ivabradine

Product NDC
69452-191
11-digit product format
694520191
Labeler code
69452
Product ID
69452-191_2eacec81-3528-a573-e063-6394a90a6da4
Type
HUMAN PRESCRIPTION DRUG
Nonproprietary name
ivabradine
Dosage form
TABLET, FILM COATED
Route
ORAL
Labeler
Bionpharma Inc.
Application
ANDA213276
Marketing category
ANDA
Marketing start
2025-03-01
Substance
IVABRADINE HYDROCHLORIDE
Active strength
7.5 mg/1
Pharmacologic classes
Hyperpolarization-activated Cyclic Nucleotide-gated Channel Antagonists [MoA], Hyperpolarization-activated Cyclic Nucleotide-gated Channel Blocker [EPC]
NDC exclude flag
No
Listing certified through
2026-12-31
Current FDA listing
Yes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 1.

Orange Book products#

Current product rows page 1 of 1 · 2 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
A213276-001IVABRADINE HYDROCHLORIDEIVABRADINE HYDROCHLORIDEEQ 5MG BASETABLET / ORALAB2024-09-05
A213276-002IVABRADINE HYDROCHLORIDEIVABRADINE HYDROCHLORIDEEQ 7.5MG BASETABLET / ORALAB2024-09-05

Therapeutic equivalence codes#

Current TE-code rows page 1 of 1 · 2 matching rows.

Application-product, TE code table
Application-productTE code
A213276-001AB
A213276-002AB

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-02-19 14:30 UTC2026-02A213276-001IVABRADINE HYDROCHLORIDEEQ 5MG BASETABLET / ORALAB2024-09-05011fe1cb6892…
2026-02-19 14:30 UTC2026-02A213276-002IVABRADINE HYDROCHLORIDEEQ 7.5MG BASETABLET / ORALAB2024-09-05011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A213276-001IVABRADINE HYDROCHLORIDEEQ 5MG BASETABLET / ORALAB2024-09-0531067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A213276-002IVABRADINE HYDROCHLORIDEEQ 7.5MG BASETABLET / ORALAB2024-09-0531067a03dcf5…
2025-08-23 18:47 UTC2025-08A213276-001IVABRADINE HYDROCHLORIDEEQ 5MG BASETABLET / ORALAB2024-09-056a471c1ec25d…
2025-08-23 18:47 UTC2025-08A213276-002IVABRADINE HYDROCHLORIDEEQ 7.5MG BASETABLET / ORALAB2024-09-056a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A213276-001IVABRADINE HYDROCHLORIDEEQ 5MG BASETABLET / ORALAB2024-09-05fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A213276-002IVABRADINE HYDROCHLORIDEEQ 7.5MG BASETABLET / ORALAB2024-09-05fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A213276-001IVABRADINE HYDROCHLORIDEEQ 5MG BASETABLET / ORALAB2024-09-05b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A213276-002IVABRADINE HYDROCHLORIDEEQ 7.5MG BASETABLET / ORALAB2024-09-05b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A213276-001IVABRADINE HYDROCHLORIDEEQ 5MG BASETABLET / ORALAB2024-09-0503ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A213276-002IVABRADINE HYDROCHLORIDEEQ 7.5MG BASETABLET / ORALAB2024-09-0503ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A213276-001IVABRADINE HYDROCHLORIDEEQ 5MG BASETABLET / ORALAB2024-09-052680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A213276-002IVABRADINE HYDROCHLORIDEEQ 7.5MG BASETABLET / ORALAB2024-09-052680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A213276-001IVABRADINE HYDROCHLORIDEEQ 5MG BASETABLET / ORALAB2024-09-055bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A213276-002IVABRADINE HYDROCHLORIDEEQ 7.5MG BASETABLET / ORALAB2024-09-055bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A213276-001IVABRADINE HYDROCHLORIDEEQ 5MG BASETABLET / ORALAB2024-09-05d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A213276-002IVABRADINE HYDROCHLORIDEEQ 7.5MG BASETABLET / ORALAB2024-09-05d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A213276-001IVABRADINE HYDROCHLORIDEEQ 5MG BASETABLET / ORALAB2024-09-05d06236e962d9…
2024-10-29 15:01 UTC2024-10A213276-002IVABRADINE HYDROCHLORIDEEQ 7.5MG BASETABLET / ORALAB2024-09-05d06236e962d9…
2026-07-26 02:55 UTC · 3 captures of this ZIP2026-06A213276-001IVABRADINE HYDROCHLORIDEEQ 5MG BASETABLET / ORALAB2024-09-05a50c72e98297…
2026-07-26 02:55 UTC · 3 captures of this ZIP2026-06A213276-002IVABRADINE HYDROCHLORIDEEQ 7.5MG BASETABLET / ORALAB2024-09-05a50c72e98297…

