Benadryl Extra Strength

Product NDC: 69968-0223
Requested package NDC: 69968-0223-2
11-digit product format: 699680223
Labeler code: 69968
Product ID: 69968-0223_26b4b1f0-5cb0-7132-e063-6394a90a2c2f
Type: HUMAN OTC DRUG
Nonproprietary name: Diphenhydramine Hydrochloride and Zinc Acetate
Dosage form: CREAM
Route: TOPICAL
Labeler: Kenvue Brands LLC
Application: M017
Marketing category: OTC MONOGRAPH DRUG
Marketing start: 2009-11-01
Substance: DIPHENHYDRAMINE HYDROCHLORIDE; ZINC ACETATE
Active strength: 20; 1 mg/g; mg/g
Pharmacologic classes: Copper Absorption Inhibitor [EPC], Decreased Copper Ion Absorption [PE], Histamine H1 Receptor Antagonists [MoA], Histamine-1 Receptor Antagonist [EPC]
NDC exclude flag: No
Listing certified through: 2026-12-31
Current FDA listing: Yes

Reported adverse events (FAERS/openFDA)#

Adverse event summaries are temporarily unavailable. Other product information remains available.

Additional Listing Data#

Finished product: Yes
Brand name base: Benadryl Extra Strength
Brand name suffix: Itch Stopping
Listing expiration: 2026-12-31

Active Ingredients#

Ingredient, Strength table
Ingredient	Strength
DIPHENHYDRAMINE HYDROCHLORIDE	20 mg/g
ZINC ACETATE	1 mg/g

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 2 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
TC2D6JAD40	Internal UNII lookup
FM5526K07A	Internal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 2 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
1087026	Internal RxNorm lookup
1111764	Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
a1c1b878-d58f-41ff-b7a8-477f28c52667	Available on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product concept	Relation	Version	Effective
f47a510b-6679-4664-b2d6-47b5c4afe7cc	Product name	4	20260217
030ce964-9b2d-45aa-b5d3-f78ce03ef61c	Product name	2	20250515
0e2e0f88-b076-afe1-4bdd-32bca4375bec	Product name	3	20250127
fb7ab793-2c12-4079-b100-a64f73bef25a	Product name	4	20240712
b0cbf770-6cc3-4aa4-9158-755110c2b9f7	Product name	2	20230717
dc7c5daa-021f-40dd-b00d-63982cb2067a	Product name	1	20230426
0306390c-dd77-4363-afe0-63c58088b2a1	Product name	1	20220120
503ea967-4b9c-48cf-9e87-c7975295849d	Product name	2	20220120
08ffbcbf-26df-b99c-1dab-64fc4cfae89f	Product name	5	20200925
816b97af-edc5-4060-aff1-b814bdbcad50	Product name	1	20190415
7cda52fc-125f-421c-8fea-bc1974370c49	Product name	2	20180703
419aab54-5d5a-4146-9453-026d4a9991be	Product name	2	20170525
99e684e6-f435-feb8-d2bb-3a546f1cb768	Product name	2	20161117
08ffbcbf-26df-b99c-1dab-64fc4cfae89f	Product name	2	20160823
25340b3b-3e4c-4ff8-abf6-3e62ec46bd0c	Product name	1	20160603
89dac932-b90a-4410-9ab1-84c53e57de25	Product name	1	20150316
190f2a5b-bbc8-65c7-fcb0-97891307b917	Product name	1	20140508
3e48c9c4-918d-5d23-2f0b-d2398b06be54	Product name	1	20140508
58f3f9b7-3b9b-a9c1-1c9f-18ac777192b8	Product name	1	20140508
865c72dd-0d94-daac-f728-ddd4ded2a79e	Product name	1	20140508
a7051cba-790b-a699-81f8-dbbbdbd9b5ac	Product name	1	20140508
b045ad64-0f28-9a02-2f9b-b34d94fb2278	Product name	1	20140508
b6082387-f592-1148-0844-bd068fd213fb	Product name	1	20140508
da108d9e-edc8-17a3-8c28-3251c6a8accc	Product name	1	20140508

