Neostigmine methylsulfate

Product NDC
70700-172
11-digit product format
707000172
Labeler code
70700
Product ID
70700-172_8649cf31-5ecf-2048-5bf0-1b6e84f190f4
Type
HUMAN PRESCRIPTION DRUG
Nonproprietary name
Neostigmine methylsulfate
Dosage form
INJECTION
Route
INTRAVENOUS
Labeler
Xiromed LLC
Application
ANDA212968
Marketing category
ANDA
Marketing start
2020-09-09
Substance
NEOSTIGMINE METHYLSULFATE
Active strength
1 mg/mL
Pharmacologic classes
Cholinesterase Inhibitor [EPC], Cholinesterase Inhibitors [MoA]
NDC exclude flag
No
Listing certified through
2026-12-31
Current FDA listing
Yes

Observed NDC auxiliary status history#

This history shows the information present in each captured FDA auxiliary file. It is not a continuous regulatory timeline, and a missing record does not establish a status.

Historic NDC status page 1 of 1 · 3 matching rows.

View current auxiliary records. · View the auxiliary file history.

Captured / source date, Dataset, Scope table
Captured / source dateDatasetScopeProduct NDCPackage NDCCodeStatusReporting periodArchiveSnapshotSource SHA-256
2025-01-11 03:41 UTC · source 2025-01-10excluded productproduct70700-172UExcluded because listing certification expiredexcluded / ndc_excluded.zip0efc9e666f02…f202fb6c5f17…
2025-01-11 03:41 UTC · source 2025-01-10excluded packagepackage70700-17270700-172-23UExcluded because listing certification expiredexcluded / ndc_excluded.zip0efc9e666f02…f202fb6c5f17…
2025-01-11 03:41 UTC · source 2025-01-10excluded packagepackage70700-17270700-172-22UExcluded because listing certification expiredexcluded / ndc_excluded.zip0efc9e666f02…f202fb6c5f17…

Source provenance: Browse the complete Orange Book source catalog · source snapshot 1.

Orange Book products#

Current product rows page 1 of 1 · 2 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
A212968-001NEOSTIGMINE METHYLSULFATENEOSTIGMINE METHYLSULFATE5MG/10ML (0.5MG/ML)SOLUTION / INTRAVENOUSAP2019-10-16
A212968-002NEOSTIGMINE METHYLSULFATENEOSTIGMINE METHYLSULFATE10MG/10ML (1MG/ML)SOLUTION / INTRAVENOUSAP2019-10-16

Therapeutic equivalence codes#

Current TE-code rows page 1 of 1 · 2 matching rows.

Application-product, TE code table
Application-productTE code
A212968-001AP
A212968-002AP

