Isotretinoin

Product NDC
68308-573
11-digit product format
683080573
Labeler code
68308
Product ID
68308-573_66d6a601-cb08-4662-a043-537a6f8d935b
Type
HUMAN PRESCRIPTION DRUG
Nonproprietary name
Isotretinoin
Dosage form
CAPSULE, LIQUID FILLED
Route
ORAL
Labeler
Mayne Pharma
Application
ANDA212333
Marketing category
ANDA
Marketing start
2021-09-21
Substance
ISOTRETINOIN
Active strength
30 mg/1
Pharmacologic classes
Retinoid [EPC], Retinoids [CS]
NDC exclude flag
No
Listing certified through
2026-12-31
Current FDA listing
Yes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 1.

Orange Book products#

Current product rows page 1 of 1 · 3 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
A212333-001ISOTRETINOINISOTRETINOIN10MGCAPSULE / ORALAB22021-09-21
A212333-002ISOTRETINOINISOTRETINOIN20MGCAPSULE / ORALAB22021-09-21
A212333-003ISOTRETINOINISOTRETINOIN30MGCAPSULE / ORALAB22021-09-21

Therapeutic equivalence codes#

Current TE-code rows page 1 of 1 · 3 matching rows.

Application-product, TE code table
Application-productTE code
A212333-001AB2
A212333-002AB2
A212333-003AB2

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Product history page 1 of 3 · 99 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-02-19 14:30 UTC2026-02A212333-001ISOTRETINOIN10MGCAPSULE / ORALAB22021-09-21011fe1cb6892…
2026-02-19 14:30 UTC2026-02A212333-002ISOTRETINOIN20MGCAPSULE / ORALAB22021-09-21011fe1cb6892…
2026-02-19 14:30 UTC2026-02A212333-003ISOTRETINOIN30MGCAPSULE / ORALAB22021-09-21011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A212333-001ISOTRETINOIN10MGCAPSULE / ORALAB22021-09-2131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A212333-002ISOTRETINOIN20MGCAPSULE / ORALAB22021-09-2131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A212333-003ISOTRETINOIN30MGCAPSULE / ORALAB22021-09-2131067a03dcf5…
2025-08-23 18:47 UTC2025-08A212333-001ISOTRETINOIN10MGCAPSULE / ORALAB22021-09-216a471c1ec25d…
2025-08-23 18:47 UTC2025-08A212333-002ISOTRETINOIN20MGCAPSULE / ORALAB22021-09-216a471c1ec25d…
2025-08-23 18:47 UTC2025-08A212333-003ISOTRETINOIN30MGCAPSULE / ORALAB22021-09-216a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A212333-001ISOTRETINOIN10MGCAPSULE / ORALAB22021-09-21fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A212333-002ISOTRETINOIN20MGCAPSULE / ORALAB22021-09-21fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A212333-003ISOTRETINOIN30MGCAPSULE / ORALAB22021-09-21fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A212333-001ISOTRETINOIN10MGCAPSULE / ORALAB22021-09-21b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A212333-002ISOTRETINOIN20MGCAPSULE / ORALAB22021-09-21b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A212333-003ISOTRETINOIN30MGCAPSULE / ORALAB22021-09-21b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A212333-001ISOTRETINOIN10MGCAPSULE / ORALAB22021-09-2103ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A212333-002ISOTRETINOIN20MGCAPSULE / ORALAB22021-09-2103ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A212333-003ISOTRETINOIN30MGCAPSULE / ORALAB22021-09-2103ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A212333-001ISOTRETINOIN10MGCAPSULE / ORALAB22021-09-212680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A212333-002ISOTRETINOIN20MGCAPSULE / ORALAB22021-09-212680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A212333-003ISOTRETINOIN30MGCAPSULE / ORALAB22021-09-212680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A212333-001ISOTRETINOIN10MGCAPSULE / ORALAB22021-09-215bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A212333-002ISOTRETINOIN20MGCAPSULE / ORALAB22021-09-215bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A212333-003ISOTRETINOIN30MGCAPSULE / ORALAB22021-09-215bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A212333-001ISOTRETINOIN10MGCAPSULE / ORALAB22021-09-21d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A212333-002ISOTRETINOIN20MGCAPSULE / ORALAB22021-09-21d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A212333-003ISOTRETINOIN30MGCAPSULE / ORALAB22021-09-21d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A212333-001ISOTRETINOIN10MGCAPSULE / ORALAB22021-09-21d06236e962d9…
2024-10-29 15:01 UTC2024-10A212333-002ISOTRETINOIN20MGCAPSULE / ORALAB22021-09-21d06236e962d9…
2024-10-29 15:01 UTC2024-10A212333-003ISOTRETINOIN30MGCAPSULE / ORALAB22021-09-21d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A212333-001ISOTRETINOIN10MGCAPSULE / ORALAB22021-09-2179d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A212333-002ISOTRETINOIN20MGCAPSULE / ORALAB22021-09-2179d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A212333-003ISOTRETINOIN30MGCAPSULE / ORALAB22021-09-2179d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A212333-001ISOTRETINOIN10MGCAPSULE / ORALAB22021-09-21301d65b070ca…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A212333-002ISOTRETINOIN20MGCAPSULE / ORALAB22021-09-21301d65b070ca…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A212333-003ISOTRETINOIN30MGCAPSULE / ORALAB22021-09-21301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A212333-001ISOTRETINOIN10MGCAPSULE / ORALAB22021-09-211e350fbaab3a…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A212333-002ISOTRETINOIN20MGCAPSULE / ORALAB22021-09-211e350fbaab3a…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A212333-003ISOTRETINOIN30MGCAPSULE / ORALAB22021-09-211e350fbaab3a…
2024-05-31 18:47 UTC2024-05A212333-001ISOTRETINOIN10MGCAPSULE / ORALAB22021-09-218072bd15b7f6…

