Amantadine Hydrochloride

Product NDC
67046-1452
11-digit product format
670461452
Labeler code
67046
Product ID
67046-1452_2d940d35-6a65-e494-e063-6394a90a9d16
Type
HUMAN PRESCRIPTION DRUG
Nonproprietary name
Amantadine Hydrochloride
Dosage form
TABLET
Route
ORAL
Labeler
Coupler LLC
Application
ANDA209035
Marketing category
ANDA
Marketing start
2025-02-07
Substance
AMANTADINE HYDROCHLORIDE
Active strength
100 mg/1
Pharmacologic classes
Influenza A M2 Protein Inhibitor [EPC], M2 Protein Inhibitors [MoA]
NDC exclude flag
No
Listing certified through
2026-12-31
Current FDA listing
Yes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 42.

Orange Book products#

Current product rows page 1 of 1 · 1 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
A209035-001AMANTADINE HYDROCHLORIDEAMANTADINE HYDROCHLORIDE100MGTABLET / ORALAB2017-06-09

Therapeutic equivalence codes#

Current TE-code rows page 1 of 1 · 1 matching rows.

Application-product, TE code table
Application-productTE code
A209035-001AB

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Product history page 1 of 2 · 42 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-08-18 06:07:402026-07A209035-001AMANTADINE HYDROCHLORIDE100MGTABLET / ORALAB2017-06-09caaa826d4ba7…
2026-02-19 14:30 UTC2026-02A209035-001AMANTADINE HYDROCHLORIDE100MGTABLET / ORALAB2017-06-09011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A209035-001AMANTADINE HYDROCHLORIDE100MGTABLET / ORALAB2017-06-0931067a03dcf5…
2025-08-23 18:47 UTC2025-08A209035-001AMANTADINE HYDROCHLORIDE100MGTABLET / ORALAB2017-06-096a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A209035-001AMANTADINE HYDROCHLORIDE100MGTABLET / ORALAB2017-06-09fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A209035-001AMANTADINE HYDROCHLORIDE100MGTABLET / ORALAB2017-06-09b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A209035-001AMANTADINE HYDROCHLORIDE100MGTABLET / ORALAB2017-06-0903ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A209035-001AMANTADINE HYDROCHLORIDE100MGTABLET / ORALAB2017-06-092680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A209035-001AMANTADINE HYDROCHLORIDE100MGTABLET / ORALAB2017-06-095bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A209035-001AMANTADINE HYDROCHLORIDE100MGTABLET / ORALAB2017-06-09d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A209035-001AMANTADINE HYDROCHLORIDE100MGTABLET / ORALAB2017-06-09d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A209035-001AMANTADINE HYDROCHLORIDE100MGTABLET / ORALAB2017-06-0979d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A209035-001AMANTADINE HYDROCHLORIDE100MGTABLET / ORALAB2017-06-09301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A209035-001AMANTADINE HYDROCHLORIDE100MGTABLET / ORALAB2017-06-091e350fbaab3a…
