Alka-Seltzer Plus Cold and Flu, BASIX
- Alka-Seltzer Plus Cold and Flu
NDC Codes#
| Product NDC | Package NDC |
|---|---|
| 66715-6531 | 66715-6531-2 |
| 66715-7831 | 66715-7831-2 |
| 66715-9831 | 66715-9831-2, 66715-9831-8, 66715-9831-9 |
Ingredients#
Every source-derived ingredient row is available through these pages.
Source Document#
openFDA label cross-check#
OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.
| Brand | Generic | Manufacturer | SPL set ID | Effective date | Available safety fields | Join |
|---|---|---|---|---|---|---|
| Alka-Seltzer Plus Cold and Flu, CVP | CHLORPHENIRAMINE MALEATE, ACETAMINOPHEN, PHENYLEPHRINE HYDROCHLORIDE, DEXTROMETHORPHAN HYDROBROMIDE TABLET | Lil' Drug Store Products, Inc. | e7a27773-69d6-9e07-e053-2a95a90af8ea | 2024-11-25 | Warnings | 66715-7831-2 66715-9831-9 66715-9831-2 66715-9831-8 66715-6531-2 66715-7831 66715-9831 66715-6531 66715653102 66715983102 66715983108 66715783102 66715983109 27c33a7d-6d48-b04c-e063-6294a90a77e2 e7a27773-69d6-9e07-e053-2a95a90af8ea |
Reported adverse events (FAERS/openFDA)#
Adverse event summaries are temporarily unavailable. Other product information remains available.