Amitriptyline Hydrochloride

Product NDC
70518-4365
11-digit product format
705184365
Labeler code
70518
Product ID
70518-4365_37efe83c-e346-eedf-e063-6394a90abc80
Type
HUMAN PRESCRIPTION DRUG
Nonproprietary name
Amitriptyline Hydrochloride
Dosage form
TABLET
Route
ORAL
Labeler
REMEDYREPACK INC.
Application
ANDA217411
Marketing category
ANDA
Marketing start
2025-06-18
Substance
AMITRIPTYLINE HYDROCHLORIDE
Active strength
75 mg/1
Pharmacologic classes
Tricyclic Antidepressant [EPC]
NDC exclude flag
No
Listing certified through
2026-12-31
Current FDA listing
Yes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 1.

Orange Book products#

Current product rows page 1 of 1 · 6 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
A217411-001AMITRIPTYLINE HYDROCHLORIDEAMITRIPTYLINE HYDROCHLORIDE10MGTABLET / ORALAB2023-05-19
A217411-002AMITRIPTYLINE HYDROCHLORIDEAMITRIPTYLINE HYDROCHLORIDE25MGTABLET / ORALAB2023-05-19
A217411-003AMITRIPTYLINE HYDROCHLORIDEAMITRIPTYLINE HYDROCHLORIDE50MGTABLET / ORALAB2023-05-19
A217411-004AMITRIPTYLINE HYDROCHLORIDEAMITRIPTYLINE HYDROCHLORIDE75MGTABLET / ORALAB2023-05-19
A217411-005AMITRIPTYLINE HYDROCHLORIDEAMITRIPTYLINE HYDROCHLORIDE100MGTABLET / ORALAB2023-05-19
A217411-006AMITRIPTYLINE HYDROCHLORIDEAMITRIPTYLINE HYDROCHLORIDE150MGTABLET / ORALAB2023-05-19

Therapeutic equivalence codes#

Current TE-code rows page 1 of 1 · 6 matching rows.

Application-product, TE code table
Application-productTE code
A217411-001AB
A217411-002AB
A217411-003AB
A217411-004AB
A217411-005AB
A217411-006AB

