Methylene blue

Product NDC
70771-1768
11-digit product format
707711768
Labeler code
70771
Product ID
70771-1768_31d0470b-20e5-4d5e-b273-81d5dd6b2180
Type
HUMAN PRESCRIPTION DRUG
Nonproprietary name
Methylene blue
Dosage form
INJECTION
Route
INTRAVENOUS
Labeler
Zydus Lifesciences Limited
Application
ANDA215636
Marketing category
ANDA
Marketing start
2023-12-05
Substance
METHYLENE BLUE
Active strength
5 mg/mL
Pharmacologic classes
Oxidation-Reduction Activity [MoA], Oxidation-Reduction Agent [EPC]
NDC exclude flag
No
Listing certified through
2027-12-31
Current FDA listing
Yes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 1.

Orange Book products#

Current product rows page 1 of 1 · 4 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
A215636-001METHYLENE BLUEMETHYLENE BLUE10MG/2ML (5MG/ML)SOLUTION / INTRAVENOUSAP2023-12-05
A215636-002METHYLENE BLUEMETHYLENE BLUE50MG/10ML (5MG/ML)SOLUTION / INTRAVENOUSAP2023-12-05
A215636-003METHYLENE BLUEMETHYLENE BLUE5MG/ML (5MG/ML)SOLUTION / INTRAVENOUSRS2026-02-02
A215636-004METHYLENE BLUEMETHYLENE BLUE100MG/10ML (10MG/ML)SOLUTION / INTRAVENOUSRS2026-03-31

Therapeutic equivalence codes#

Current TE-code rows page 1 of 1 · 2 matching rows.

Application-product, TE code table
Application-productTE code
A215636-001AP
A215636-002AP

