Leucovorin Calcium

Product NDC
68001-416
11-digit product format
680010416
Labeler code
68001
Product ID
68001-416_d5ee26ca-d963-687f-e053-2a95a90a2a50
Type
HUMAN PRESCRIPTION DRUG
Nonproprietary name
Leucovorin Calcium
Dosage form
INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION
Route
INTRAMUSCULAR; INTRAVENOUS
Labeler
BluePoint Laboratories
Application
ANDA089717
Marketing category
ANDA
Marketing start
2019-09-26
Substance
LEUCOVORIN CALCIUM
Active strength
100 mg/10mL
Pharmacologic classes
Folate Analog [EPC], Folic Acid [CS]
NDC exclude flag
No
Listing certified through
2026-12-31
Current FDA listing
Yes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 1.

Orange Book products#

Current product rows page 1 of 1 · 1 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
A089717-001LEUCOVORIN CALCIUMLEUCOVORIN CALCIUMEQ 100MG BASE/VIALINJECTABLE / INJECTIONAPRS1988-03-28

Therapeutic equivalence codes#

Current TE-code rows page 1 of 1 · 1 matching rows.

Application-product, TE code table
Application-productTE code
A089717-001AP

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Product history page 1 of 2 · 41 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-02-19 14:30 UTC2026-02A089717-001LEUCOVORIN CALCIUMEQ 100MG BASE/VIALINJECTABLE / INJECTIONAPRS1988-03-28011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A089717-001LEUCOVORIN CALCIUMEQ 100MG BASE/VIALINJECTABLE / INJECTIONAPRS1988-03-2831067a03dcf5…
2025-08-23 18:47 UTC2025-08A089717-001LEUCOVORIN CALCIUMEQ 100MG BASE/VIALINJECTABLE / INJECTIONAPRS1988-03-286a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A089717-001LEUCOVORIN CALCIUMEQ 100MG BASE/VIALINJECTABLE / INJECTIONAPRS1988-03-28fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A089717-001LEUCOVORIN CALCIUMEQ 100MG BASE/VIALINJECTABLE / INJECTIONAPRS1988-03-28b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A089717-001LEUCOVORIN CALCIUMEQ 100MG BASE/VIALINJECTABLE / INJECTIONAPRS1988-03-2803ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A089717-001LEUCOVORIN CALCIUMEQ 100MG BASE/VIALINJECTABLE / INJECTIONAPRS1988-03-282680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A089717-001LEUCOVORIN CALCIUMEQ 100MG BASE/VIALINJECTABLE / INJECTIONAPRS1988-03-285bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A089717-001LEUCOVORIN CALCIUMEQ 100MG BASE/VIALINJECTABLE / INJECTIONAPRS1988-03-28d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A089717-001LEUCOVORIN CALCIUMEQ 100MG BASE/VIALINJECTABLE / INJECTIONAPRS1988-03-28d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A089717-001LEUCOVORIN CALCIUMEQ 100MG BASE/VIALINJECTABLE / INJECTIONAPRS1988-03-2879d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A089717-001LEUCOVORIN CALCIUMEQ 100MG BASE/VIALINJECTABLE / INJECTIONAPRS1988-03-28301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A089717-001LEUCOVORIN CALCIUMEQ 100MG BASE/VIALINJECTABLE / INJECTIONAPRS1988-03-281e350fbaab3a…
2024-05-31 18:47 UTC2024-05A089717-001LEUCOVORIN CALCIUMEQ 100MG BASE/VIALINJECTABLE / INJECTIONAPRS1988-03-288072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06A089717-001LEUCOVORIN CALCIUMEQ 100MG BASE/VIALINJECTABLE / INJECTIONAPRS1988-03-285c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04A089717-001LEUCOVORIN CALCIUMEQ 100MG BASE/VIALINJECTABLE / INJECTIONAPRS1988-03-285d02ea3f76ae…