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Product history page 1 of 4 · 132 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-02-19 14:30 UTC2026-02A217411-001AMITRIPTYLINE HYDROCHLORIDE10MGTABLET / ORALAB2023-05-19011fe1cb6892…
2026-02-19 14:30 UTC2026-02A217411-002AMITRIPTYLINE HYDROCHLORIDE25MGTABLET / ORALAB2023-05-19011fe1cb6892…
2026-02-19 14:30 UTC2026-02A217411-003AMITRIPTYLINE HYDROCHLORIDE50MGTABLET / ORALAB2023-05-19011fe1cb6892…
2026-02-19 14:30 UTC2026-02A217411-004AMITRIPTYLINE HYDROCHLORIDE75MGTABLET / ORALAB2023-05-19011fe1cb6892…
2026-02-19 14:30 UTC2026-02A217411-005AMITRIPTYLINE HYDROCHLORIDE100MGTABLET / ORALAB2023-05-19011fe1cb6892…
2026-02-19 14:30 UTC2026-02A217411-006AMITRIPTYLINE HYDROCHLORIDE150MGTABLET / ORALAB2023-05-19011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A217411-001AMITRIPTYLINE HYDROCHLORIDE10MGTABLET / ORALAB2023-05-1931067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A217411-002AMITRIPTYLINE HYDROCHLORIDE25MGTABLET / ORALAB2023-05-1931067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A217411-003AMITRIPTYLINE HYDROCHLORIDE50MGTABLET / ORALAB2023-05-1931067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A217411-004AMITRIPTYLINE HYDROCHLORIDE75MGTABLET / ORALAB2023-05-1931067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A217411-005AMITRIPTYLINE HYDROCHLORIDE100MGTABLET / ORALAB2023-05-1931067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A217411-006AMITRIPTYLINE HYDROCHLORIDE150MGTABLET / ORALAB2023-05-1931067a03dcf5…
2025-08-23 18:47 UTC2025-08A217411-001AMITRIPTYLINE HYDROCHLORIDE10MGTABLET / ORALAB2023-05-196a471c1ec25d…
2025-08-23 18:47 UTC2025-08A217411-002AMITRIPTYLINE HYDROCHLORIDE25MGTABLET / ORALAB2023-05-196a471c1ec25d…
2025-08-23 18:47 UTC2025-08A217411-003AMITRIPTYLINE HYDROCHLORIDE50MGTABLET / ORALAB2023-05-196a471c1ec25d…
2025-08-23 18:47 UTC2025-08A217411-004AMITRIPTYLINE HYDROCHLORIDE75MGTABLET / ORALAB2023-05-196a471c1ec25d…
2025-08-23 18:47 UTC2025-08A217411-005AMITRIPTYLINE HYDROCHLORIDE100MGTABLET / ORALAB2023-05-196a471c1ec25d…
2025-08-23 18:47 UTC2025-08A217411-006AMITRIPTYLINE HYDROCHLORIDE150MGTABLET / ORALAB2023-05-196a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A217411-001AMITRIPTYLINE HYDROCHLORIDE10MGTABLET / ORALAB2023-05-19fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A217411-002AMITRIPTYLINE HYDROCHLORIDE25MGTABLET / ORALAB2023-05-19fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A217411-003AMITRIPTYLINE HYDROCHLORIDE50MGTABLET / ORALAB2023-05-19fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A217411-004AMITRIPTYLINE HYDROCHLORIDE75MGTABLET / ORALAB2023-05-19fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A217411-005AMITRIPTYLINE HYDROCHLORIDE100MGTABLET / ORALAB2023-05-19fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A217411-006AMITRIPTYLINE HYDROCHLORIDE150MGTABLET / ORALAB2023-05-19fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A217411-001AMITRIPTYLINE HYDROCHLORIDE10MGTABLET / ORALAB2023-05-19b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A217411-002AMITRIPTYLINE HYDROCHLORIDE25MGTABLET / ORALAB2023-05-19b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A217411-003AMITRIPTYLINE HYDROCHLORIDE50MGTABLET / ORALAB2023-05-19b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A217411-004AMITRIPTYLINE HYDROCHLORIDE75MGTABLET / ORALAB2023-05-19b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A217411-005AMITRIPTYLINE HYDROCHLORIDE100MGTABLET / ORALAB2023-05-19b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A217411-006AMITRIPTYLINE HYDROCHLORIDE150MGTABLET / ORALAB2023-05-19b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A217411-001AMITRIPTYLINE HYDROCHLORIDE10MGTABLET / ORALAB2023-05-1903ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A217411-002AMITRIPTYLINE HYDROCHLORIDE25MGTABLET / ORALAB2023-05-1903ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A217411-003AMITRIPTYLINE HYDROCHLORIDE50MGTABLET / ORALAB2023-05-1903ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A217411-004AMITRIPTYLINE HYDROCHLORIDE75MGTABLET / ORALAB2023-05-1903ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A217411-005AMITRIPTYLINE HYDROCHLORIDE100MGTABLET / ORALAB2023-05-1903ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A217411-006AMITRIPTYLINE HYDROCHLORIDE150MGTABLET / ORALAB2023-05-1903ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A217411-001AMITRIPTYLINE HYDROCHLORIDE10MGTABLET / ORALAB2023-05-192680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A217411-002AMITRIPTYLINE HYDROCHLORIDE25MGTABLET / ORALAB2023-05-192680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A217411-003AMITRIPTYLINE HYDROCHLORIDE50MGTABLET / ORALAB2023-05-192680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A217411-004AMITRIPTYLINE HYDROCHLORIDE75MGTABLET / ORALAB2023-05-192680178bc6a6…