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Product history page 1 of 2 · 78 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-02-19 14:30 UTC2026-02A212968-001NEOSTIGMINE METHYLSULFATE5MG/10ML (0.5MG/ML)SOLUTION / INTRAVENOUSAP2019-10-16011fe1cb6892…
2026-02-19 14:30 UTC2026-02A212968-002NEOSTIGMINE METHYLSULFATE10MG/10ML (1MG/ML)SOLUTION / INTRAVENOUSAP2019-10-16011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A212968-001NEOSTIGMINE METHYLSULFATE5MG/10ML (0.5MG/ML)SOLUTION / INTRAVENOUSAP2019-10-1631067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A212968-002NEOSTIGMINE METHYLSULFATE10MG/10ML (1MG/ML)SOLUTION / INTRAVENOUSAP2019-10-1631067a03dcf5…
2025-08-23 18:47 UTC2025-08A212968-001NEOSTIGMINE METHYLSULFATE5MG/10ML (0.5MG/ML)SOLUTION / INTRAVENOUSAP2019-10-166a471c1ec25d…
2025-08-23 18:47 UTC2025-08A212968-002NEOSTIGMINE METHYLSULFATE10MG/10ML (1MG/ML)SOLUTION / INTRAVENOUSAP2019-10-166a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A212968-001NEOSTIGMINE METHYLSULFATE5MG/10ML (0.5MG/ML)SOLUTION / INTRAVENOUSAP2019-10-16fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A212968-002NEOSTIGMINE METHYLSULFATE10MG/10ML (1MG/ML)SOLUTION / INTRAVENOUSAP2019-10-16fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A212968-001NEOSTIGMINE METHYLSULFATE5MG/10ML (0.5MG/ML)SOLUTION / INTRAVENOUSAP2019-10-16b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A212968-002NEOSTIGMINE METHYLSULFATE10MG/10ML (1MG/ML)SOLUTION / INTRAVENOUSAP2019-10-16b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A212968-001NEOSTIGMINE METHYLSULFATE5MG/10ML (0.5MG/ML)SOLUTION / INTRAVENOUSAP2019-10-1603ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A212968-002NEOSTIGMINE METHYLSULFATE10MG/10ML (1MG/ML)SOLUTION / INTRAVENOUSAP2019-10-1603ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A212968-001NEOSTIGMINE METHYLSULFATE5MG/10ML (0.5MG/ML)SOLUTION / INTRAVENOUSAP2019-10-162680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A212968-002NEOSTIGMINE METHYLSULFATE10MG/10ML (1MG/ML)SOLUTION / INTRAVENOUSAP2019-10-162680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A212968-001NEOSTIGMINE METHYLSULFATE5MG/10ML (0.5MG/ML)SOLUTION / INTRAVENOUSAP2019-10-165bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A212968-002NEOSTIGMINE METHYLSULFATE10MG/10ML (1MG/ML)SOLUTION / INTRAVENOUSAP2019-10-165bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A212968-001NEOSTIGMINE METHYLSULFATE5MG/10ML (0.5MG/ML)SOLUTION / INTRAVENOUSAP2019-10-16d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A212968-002NEOSTIGMINE METHYLSULFATE10MG/10ML (1MG/ML)SOLUTION / INTRAVENOUSAP2019-10-16d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A212968-001NEOSTIGMINE METHYLSULFATE5MG/10ML (0.5MG/ML)SOLUTION / INTRAVENOUSAP2019-10-16d06236e962d9…
2024-10-29 15:01 UTC2024-10A212968-002NEOSTIGMINE METHYLSULFATE10MG/10ML (1MG/ML)SOLUTION / INTRAVENOUSAP2019-10-16d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A212968-001NEOSTIGMINE METHYLSULFATE5MG/10ML (0.5MG/ML)SOLUTION / INTRAVENOUSAP2019-10-1679d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A212968-002NEOSTIGMINE METHYLSULFATE10MG/10ML (1MG/ML)SOLUTION / INTRAVENOUSAP2019-10-1679d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A212968-001NEOSTIGMINE METHYLSULFATE5MG/10ML (0.5MG/ML)SOLUTION / INTRAVENOUSAP2019-10-16301d65b070ca…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A212968-002NEOSTIGMINE METHYLSULFATE10MG/10ML (1MG/ML)SOLUTION / INTRAVENOUSAP2019-10-16301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A212968-001NEOSTIGMINE METHYLSULFATE5MG/10ML (0.5MG/ML)SOLUTION / INTRAVENOUSAP2019-10-161e350fbaab3a…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A212968-002NEOSTIGMINE METHYLSULFATE10MG/10ML (1MG/ML)SOLUTION / INTRAVENOUSAP2019-10-161e350fbaab3a…
2024-05-31 18:47 UTC2024-05A212968-001NEOSTIGMINE METHYLSULFATE5MG/10ML (0.5MG/ML)SOLUTION / INTRAVENOUSAP2019-10-168072bd15b7f6…
2024-05-31 18:47 UTC2024-05A212968-002NEOSTIGMINE METHYLSULFATE10MG/10ML (1MG/ML)SOLUTION / INTRAVENOUSAP2019-10-168072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06A212968-001NEOSTIGMINE METHYLSULFATE5MG/10ML (0.5MG/ML)SOLUTION / INTRAVENOUSAP2019-10-165c6f7cd8ea54…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06A212968-002NEOSTIGMINE METHYLSULFATE10MG/10ML (1MG/ML)SOLUTION / INTRAVENOUSAP2019-10-165c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04A212968-001NEOSTIGMINE METHYLSULFATE5MG/10ML (0.5MG/ML)SOLUTION / INTRAVENOUSAP2019-10-165d02ea3f76ae…
2022-04-08 23:34 UTC2022-04A212968-002NEOSTIGMINE METHYLSULFATE10MG/10ML (1MG/ML)SOLUTION / INTRAVENOUSAP2019-10-165d02ea3f76ae…
2022-04-04 05:41 UTC2022-04A212968-001NEOSTIGMINE METHYLSULFATE5MG/10ML (0.5MG/ML)SOLUTION / INTRAVENOUSAP2019-10-164b0b4de00fa7…
2022-04-04 05:41 UTC2022-04A212968-002NEOSTIGMINE METHYLSULFATE10MG/10ML (1MG/ML)SOLUTION / INTRAVENOUSAP2019-10-164b0b4de00fa7…
2019-12-13 00:20 UTC2019-12A212968-001NEOSTIGMINE METHYLSULFATE5MG/10ML (0.5MG/ML)SOLUTION / INTRAVENOUSAP2019-10-1674a2ff9319b5…
2019-12-13 00:20 UTC2019-12A212968-002NEOSTIGMINE METHYLSULFATE10MG/10ML (1MG/ML)SOLUTION / INTRAVENOUSAP2019-10-1674a2ff9319b5…
2022-03-09 01:35 UTC2022-03A212968-001NEOSTIGMINE METHYLSULFATE5MG/10ML (0.5MG/ML)SOLUTION / INTRAVENOUSAP2019-10-16bb7c543d1eb4…
2022-03-09 01:35 UTC2022-03A212968-002NEOSTIGMINE METHYLSULFATE10MG/10ML (1MG/ML)SOLUTION / INTRAVENOUSAP2019-10-16bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12A212968-001NEOSTIGMINE METHYLSULFATE5MG/10ML (0.5MG/ML)SOLUTION / INTRAVENOUSAP2019-10-16782e0a99824c…
2021-12-28 21:50 UTC2021-12A212968-002NEOSTIGMINE METHYLSULFATE10MG/10ML (1MG/ML)SOLUTION / INTRAVENOUSAP2019-10-16782e0a99824c…

