Benadryl
- Product NDC
- 66715-9706
- 11-digit product format
- 667159706
- Labeler code
- 66715
- Product ID
- 66715-9706_2783d396-2842-91e9-e063-6294a90a88fe
- Type
- HUMAN OTC DRUG
- Nonproprietary name
- Diphenhydramine Hydrochloride
- Dosage form
- TABLET, FILM COATED
- Route
- ORAL
- Labeler
- Lil' Drug Store Products, Inc.
- Application
- M012
- Marketing category
- OTC MONOGRAPH DRUG
- Marketing start
- 2010-09-16
- Substance
- DIPHENHYDRAMINE HYDROCHLORIDE
- Active strength
- 25 mg/1
- Pharmacologic classes
- Histamine H1 Receptor Antagonists [MoA], Histamine-1 Receptor Antagonist [EPC]
- NDC exclude flag
- No
- Listing certified through
- 2026-12-31
- Current FDA listing
- Yes
NDC auxiliary status#
These records are reproduced from FDA’s unfinished, excluded, and compounder listings. They describe what appeared in the source files; a missing record does not establish a regulatory status. View all current auxiliary records, including entries without an NDC. · View the auxiliary file history.
| Dataset | Scope | Product NDC | Package NDC | Code | Status | Reporting period | Source date |
|---|---|---|---|---|---|---|---|
| excluded package | package | 66715-9706 | 66715-9706-1 | D | Discontinued by firm | 2026-10-21 |
Observed NDC auxiliary status history#
This history shows the information present in each captured FDA auxiliary file. It is not a continuous regulatory timeline, and a missing record does not establish a status.
| Captured / source date | Snapshot | Source SHA-256 |
|---|---|---|
| 2025-12-14 17:58 UTC · source 2025-12-05 | d630ba8d3edf… | 732f749b63fb… |
| 2025-08-27 00:01 UTC · source 2025-08-26 | f5e01cc5f278… | a2eaf40c39c3… |
| 2025-04-01 02:39 UTC · source 2025-03-31 | 2ef7874e63bc… | 57b86245f4fa… |
| 2025-03-28 20:22 UTC · source 2025-03-28 | a1b67e2a42f9… | c4cf2c586c0d… |
| 2025-03-22 03:12 UTC · source 2025-03-21 | cfe11265f3b6… | 090c488252e2… |
| 2025-03-10 12:48 UTC · source 2025-03-10 | cdf11ea48f46… | ba0047e9e063… |
| 2025-02-02 03:52 UTC · source 2025-01-31 | 302b2466d912… | e7b80fea0513… |
| 2025-01-20 13:05 UTC · source 2025-01-20 | ed331223b511… | 672a5bd82f5f… |
| 2025-01-11 03:41 UTC · source 2025-01-10 | 0efc9e666f02… | f202fb6c5f17… |
| 2024-11-09 02:27 UTC · source 2024-11-08 | ad56d346431e… | cc804d4bbf1e… |
| 2024-10-04 04:10 UTC · source 2024-10-03 | 367a005e9d99… | 383a685ebd0f… |
| 2024-07-10 04:00 UTC · source 2024-07-09 | 557ba5c1ecfa… | 9c80585c8c6e… |
Reported adverse events (FAERS/openFDA)#
Adverse event summaries are temporarily unavailable. Other product information remains available.
Additional Listing Data#
- Finished product
- Yes
- Brand name base
- Benadryl
- Listing expiration
- 2026-12-31
Active Ingredients#
| Ingredient | Strength |
|---|---|
| DIPHENHYDRAMINE HYDROCHLORIDE | 25 mg/1 |
Harmonized UNII identifiers#
| Identifier | FDA.report destination |
|---|---|
| TC2D6JAD40 | Internal UNII lookup |
Harmonized RxCUI identifiers#
Harmonized SPL set identifiers#
| Identifier | FDA.report destination |
|---|---|
| de2a64ce-c169-4162-b79e-d3809bea2147 | Available on FDA.report |
DailyMed Product Concepts#
| Product concept | Relation | Version | Effective |
|---|---|---|---|
| 0e2e0f88-b076-afe1-4bdd-32bca4375bec | Product name | 3 | 20250127 |
| 3e48c9c4-918d-5d23-2f0b-d2398b06be54 | Product name | 1 | 20140508 |
| 865c72dd-0d94-daac-f728-ddd4ded2a79e | Product name | 1 | 20140508 |
DailyMed Package Descriptions#
| Package NDC | Product | Description | Form | Quantity | Strength | SPL version |
|---|---|---|---|---|---|---|
| 66715-9706-1 | Benadryl | 2 in 1 POUCH | TABLET, FILM COATED | 2 | 10 | |
| 66715-9706-1 | Benadryl | 1 in 1 CARTON | TABLET, FILM COATED | 1 | 10 | |
| 66715-9706-2 | Benadryl | 2 in 1 CARTON | TABLET, FILM COATED | 2 | 10 | |
| 66715-9706-2 | Benadryl | 2 in 1 POUCH | TABLET, FILM COATED | 2 | 10 | |
| 66715-9706-3 | Benadryl | 3 in 1 CARTON | TABLET, FILM COATED | 3 | 10 | |
| 66715-9706-3 | Benadryl | 2 in 1 POUCH | TABLET, FILM COATED | 2 | 10 |
DailyMed Socrata Ingredients#
DailyMed Dashboard NDC Coverage#
| NDC | Dashboard title | SPL version | Validation | Dashboard ZIP |
|---|---|---|---|---|
| 66715-9706 | BENADRYL (DIPHENHYDRAMINE HYDROCHLORIDE) TABLET, FILM COATED [LIL' DRUG STORE PRODUCTS, INC.] | 10 | Current NDC, Legacy NDC, 6 package rows | 20241123_de2a64ce-c169-4162-b79e-d3809bea2147.zip |
openFDA label cross-check#
OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.
