Pemetrexed

Product NDC
71288-145
11-digit product format
712880145
Labeler code
71288
Product ID
71288-145_b369ac27-0118-4e53-be05-c9ba2dbf6875
Type
HUMAN PRESCRIPTION DRUG
Nonproprietary name
Pemetrexed disodium
Dosage form
INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION
Route
INTRAVENOUS
Labeler
Meitheal Pharmaceuticals Inc.
Application
ANDA215479
Marketing category
ANDA
Marketing start
2022-12-13
Substance
PEMETREXED DISODIUM HEPTAHYDRATE
Active strength
100 mg/4.2mL
Pharmacologic classes
Folate Analog Metabolic Inhibitor [EPC], Folic Acid Metabolism Inhibitors [MoA]
NDC exclude flag
No
Listing certified through
2026-12-31
Current FDA listing
Yes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 1.

Orange Book products#

Current product rows page 1 of 1 · 4 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
A215479-001PEMETREXED DISODIUMPEMETREXED DISODIUMEQ 100MG BASE/VIALPOWDER / INTRAVENOUSAP2022-12-13
A215479-002PEMETREXED DISODIUMPEMETREXED DISODIUMEQ 500MG BASE/VIALPOWDER / INTRAVENOUSAP2022-12-13
A215479-003PEMETREXED DISODIUMPEMETREXED DISODIUMEQ 750MG BASE/VIALPOWDER / INTRAVENOUSAP2022-12-13
A215479-004PEMETREXED DISODIUMPEMETREXED DISODIUMEQ 1GM BASE/VIALPOWDER / INTRAVENOUSAP2022-12-13

Therapeutic equivalence codes#

Current TE-code rows page 1 of 1 · 4 matching rows.

Application-product, TE code table
Application-productTE code
A215479-001AP
A215479-002AP
A215479-003AP
A215479-004AP

