Timolol Maleate

Product NDC
67877-229
Requested package NDC
67877-229-11
11-digit product format
678770229
Labeler code
67877
Product ID
67877-229_5f58b262-3991-4c70-b7b2-b518e7cfb1fe
Type
HUMAN PRESCRIPTION DRUG
Nonproprietary name
Timolol Maleate
Dosage form
SOLUTION
Route
OPHTHALMIC
Labeler
Ascend Laboratories, LLC
Application
ANDA077259
Marketing category
ANDA
Marketing start
2011-03-09
Marketing end
0000-00-00
Substance
TIMOLOL MALEATE
Active strength
5 mg/mL
Pharmacologic classes
Adrenergic beta-Antagonists [MoA],beta-Adrenergic Blocker [EPC]
NDC exclude flag
No
Listing certified through
2020-12-31
Current FDA listing
Historical FDA.report record

NDC auxiliary status#

These records are reproduced from FDA’s unfinished, excluded, and compounder listings. They describe what appeared in the source files; a missing record does not establish a regulatory status. View all current auxiliary records, including entries without an NDC. · View the auxiliary file history.

Current NDC status page 1 of 1 · 1 matching rows.

Dataset, Scope, Product NDC table
DatasetScopeProduct NDCPackage NDCCodeStatusReporting periodSource date
excluded packagepackage67877-22967877-229-11DDiscontinued by firm2026-08-11

Observed NDC auxiliary status history#

This history shows the information present in each captured FDA auxiliary file. It is not a continuous regulatory timeline, and a missing record does not establish a status.

Historic NDC status page 1 of 1 · 15 matching rows.

View current auxiliary records. · View the auxiliary file history.

Captured / source date, Snapshot, Source SHA-256 table
Captured / source dateSnapshotSource SHA-256
2025-12-14 17:58 UTC · source 2025-12-05d630ba8d3edf…732f749b63fb…
2025-08-27 00:01 UTC · source 2025-08-26f5e01cc5f278…a2eaf40c39c3…
2025-04-01 02:39 UTC · source 2025-03-312ef7874e63bc…57b86245f4fa…
2025-03-28 20:22 UTC · source 2025-03-28a1b67e2a42f9…c4cf2c586c0d…
2025-03-22 03:12 UTC · source 2025-03-21cfe11265f3b6…090c488252e2…
2025-03-10 12:48 UTC · source 2025-03-10cdf11ea48f46…ba0047e9e063…
2025-02-02 03:52 UTC · source 2025-01-31302b2466d912…e7b80fea0513…
2025-01-20 13:05 UTC · source 2025-01-20ed331223b511…672a5bd82f5f…
2025-01-11 03:41 UTC · source 2025-01-100efc9e666f02…f202fb6c5f17…
2024-11-09 02:27 UTC · source 2024-11-08ad56d346431e…cc804d4bbf1e…
2024-10-04 04:10 UTC · source 2024-10-03367a005e9d99…383a685ebd0f…
2024-07-10 04:00 UTC · source 2024-07-09557ba5c1ecfa…9c80585c8c6e…
2024-05-28 21:12 UTC · source 2024-05-288af77b9d5b6f…d9bbb34c5368…
2024-05-15 03:39 UTC · source 2024-05-14834df4deac94…adcc014656a3…
2024-03-11 06:39 UTC · source 2024-03-081332a3947898…d4bfe170f9cd…

Source provenance: Browse the complete Orange Book source catalog · source snapshot 1.

Orange Book products#

Current product rows page 1 of 1 · 2 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
A077259-001TIMOLOL MALEATETIMOLOL MALEATEEQ 0.25% BASESOLUTION/DROPS / OPHTHALMICAT12008-04-30
A077259-002TIMOLOL MALEATETIMOLOL MALEATEEQ 0.5% BASESOLUTION/DROPS / OPHTHALMICAT12008-04-30

Therapeutic equivalence codes#

Current TE-code rows page 1 of 1 · 2 matching rows.

