Esmolol Hydrochloride

Product NDC
67457-182
11-digit product format
674570182
Labeler code
67457
Product ID
67457-182_677a4e72-7b0a-4f6c-b82e-091d93588566
Type
HUMAN PRESCRIPTION DRUG
Nonproprietary name
esmolol hydrochloride
Dosage form
INJECTION, SOLUTION
Route
INTRAVENOUS
Labeler
Mylan Institutional LLC
Application
ANDA076474
Marketing category
ANDA
Marketing start
2007-05-29
Substance
ESMOLOL HYDROCHLORIDE
Active strength
10 mg/mL
Pharmacologic classes
Adrenergic beta-Antagonists [MoA], beta-Adrenergic Blocker [EPC]
NDC exclude flag
No
Listing certified through
2026-12-31
Current FDA listing
Yes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 1.

Orange Book products#

Current product rows page 1 of 1 · 1 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
A076474-001ESMOLOL HYDROCHLORIDEESMOLOL HYDROCHLORIDE10MG/MLINJECTABLE / INJECTIONAP2005-05-02

Therapeutic equivalence codes#

Current TE-code rows page 1 of 1 · 1 matching rows.

Application-product, TE code table
Application-productTE code
A076474-001AP

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Product history page 1 of 2 · 41 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-02-19 14:30 UTC2026-02A076474-001ESMOLOL HYDROCHLORIDE10MG/MLINJECTABLE / INJECTIONAP2005-05-02011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A076474-001ESMOLOL HYDROCHLORIDE10MG/MLINJECTABLE / INJECTIONAP2005-05-0231067a03dcf5…
2025-08-23 18:47 UTC2025-08A076474-001ESMOLOL HYDROCHLORIDE10MG/MLINJECTABLE / INJECTIONAP2005-05-026a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A076474-001ESMOLOL HYDROCHLORIDE10MG/MLINJECTABLE / INJECTIONAP2005-05-02fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A076474-001ESMOLOL HYDROCHLORIDE10MG/MLINJECTABLE / INJECTIONAP2005-05-02b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A076474-001ESMOLOL HYDROCHLORIDE10MG/MLINJECTABLE / INJECTIONAP2005-05-0203ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A076474-001ESMOLOL HYDROCHLORIDE10MG/MLINJECTABLE / INJECTIONAP2005-05-022680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A076474-001ESMOLOL HYDROCHLORIDE10MG/MLINJECTABLE / INJECTIONAP2005-05-025bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A076474-001ESMOLOL HYDROCHLORIDE10MG/MLINJECTABLE / INJECTIONAP2005-05-02d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A076474-001ESMOLOL HYDROCHLORIDE10MG/MLINJECTABLE / INJECTIONAP2005-05-02d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A076474-001ESMOLOL HYDROCHLORIDE10MG/MLINJECTABLE / INJECTIONAP2005-05-0279d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A076474-001ESMOLOL HYDROCHLORIDE10MG/MLINJECTABLE / INJECTIONAP2005-05-02301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A076474-001ESMOLOL HYDROCHLORIDE10MG/MLINJECTABLE / INJECTIONAP2005-05-021e350fbaab3a…
2024-05-31 18:47 UTC2024-05A076474-001ESMOLOL HYDROCHLORIDE10MG/MLINJECTABLE / INJECTIONAP2005-05-028072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06A076474-001ESMOLOL HYDROCHLORIDE10MG/MLINJECTABLE / INJECTIONAP2005-05-025c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04A076474-001ESMOLOL HYDROCHLORIDE10MG/MLINJECTABLE / INJECTIONAP2005-05-025d02ea3f76ae…