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Product history page 1 of 3 · 96 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-02-19 14:30 UTC2026-02A215479-001PEMETREXED DISODIUMEQ 100MG BASE/VIALPOWDER / INTRAVENOUSAP2022-12-13011fe1cb6892…
2026-02-19 14:30 UTC2026-02A215479-002PEMETREXED DISODIUMEQ 500MG BASE/VIALPOWDER / INTRAVENOUSAP2022-12-13011fe1cb6892…
2026-02-19 14:30 UTC2026-02A215479-003PEMETREXED DISODIUMEQ 750MG BASE/VIALPOWDER / INTRAVENOUSAP2022-12-13011fe1cb6892…
2026-02-19 14:30 UTC2026-02A215479-004PEMETREXED DISODIUMEQ 1GM BASE/VIALPOWDER / INTRAVENOUSAP2022-12-13011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A215479-001PEMETREXED DISODIUMEQ 100MG BASE/VIALPOWDER / INTRAVENOUSAP2022-12-1331067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A215479-002PEMETREXED DISODIUMEQ 500MG BASE/VIALPOWDER / INTRAVENOUSAP2022-12-1331067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A215479-003PEMETREXED DISODIUMEQ 750MG BASE/VIALPOWDER / INTRAVENOUSAP2022-12-1331067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A215479-004PEMETREXED DISODIUMEQ 1GM BASE/VIALPOWDER / INTRAVENOUSAP2022-12-1331067a03dcf5…
2025-08-23 18:47 UTC2025-08A215479-001PEMETREXED DISODIUMEQ 100MG BASE/VIALPOWDER / INTRAVENOUSAP2022-12-136a471c1ec25d…
2025-08-23 18:47 UTC2025-08A215479-002PEMETREXED DISODIUMEQ 500MG BASE/VIALPOWDER / INTRAVENOUSAP2022-12-136a471c1ec25d…
2025-08-23 18:47 UTC2025-08A215479-003PEMETREXED DISODIUMEQ 750MG BASE/VIALPOWDER / INTRAVENOUSAP2022-12-136a471c1ec25d…
2025-08-23 18:47 UTC2025-08A215479-004PEMETREXED DISODIUMEQ 1GM BASE/VIALPOWDER / INTRAVENOUSAP2022-12-136a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A215479-001PEMETREXED DISODIUMEQ 100MG BASE/VIALPOWDER / INTRAVENOUSAP2022-12-13fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A215479-002PEMETREXED DISODIUMEQ 500MG BASE/VIALPOWDER / INTRAVENOUSAP2022-12-13fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A215479-003PEMETREXED DISODIUMEQ 750MG BASE/VIALPOWDER / INTRAVENOUSAP2022-12-13fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A215479-004PEMETREXED DISODIUMEQ 1GM BASE/VIALPOWDER / INTRAVENOUSAP2022-12-13fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A215479-001PEMETREXED DISODIUMEQ 100MG BASE/VIALPOWDER / INTRAVENOUSAP2022-12-13b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A215479-002PEMETREXED DISODIUMEQ 500MG BASE/VIALPOWDER / INTRAVENOUSAP2022-12-13b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A215479-003PEMETREXED DISODIUMEQ 750MG BASE/VIALPOWDER / INTRAVENOUSAP2022-12-13b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A215479-004PEMETREXED DISODIUMEQ 1GM BASE/VIALPOWDER / INTRAVENOUSAP2022-12-13b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A215479-001PEMETREXED DISODIUMEQ 100MG BASE/VIALPOWDER / INTRAVENOUSAP2022-12-1303ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A215479-002PEMETREXED DISODIUMEQ 500MG BASE/VIALPOWDER / INTRAVENOUSAP2022-12-1303ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A215479-003PEMETREXED DISODIUMEQ 750MG BASE/VIALPOWDER / INTRAVENOUSAP2022-12-1303ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A215479-004PEMETREXED DISODIUMEQ 1GM BASE/VIALPOWDER / INTRAVENOUSAP2022-12-1303ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A215479-001PEMETREXED DISODIUMEQ 100MG BASE/VIALPOWDER / INTRAVENOUSAP2022-12-132680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A215479-002PEMETREXED DISODIUMEQ 500MG BASE/VIALPOWDER / INTRAVENOUSAP2022-12-132680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A215479-003PEMETREXED DISODIUMEQ 750MG BASE/VIALPOWDER / INTRAVENOUSAP2022-12-132680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A215479-004PEMETREXED DISODIUMEQ 1GM BASE/VIALPOWDER / INTRAVENOUSAP2022-12-132680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A215479-001PEMETREXED DISODIUMEQ 100MG BASE/VIALPOWDER / INTRAVENOUSAP2022-12-135bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A215479-002PEMETREXED DISODIUMEQ 500MG BASE/VIALPOWDER / INTRAVENOUSAP2022-12-135bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A215479-003PEMETREXED DISODIUMEQ 750MG BASE/VIALPOWDER / INTRAVENOUSAP2022-12-135bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A215479-004PEMETREXED DISODIUMEQ 1GM BASE/VIALPOWDER / INTRAVENOUSAP2022-12-135bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A215479-001PEMETREXED DISODIUMEQ 100MG BASE/VIALPOWDER / INTRAVENOUSAP2022-12-13d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A215479-002PEMETREXED DISODIUMEQ 500MG BASE/VIALPOWDER / INTRAVENOUSAP2022-12-13d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A215479-003PEMETREXED DISODIUMEQ 750MG BASE/VIALPOWDER / INTRAVENOUSAP2022-12-13d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A215479-004PEMETREXED DISODIUMEQ 1GM BASE/VIALPOWDER / INTRAVENOUSAP2022-12-13d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A215479-001PEMETREXED DISODIUMEQ 100MG BASE/VIALPOWDER / INTRAVENOUSAP2022-12-13d06236e962d9…
2024-10-29 15:01 UTC2024-10A215479-002PEMETREXED DISODIUMEQ 500MG BASE/VIALPOWDER / INTRAVENOUSAP2022-12-13d06236e962d9…
2024-10-29 15:01 UTC2024-10A215479-003PEMETREXED DISODIUMEQ 750MG BASE/VIALPOWDER / INTRAVENOUSAP2022-12-13d06236e962d9…
2024-10-29 15:01 UTC2024-10A215479-004PEMETREXED DISODIUMEQ 1GM BASE/VIALPOWDER / INTRAVENOUSAP2022-12-13d06236e962d9…

Observed Orange Book normalized TE history#

Normalized TE history page 1 of 3 · 96 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTE codeOrderSource SHA-256
2026-02-19 14:30 UTC2026-02A215479-001AP1011fe1cb6892…
2026-02-19 14:30 UTC2026-02A215479-002AP1011fe1cb6892…
2026-02-19 14:30 UTC2026-02A215479-003AP1011fe1cb6892…
2026-02-19 14:30 UTC2026-02A215479-004AP1011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A215479-001AP131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A215479-002AP131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A215479-003AP131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A215479-004AP131067a03dcf5…
2025-08-23 18:47 UTC2025-08A215479-001AP16a471c1ec25d…
2025-08-23 18:47 UTC2025-08A215479-002AP16a471c1ec25d…
2025-08-23 18:47 UTC2025-08A215479-003AP16a471c1ec25d…
2025-08-23 18:47 UTC2025-08A215479-004AP16a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A215479-001AP1fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A215479-002AP1fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A215479-003AP1fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A215479-004AP1fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A215479-001AP1b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A215479-002AP1b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A215479-003AP1b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A215479-004AP1b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A215479-001AP103ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A215479-002AP103ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A215479-003AP103ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A215479-004AP103ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A215479-001AP12680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A215479-002AP12680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A215479-003AP12680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A215479-004AP12680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A215479-001AP15bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A215479-002AP15bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A215479-003AP15bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A215479-004AP15bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A215479-001AP1d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A215479-002AP1d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A215479-003AP1d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A215479-004AP1d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A215479-001AP1d06236e962d9…
2024-10-29 15:01 UTC2024-10A215479-002AP1d06236e962d9…
2024-10-29 15:01 UTC2024-10A215479-003AP1d06236e962d9…
2024-10-29 15:01 UTC2024-10A215479-004AP1d06236e962d9…