Observed Orange Book normalized TE history#

Normalized TE history page 1 of 2 · 78 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTE codeOrderSource SHA-256
2026-02-19 14:30 UTC2026-02A212968-001AP1011fe1cb6892…
2026-02-19 14:30 UTC2026-02A212968-002AP1011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A212968-001AP131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A212968-002AP131067a03dcf5…
2025-08-23 18:47 UTC2025-08A212968-001AP16a471c1ec25d…
2025-08-23 18:47 UTC2025-08A212968-002AP16a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A212968-001AP1fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A212968-002AP1fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A212968-001AP1b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A212968-002AP1b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A212968-001AP103ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A212968-002AP103ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A212968-001AP12680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A212968-002AP12680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A212968-001AP15bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A212968-002AP15bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A212968-001AP1d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A212968-002AP1d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A212968-001AP1d06236e962d9…
2024-10-29 15:01 UTC2024-10A212968-002AP1d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A212968-001AP179d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A212968-002AP179d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A212968-001AP1301d65b070ca…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A212968-002AP1301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A212968-001AP11e350fbaab3a…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A212968-002AP11e350fbaab3a…
2024-05-31 18:47 UTC2024-05A212968-001AP18072bd15b7f6…
2024-05-31 18:47 UTC2024-05A212968-002AP18072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06A212968-001AP15c6f7cd8ea54…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06A212968-002AP15c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04A212968-001AP15d02ea3f76ae…
2022-04-08 23:34 UTC2022-04A212968-002AP15d02ea3f76ae…
2022-04-04 05:41 UTC2022-04A212968-001AP14b0b4de00fa7…
2022-04-04 05:41 UTC2022-04A212968-002AP14b0b4de00fa7…
2019-12-13 00:20 UTC2019-12A212968-001AP174a2ff9319b5…
2019-12-13 00:20 UTC2019-12A212968-002AP174a2ff9319b5…
2022-03-09 01:35 UTC2022-03A212968-001AP1bb7c543d1eb4…
2022-03-09 01:35 UTC2022-03A212968-002AP1bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12A212968-001AP1782e0a99824c…
2021-12-28 21:50 UTC2021-12A212968-002AP1782e0a99824c…

Additional Listing Data#

Finished product
Yes
Brand name base
Neostigmine methylsulfate
Listing expiration
2026-12-31