Application-product, TE code table
Application-productTE code
A077259-001AT1
A077259-002AT1

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Product history page 1 of 3 · 82 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-02-19 14:30 UTC2026-02A077259-001TIMOLOL MALEATEEQ 0.25% BASESOLUTION/DROPS / OPHTHALMICAT12008-04-30011fe1cb6892…
2026-02-19 14:30 UTC2026-02A077259-002TIMOLOL MALEATEEQ 0.5% BASESOLUTION/DROPS / OPHTHALMICAT12008-04-30011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A077259-001TIMOLOL MALEATEEQ 0.25% BASESOLUTION/DROPS / OPHTHALMICAT12008-04-3031067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A077259-002TIMOLOL MALEATEEQ 0.5% BASESOLUTION/DROPS / OPHTHALMICAT12008-04-3031067a03dcf5…
2025-08-23 18:47 UTC2025-08A077259-001TIMOLOL MALEATEEQ 0.25% BASESOLUTION/DROPS / OPHTHALMICAT12008-04-306a471c1ec25d…
2025-08-23 18:47 UTC2025-08A077259-002TIMOLOL MALEATEEQ 0.5% BASESOLUTION/DROPS / OPHTHALMICAT12008-04-306a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A077259-001TIMOLOL MALEATEEQ 0.25% BASESOLUTION/DROPS / OPHTHALMICAT12008-04-30fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A077259-002TIMOLOL MALEATEEQ 0.5% BASESOLUTION/DROPS / OPHTHALMICAT12008-04-30fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A077259-001TIMOLOL MALEATEEQ 0.25% BASESOLUTION/DROPS / OPHTHALMICAT12008-04-30b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A077259-002TIMOLOL MALEATEEQ 0.5% BASESOLUTION/DROPS / OPHTHALMICAT12008-04-30b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A077259-001TIMOLOL MALEATEEQ 0.25% BASESOLUTION/DROPS / OPHTHALMICAT12008-04-3003ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A077259-002TIMOLOL MALEATEEQ 0.5% BASESOLUTION/DROPS / OPHTHALMICAT12008-04-3003ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A077259-001TIMOLOL MALEATEEQ 0.25% BASESOLUTION/DROPS / OPHTHALMICAT12008-04-302680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A077259-002TIMOLOL MALEATEEQ 0.5% BASESOLUTION/DROPS / OPHTHALMICAT12008-04-302680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A077259-001TIMOLOL MALEATEEQ 0.25% BASESOLUTION/DROPS / OPHTHALMICAT12008-04-305bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A077259-002TIMOLOL MALEATEEQ 0.5% BASESOLUTION/DROPS / OPHTHALMICAT12008-04-305bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A077259-001TIMOLOL MALEATEEQ 0.25% BASESOLUTION/DROPS / OPHTHALMICAT12008-04-30d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A077259-002TIMOLOL MALEATEEQ 0.5% BASESOLUTION/DROPS / OPHTHALMICAT12008-04-30d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A077259-001TIMOLOL MALEATEEQ 0.25% BASESOLUTION/DROPS / OPHTHALMICAT12008-04-30d06236e962d9…
2024-10-29 15:01 UTC2024-10A077259-002TIMOLOL MALEATEEQ 0.5% BASESOLUTION/DROPS / OPHTHALMICAT12008-04-30d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A077259-001TIMOLOL MALEATEEQ 0.25% BASESOLUTION/DROPS / OPHTHALMICAT12008-04-3079d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A077259-002TIMOLOL MALEATEEQ 0.5% BASESOLUTION/DROPS / OPHTHALMICAT12008-04-3079d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A077259-001TIMOLOL MALEATEEQ 0.25% BASESOLUTION/DROPS / OPHTHALMICAT12008-04-30301d65b070ca…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A077259-002TIMOLOL MALEATEEQ 0.5% BASESOLUTION/DROPS / OPHTHALMICAT12008-04-30301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A077259-001TIMOLOL MALEATEEQ 0.25% BASESOLUTION/DROPS / OPHTHALMICAT12008-04-301e350fbaab3a…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A077259-002TIMOLOL MALEATEEQ 0.5% BASESOLUTION/DROPS / OPHTHALMICAT12008-04-301e350fbaab3a…
2024-05-31 18:47 UTC2024-05A077259-001TIMOLOL MALEATEEQ 0.25% BASESOLUTION/DROPS / OPHTHALMICAT12008-04-308072bd15b7f6…
2024-05-31 18:47 UTC2024-05A077259-002TIMOLOL MALEATEEQ 0.5% BASESOLUTION/DROPS / OPHTHALMICAT12008-04-308072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06A077259-001TIMOLOL MALEATEEQ 0.25% BASESOLUTION/DROPS / OPHTHALMICAT12008-04-305c6f7cd8ea54…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06A077259-002TIMOLOL MALEATEEQ 0.5% BASESOLUTION/DROPS / OPHTHALMICAT12008-04-305c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04A077259-001TIMOLOL MALEATEEQ 0.25% BASESOLUTION/DROPS / OPHTHALMICAT12008-04-305d02ea3f76ae…
2022-04-08 23:34 UTC2022-04A077259-002TIMOLOL MALEATEEQ 0.5% BASESOLUTION/DROPS / OPHTHALMICAT12008-04-305d02ea3f76ae…
2022-04-04 05:41 UTC2022-04A077259-001TIMOLOL MALEATEEQ 0.25% BASESOLUTION/DROPS / OPHTHALMICAT12008-04-304b0b4de00fa7…
2022-04-04 05:41 UTC2022-04A077259-002TIMOLOL MALEATEEQ 0.5% BASESOLUTION/DROPS / OPHTHALMICAT12008-04-304b0b4de00fa7…
2019-12-13 00:20 UTC2019-12A077259-001TIMOLOL MALEATEEQ 0.25% BASESOLUTION/DROPS / OPHTHALMICAT2008-04-3074a2ff9319b5…
2019-12-13 00:20 UTC2019-12A077259-002TIMOLOL MALEATEEQ 0.5% BASESOLUTION/DROPS / OPHTHALMICAT12008-04-3074a2ff9319b5…
2022-03-09 01:35 UTC2022-03A077259-001TIMOLOL MALEATEEQ 0.25% BASESOLUTION/DROPS / OPHTHALMICAT12008-04-30bb7c543d1eb4…
2022-03-09 01:35 UTC2022-03A077259-002TIMOLOL MALEATEEQ 0.5% BASESOLUTION/DROPS / OPHTHALMICAT12008-04-30bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12A077259-001TIMOLOL MALEATEEQ 0.25% BASESOLUTION/DROPS / OPHTHALMICAT2008-04-30782e0a99824c…
2021-12-28 21:50 UTC2021-12A077259-002TIMOLOL MALEATEEQ 0.5% BASESOLUTION/DROPS / OPHTHALMICAT12008-04-30782e0a99824c…