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDC	Product	Description	Form	Quantity	Strength	SPL version
69968-0223-1	Benadryl Extra StrengthItch Stopping	1 in 1 CARTON	CREAM	1		10
69968-0223-1	Benadryl Extra StrengthItch Stopping	28.3 g in 1 TUBE	CREAM	28.3		10
69968-0223-2	Benadryl Extra StrengthItch Stopping	28.3 g in 1 TUBE	CREAM	28.3		10
69968-0223-1	Johnson and Johnson All Purpose First Aid Kit	28.3 g in 1 TUBE	CREAM	28.3 g	20 mg in 1g	7
69968-0223-1	Johnson and Johnson All Purpose First Aid Kit	1 in 1 CARTON	CREAM		1 mg in 1g	7
69968-0223-1	Johnson and Johnson First Aid All Purpose160 CT	1 in 1 CARTON	CREAM		20 mg in 1g	3
69968-0223-1	Johnson and Johnson First Aid All Purpose160 CT	28.3 g in 1 TUBE	CREAM	28.3 g	1 mg in 1g	3

DailyMed Billing Units#

Package NDC, Billing unit, Product NDC table
Package NDC	Billing unit	Product NDC	DailyMed indexing SPL	SPL version	Effective
69968-0223-1	GM - Gram	69968-0223	6bb12e4b-56e2-4424-9641-c234236d08c9	1	2019-09-05

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDC	Dashboard title	SPL version	Validation	Dashboard ZIP
69968-0223	BENADRYL EXTRA STRENGTH ITCH STOPPING (DIPHENHYDRAMINE HYDROCHLORIDE AND ZINC ACETATE) CREAM [KENVUE BRANDS LLC]	10	Current NDC, Legacy NDC, 3 package rows	20241116_a1c1b878-d58f-41ff-b7a8-477f28c52667.zip
69968-0223	JOHNSON AND JOHNSON ALL PURPOSE FIRST AID KIT (ACETAMINOPHEN, DIPHENHYDRAMINE HYDROCHLORIDE, ZINC ACETATE, NEOMYCIN SULFATE, POLYMYXIN B SULFATE, AND PRAMOXINE HYDROCHLORIDE) KIT [KENVUE BRANDS LLC]	6	Current NDC, Legacy NDC	20241116_5cdb47c5-7951-4279-8a05-0a3199d3dd45.zip
69968-0223	JOHNSON AND JOHNSON FIRST AID ALL PURPOSE 160 CT (ACETAMINOPHEN, DIPHENHYDRAMINE HYDROCHLORIDE, ZINC ACETATE, NEOMYCIN SULFATE, POLYMYXIN B SULFATE, AND PRAMOXINE HYDROCHLORIDE) KIT [KENVUE BRANDS LLC]	2	Current NDC, Legacy NDC	20241116_f3933330-2550-4a88-e053-2a95a90a3997.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 156 · 3,115 matching rows.