Additional Listing Data#

Finished product
Yes
Brand name base
Pemetrexed
Listing expiration
2026-12-31

Active Ingredients#

Ingredient, Strength table
IngredientStrength
PEMETREXED DISODIUM HEPTAHYDRATE100 mg/4.2mL

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
9T47E4OM16Internal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 4 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
1728072Internal RxNorm lookup
1728077Internal RxNorm lookup
2601728Internal RxNorm lookup
2602136Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
b185f459-5489-4e18-8521-1686b5d16f67Available on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product conceptRelationVersionEffective
6b7ab8f1-bb38-4c30-8b8b-003c0fe639eaProduct name120250303
0976ea44-ea26-403d-a39d-71fffc6a3d33Product name420250225
f15e8921-7cd5-4c00-9cde-9fa0c9eaca68Product name120231013
0bb393b5-af67-4798-84a7-b797956b02a5Product name120230830
7ea5dc07-b4d4-439d-8145-a10a534148e7Product name120230320
a620f3f0-1e13-41d6-a838-d5407971d39eProduct name120230313
8766e415-735a-4d2c-b173-894ecced3fd9Product name120230308

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDCProductDescriptionFormQuantityStrengthSPL version
71288-145-10Pemetrexed1 in 1 CARTONINJECTION, POWDER, LYOPHILIZED,14
71288-145-10Pemetrexed4.2 mL in 1 VIAL, SINGLE-DOSEINJECTION, POWDER, LYOPHILIZED,4.24

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDCDashboard titleSPL versionValidationDashboard ZIP
71288-145PEMETREXED (PEMETREXED DISODIUM) INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION [MEITHEAL PHARMACEUTICALS INC.]4Current NDC, Legacy NDC, 2 package rows20221223_b185f459-5489-4e18-8521-1686b5d16f67.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 1 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
PemetrexedPEMETREXED DISODIUMMeitheal Pharmaceuticals Inc.b185f459-5489-4e18-8521-1686b5d16f672022-12-21Warnings, Adverse reactionsExact identifier
application applno (ANDA): 215479
application number: ANDA215479
ndc (product): 71288-145

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUIRxNorm stringTTYDailyMedSPL version
2601728PEMEtrexed 1 GM InjectionPSNb185f459-5489-4e18-8521-1686b5d16f674
1728077PEMEtrexed 100 MG InjectionPSNb185f459-5489-4e18-8521-1686b5d16f674
1728072PEMEtrexed 500 MG InjectionPSNb185f459-5489-4e18-8521-1686b5d16f674
2602136PEMEtrexed 750 MG InjectionPSNb185f459-5489-4e18-8521-1686b5d16f674
1728077pemetrexed 100 MG InjectionSCDb185f459-5489-4e18-8521-1686b5d16f674
2601728pemetrexed 1000 MG InjectionSCDb185f459-5489-4e18-8521-1686b5d16f674
1728072pemetrexed 500 MG InjectionSCDb185f459-5489-4e18-8521-1686b5d16f674
2602136pemetrexed 750 MG InjectionSCDb185f459-5489-4e18-8521-1686b5d16f674
2601728pemetrexed (as disodium heptahydrate) 1 GM InjectionSYb185f459-5489-4e18-8521-1686b5d16f674
2601728pemetrexed (as disodium heptahydrate) 1000 MG InjectionSYb185f459-5489-4e18-8521-1686b5d16f674
2602136pemetrexed (as disodium heptahydrate) 750 MG InjectionSYb185f459-5489-4e18-8521-1686b5d16f674
1728077pemetrexed 100 MG InjectionSYb185f459-5489-4e18-8521-1686b5d16f674
1728072pemetrexed 500 MG InjectionSYb185f459-5489-4e18-8521-1686b5d16f674

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionMarketing startMarketing endSampleExclude flagStatus
71288-145-10712880145101 VIAL, SINGLE-DOSE in 1 CARTON (71288-145-10) / 4.2 mL in 1 VIAL, SINGLE-DOSE2022-12-130000-00-00NoNoCurrent