Observed Orange Book normalized TE history#

Captured, Edition, Application-product table
CapturedEditionApplication-productTE codeOrderSource SHA-256
2026-02-19 14:30 UTC2026-02A213276-001AB1011fe1cb6892…
2026-02-19 14:30 UTC2026-02A213276-002AB1011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A213276-001AB131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A213276-002AB131067a03dcf5…
2025-08-23 18:47 UTC2025-08A213276-001AB16a471c1ec25d…
2025-08-23 18:47 UTC2025-08A213276-002AB16a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A213276-001AB1fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A213276-002AB1fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A213276-001AB1b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A213276-002AB1b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A213276-001AB103ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A213276-002AB103ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A213276-001AB12680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A213276-002AB12680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A213276-001AB15bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A213276-002AB15bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A213276-001AB1d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A213276-002AB1d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A213276-001AB1d06236e962d9…
2024-10-29 15:01 UTC2024-10A213276-002AB1d06236e962d9…
2026-07-26 02:55 UTC · 3 captures of this ZIP2026-06A213276-001AB1a50c72e98297…
2026-07-26 02:55 UTC · 3 captures of this ZIP2026-06A213276-002AB1a50c72e98297…

openFDA label cross-check#

Cross-check layer: openFDA label JSON enriches search and identifies hydration gaps. The DailyMed Structured Product Label remains the canonical label presentation on FDA.report. Every label matching the complete exact-identifier union is deduplicated and paginated below.

Matched openFDA labels page 1 of 1 · 1 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
ivabradineIVABRADINEBionpharma Inc.2ead1cf3-e61a-49c4-e063-6294a90a330f2025-02-24Warnings, Adverse reactionsExact identifier
application applno (ANDA): 213276
application number: ANDA213276
ndc (product): 69452-191

Additional Listing Data#

Finished product
Yes
Brand name base
ivabradine
Listing expiration
2026-12-31

Active Ingredients#

Ingredient, Strength table
IngredientStrength
IVABRADINE HYDROCHLORIDE7.5 mg/1

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
TP19837BZKInternal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 2 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
1649485Internal RxNorm lookup
1649493Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
2ead1cf3-e61a-49c4-e063-6294a90a330fAvailable on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product conceptRelationVersionEffective
eebd3ed3-f483-47f1-9e64-83ee4010ac6eProduct name520260130

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDCProductDescriptionFormQuantityStrengthSPL version
69452-191-17ivabradine60 in 1 BOTTLETABLET, FILM COATED601
69452-191-30ivabradine500 in 1 BOTTLETABLET, FILM COATED5001

DailyMed Billing Units#

Package NDC, Billing unit, Product NDC table
Package NDCBilling unitProduct NDCDailyMed indexing SPLSPL versionEffective
69452-191-17EA - Each69452-19104965fa5-2e4a-42f1-9043-eccbae9ddc0e12025-05-14

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDCDashboard titleSPL versionValidationDashboard ZIP
69452-191IVABRADINE TABLET, FILM COATED [BIONPHARMA INC.]1Current NDC, 2 package rows20250302_2ead1cf3-e61a-49c4-e063-6294a90a330f.zip

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUIRxNorm stringTTYDailyMedSPL version
1649485ivabradine 5 MG Oral TabletPSN2ead1cf3-e61a-49c4-e063-6294a90a330f1
1649493ivabradine 7.5 MG Oral TabletPSN2ead1cf3-e61a-49c4-e063-6294a90a330f1
1649485ivabradine 5 MG Oral TabletSCD2ead1cf3-e61a-49c4-e063-6294a90a330f1
1649493ivabradine 7.5 MG Oral TabletSCD2ead1cf3-e61a-49c4-e063-6294a90a330f1
1649485ivabradine 5 MG (as ivabradine HCl 5.39 MG) Oral TabletSY2ead1cf3-e61a-49c4-e063-6294a90a330f1
1649493ivabradine 7.5 MG (as ivabradine HCl 8.085 MG) Oral TabletSY2ead1cf3-e61a-49c4-e063-6294a90a330f1

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionMarketing startSampleExclude flagStatus
69452-191-176945201911760 TABLET, FILM COATED in 1 BOTTLE (69452-191-17) 2025-03-01NoNoCurrent
69452-191-3069452019130500 TABLET, FILM COATED in 1 BOTTLE (69452-191-30) 2025-03-01NoNoCurrent