| Brand | Generic | Manufacturer | SPL set ID | Effective date | Available safety fields | Join |
|---|---|---|---|---|---|---|
| Head Congestion plus Flu Severe PE | ACETAMINOPHEN, DEXTROMETHORPHAN HYDROBROMIDE, GUAIFENESIN, AND PHENYLEPHRINE HYDROCHLORIDE | VALU MERCHANDISERS COMPANY | f6401b58-8cf8-4067-e053-2995a90a68fc | 2025-12-11 | Warnings | M012 |
| Sinus Relief Pressure, Pain and Cough | ACETAMINOPHEN, DEXTROMETHORPHAN HYDROBROMIDE, GUAIFENESIN, AND PHENYLEPHRINE HYDROCHLORIDE | VALU MERCHANDISERS COMPANY | b1ba37b8-4558-0808-e053-2995a90a9f5e | 2025-12-11 | Warnings | M012 |
| Allergy Relief | DIPHENHYDRAMINE HYDROCHLORIDE | VALU MERCHANDISERS COMPANY | b84f37bc-be37-4f2b-83ee-d7d134184490 | 2025-12-11 | Warnings | M012 |
| Mucus Relief Cold Flu and Sore Throat | ACETAMINOPHEN, DEXTROMETHORPHAN HYDROBROMIDE, GUAIFENESIN, AND PHENYLEPHRINE HYDROCHLORIDE | VALU MERCHANDISERS COMPANY | b1b7c7fc-1068-f486-e053-2a95a90a8e8c | 2025-12-11 | Warnings | M012 |
| Mucus Relief Cold and Flu All in One | ACETAMINOPHEN, DEXTROMETHORPHAN HYDROBROMIDE, GUAIFENESIN, AND PHENYLEPHRINE HYDROCHLORIDE | VALU MERCHANDISERS COMPANY | b1b9e0da-2c54-8b31-e053-2995a90a690b | 2025-12-11 | Warnings | M012 |
| Sinus Relief Daytime, Nighttime, Maximum Strength | ACETAMINOPHEN, DIPHENHYDRAMINE HCL, GUAIFENESIN, PHENYLEPHRINE HCL | CVS PHARMACY | f6b3ca40-7638-477f-b800-4c28c40ff0a8 | 2025-12-11 | Warnings | M012 |
| Allergy Relief | ACETAMINOPHEN, DIPHENHYDRAMINE HCL, PHENYLEPHRINE HCL | Walgreen Company | 0a6e3251-02e0-42c1-bdf3-51c77f88c17f | 2025-12-11 | Warnings | M012 |
| topcare nite time cold and flu | ACETAMINOPHEN, DEXTROMETHORPHAN HBR, DOXYLAMINE SUCCINATE | Topco Associates LLC | 516ab016-31f9-4829-8b94-2f968933093c | 2025-12-11 | Warnings | M012 |
| Sinus PE Congestion | DIPHENHYDRAMINE HCL, PHENYLEPHRINE HCL | Walgreen Company | 5b9151b7-3e40-4f37-b3e0-4c0fa0115b71 | 2025-12-10 | Warnings | M012 |
| Cough and Cold HBP | CHLORPHENIRAMINE MALEATE, DEXTROMETHORPHAN HBR | Discount Drug Mart | 2344c048-0550-4c31-b54e-a198910c490e | 2025-12-10 | Warnings | M012 |
| CVS Maximum Strength Cold and Flu Relief | ACETAMINOPHEN, DEXTROMETHORPHAN HYDROBROMIDE, GUAIFENESIN ,PHENYLEPHRINE HCL | CVS PHARMACY, INC | cf4eb4c4-68e0-4478-a81c-d3d1e66f5cc5 | 2025-12-10 | Warnings | M012 |
| Tylenol Cold plus Flu Severe, Lil Drug Store | ACETAMINOPHEN, DEXTROMETHORPHAN HYDROBROMIDE, GUAIFENESIN, AND PHENYLEPHRINE HYDROCHLORIDE | Lil Drug Store Products, Inc | f395c196-62d7-47ff-b38d-af37adf5980b | 2025-12-10 | Warnings | M012 |
| Tylenol Sinus Severe, Lil Drug Store | ACETAMINOPHEN, GUAIFENESIN, AND PHENYLEPHRINE HYDROCHLORIDE | Lil Drug Store Products, Inc | 88b68447-b016-4d5b-a5e3-c4ebccb14f8c | 2025-12-10 | Warnings | M012 |