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-02-19 14:30 UTC2026-02A215636-001METHYLENE BLUE10MG/2ML (5MG/ML)SOLUTION / INTRAVENOUSAP2023-12-05011fe1cb6892…
2026-02-19 14:30 UTC2026-02A215636-002METHYLENE BLUE50MG/10ML (5MG/ML)SOLUTION / INTRAVENOUSAP2023-12-05011fe1cb6892…
2026-02-19 14:30 UTC2026-02A215636-003METHYLENE BLUE5MG/ML (5MG/ML)SOLUTION / INTRAVENOUSRS2026-02-02011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A215636-001METHYLENE BLUE10MG/2ML (5MG/ML)SOLUTION / INTRAVENOUSAP2023-12-0531067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A215636-002METHYLENE BLUE50MG/10ML (5MG/ML)SOLUTION / INTRAVENOUSAP2023-12-0531067a03dcf5…
2025-08-23 18:47 UTC2025-08A215636-001METHYLENE BLUE10MG/2ML (5MG/ML)SOLUTION / INTRAVENOUSAP2023-12-056a471c1ec25d…
2025-08-23 18:47 UTC2025-08A215636-002METHYLENE BLUE50MG/10ML (5MG/ML)SOLUTION / INTRAVENOUSAP2023-12-056a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A215636-001METHYLENE BLUE10MG/2ML (5MG/ML)SOLUTION / INTRAVENOUSAP2023-12-05fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A215636-002METHYLENE BLUE50MG/10ML (5MG/ML)SOLUTION / INTRAVENOUSAP2023-12-05fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A215636-001METHYLENE BLUE10MG/2ML (5MG/ML)SOLUTION / INTRAVENOUSAP2023-12-05b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A215636-002METHYLENE BLUE50MG/10ML (5MG/ML)SOLUTION / INTRAVENOUSAP2023-12-05b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A215636-001METHYLENE BLUE10MG/2ML (5MG/ML)SOLUTION / INTRAVENOUSAP2023-12-0503ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A215636-002METHYLENE BLUE50MG/10ML (5MG/ML)SOLUTION / INTRAVENOUSAP2023-12-0503ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A215636-001METHYLENE BLUE10MG/2ML (5MG/ML)SOLUTION / INTRAVENOUSAP2023-12-052680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A215636-002METHYLENE BLUE50MG/10ML (5MG/ML)SOLUTION / INTRAVENOUSAP2023-12-052680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A215636-001METHYLENE BLUE10MG/2ML (5MG/ML)SOLUTION / INTRAVENOUSAP2023-12-055bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A215636-002METHYLENE BLUE50MG/10ML (5MG/ML)SOLUTION / INTRAVENOUSAP2023-12-055bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A215636-001METHYLENE BLUE10MG/2ML (5MG/ML)SOLUTION / INTRAVENOUSAP2023-12-05d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A215636-002METHYLENE BLUE50MG/10ML (5MG/ML)SOLUTION / INTRAVENOUSAP2023-12-05d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A215636-001METHYLENE BLUE10MG/2ML (5MG/ML)SOLUTION / INTRAVENOUSAP2023-12-05d06236e962d9…
2024-10-29 15:01 UTC2024-10A215636-002METHYLENE BLUE50MG/10ML (5MG/ML)SOLUTION / INTRAVENOUSAP2023-12-05d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A215636-001METHYLENE BLUE10MG/2ML (5MG/ML)SOLUTION / INTRAVENOUSAP2023-12-0579d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A215636-002METHYLENE BLUE50MG/10ML (5MG/ML)SOLUTION / INTRAVENOUSAP2023-12-0579d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A215636-001METHYLENE BLUE10MG/2ML (5MG/ML)SOLUTION / INTRAVENOUSAP2023-12-05301d65b070ca…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A215636-002METHYLENE BLUE50MG/10ML (5MG/ML)SOLUTION / INTRAVENOUSAP2023-12-05301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A215636-001METHYLENE BLUE10MG/2ML (5MG/ML)SOLUTION / INTRAVENOUSAP2023-12-051e350fbaab3a…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A215636-002METHYLENE BLUE50MG/10ML (5MG/ML)SOLUTION / INTRAVENOUSAP2023-12-051e350fbaab3a…
2024-05-31 18:47 UTC2024-05A215636-001METHYLENE BLUE10MG/2ML (5MG/ML)SOLUTION / INTRAVENOUSAP2023-12-058072bd15b7f6…
2024-05-31 18:47 UTC2024-05A215636-002METHYLENE BLUE50MG/10ML (5MG/ML)SOLUTION / INTRAVENOUSAP2023-12-058072bd15b7f6…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A215636-001METHYLENE BLUE10MG/2ML (5MG/ML)SOLUTION / INTRAVENOUSAP2023-12-056a51e52b5d6a…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A215636-002METHYLENE BLUE50MG/10ML (5MG/ML)SOLUTION / INTRAVENOUSAP2023-12-056a51e52b5d6a…
2024-02-18 07:12 UTC2024-02A215636-001METHYLENE BLUE10MG/2ML (5MG/ML)SOLUTION / INTRAVENOUSAP2023-12-051c564ffb4f44…
2024-02-18 07:12 UTC2024-02A215636-002METHYLENE BLUE50MG/10ML (5MG/ML)SOLUTION / INTRAVENOUSAP2023-12-051c564ffb4f44…
2023-12-20 04:57 UTC2023-12A215636-001METHYLENE BLUE10MG/2ML (5MG/ML)SOLUTION / INTRAVENOUSAP2023-12-05ea1830bbd6c7…
2023-12-20 04:57 UTC2023-12A215636-002METHYLENE BLUE50MG/10ML (5MG/ML)SOLUTION / INTRAVENOUSAP2023-12-05ea1830bbd6c7…
2026-07-26 02:55 UTC · 3 captures of this ZIP2026-06A215636-001METHYLENE BLUE10MG/2ML (5MG/ML)SOLUTION / INTRAVENOUSAP2023-12-05a50c72e98297…
2026-07-26 02:55 UTC · 3 captures of this ZIP2026-06A215636-002METHYLENE BLUE50MG/10ML (5MG/ML)SOLUTION / INTRAVENOUSAP2023-12-05a50c72e98297…
2026-07-26 02:55 UTC · 3 captures of this ZIP2026-06A215636-003METHYLENE BLUE5MG/ML (5MG/ML)SOLUTION / INTRAVENOUSRS2026-02-02a50c72e98297…
2026-07-26 02:55 UTC · 3 captures of this ZIP2026-06A215636-004METHYLENE BLUE100MG/10ML (10MG/ML)SOLUTION / INTRAVENOUSRS2026-03-31a50c72e98297…