Brand, Generic, Manufacturer table
Brand	Generic	Manufacturer	SPL set ID	Effective date	Available safety fields	Join
JenGufun LIDOCAINE KNEE Patch	LIDOCAINE KNEE PATCH	Henan Kangdi Medical Devices Co., Ltd.	5b1d8508-b993-7a8d-e063-6294a90ae306	2026-09-10	Warnings	Exact identifier application number: M017
Wart Corn Remover	SALICYLIC ACID	HONG KONG FOREVER YOUNG TRADING CO., LIMITED	5b0cd6e0-f220-4ebd-e063-6294a90ade67	2026-09-09	Warnings	Exact identifier application number: M017
Magic Cream	PAIN RELIEVING OINTMENT	Jiangxi Baikang Medical Products Co., Ltd.	5b0f2515-47e9-603f-e063-6294a90af9d4	2026-09-09	Warnings	Exact identifier application number: M017
Burn Gel	LIDOCAINE HCI	Trifecta Pharmaceuticals USA LLC	e9d3e9be-1036-fad0-e053-2a95a90a6efe	2026-09-09	Warnings	Exact identifier application number: M017
4% Lidocaine Pain Relief Patch	LIDOCAINE 4%	Guangxi Keyun E-commerce Co., Ltd.	5b197cd8-542f-38b4-e063-6294a90ad7d3	2026-09-09	Warnings	Exact identifier application number: M017
Pain Relieving Lidocaine Patch	LIDOCAINE	YYBA CORP	af8c84fd-224c-72b3-e053-2a95a90a9568	2026-09-07	Warnings	Exact identifier application number: M017
American Safety First Aid	LIDOCAINE HCL	Orazen Inc	ea2f776b-dfd0-6ce4-e053-2995a90af009	2026-09-07	Warnings	Exact identifier application number: M017
MEDI-FIRST Topical Analgesic	LIDOCAINE HCI	Ultra Distributors Inc	b6f288f7-9ae3-215e-e053-2a95a90aedf6	2026-09-07	Warnings	Exact identifier application number: M017
MEDI-FIRST	BENZALKONIUM CHLORIDE, LIDOCAINE	Orazen Inc	f508434f-5948-7134-e053-2a95a90a03d7	2026-09-05	Warnings	Exact identifier application number: M017
MEDI-FIRST	BENZALKONIUM CHLORIDE, LIDOCAINE	Orazen Inc	f522fb0b-3d86-b228-e053-2a95a90a55e9	2026-09-05	Warnings	Exact identifier application number: M017
SurviveX Anti-itch Cream	SURVIVEX HYDROCORTISONE	Nantong Health & Beyond Hygienic Products Inc.	5a7a1141-d3b1-0ee8-e063-6294a90a16aa	2026-09-04	Warnings	Exact identifier application number: M017
NeuroNesic Pain Relieving Cream	CAPSAICIN	Blaine Labs Inc.	7107c13d-bf59-4c0a-84fe-725a9fca2691	2026-09-04	Warnings	Exact identifier application number: M017
Neoteric Diabetic Skin Care 1 oz.	DIMETHICONE	RNA PHARMA LLC	5a944486-9591-f583-e063-6394a90aa04b	2026-09-03	Warnings	Exact identifier application number: M017
Equate Menthol Pain Relieving	MENTHOL	Wal-Mart Stores Inc	d5b0a7f1-4e23-426b-bb7e-aaa251ad4ffc	2026-09-03	Warnings	Exact identifier application number: M017
ZHI Technologies	LIDOCAINE, MENTHOL	ZHI Technologies, Inc.	6717e995-4d2d-49e8-8ecf-7c62557dfdef	2026-09-03	Warnings	Exact identifier application number: M017
Komxsum LIDOCAINE Cream	LIDOCAINE 4% CREAM	Wenzhou Yuyuan Pharmaceutical Co., Ltd.	5a9feae0-9be4-e736-e063-6294a90abe55	2026-09-03	Warnings	Exact identifier application number: M017
FREEZE EASE Roll-On	MENTHOL	Global America Group LLC	1869cc0d-a056-45de-aede-23b09b61ed12	2026-09-02	Warnings	Exact identifier application number: M017
Gaimoa Lidocaine Pain Relief Gel Patches	LIDOCAINE PAIN RELIEF GEL PATCHES	Henan Enokon Medical Instrument Co., Ltd.	5a68fe67-5c15-af9a-e063-6294a90a7ec1	2026-09-01	Warnings	Exact identifier application number: M017
CVS Cortisone Liquid	HYDROCORTISONE	CVS Pharmacy	42df45a9-d449-090a-e063-6394a90a9ee4	2026-09-01	Warnings	Exact identifier application number: M017
Ramedica Herbal Wonder Balm	CAMPHOR, MENTHOL	Ramedicare Sdn. Bhd.	cfb2ea0e-a1f6-4fdf-b866-346bbe78788f	2026-09-01	Warnings	Exact identifier application number: M017

UNII, Preferred term, Registry number table
UNII	Preferred term	Registry number	Matched term
TC2D6JAD40	DIPHENHYDRAMINE HYDROCHLORIDE	147-24-0	DIPHENHYDRAMINE HYDROCHLORIDE
FM5526K07A	ZINC ACETATE	5970-45-6	ZINC ACETATE