2022-04-04 05:41 UTC2022-04A089717-001LEUCOVORIN CALCIUMEQ 100MG BASE/VIALINJECTABLE / INJECTIONAPRS1988-03-284b0b4de00fa7…
2019-12-13 00:20 UTC2019-12A089717-001LEUCOVORIN CALCIUMEQ 100MG BASE/VIALINJECTABLE / INJECTIONAPRS1988-03-2874a2ff9319b5…
2022-03-09 01:35 UTC2022-03A089717-001LEUCOVORIN CALCIUMEQ 100MG BASE/VIALINJECTABLE / INJECTIONAPRS1988-03-28bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12A089717-001LEUCOVORIN CALCIUMEQ 100MG BASE/VIALINJECTABLE / INJECTIONAPRS1988-03-28782e0a99824c…
2021-05-05 16:15 UTC · 3 captures of this ZIP2021-05A089717-001LEUCOVORIN CALCIUMEQ 100MG BASE/VIALINJECTABLE / INJECTIONAPRS1988-03-2887673890dc5c…
2021-03-12 10:30 UTC2021-03A089717-001LEUCOVORIN CALCIUMEQ 100MG BASE/VIALINJECTABLE / INJECTIONAPRS1988-03-285aa47cf7b7d7…
2020-12-22 03:56 UTC2020-12A089717-001LEUCOVORIN CALCIUMEQ 100MG BASE/VIALINJECTABLE / INJECTIONAPRS1988-03-288869cabd3fbd…
2020-11-12 02:37 UTC2020-11A089717-001LEUCOVORIN CALCIUMEQ 100MG BASE/VIALINJECTABLE / INJECTIONAPRS1988-03-28c0c555d07b60…
2019-12-14 00:12 UTC2019-12A089717-001LEUCOVORIN CALCIUMEQ 100MG BASE/VIALINJECTABLE / INJECTIONAPRS1988-03-283f01610625f2…
2019-09-15 20:21 UTC2019-09A089717-001LEUCOVORIN CALCIUMEQ 100MG BASE/VIALINJECTABLE / INJECTIONAPRS1988-03-28b00525d2431f…
2019-07-19 19:46 UTC2019-07A089717-001LEUCOVORIN CALCIUMEQ 100MG BASE/VIALINJECTABLE / INJECTIONAPRS1988-03-28ea99ee380514…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A089717-001LEUCOVORIN CALCIUMEQ 100MG BASE/VIALINJECTABLE / INJECTIONAPRS1988-03-286a51e52b5d6a…
2024-02-18 07:12 UTC2024-02A089717-001LEUCOVORIN CALCIUMEQ 100MG BASE/VIALINJECTABLE / INJECTIONAPRS1988-03-281c564ffb4f44…
2023-12-20 04:57 UTC2023-12A089717-001LEUCOVORIN CALCIUMEQ 100MG BASE/VIALINJECTABLE / INJECTIONAPRS1988-03-28ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11A089717-001LEUCOVORIN CALCIUMEQ 100MG BASE/VIALINJECTABLE / INJECTIONAPRS1988-03-28a72a2bbeb626…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10A089717-001LEUCOVORIN CALCIUMEQ 100MG BASE/VIALINJECTABLE / INJECTIONAPRS1988-03-289b2671bbb829…
2023-07-15 15:27 UTC · 2 captures of this ZIP2023-07A089717-001LEUCOVORIN CALCIUMEQ 100MG BASE/VIALINJECTABLE / INJECTIONAPRS1988-03-28a67488948f0b…
2023-06-13 01:57 UTC · 3 captures of this ZIP2023-06A089717-001LEUCOVORIN CALCIUMEQ 100MG BASE/VIALINJECTABLE / INJECTIONAPRS1988-03-283f0d92c62455…
2023-05-13 08:27 UTC2023-05A089717-001LEUCOVORIN CALCIUMEQ 100MG BASE/VIALINJECTABLE / INJECTIONAPRS1988-03-28053a50430f4f…
2023-01-26 05:58 UTC2023-01A089717-001LEUCOVORIN CALCIUMEQ 100MG BASE/VIALINJECTABLE / INJECTIONAPRS1988-03-283bdfa0b2c4d7…
2022-11-12 20:34 UTC · 5 captures of this ZIP2022-11A089717-001LEUCOVORIN CALCIUMEQ 100MG BASE/VIALINJECTABLE / INJECTIONAPRS1988-03-283a93d1ddd44b…
2022-10-28 04:53 UTC2022-10A089717-001LEUCOVORIN CALCIUMEQ 100MG BASE/VIALINJECTABLE / INJECTIONAPRS1988-03-28f41ea6bd6efb…
2022-09-29 23:25 UTC2022-09A089717-001LEUCOVORIN CALCIUMEQ 100MG BASE/VIALINJECTABLE / INJECTIONAPRS1988-03-28e64feba35796…
2022-07-09 03:26 UTC · 3 captures of this ZIP2022-07A089717-001LEUCOVORIN CALCIUMEQ 100MG BASE/VIALINJECTABLE / INJECTIONAPRS1988-03-28cb3db0bc1861…