Observed Orange Book normalized TE history#

Captured, Edition, Application-product table
CapturedEditionApplication-productTE codeOrderSource SHA-256
2026-02-19 14:30 UTC2026-02A215636-001AP1011fe1cb6892…
2026-02-19 14:30 UTC2026-02A215636-002AP1011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A215636-001AP131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A215636-002AP131067a03dcf5…
2025-08-23 18:47 UTC2025-08A215636-001AP16a471c1ec25d…
2025-08-23 18:47 UTC2025-08A215636-002AP16a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A215636-001AP1fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A215636-002AP1fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A215636-001AP1b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A215636-002AP1b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A215636-001AP103ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A215636-002AP103ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A215636-001AP12680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A215636-002AP12680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A215636-001AP15bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A215636-002AP15bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A215636-001AP1d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A215636-002AP1d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A215636-001AP1d06236e962d9…
2024-10-29 15:01 UTC2024-10A215636-002AP1d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A215636-001AP179d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A215636-002AP179d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A215636-001AP1301d65b070ca…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A215636-002AP1301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A215636-001AP11e350fbaab3a…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A215636-002AP11e350fbaab3a…
2024-05-31 18:47 UTC2024-05A215636-001AP18072bd15b7f6…
2024-05-31 18:47 UTC2024-05A215636-002AP18072bd15b7f6…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A215636-001AP16a51e52b5d6a…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A215636-002AP16a51e52b5d6a…
2024-02-18 07:12 UTC2024-02A215636-001AP11c564ffb4f44…
2024-02-18 07:12 UTC2024-02A215636-002AP11c564ffb4f44…
2023-12-20 04:57 UTC2023-12A215636-001AP1ea1830bbd6c7…
2023-12-20 04:57 UTC2023-12A215636-002AP1ea1830bbd6c7…
2026-07-26 02:55 UTC · 3 captures of this ZIP2026-06A215636-001AP1a50c72e98297…
2026-07-26 02:55 UTC · 3 captures of this ZIP2026-06A215636-002AP1a50c72e98297…

Additional Listing Data#

Finished product
Yes
Brand name base
Methylene blue
Listing expiration
2027-12-31

Active Ingredients#

Ingredient, Strength table
IngredientStrength
METHYLENE BLUE5 mg/mL

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
T42P99266KInternal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 3 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
1737852Internal RxNorm lookup
1788984Internal RxNorm lookup
2199323Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
df3568d6-d509-4c93-9a92-0e3d1d8514dcAvailable on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product conceptRelationVersionEffective
c39b72c3-7732-4ed2-a995-e6aa3a665a54Product name320250819

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDCProductDescriptionFormQuantityStrengthSPL version
70771-1768-1Methylene blue10 mL in 1 VIALINJECTION103
70771-1768-5Methylene blue5 in 1 CARTONINJECTION53

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDCDashboard titleSPL versionValidationDashboard ZIP
70771-1768METHYLENE BLUE INJECTION [ZYDUS LIFESCIENCES LIMITED]2Current NDC, 2 package rows20240426_df3568d6-d509-4c93-9a92-0e3d1d8514dc.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 2 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
Methylene blueMETHYLENE BLUEZydus Lifesciences Limiteddf3568d6-d509-4c93-9a92-0e3d1d8514dc2026-04-02Exact identifier
application applno (ANDA): 215636
application number: ANDA215636
ndc (product): 70771-1768
Methylene blueMETHYLENE BLUEZydus Pharmaceuticals USA Inc.8c56fbad-a449-4ed4-a55f-1694e4e8e26a2026-04-02Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 215636
application number: ANDA215636

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUIRxNorm stringTTYDailyMedSPL version
2199323methylene blue 10 MG in 2 mL InjectionPSNdf3568d6-d509-4c93-9a92-0e3d1d8514dc3
1737852methylene blue 100 MG in 10 ML (1 % ) InjectionPSNdf3568d6-d509-4c93-9a92-0e3d1d8514dc3
1788984methylene blue 50 MG in 10 ML InjectionPSNdf3568d6-d509-4c93-9a92-0e3d1d8514dc3
173785210 ML methylene blue 10 MG/ML InjectionSCDdf3568d6-d509-4c93-9a92-0e3d1d8514dc3
178898410 ML methylene blue 5 MG/ML InjectionSCDdf3568d6-d509-4c93-9a92-0e3d1d8514dc3
21993232 ML methylene blue 5 MG/ML InjectionSCDdf3568d6-d509-4c93-9a92-0e3d1d8514dc3
2199323methylene blue 10 MG per 2 ML InjectionSYdf3568d6-d509-4c93-9a92-0e3d1d8514dc3
1737852methylene blue 100 MG per 10 ML (1 % ) InjectionSYdf3568d6-d509-4c93-9a92-0e3d1d8514dc3
1788984methylene blue 50 MG per 10 ML InjectionSYdf3568d6-d509-4c93-9a92-0e3d1d8514dc3

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionUnitsMarketing startSampleExclude flagStatus
70771-1768-17077117680110 mL in 1 VIAL10 mlHistorical
70771-1768-5707711768055 VIAL in 1 CARTON (70771-1768-5) / 10 mL in 1 VIAL (70771-1768-1) 5 vial2023-12-05NoNoCurrent