Observed Orange Book normalized TE history#

Normalized TE history page 1 of 4 · 132 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTE codeOrderSource SHA-256
2026-02-19 14:30 UTC2026-02A217411-001AB1011fe1cb6892…
2026-02-19 14:30 UTC2026-02A217411-002AB1011fe1cb6892…
2026-02-19 14:30 UTC2026-02A217411-003AB1011fe1cb6892…
2026-02-19 14:30 UTC2026-02A217411-004AB1011fe1cb6892…
2026-02-19 14:30 UTC2026-02A217411-005AB1011fe1cb6892…
2026-02-19 14:30 UTC2026-02A217411-006AB1011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A217411-001AB131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A217411-002AB131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A217411-003AB131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A217411-004AB131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A217411-005AB131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A217411-006AB131067a03dcf5…
2025-08-23 18:47 UTC2025-08A217411-001AB16a471c1ec25d…
2025-08-23 18:47 UTC2025-08A217411-002AB16a471c1ec25d…
2025-08-23 18:47 UTC2025-08A217411-003AB16a471c1ec25d…
2025-08-23 18:47 UTC2025-08A217411-004AB16a471c1ec25d…
2025-08-23 18:47 UTC2025-08A217411-005AB16a471c1ec25d…
2025-08-23 18:47 UTC2025-08A217411-006AB16a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A217411-001AB1fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A217411-002AB1fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A217411-003AB1fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A217411-004AB1fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A217411-005AB1fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A217411-006AB1fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A217411-001AB1b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A217411-002AB1b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A217411-003AB1b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A217411-004AB1b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A217411-005AB1b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A217411-006AB1b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A217411-001AB103ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A217411-002AB103ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A217411-003AB103ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A217411-004AB103ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A217411-005AB103ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A217411-006AB103ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A217411-001AB12680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A217411-002AB12680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A217411-003AB12680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A217411-004AB12680178bc6a6…