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUI	RxNorm string	TTY	DailyMed	SPL version
1111764	Benadryl Itch Stopping, Extra Strength 2 % / 0.1 % Topical Cream	PSN	a1c1b878-d58f-41ff-b7a8-477f28c52667	10
1087026	diphenhydrAMINE HCl 2 % / zinc acetate 0.1 % Topical Cream	PSN	a1c1b878-d58f-41ff-b7a8-477f28c52667	10
1111764	diphenhydramine hydrochloride 20 MG/ML / zinc acetate 1 MG/ML Topical Cream [Benadryl Itch Stopping]	SBD	a1c1b878-d58f-41ff-b7a8-477f28c52667	10
1087026	diphenhydramine hydrochloride 20 MG/ML / zinc acetate 1 MG/ML Topical Cream	SCD	a1c1b878-d58f-41ff-b7a8-477f28c52667	10
1111764	Benadryl Itch Stopping, Extra Strength (diphenhydramine hydrochloride 2 % / zinc acetate 0.1 % ) Topical Cream	SY	a1c1b878-d58f-41ff-b7a8-477f28c52667	10
1087026	diphenhydramine hydrochloride 2 % / zinc acetate 0.1 % Topical Cream	SY	a1c1b878-d58f-41ff-b7a8-477f28c52667	10
198440	acetaminophen 500 MG Oral Tablet	PSN	5cdb47c5-7951-4279-8a05-0a3199d3dd45	7
1111764	Benadryl Itch Stopping, Extra Strength 2 % / 0.1 % Topical Cream	PSN	5cdb47c5-7951-4279-8a05-0a3199d3dd45	7
1087026	diphenhydrAMINE HCl 2 % / zinc acetate 0.1 % Topical Cream	PSN	5cdb47c5-7951-4279-8a05-0a3199d3dd45	7
1359360	neomycin 3.5 MG / polymyxin B 10,000 UNT / pramoxine HCl 10 MG per GM Topical Cream	PSN	5cdb47c5-7951-4279-8a05-0a3199d3dd45	7
209459	Tylenol Extra Strength 500 MG Oral Tablet	PSN	5cdb47c5-7951-4279-8a05-0a3199d3dd45	7
209459	acetaminophen 500 MG Oral Tablet [Tylenol]	SBD	5cdb47c5-7951-4279-8a05-0a3199d3dd45	7
1111764	diphenhydramine hydrochloride 20 MG/ML / zinc acetate 1 MG/ML Topical Cream [Benadryl Itch Stopping]	SBD	5cdb47c5-7951-4279-8a05-0a3199d3dd45	7
198440	acetaminophen 500 MG Oral Tablet	SCD	5cdb47c5-7951-4279-8a05-0a3199d3dd45	7
1087026	diphenhydramine hydrochloride 20 MG/ML / zinc acetate 1 MG/ML Topical Cream	SCD	5cdb47c5-7951-4279-8a05-0a3199d3dd45	7
1359360	neomycin 3.5 MG/ML / polymyxin B 10000 UNT/ML / pramoxine hydrochloride 10 MG/ML Topical Cream	SCD	5cdb47c5-7951-4279-8a05-0a3199d3dd45	7
198440	APAP 500 MG Oral Tablet	SY	5cdb47c5-7951-4279-8a05-0a3199d3dd45	7
209459	APAP 500 MG Oral Tablet [Tylenol]	SY	5cdb47c5-7951-4279-8a05-0a3199d3dd45	7
1111764	Benadryl Itch Stopping, Extra Strength (diphenhydramine hydrochloride 2 % / zinc acetate 0.1 % ) Topical Cream	SY	5cdb47c5-7951-4279-8a05-0a3199d3dd45	7
1087026	diphenhydramine hydrochloride 2 % / zinc acetate 0.1 % Topical Cream	SY	5cdb47c5-7951-4279-8a05-0a3199d3dd45	7
1359360	neomycin (as neomycin sulfate) 0.35 % / polymyxin B (as polymyxin B sulfate) 10,000 UNT/ML / pramoxine (as pramoxine HCl) 1 % Topical Cream	SY	5cdb47c5-7951-4279-8a05-0a3199d3dd45	7
1359360	neomycin 0.35 % / polymyxin B 10,000 UNT/ML / pramoxine HCl 1 % Topical Cream	SY	5cdb47c5-7951-4279-8a05-0a3199d3dd45	7
1359360	neomycin 3.5 MG / polymyxin B 10,000 UNT / pramoxine HCl 10 MG per GM Topical Cream	SY	5cdb47c5-7951-4279-8a05-0a3199d3dd45	7
209459	Tylenol 500 MG Oral Tablet	SY	5cdb47c5-7951-4279-8a05-0a3199d3dd45	7