2022-04-04 05:41 UTC2022-04A076474-001ESMOLOL HYDROCHLORIDE10MG/MLINJECTABLE / INJECTIONAP2005-05-024b0b4de00fa7…
2019-12-13 00:20 UTC2019-12A076474-001ESMOLOL HYDROCHLORIDE10MG/MLINJECTABLE / INJECTIONAP2005-05-0274a2ff9319b5…
2022-03-09 01:35 UTC2022-03A076474-001ESMOLOL HYDROCHLORIDE10MG/MLINJECTABLE / INJECTIONAP2005-05-02bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12A076474-001ESMOLOL HYDROCHLORIDE10MG/MLINJECTABLE / INJECTIONAP2005-05-02782e0a99824c…
2021-05-05 16:15 UTC · 3 captures of this ZIP2021-05A076474-001ESMOLOL HYDROCHLORIDE10MG/MLINJECTABLE / INJECTIONAP2005-05-0287673890dc5c…
2021-03-12 10:30 UTC2021-03A076474-001ESMOLOL HYDROCHLORIDE10MG/MLINJECTABLE / INJECTIONAP2005-05-025aa47cf7b7d7…
2020-12-22 03:56 UTC2020-12A076474-001ESMOLOL HYDROCHLORIDE10MG/MLINJECTABLE / INJECTIONAP2005-05-028869cabd3fbd…
2020-11-12 02:37 UTC2020-11A076474-001ESMOLOL HYDROCHLORIDE10MG/MLINJECTABLE / INJECTIONAP2005-05-02c0c555d07b60…
2019-12-14 00:12 UTC2019-12A076474-001ESMOLOL HYDROCHLORIDE10MG/MLINJECTABLE / INJECTIONAP2005-05-023f01610625f2…
2019-09-15 20:21 UTC2019-09A076474-001ESMOLOL HYDROCHLORIDE10MG/MLINJECTABLE / INJECTIONAP2005-05-02b00525d2431f…
2019-07-19 19:46 UTC2019-07A076474-001ESMOLOL HYDROCHLORIDE10MG/MLINJECTABLE / INJECTIONAP2005-05-02ea99ee380514…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A076474-001ESMOLOL HYDROCHLORIDE10MG/MLINJECTABLE / INJECTIONAP2005-05-026a51e52b5d6a…
2024-02-18 07:12 UTC2024-02A076474-001ESMOLOL HYDROCHLORIDE10MG/MLINJECTABLE / INJECTIONAP2005-05-021c564ffb4f44…
2023-12-20 04:57 UTC2023-12A076474-001ESMOLOL HYDROCHLORIDE10MG/MLINJECTABLE / INJECTIONAP2005-05-02ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11A076474-001ESMOLOL HYDROCHLORIDE10MG/MLINJECTABLE / INJECTIONAP2005-05-02a72a2bbeb626…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10A076474-001ESMOLOL HYDROCHLORIDE10MG/MLINJECTABLE / INJECTIONAP2005-05-029b2671bbb829…
2023-07-15 15:27 UTC · 2 captures of this ZIP2023-07A076474-001ESMOLOL HYDROCHLORIDE10MG/MLINJECTABLE / INJECTIONAP2005-05-02a67488948f0b…
2023-06-13 01:57 UTC · 3 captures of this ZIP2023-06A076474-001ESMOLOL HYDROCHLORIDE10MG/MLINJECTABLE / INJECTIONAP2005-05-023f0d92c62455…
2023-05-13 08:27 UTC2023-05A076474-001ESMOLOL HYDROCHLORIDE10MG/MLINJECTABLE / INJECTIONAP2005-05-02053a50430f4f…
2023-01-26 05:58 UTC2023-01A076474-001ESMOLOL HYDROCHLORIDE10MG/MLINJECTABLE / INJECTIONAP2005-05-023bdfa0b2c4d7…
2022-11-12 20:34 UTC · 5 captures of this ZIP2022-11A076474-001ESMOLOL HYDROCHLORIDE10MG/MLINJECTABLE / INJECTIONAP2005-05-023a93d1ddd44b…
2022-10-28 04:53 UTC2022-10A076474-001ESMOLOL HYDROCHLORIDE10MG/MLINJECTABLE / INJECTIONAP2005-05-02f41ea6bd6efb…
2022-09-29 23:25 UTC2022-09A076474-001ESMOLOL HYDROCHLORIDE10MG/MLINJECTABLE / INJECTIONAP2005-05-02e64feba35796…
2022-07-09 03:26 UTC · 3 captures of this ZIP2022-07A076474-001ESMOLOL HYDROCHLORIDE10MG/MLINJECTABLE / INJECTIONAP2005-05-02cb3db0bc1861…