2024-05-31 18:47 UTC2024-05A209035-001AMANTADINE HYDROCHLORIDE100MGTABLET / ORALAB2017-06-098072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06A209035-001AMANTADINE HYDROCHLORIDE100MGTABLET / ORALBX2017-06-095c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04A209035-001AMANTADINE HYDROCHLORIDE100MGTABLET / ORALBX2017-06-095d02ea3f76ae…
2022-04-04 05:41 UTC2022-04A209035-001AMANTADINE HYDROCHLORIDE100MGTABLET / ORALBX2017-06-094b0b4de00fa7…
2019-12-13 00:20 UTC2019-12A209035-001AMANTADINE HYDROCHLORIDE100MGTABLET / ORALAB2017-06-0974a2ff9319b5…
2022-03-09 01:35 UTC2022-03A209035-001AMANTADINE HYDROCHLORIDE100MGTABLET / ORALBX2017-06-09bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12A209035-001AMANTADINE HYDROCHLORIDE100MGTABLET / ORALBX2017-06-09782e0a99824c…
2021-05-05 16:15 UTC · 3 captures of this ZIP2021-05A209035-001AMANTADINE HYDROCHLORIDE100MGTABLET / ORALAB2017-06-0987673890dc5c…
2021-03-12 10:30 UTC2021-03A209035-001AMANTADINE HYDROCHLORIDE100MGTABLET / ORALAB2017-06-095aa47cf7b7d7…
2020-12-22 03:56 UTC2020-12A209035-001AMANTADINE HYDROCHLORIDE100MGTABLET / ORALAB2017-06-098869cabd3fbd…
2020-11-12 02:37 UTC2020-11A209035-001AMANTADINE HYDROCHLORIDE100MGTABLET / ORALAB2017-06-09c0c555d07b60…
2019-12-14 00:12 UTC2019-12A209035-001AMANTADINE HYDROCHLORIDE100MGTABLET / ORALAB2017-06-093f01610625f2…
2019-09-15 20:21 UTC2019-09A209035-001AMANTADINE HYDROCHLORIDE100MGTABLET / ORALAB2017-06-09b00525d2431f…
2019-07-19 19:46 UTC2019-07A209035-001AMANTADINE HYDROCHLORIDE100MGTABLET / ORALAB2017-06-09ea99ee380514…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A209035-001AMANTADINE HYDROCHLORIDE100MGTABLET / ORALAB2017-06-096a51e52b5d6a…
2024-02-18 07:12 UTC2024-02A209035-001AMANTADINE HYDROCHLORIDE100MGTABLET / ORALAB2017-06-091c564ffb4f44…
2023-12-20 04:57 UTC2023-12A209035-001AMANTADINE HYDROCHLORIDE100MGTABLET / ORALAB2017-06-09ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11A209035-001AMANTADINE HYDROCHLORIDE100MGTABLET / ORALAB2017-06-09a72a2bbeb626…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10A209035-001AMANTADINE HYDROCHLORIDE100MGTABLET / ORALAB2017-06-099b2671bbb829…
2023-07-15 15:27 UTC · 2 captures of this ZIP2023-07A209035-001AMANTADINE HYDROCHLORIDE100MGTABLET / ORALAB2017-06-09a67488948f0b…
2023-06-13 01:57 UTC · 3 captures of this ZIP2023-06A209035-001AMANTADINE HYDROCHLORIDE100MGTABLET / ORALAB2017-06-093f0d92c62455…
2023-05-13 08:27 UTC2023-05A209035-001AMANTADINE HYDROCHLORIDE100MGTABLET / ORALAB2017-06-09053a50430f4f…
2023-01-26 05:58 UTC2023-01A209035-001AMANTADINE HYDROCHLORIDE100MGTABLET / ORALBX2017-06-093bdfa0b2c4d7…
2022-11-12 20:34 UTC · 5 captures of this ZIP2022-11A209035-001AMANTADINE HYDROCHLORIDE100MGTABLET / ORALBX2017-06-093a93d1ddd44b…
2022-10-28 04:53 UTC2022-10A209035-001AMANTADINE HYDROCHLORIDE100MGTABLET / ORALBX2017-06-09f41ea6bd6efb…
2022-09-29 23:25 UTC2022-09A209035-001AMANTADINE HYDROCHLORIDE100MGTABLET / ORALBX2017-06-09e64feba35796…