209459	Tylenol Extra Strength 500 MG Oral Tablet	SY	5cdb47c5-7951-4279-8a05-0a3199d3dd45	7
198440	acetaminophen 500 MG Oral Tablet	PSN	f3933330-2550-4a88-e053-2a95a90a3997	3
1111764	Benadryl Itch Stopping, Extra Strength 2 % / 0.1 % Topical Cream	PSN	f3933330-2550-4a88-e053-2a95a90a3997	3
1087026	diphenhydrAMINE HCl 2 % / zinc acetate 0.1 % Topical Cream	PSN	f3933330-2550-4a88-e053-2a95a90a3997	3
1359360	neomycin 3.5 MG / polymyxin B 10,000 UNT / pramoxine HCl 10 MG per GM Topical Cream	PSN	f3933330-2550-4a88-e053-2a95a90a3997	3
209459	Tylenol Extra Strength 500 MG Oral Tablet	PSN	f3933330-2550-4a88-e053-2a95a90a3997	3
209459	acetaminophen 500 MG Oral Tablet [Tylenol]	SBD	f3933330-2550-4a88-e053-2a95a90a3997	3
1111764	diphenhydramine hydrochloride 20 MG/ML / zinc acetate 1 MG/ML Topical Cream [Benadryl Itch Stopping]	SBD	f3933330-2550-4a88-e053-2a95a90a3997	3
198440	acetaminophen 500 MG Oral Tablet	SCD	f3933330-2550-4a88-e053-2a95a90a3997	3
1087026	diphenhydramine hydrochloride 20 MG/ML / zinc acetate 1 MG/ML Topical Cream	SCD	f3933330-2550-4a88-e053-2a95a90a3997	3
1359360	neomycin 3.5 MG/ML / polymyxin B 10000 UNT/ML / pramoxine hydrochloride 10 MG/ML Topical Cream	SCD	f3933330-2550-4a88-e053-2a95a90a3997	3
198440	APAP 500 MG Oral Tablet	SY	f3933330-2550-4a88-e053-2a95a90a3997	3
209459	APAP 500 MG Oral Tablet [Tylenol]	SY	f3933330-2550-4a88-e053-2a95a90a3997	3
1111764	Benadryl Itch Stopping, Extra Strength (diphenhydramine hydrochloride 2 % / zinc acetate 0.1 % ) Topical Cream	SY	f3933330-2550-4a88-e053-2a95a90a3997	3
1087026	diphenhydramine hydrochloride 2 % / zinc acetate 0.1 % Topical Cream	SY	f3933330-2550-4a88-e053-2a95a90a3997	3
1359360	neomycin (as neomycin sulfate) 0.35 % / polymyxin B (as polymyxin B sulfate) 10,000 UNT/ML / pramoxine (as pramoxine HCl) 1 % Topical Cream	SY	f3933330-2550-4a88-e053-2a95a90a3997	3
1359360	neomycin 0.35 % / polymyxin B 10,000 UNT/ML / pramoxine HCl 1 % Topical Cream	SY	f3933330-2550-4a88-e053-2a95a90a3997	3
1359360	neomycin 3.5 MG / polymyxin B 10,000 UNT / pramoxine HCl 10 MG per GM Topical Cream	SY	f3933330-2550-4a88-e053-2a95a90a3997	3
209459	Tylenol 500 MG Oral Tablet	SY	f3933330-2550-4a88-e053-2a95a90a3997	3
209459	Tylenol Extra Strength 500 MG Oral Tablet	SY	f3933330-2550-4a88-e053-2a95a90a3997	3

Packages#

Package NDC, 11-digit format, Description table
Package NDC	11-digit format	Description	Units	Marketing start	Sample	Exclude flag	Status
69968-0223-2	69968022302	28.3 g in 1 TUBE (69968-0223-2)	28.3 g	2009-11-01	No	No	Current

Title, Manufacturer, Effective date table
Title	Manufacturer	Effective date	Type	Version
Johnson and Johnson All Purpose First Aid Kit	Kenvue Brands LLC	2025-11-06	HUMAN OTC DRUG LABEL	7
Johnson and Johnson First Aid Kit All Purpose 160 CT	Kenvue Brands LLC	2025-11-06	HUMAN OTC DRUG LABEL	3
Benadryl ® EXTRA STRENGTH ITCH STOPPING CREAM	Kenvue Brands LLC	2024-11-12	HUMAN OTC DRUG LABEL	10