Observed Orange Book normalized TE history#

Normalized TE history page 1 of 2 · 41 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTE codeOrderSource SHA-256
2026-02-19 14:30 UTC2026-02A089717-001AP1011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A089717-001AP131067a03dcf5…
2025-08-23 18:47 UTC2025-08A089717-001AP16a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A089717-001AP1fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A089717-001AP1b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A089717-001AP103ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A089717-001AP12680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A089717-001AP15bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A089717-001AP1d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A089717-001AP1d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A089717-001AP179d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A089717-001AP1301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A089717-001AP11e350fbaab3a…
2024-05-31 18:47 UTC2024-05A089717-001AP18072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06A089717-001AP15c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04A089717-001AP15d02ea3f76ae…
2022-04-04 05:41 UTC2022-04A089717-001AP14b0b4de00fa7…
2019-12-13 00:20 UTC2019-12A089717-001AP174a2ff9319b5…
2022-03-09 01:35 UTC2022-03A089717-001AP1bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12A089717-001AP1782e0a99824c…
2021-05-05 16:15 UTC · 3 captures of this ZIP2021-05A089717-001AP187673890dc5c…
2021-03-12 10:30 UTC2021-03A089717-001AP15aa47cf7b7d7…
2020-12-22 03:56 UTC2020-12A089717-001AP18869cabd3fbd…
2020-11-12 02:37 UTC2020-11A089717-001AP1c0c555d07b60…
2019-12-14 00:12 UTC2019-12A089717-001AP13f01610625f2…
2019-09-15 20:21 UTC2019-09A089717-001AP1b00525d2431f…
2019-07-19 19:46 UTC2019-07A089717-001AP1ea99ee380514…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A089717-001AP16a51e52b5d6a…
2024-02-18 07:12 UTC2024-02A089717-001AP11c564ffb4f44…
2023-12-20 04:57 UTC2023-12A089717-001AP1ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11A089717-001AP1a72a2bbeb626…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10A089717-001AP19b2671bbb829…
2023-07-15 15:27 UTC · 2 captures of this ZIP2023-07A089717-001AP1a67488948f0b…
2023-06-13 01:57 UTC · 3 captures of this ZIP2023-06A089717-001AP13f0d92c62455…
2023-05-13 08:27 UTC2023-05A089717-001AP1053a50430f4f…
2023-01-26 05:58 UTC2023-01A089717-001AP13bdfa0b2c4d7…
2022-11-12 20:34 UTC · 5 captures of this ZIP2022-11A089717-001AP13a93d1ddd44b…
2022-10-28 04:53 UTC2022-10A089717-001AP1f41ea6bd6efb…
2022-09-29 23:25 UTC2022-09A089717-001AP1e64feba35796…
2022-07-09 03:26 UTC · 3 captures of this ZIP2022-07A089717-001AP1cb3db0bc1861…

Additional Listing Data#

Finished product
Yes
Brand name base
Leucovorin Calcium
Listing expiration
2026-12-31