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 2 · 23 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
Amitriptyline HydrochlorideAMITRIPTYLINE HYDROCHLORIDEREMEDYREPACK INC.5dc3c2d7-60a2-4754-be33-1f9401c925a42026-06-12Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 217411
application number: ANDA217411
Amitriptyline HydrochlorideAMITRIPTYLINE HYDROCHLORIDEPreferred Pharmaceuticals Inc.b2f822aa-23c0-4833-afc8-f5a611b9ad5a2026-02-23Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 217411
application number: ANDA217411
Amitriptyline HydrochlorideAMITRIPTYLINE HYDROCHLORIDEPreferred Pharmaceuticals Inc.147d2f8f-842d-4f09-86b0-a66edce277782026-01-23Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 217411
application number: ANDA217411
Amitriptyline HydrochlorideAMITRIPTYLINE HYDROCHLORIDEPreferred Pharmaceuticals Inc.54485767-d7c5-4927-ae52-08537a7a91e82026-01-20Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 217411
application number: ANDA217411
Amitriptyline HydrochlorideAMITRIPTYLINE HYDROCHLORIDEST. MARY'S MEDICAL PARK PHARMACY485b87c3-2a51-133b-e063-6294a90a95c32026-01-14Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 217411
application number: ANDA217411
Amitriptyline HydrochlorideAMITRIPTYLINE HYDROCHLORIDEPreferred Pharmaceuticals Inc.15c2afe3-3309-4abc-87d1-f3eab8d89b202025-11-17Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 217411
application number: ANDA217411
Amitriptyline HydrochlorideAMITRIPTYLINE HYDROCHLORIDEREMEDYREPACK INC.4132f91e-6f24-476a-9028-bab86ad0598e2025-10-17Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 217411
application number: ANDA217411
Amitriptyline HydrochlorideAMITRIPTYLINE HYDROCHLORIDEREMEDYREPACK INC.bb02d7b8-8f1a-4cc4-b763-223e6894f02c2025-09-25Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 217411
application number: ANDA217411
Amitriptyline HydrochlorideAMITRIPTYLINE HYDROCHLORIDEA-S Medication Solutions9110367c-4104-4836-8af3-649f86b0b3ea2025-07-09Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 217411
application number: ANDA217411
Amitriptyline HydrochlorideAMITRIPTYLINE HYDROCHLORIDEMajor Pharmaceuticals29ec1221-04d8-4b21-822e-2779fcaae62c2025-06-27Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 217411
application number: ANDA217411
Amitriptyline HydrochlorideAMITRIPTYLINE HYDROCHLORIDEA-S Medication Solutions85574987-8d31-4bd0-b829-bb154ef212f52025-06-24Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 217411
application number: ANDA217411
Amitriptyline HydrochlorideAMITRIPTYLINE HYDROCHLORIDEREMEDYREPACK INC.e0aa02a9-3e2d-44c5-a6b9-843c801022492025-06-19Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 217411
application number: ANDA217411
ndc (product): 70518-4365
Amitriptyline HydrochlorideAMITRIPTYLINE HYDROCHLORIDEST. MARY'S MEDICAL PARK PHARMACY35a6e911-507a-ef0d-e063-6294a90a07e12025-05-21Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 217411
application number: ANDA217411
Amitriptyline HydrochlorideAMITRIPTYLINE HYDROCHLORIDEST. MARY'S MEDICAL PARK PHARMACY35a7ce7d-4a29-e3f0-e063-6294a90ad66f2025-05-21Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 217411
application number: ANDA217411
Amitriptyline HydrochlorideAMITRIPTYLINE HYDROCHLORIDERising Pharma Holdings, Inc.a219a68e-7ce5-4e9d-a0de-ec76960040f62025-04-03Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 217411
application number: ANDA217411
Amitriptyline HydrochlorideAMITRIPTYLINE HYDROCHLORIDEAdvanced Rx of Tennessee, LLC19b0c015-c07f-63b7-e063-6394a90a60602024-11-18Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 217411
application number: ANDA217411
Amitriptyline HCLAMITRIPTYLINE HCLDirect_rx227affe9-36ee-2423-e063-6394a90a58f62024-09-19Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 217411
application number: ANDA217411
Amitriptyline HydrochlorideAMITRIPTYLINE HYDROCHLORIDEBryant Ranch Prepack3d9292dc-49a0-46f4-9980-3e8d57121d432024-09-16Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 217411
application number: ANDA217411
Amitriptyline HydrochlorideAMITRIPTYLINE HYDROCHLORIDEAdvanced Rx of Tennessee, LLC20aff9dc-98a7-6061-e063-6394a90a2aab2024-08-27Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 217411
application number: ANDA217411
Amitriptyline HydrochlorideAMITRIPTYLINE HYDROCHLORIDEBryant Ranch Prepacka726f82c-1018-44ee-ab1f-f5d34e6b388e2024-08-16Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 217411
application number: ANDA217411

Additional Listing Data#

Finished product
Yes
Brand name base
Amitriptyline Hydrochloride
Listing expiration
2026-12-31

Active Ingredients#

Ingredient, Strength table
IngredientStrength
AMITRIPTYLINE HYDROCHLORIDE75 mg/1

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
26LUD4JO9KInternal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
856853Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
e0aa02a9-3e2d-44c5-a6b9-843c80102249Available on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product conceptRelationVersionEffective
e5006e90-7f2e-4341-bcdb-f83027a8fc39Product name620240611
6f1277d7-db3a-63fa-be84-d390d1482706Product name120140508
aa9828b2-adf8-0dd3-9f6c-b68f39e467c1Product name120140508

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDCProductDescriptionFormQuantityStrengthSPL version
70518-4365-0Amitriptyline Hydrochloride30 in 1 BOTTLE, PLASTICTABLET301

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUIRxNorm stringTTYDailyMedSPL version
856853amitriptyline HCl 75 MG Oral TabletPSNe0aa02a9-3e2d-44c5-a6b9-843c801022491
856853amitriptyline hydrochloride 75 MG Oral TabletSCDe0aa02a9-3e2d-44c5-a6b9-843c801022491

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionUnitsMarketing startSampleExclude flagStatus
70518-4365-07051843650030 TABLET in 1 BOTTLE, PLASTIC (70518-4365-0) 30 tablet2025-06-18NoNoCurrent