Observed Orange Book normalized TE history#

Normalized TE history page 1 of 2 · 41 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTE codeOrderSource SHA-256
2026-02-19 14:30 UTC2026-02A076474-001AP1011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A076474-001AP131067a03dcf5…
2025-08-23 18:47 UTC2025-08A076474-001AP16a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A076474-001AP1fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A076474-001AP1b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A076474-001AP103ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A076474-001AP12680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A076474-001AP15bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A076474-001AP1d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A076474-001AP1d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A076474-001AP179d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A076474-001AP1301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A076474-001AP11e350fbaab3a…
2024-05-31 18:47 UTC2024-05A076474-001AP18072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06A076474-001AP15c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04A076474-001AP15d02ea3f76ae…
2022-04-04 05:41 UTC2022-04A076474-001AP14b0b4de00fa7…
2019-12-13 00:20 UTC2019-12A076474-001AP174a2ff9319b5…
2022-03-09 01:35 UTC2022-03A076474-001AP1bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12A076474-001AP1782e0a99824c…
2021-05-05 16:15 UTC · 3 captures of this ZIP2021-05A076474-001AP187673890dc5c…
2021-03-12 10:30 UTC2021-03A076474-001AP15aa47cf7b7d7…
2020-12-22 03:56 UTC2020-12A076474-001AP18869cabd3fbd…
2020-11-12 02:37 UTC2020-11A076474-001AP1c0c555d07b60…
2019-12-14 00:12 UTC2019-12A076474-001AP13f01610625f2…
2019-09-15 20:21 UTC2019-09A076474-001AP1b00525d2431f…
2019-07-19 19:46 UTC2019-07A076474-001AP1ea99ee380514…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A076474-001AP16a51e52b5d6a…
2024-02-18 07:12 UTC2024-02A076474-001AP11c564ffb4f44…
2023-12-20 04:57 UTC2023-12A076474-001AP1ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11A076474-001AP1a72a2bbeb626…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10A076474-001AP19b2671bbb829…
2023-07-15 15:27 UTC · 2 captures of this ZIP2023-07A076474-001AP1a67488948f0b…
2023-06-13 01:57 UTC · 3 captures of this ZIP2023-06A076474-001AP13f0d92c62455…
2023-05-13 08:27 UTC2023-05A076474-001AP1053a50430f4f…
2023-01-26 05:58 UTC2023-01A076474-001AP13bdfa0b2c4d7…
2022-11-12 20:34 UTC · 5 captures of this ZIP2022-11A076474-001AP13a93d1ddd44b…
2022-10-28 04:53 UTC2022-10A076474-001AP1f41ea6bd6efb…
2022-09-29 23:25 UTC2022-09A076474-001AP1e64feba35796…
2022-07-09 03:26 UTC · 3 captures of this ZIP2022-07A076474-001AP1cb3db0bc1861…

Additional Listing Data#

Finished product
Yes
Brand name base
Esmolol Hydrochloride
Listing expiration
2026-12-31

Active Ingredients#

Ingredient, Strength table
IngredientStrength
ESMOLOL HYDROCHLORIDE10 mg/mL

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
V05260LC8DInternal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
1736546Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
94f069f9-dd52-4a69-a103-ebdb4294f088Available on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product conceptRelationVersionEffective
a21a21e5-f36d-4c1f-8918-def921b8f7e3Product name320250124
ab3d10ea-fe48-4811-8e72-bb51600b35f9Product name520230103
9cb9173b-3912-466b-8256-366e71d49fceProduct name120190402
48747306-602a-42cc-957b-5b0c69158eeeProduct name120180604
db5ebcdb-b6ae-21cd-4dc5-76cd84b5578bProduct name120140508

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDCProductDescriptionFormQuantityStrengthSPL version
67457-182-00Esmolol Hydrochloride10 mL in 1 VIALINJECTION, SOLUTION1011
67457-182-10Esmolol Hydrochloride10 in 1 CARTONINJECTION, SOLUTION1011

DailyMed Billing Units#

Package NDC, Billing unit, Product NDC table
Package NDCBilling unitProduct NDCDailyMed indexing SPLSPL versionEffective
67457-182-00ML - Milliliter67457-182e6e9201b-9f8e-45bc-be83-efc5ae87893d12015-10-02
67457-182-10ML - Milliliter67457-18233dc64ce-7de4-459d-a777-22d372c2971012012-07-24

DailyMed Socrata Ingredients#

Ingredient, Type, UNII table
IngredientTypeUNIIDailyMed labelSPL versionUploaded
ESMOLOL HYDROCHLORIDEACTIVE INGREDIENTV05260LC8DESMOLOL HYDROCHLORIDE INJECTION, SOLUTION [MYLAN INSTITUTIONAL LLC]4
ESMOLOLACTIVE MOIETYMDY902UXSRESMOLOL HYDROCHLORIDE INJECTION, SOLUTION [MYLAN INSTITUTIONAL LLC]4
ACETIC ACIDINACTIVE INGREDIENTQ40Q9N063PESMOLOL HYDROCHLORIDE INJECTION, SOLUTION [MYLAN INSTITUTIONAL LLC]4
HYDROCHLORIC ACIDINACTIVE INGREDIENTQTT17582CBESMOLOL HYDROCHLORIDE INJECTION, SOLUTION [MYLAN INSTITUTIONAL LLC]4
SODIUM ACETATE ANHYDROUSINACTIVE INGREDIENTNVG71ZZ7P0ESMOLOL HYDROCHLORIDE INJECTION, SOLUTION [MYLAN INSTITUTIONAL LLC]4
SODIUM HYDROXIDEINACTIVE INGREDIENT55X04QC32IESMOLOL HYDROCHLORIDE INJECTION, SOLUTION [MYLAN INSTITUTIONAL LLC]4
WATERINACTIVE INGREDIENT059QF0KO0RESMOLOL HYDROCHLORIDE INJECTION, SOLUTION [MYLAN INSTITUTIONAL LLC]4
ESMOLOL HYDROCHLORIDEACTIVE INGREDIENTV05260LC8DESMOLOL HYDROCHLORIDE INJECTION [GENERAL INJECTABLES AND VACCINES, INC.]1
ESMOLOLACTIVE MOIETYMDY902UXSRESMOLOL HYDROCHLORIDE INJECTION [GENERAL INJECTABLES AND VACCINES, INC.]1
ACETIC ACIDINACTIVE INGREDIENTQ40Q9N063PESMOLOL HYDROCHLORIDE INJECTION [GENERAL INJECTABLES AND VACCINES, INC.]1
HYDROCHLORIC ACIDINACTIVE INGREDIENTQTT17582CBESMOLOL HYDROCHLORIDE INJECTION [GENERAL INJECTABLES AND VACCINES, INC.]1
SODIUM ACETATE ANHYDROUSINACTIVE INGREDIENTNVG71ZZ7P0ESMOLOL HYDROCHLORIDE INJECTION [GENERAL INJECTABLES AND VACCINES, INC.]1
SODIUM HYDROXIDEINACTIVE INGREDIENT55X04QC32IESMOLOL HYDROCHLORIDE INJECTION [GENERAL INJECTABLES AND VACCINES, INC.]1
WATERINACTIVE INGREDIENT059QF0KO0RESMOLOL HYDROCHLORIDE INJECTION [GENERAL INJECTABLES AND VACCINES, INC.]1