| Allergy Relief | DIPHENHYDRAMINE HCL | Family Dollar Services Inc | d956f1b8-91f8-424b-bb6c-704c445b6f4c | 2025-12-10 | Warnings | M012 |
| good neighbor pharmacy day time cold and flu | ACETAMINOPHEN, DEXTROMETHORPHAN HBR, PHENYLEPHRINE HCL | Amerisource Bergen | e5c1bd96-d27d-49c1-b3b8-eee53a145ef5 | 2025-12-10 | Warnings | M012 |
| NiteTime SEVERE Cold and Flu Relief SOFTGELS | ACETAMINOPHEN, DEXTROMETHORPHAN HYDROBROMIDE, DOXYLAMINE SUCCINATE, PHENYLEPHRINE HYDROCHLORIDE | Topco Associates LLC | 3ffe67bf-2c66-61e6-e063-6394a90a7f8f | 2025-12-10 | Warnings | M012 |
| DayTime SEVERE Cold and Flu Relief SOFTGELS | ACETAMINOPHEN, DEXTROMETHORPHAN HYDROBROMIDE, GUAIFENESIN, PHENYLEPHRINE HYDROCHLORIDE | Topco Associates LLC | 3ffe0f43-b92a-f947-e063-6394a90ab72c | 2025-12-10 | Warnings | M012 |
| MAXIMUM STRENGTH Sinus Relief Day and Night SOFTGELS - 24 ct | ACETAMINOPHEN, DEXTROMETHORPHAN HYDROBROMIDE, GUAIFENESIN, DOXYLAMINE SUCCINATE, PHENYLEPHRINE HYDROCHLORIDE | Topco Associates LLC | a7285fe0-5a5b-42c4-be47-9a07a2ba75e8 | 2025-12-10 | Warnings | M012 |
| Cold and Flu Relief Nighttime | ACETAMINOPHEN, DEXTROMETHORPHAN HYDROBROMIDE, DOXYLAMINE SUCCINATE | Rite Aid Corporation | f9b8dbe1-7ff9-4320-850c-6e86e98d4393 | 2025-12-09 | Warnings | M012 |
| Severe Nasal | OXYMETAZOLINE HYDROCHLORIDE 0.05% | ALAINA HEALTHCARE PRIVATE LIMITED | 27747a10-8d1d-41c2-80b9-45452f3b9abc | 2025-12-09 | Warnings | M012 |
DailyMed RxNorm Mappings#
| RxCUI | RxNorm string | TTY | DailyMed | SPL version |
|---|---|---|---|---|
| 1049632 | Benadryl 25 MG Oral Tablet | PSN | de2a64ce-c169-4162-b79e-d3809bea2147 | 10 |
| 1049630 | diphenhydrAMINE HCl 25 MG Oral Tablet | PSN | de2a64ce-c169-4162-b79e-d3809bea2147 | 10 |
| 1049632 | diphenhydramine hydrochloride 25 MG Oral Tablet [Benadryl] | SBD | de2a64ce-c169-4162-b79e-d3809bea2147 | 10 |
| 1049630 | diphenhydramine hydrochloride 25 MG Oral Tablet | SCD | de2a64ce-c169-4162-b79e-d3809bea2147 | 10 |
| 1049632 | Benadryl 25 MG Oral Tablet | SY | de2a64ce-c169-4162-b79e-d3809bea2147 | 10 |
| 1049632 | Benadryl Allergy Ultratab 25 MG Oral Tablet | SY | de2a64ce-c169-4162-b79e-d3809bea2147 | 10 |
Packages#
| Package NDC | 11-digit format | Description | Units | Marketing start | Marketing end | Sample | Exclude flag | Status |
|---|---|---|---|---|---|---|---|---|
| 66715-9706-1 | 66715970601 | 2 in 1 POUCH | Historical | |||||
| 66715-9706-2 | 66715970602 | 2 POUCH in 1 CARTON (66715-9706-2) / 2 TABLET, FILM COATED in 1 POUCH | 2 pouch | 2018-12-14 | 0000-00-00 | No | No | Current |
| 66715-9706-3 | 66715970603 | 3 POUCH in 1 CARTON (66715-9706-3) / 2 TABLET, FILM COATED in 1 POUCH | 3 pouch | 2018-12-14 | 0000-00-00 | No | No | Current |