Active Ingredients#

Ingredient, Strength table
IngredientStrength
NEOSTIGMINE METHYLSULFATE1 mg/mL

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
98IMH7M386Internal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 2 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
311935Internal RxNorm lookup
311936Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
801225d9-eb71-dbef-e860-4caf7a22f27fAvailable on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product conceptRelationVersionEffective
f58f10d3-5fa9-4c2e-9a6e-77029e9ed80bProduct name120231002
6c2b16d0-96e9-444e-98c5-9883cd6eb72dProduct name220230316
6bd95106-a412-1dad-b9cc-4cb74bfb27ceProduct name220230315
ad279e69-d021-f6bd-1150-2b55f23832d5Product name920211014
48747306-602a-42cc-957b-5b0c69158eeeProduct name120180604
d5e51f11-ad28-caa4-4b49-4143974782adProduct name120150831
290f523a-f9db-9774-b5a9-e1f908ac1782Product name120150828
0ca1d589-929b-4b33-bc5b-1d84abdafa6aProduct name120150324
fc363c46-397b-4476-ac0f-70e43e8e4592Product name120150324
c6b65c52-69c7-df49-550a-a50c137f6218Product name120140508
db5ebcdb-b6ae-21cd-4dc5-76cd84b5578bProduct name120140508

DailyMed Billing Units#

Package NDC, Billing unit, Product NDC table
Package NDCBilling unitProduct NDCDailyMed indexing SPLSPL versionEffective
70700-172-22ML - Milliliter70700-172b5c2a670-6cfd-4ec0-8e25-7976385fe9f312020-09-14
70700-172-23ML - Milliliter70700-172b51daa78-89d0-4d71-95ac-fabba2cf872b12020-09-14

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDCDashboard titleSPL versionValidationDashboard ZIP
70700-172NEOSTIGMINE METHYLSULFATE INJECTION [XIROMED LLC]6Current NDC, Legacy NDC20250112_801225d9-eb71-dbef-e860-4caf7a22f27f.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 3 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
Neostigmine methylsulfateNEOSTIGMINE METHYLSULFATEGland Pharma Limited4eab6184-1771-4c15-a127-4eb3e47affc22026-01-31Warnings, Adverse reactionsExact identifier
application applno (ANDA): 212968
application number: ANDA212968
Neostigmine methylsulfateNEOSTIGMINE METHYLSULFATEProPharma Distribution3857462f-2d3c-bada-e063-6294a90a74382025-07-18Warnings, Adverse reactionsExact identifier
application applno (ANDA): 212968
application number: ANDA212968
Neostigmine methylsulfateNEOSTIGMINE METHYLSULFATEXiromed LLC801225d9-eb71-dbef-e860-4caf7a22f27f2021-10-13Warnings, Adverse reactionsExact identifier
application applno (ANDA): 212968
application number: ANDA212968
ndc (product): 70700-172

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUIRxNorm stringTTYDailyMedSPL version
311935neostigmine methylsulfate 0.5 MG/ML Injectable SolutionPSN801225d9-eb71-dbef-e860-4caf7a22f27f6
311936neostigmine methylsulfate 1 MG/ML Injectable SolutionPSN801225d9-eb71-dbef-e860-4caf7a22f27f6
311935neostigmine methylsulfate 0.5 MG/ML Injectable SolutionSCD801225d9-eb71-dbef-e860-4caf7a22f27f6
311936neostigmine methylsulfate 1 MG/ML Injectable SolutionSCD801225d9-eb71-dbef-e860-4caf7a22f27f6
311935neostigmine methylsulfate 0.5 MG/ML Injectable SolutionSY801225d9-eb71-dbef-e860-4caf7a22f27f6
311936neostigmine methylsulfate 1 MG/ML Injectable SolutionSY801225d9-eb71-dbef-e860-4caf7a22f27f6
311936neostigmine methylsulfate 1 MG/ML Injectable SolutionPSN3857462f-2d3c-bada-e063-6294a90a74383
311936neostigmine methylsulfate 1 MG/ML Injectable SolutionSCD3857462f-2d3c-bada-e063-6294a90a74383
311936neostigmine methylsulfate 1 MG/ML Injectable SolutionSY3857462f-2d3c-bada-e063-6294a90a74383

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionMarketing startMarketing endSampleExclude flagStatus
70700-172-22707000172221 VIAL, MULTI-DOSE in 1 CARTON (70700-172-22) / 10 mL in 1 VIAL, MULTI-DOSE2020-09-090000-00-00NoNoCurrent
70700-172-237070001722310 VIAL, MULTI-DOSE in 1 CARTON (70700-172-23) / 10 mL in 1 VIAL, MULTI-DOSE2020-09-090000-00-00NoNoCurrent