Observed Orange Book normalized TE history#

Normalized TE history page 1 of 3 · 99 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTE codeOrderSource SHA-256
2026-02-19 14:30 UTC2026-02A212333-001AB21011fe1cb6892…
2026-02-19 14:30 UTC2026-02A212333-002AB21011fe1cb6892…
2026-02-19 14:30 UTC2026-02A212333-003AB21011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A212333-001AB2131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A212333-002AB2131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A212333-003AB2131067a03dcf5…
2025-08-23 18:47 UTC2025-08A212333-001AB216a471c1ec25d…
2025-08-23 18:47 UTC2025-08A212333-002AB216a471c1ec25d…
2025-08-23 18:47 UTC2025-08A212333-003AB216a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A212333-001AB21fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A212333-002AB21fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A212333-003AB21fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A212333-001AB21b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A212333-002AB21b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A212333-003AB21b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A212333-001AB2103ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A212333-002AB2103ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A212333-003AB2103ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A212333-001AB212680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A212333-002AB212680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A212333-003AB212680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A212333-001AB215bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A212333-002AB215bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A212333-003AB215bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A212333-001AB21d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A212333-002AB21d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A212333-003AB21d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A212333-001AB21d06236e962d9…
2024-10-29 15:01 UTC2024-10A212333-002AB21d06236e962d9…
2024-10-29 15:01 UTC2024-10A212333-003AB21d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A212333-001AB2179d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A212333-002AB2179d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A212333-003AB2179d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A212333-001AB21301d65b070ca…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A212333-002AB21301d65b070ca…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A212333-003AB21301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A212333-001AB211e350fbaab3a…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A212333-002AB211e350fbaab3a…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A212333-003AB211e350fbaab3a…
2024-05-31 18:47 UTC2024-05A212333-001AB218072bd15b7f6…

Additional Listing Data#

Finished product
Yes
Brand name base
Isotretinoin
Listing expiration
2026-12-31

Active Ingredients#

Ingredient, Strength table
IngredientStrength
ISOTRETINOIN30 mg/1

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
EH28UP18IFInternal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 3 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
197843Internal RxNorm lookup
197844Internal RxNorm lookup
403930Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
ebe1b3e3-1013-4cf6-bdc8-2baa3dc26e16Available on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product conceptRelationVersionEffective
8300c0f6-79a4-735b-88ec-d781bfffdb10Product name520260305
644afe93-ba9b-4043-8e40-a9fe9af2d5d7Product name220250616
baf7f49c-75b6-496b-a00e-8e766a8e4f03Product name120210127
e5fedfa5-6b96-4769-872b-95d1e7f3a85aProduct name120200415
ebc62596-fc97-4d03-9483-7ba095d25db7Product name120151210
0ca1d589-929b-4b33-bc5b-1d84abdafa6aProduct name120150324
fc363c46-397b-4476-ac0f-70e43e8e4592Product name120150324

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDCProductDescriptionFormQuantityStrengthSPL version
68308-573-01Isotretinoin10 in 1 BLISTER PACKCAPSULE, LIQUID FILLED102
68308-573-30Isotretinoin3 in 1 BOXCAPSULE, LIQUID FILLED32

DailyMed Billing Units#

Package NDC, Billing unit, Product NDC table
Package NDCBilling unitProduct NDCDailyMed indexing SPLSPL versionEffective
68308-573-01EA - Each68308-57398e6dc83-393d-4374-9504-6be214fc07d012021-10-08
68308-573-30EA - Each68308-5730581fd12-3ad3-4a3d-bcab-00cb2a94c5f012021-10-08

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDCDashboard titleSPL versionValidationDashboard ZIP
68308-573ISOTRETINOIN CAPSULE, LIQUID FILLED [MAYNE PHARMA]2Current NDC, Legacy NDC, 2 package rows20221105_ebe1b3e3-1013-4cf6-bdc8-2baa3dc26e16.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 2 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
IsotretinoinISOTRETINOINUpsher-Smith Laboratories, LLC08529687-26b2-41e5-b6fb-35b4c0d891fe2026-02-13Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 212333
application number: ANDA212333
IsotretinoinISOTRETINOINMayne Pharmaebe1b3e3-1013-4cf6-bdc8-2baa3dc26e162022-11-03Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 212333
application number: ANDA212333
ndc (product): 68308-573

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUIRxNorm stringTTYDailyMedSPL version
197843ISOtretinoin 10 MG Oral CapsulePSNebe1b3e3-1013-4cf6-bdc8-2baa3dc26e162
197844ISOtretinoin 20 MG Oral CapsulePSNebe1b3e3-1013-4cf6-bdc8-2baa3dc26e162
403930ISOtretinoin 30 MG Oral CapsulePSNebe1b3e3-1013-4cf6-bdc8-2baa3dc26e162
197843isotretinoin 10 MG Oral CapsuleSCDebe1b3e3-1013-4cf6-bdc8-2baa3dc26e162
197844isotretinoin 20 MG Oral CapsuleSCDebe1b3e3-1013-4cf6-bdc8-2baa3dc26e162
403930isotretinoin 30 MG Oral CapsuleSCDebe1b3e3-1013-4cf6-bdc8-2baa3dc26e162

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionUnitsMarketing startMarketing endSampleExclude flagStatus
68308-573-016830805730110 in 1 BLISTER PACKHistorical
68308-573-30683080573303 BLISTER PACK in 1 BOX (68308-573-30) / 10 CAPSULE, LIQUID FILLED in 1 BLISTER PACK (68308-573-01) 3 blister pack2021-09-210000-00-00NoNoCurrent