Observed Orange Book normalized TE history#

Normalized TE history page 1 of 3 · 82 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTE codeOrderSource SHA-256
2026-02-19 14:30 UTC2026-02A077259-001AT11011fe1cb6892…
2026-02-19 14:30 UTC2026-02A077259-002AT11011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A077259-001AT1131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A077259-002AT1131067a03dcf5…
2025-08-23 18:47 UTC2025-08A077259-001AT116a471c1ec25d…
2025-08-23 18:47 UTC2025-08A077259-002AT116a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A077259-001AT11fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A077259-002AT11fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A077259-001AT11b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A077259-002AT11b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A077259-001AT1103ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A077259-002AT1103ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A077259-001AT112680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A077259-002AT112680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A077259-001AT115bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A077259-002AT115bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A077259-001AT11d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A077259-002AT11d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A077259-001AT11d06236e962d9…
2024-10-29 15:01 UTC2024-10A077259-002AT11d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A077259-001AT1179d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A077259-002AT1179d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A077259-001AT11301d65b070ca…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A077259-002AT11301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A077259-001AT111e350fbaab3a…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A077259-002AT111e350fbaab3a…
2024-05-31 18:47 UTC2024-05A077259-001AT118072bd15b7f6…
2024-05-31 18:47 UTC2024-05A077259-002AT118072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06A077259-001AT115c6f7cd8ea54…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06A077259-002AT115c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04A077259-001AT115d02ea3f76ae…
2022-04-08 23:34 UTC2022-04A077259-002AT115d02ea3f76ae…
2022-04-04 05:41 UTC2022-04A077259-001AT114b0b4de00fa7…
2022-04-04 05:41 UTC2022-04A077259-002AT114b0b4de00fa7…
2019-12-13 00:20 UTC2019-12A077259-001AT174a2ff9319b5…
2019-12-13 00:20 UTC2019-12A077259-002AT1174a2ff9319b5…
2022-03-09 01:35 UTC2022-03A077259-001AT11bb7c543d1eb4…
2022-03-09 01:35 UTC2022-03A077259-002AT11bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12A077259-001AT1782e0a99824c…
2021-12-28 21:50 UTC2021-12A077259-002AT11782e0a99824c…