Observed Orange Book normalized TE history#

Normalized TE history page 1 of 2 · 42 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTE codeOrderSource SHA-256
2026-08-18 06:07:402026-07A209035-001AB1caaa826d4ba7…
2026-02-19 14:30 UTC2026-02A209035-001AB1011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A209035-001AB131067a03dcf5…
2025-08-23 18:47 UTC2025-08A209035-001AB16a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A209035-001AB1fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A209035-001AB1b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A209035-001AB103ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A209035-001AB12680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A209035-001AB15bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A209035-001AB1d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A209035-001AB1d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A209035-001AB179d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A209035-001AB1301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A209035-001AB11e350fbaab3a…
2024-05-31 18:47 UTC2024-05A209035-001AB18072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06A209035-001BX15c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04A209035-001BX15d02ea3f76ae…
2022-04-04 05:41 UTC2022-04A209035-001BX14b0b4de00fa7…
2019-12-13 00:20 UTC2019-12A209035-001AB174a2ff9319b5…
2022-03-09 01:35 UTC2022-03A209035-001BX1bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12A209035-001BX1782e0a99824c…
2021-05-05 16:15 UTC · 3 captures of this ZIP2021-05A209035-001AB187673890dc5c…
2021-03-12 10:30 UTC2021-03A209035-001AB15aa47cf7b7d7…
2020-12-22 03:56 UTC2020-12A209035-001AB18869cabd3fbd…
2020-11-12 02:37 UTC2020-11A209035-001AB1c0c555d07b60…
2019-12-14 00:12 UTC2019-12A209035-001AB13f01610625f2…
2019-09-15 20:21 UTC2019-09A209035-001AB1b00525d2431f…
2019-07-19 19:46 UTC2019-07A209035-001AB1ea99ee380514…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A209035-001AB16a51e52b5d6a…
2024-02-18 07:12 UTC2024-02A209035-001AB11c564ffb4f44…
2023-12-20 04:57 UTC2023-12A209035-001AB1ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11A209035-001AB1a72a2bbeb626…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10A209035-001AB19b2671bbb829…
2023-07-15 15:27 UTC · 2 captures of this ZIP2023-07A209035-001AB1a67488948f0b…
2023-06-13 01:57 UTC · 3 captures of this ZIP2023-06A209035-001AB13f0d92c62455…
2023-05-13 08:27 UTC2023-05A209035-001AB1053a50430f4f…
2023-01-26 05:58 UTC2023-01A209035-001BX13bdfa0b2c4d7…
2022-11-12 20:34 UTC · 5 captures of this ZIP2022-11A209035-001BX13a93d1ddd44b…
2022-10-28 04:53 UTC2022-10A209035-001BX1f41ea6bd6efb…
2022-09-29 23:25 UTC2022-09A209035-001BX1e64feba35796…

Additional Listing Data#

Finished product
Yes
Brand name base
Amantadine Hydrochloride
Listing expiration
2026-12-31

Active Ingredients#

Ingredient, Strength table
IngredientStrength
AMANTADINE HYDROCHLORIDE100 mg/1

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
M6Q1EO9TD0Internal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
849395Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
2d94073b-c064-c280-e063-6294a90af145Available on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product conceptRelationVersionEffective
519d6abc-639d-2962-cced-abbf8b16aad4Product name720250401
82f46845-b4c7-48da-a389-ba5721b956c9Product name220250325
d2c037c0-5ebf-d224-252f-2549922c21c7Product name720240208
b7b57a62-2f7f-1a22-2cb2-eaa5c08d4721Product name220220224
14e11aaf-885f-472f-a02a-c6a3f28df907Product name120180515
82f46845-b4c7-48da-a389-ba5721b956c9Product name120171103

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDCProductDescriptionFormQuantityStrengthSPL version
67046-1452-3Amantadine Hydrochloride30 in 1 BLISTER PACKTABLET301

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDCDashboard titleSPL versionValidationDashboard ZIP
67046-1452AMANTADINE HYDROCHLORIDE TABLET [COUPLER LLC]1Current NDC, 1 package rows20250210_2d94073b-c064-c280-e063-6294a90af145.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 3 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
Amantadine HydrochlorideAMANTADINE HYDROCHLORIDEStrides Pharma Inc.9a99bb98-82a4-4b9e-9216-554dade72a3c2025-12-12Warnings, Adverse reactionsExact identifier
application applno (ANDA): 209035
application number: ANDA209035
Amantadine HydrochlorideAMANTADINE HYDROCHLORIDECoupler LLC2d94073b-c064-c280-e063-6294a90af1452025-02-07Warnings, Adverse reactionsExact identifier
application applno (ANDA): 209035
application number: ANDA209035
ndc (product): 67046-1452
Amantadine HCLAMANTADINE HCLDirect_Rx1211ebf4-3169-20ca-e063-6294a90aee4d2024-02-29Warnings, Adverse reactionsExact identifier
application applno (ANDA): 209035
application number: ANDA209035

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUIRxNorm stringTTYDailyMedSPL version
849395amantadine HCl 100 MG Oral TabletPSN2d94073b-c064-c280-e063-6294a90af1451
849395amantadine hydrochloride 100 MG Oral TabletSCD2d94073b-c064-c280-e063-6294a90af1451

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionUnitsMarketing startSampleExclude flagStatus
67046-1452-36704614520330 TABLET in 1 BLISTER PACK (67046-1452-3) 30 tablet2025-02-07NoNoCurrent