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDCDashboard titleSPL versionValidationDashboard ZIP
67457-182ESMOLOL HYDROCHLORIDE INJECTION, SOLUTION [MYLAN INSTITUTIONAL LLC]11Current NDC, Legacy NDC, 2 package rows20250522_94f069f9-dd52-4a69-a103-ebdb4294f088.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 3 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
Esmolol HydrochlorideESMOLOL HYDROCHLORIDEHenry Schein, Inc.9c1e3a64-0ef0-4071-ad6f-63ff8789b1982025-06-18Warnings, Adverse reactionsExact identifier
application applno (ANDA): 076474
application number: ANDA076474
Esmolol HydrochlorideESMOLOL HYDROCHLORIDEMylan Institutional LLC94f069f9-dd52-4a69-a103-ebdb4294f0882025-02-27Warnings, Adverse reactionsExact identifier
application applno (ANDA): 076474
application number: ANDA076474
ndc (product): 67457-182
ESMOLOL HYDROCHLORIDEESMOLOL HYDROCHLORIDEHF Acquisition Co LLC, DBA HealthFirst789730fa-eaca-4986-e053-2a91aa0a53392024-02-19Warnings, Adverse reactionsExact identifier
application applno (ANDA): 076474
application number: ANDA076474

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUIRxNorm stringTTYDailyMedSPL version
1736546esmolol HCl 100 MG in 10 ML InjectionPSN94f069f9-dd52-4a69-a103-ebdb4294f08811
173654610 ML esmolol hydrochloride 10 MG/ML InjectionSCD94f069f9-dd52-4a69-a103-ebdb4294f08811
1736546esmolol HCl 100 MG per 10 ML InjectionSY94f069f9-dd52-4a69-a103-ebdb4294f08811
1736546esmolol HCl 100 MG in 10 ML InjectionPSN789730fa-eaca-4986-e053-2a91aa0a53395
173654610 ML esmolol hydrochloride 10 MG/ML InjectionSCD789730fa-eaca-4986-e053-2a91aa0a53395
1736546esmolol HCl 100 MG per 10 ML InjectionSY789730fa-eaca-4986-e053-2a91aa0a53395
1736546esmolol HCl 100 MG in 10 ML InjectionPSN9c1e3a64-0ef0-4071-ad6f-63ff8789b1982
173654610 ML esmolol hydrochloride 10 MG/ML InjectionSCD9c1e3a64-0ef0-4071-ad6f-63ff8789b1982
1736546esmolol HCl 100 MG per 10 ML InjectionSY9c1e3a64-0ef0-4071-ad6f-63ff8789b1982
1736546esmolol HCl 100 MG in 10 ML InjectionPSN55def2c7-b354-47e6-bd25-6ecd928607951
173654610 ML esmolol hydrochloride 10 MG/ML InjectionSCD55def2c7-b354-47e6-bd25-6ecd928607951
1736546esmolol HCl 100 MG per 10 ML InjectionSY55def2c7-b354-47e6-bd25-6ecd928607951

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionUnitsMarketing startMarketing endSampleExclude flagStatus
67457-182-006745701820010 mL in 1 VIAL10 mlHistorical
67457-182-106745701821010 VIAL in 1 CARTON (67457-182-10) / 10 mL in 1 VIAL (67457-182-00) 10 vial2007-05-290000-00-00NoNoCurrent