DailyMed Product Concepts#

Product concept, Relation, Version table
Product conceptRelationVersionEffective
c6c0c444-a6ba-2fb5-a7bc-7f0443fa5791Product name420251208
73103a56-9f57-4f32-a306-a42bfa2fea36Product name120250505
425025fc-f910-4afe-815b-58d4486ed4f7Product name420250331
26c5ddae-5c69-622d-e599-5fd583634968Product name420250313
ee780602-134c-4c60-a2f0-e973ba549cd4Product name220250304
03f77cb2-b4ad-3c11-8781-787b5ece4291Product name320240507
273981e4-09e7-45cc-967c-554f628ededfProduct name320230627
97dad5a2-c524-a7b5-dede-82edefe9ce62Product name720220929
d11e749b-f93e-0ce3-ceda-28fe03d8081dProduct name220190731

FDA-Initiated Inactive NDC Indexing#

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDCProductDescriptionFormQuantityStrengthSPL version
67877-229-11Timolol Maleate1 in 1 CARTONSOLUTION15
67877-229-11Timolol Maleate10 mL in 1 BOTTLE, DISPENSINGSOLUTION105
67877-229-15Timolol Maleate1 in 1 CARTONSOLUTION15
67877-229-15Timolol Maleate15 mL in 1 BOTTLE, DISPENSINGSOLUTION155
67877-229-55Timolol Maleate1 in 1 CARTONSOLUTION15
67877-229-55Timolol Maleate5 mL in 1 BOTTLE, DISPENSINGSOLUTION55

DailyMed Socrata Ingredients#

Ingredient, Type, UNII table
IngredientTypeUNIIDailyMed labelSPL versionUploaded
TIMOLOL MALEATEACTIVE INGREDIENTP8Y54F701RTIMOLOL MALEATE SOLUTION [ASCEND LABORATORIES, LLC]4
TIMOLOL ANHYDROUSACTIVE MOIETY5JKY92S7BRTIMOLOL MALEATE SOLUTION [ASCEND LABORATORIES, LLC]4
BENZALKONIUM CHLORIDEINACTIVE INGREDIENTF5UM2KM3W7TIMOLOL MALEATE SOLUTION [ASCEND LABORATORIES, LLC]4
SODIUM CHLORIDEINACTIVE INGREDIENT451W47IQ8XTIMOLOL MALEATE SOLUTION [ASCEND LABORATORIES, LLC]4
SODIUM HYDROXIDEINACTIVE INGREDIENT55X04QC32ITIMOLOL MALEATE SOLUTION [ASCEND LABORATORIES, LLC]4
SODIUM PHOSPHATE, DIBASICINACTIVE INGREDIENTGR686LBA74TIMOLOL MALEATE SOLUTION [ASCEND LABORATORIES, LLC]4
SODIUM PHOSPHATE, MONOBASICINACTIVE INGREDIENT3980JIH2SWTIMOLOL MALEATE SOLUTION [ASCEND LABORATORIES, LLC]4
WATERINACTIVE INGREDIENT059QF0KO0RTIMOLOL MALEATE SOLUTION [ASCEND LABORATORIES, LLC]4

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDCDashboard titleSPL versionValidationDashboard ZIP
67877-229TIMOLOL MALEATE SOLUTION [ASCEND LABORATORIES, LLC]5Legacy NDC, 6 package rows20190101_85724f95-6fc9-4f0c-b69d-05a23b093e2b.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 1 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
TIMOLOL MALEATETIMOLOL MALEATERising Pharma Holdings, Inc.2ed21930-1e05-46de-8acd-cb6f4798a7fa2025-05-09Warnings, Adverse reactionsExact identifier
application applno (ANDA): 077259
application number: ANDA077259

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUIRxNorm stringTTYDailyMedSPL version
1992303timolol 0.5 % 12HR Ophthalmic SolutionPSN85724f95-6fc9-4f0c-b69d-05a23b093e2b5
199230312 HR timolol 5 MG/ML Ophthalmic SolutionSCD85724f95-6fc9-4f0c-b69d-05a23b093e2b5
1992303timolol 0.5 % (as timolol maleate 6.8 MG/ML) 12 HR Ophthalmic SolutionSY85724f95-6fc9-4f0c-b69d-05a23b093e2b5
1992303timolol 0.5 % 12 HR Ophthalmic SolutionSY85724f95-6fc9-4f0c-b69d-05a23b093e2b5

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionMarketing startMarketing endSampleExclude flagStatus
67877-229-11678770229111 BOTTLE, DISPENSING in 1 CARTON (67877-229-11) > 10 mL in 1 BOTTLE, DISPENSING2011-03-090000-00-00NoNoCurrent