Active Ingredients#

Ingredient, Strength table
IngredientStrength
LEUCOVORIN CALCIUM100 mg/10mL

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
RPR1R4C0P4Internal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 3 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
237788Internal RxNorm lookup
1803932Internal RxNorm lookup
1803937Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
e9b47126-8b52-43ff-85c4-33d32b3d8326Available on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product conceptRelationVersionEffective
31adef49-84cb-4c51-b122-69e924e10ea3Product name420240827
df40773e-fe5a-474c-8d32-d19c7094e396Product name220240813
cd1aa5b9-18a7-4dc4-8a13-b5c677c859a2Product name120231116
38866763-6a8e-4096-95c3-082a000c243dProduct name120230809
7ce39568-aceb-b33a-23ed-c4964cdcf486Product name220210211
6c712ad1-eecf-448f-84d9-5c0c307a7112Product name120161130

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDCProductDescriptionFormQuantityStrengthSPL version
68001-416-36Leucovorin Calcium1 in 1 BOXINJECTION, POWDER, LYOPHILIZED,13
68001-416-36Leucovorin Calcium10 mL in 1 VIALINJECTION, POWDER, LYOPHILIZED,103

DailyMed Billing Units#

Package NDC, Billing unit, Product NDC table
Package NDCBilling unitProduct NDCDailyMed indexing SPLSPL versionEffective
68001-416-36EA - Each68001-416fbf25a6e-2558-4d55-a916-a09d0d575a2512019-12-10

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDCDashboard titleSPL versionValidationDashboard ZIP
68001-416LEUCOVORIN CALCIUM INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION [BLUEPOINT LABORATORIES]3Current NDC, Legacy NDC, 2 package rows20220125_e9b47126-8b52-43ff-85c4-33d32b3d8326.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 2 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
Leucovorin CalciumLEUCOVORIN CALCIUMBluePoint Laboratoriese9b47126-8b52-43ff-85c4-33d32b3d83262022-01-19Warnings, Adverse reactionsExact identifier
application applno (ANDA): 089717
application number: ANDA089717
ndc (product): 68001-416
Leucovorin CalciumLEUCOVORIN CALCIUMHikma Pharmaceuticals USA Inc.cc52077f-5663-4f79-a273-0aecf655e0382021-10-22Warnings, Adverse reactionsExact identifier
application applno (ANDA): 089717
application number: ANDA089717

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUIRxNorm stringTTYDailyMedSPL version
1803932leucovorin 100 MG InjectionPSNe9b47126-8b52-43ff-85c4-33d32b3d83263
1803937leucovorin 200 MG InjectionPSNe9b47126-8b52-43ff-85c4-33d32b3d83263
237788leucovorin 350 MG InjectionPSNe9b47126-8b52-43ff-85c4-33d32b3d83263
1803932leucovorin 100 MG InjectionSCDe9b47126-8b52-43ff-85c4-33d32b3d83263
1803937leucovorin 200 MG InjectionSCDe9b47126-8b52-43ff-85c4-33d32b3d83263
237788leucovorin 350 MG InjectionSCDe9b47126-8b52-43ff-85c4-33d32b3d83263
1803932leucovorin (as leucovorin calcium) 100 MG InjectionSYe9b47126-8b52-43ff-85c4-33d32b3d83263
1803937leucovorin (as leucovorin calcium) 200 MG InjectionSYe9b47126-8b52-43ff-85c4-33d32b3d83263
237788leucovorin (as leucovorin calcium) 350 MG InjectionSYe9b47126-8b52-43ff-85c4-33d32b3d83263
237788leucovorin 350 MG per 17.5 ML Lyophilized Powder for InjectionSYe9b47126-8b52-43ff-85c4-33d32b3d83263

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionUnitsMarketing startMarketing endSampleExclude flagStatus
68001-416-36680010416361 VIAL in 1 BOX (68001-416-36) / 10 mL in 1 VIAL1 vial2019-09-260000-00-00NoNoCurrent