Allergy Relief

Product NDC: 72090-021
Requested package NDC: 72090-021-10
11-digit product format: 720900021
Labeler code: 72090
Product ID: 72090-021_73414302-0de0-4cb0-9f6d-243b0345a166
Type: HUMAN OTC DRUG
Nonproprietary name: Diphenhydramine HCl 25 mg
Dosage form: TABLET
Route: ORAL
Labeler: Pioneer Life Sciences, LLC
Application: M012
Marketing category: OTC MONOGRAPH DRUG
Marketing start: 2020-06-29
Substance: DIPHENHYDRAMINE HYDROCHLORIDE
Active strength: 25 mg/1
Pharmacologic classes: Histamine H1 Receptor Antagonists [MoA], Histamine-1 Receptor Antagonist [EPC]
NDC exclude flag: No
Listing certified through: 2026-12-31
Current FDA listing: Yes

Observed NDC auxiliary status history#

This history shows the information present in each captured FDA auxiliary file. It is not a continuous regulatory timeline, and a missing record does not establish a status.

Historic NDC status page 1 of 1 · 4 matching rows.

View current auxiliary records. · View the auxiliary file history.

Captured / source date, Snapshot, Source SHA-256 table
Captured / source date	Snapshot	Source SHA-256
2024-03-11 06:39 UTC · source 2024-03-08	`1332a3947898…`	`d4bfe170f9cd…`
2022-08-30 03:57 UTC · source 2022-08-29	`fb8cb913e6d1…`	`eb8c232b6be0…`
2022-04-09 23:13 UTC · source 2022-04-08	`86f5da6cb304…`	`a595104c45d7…`
2022-04-04 05:40 UTC · source 2022-04-01	`bd6a592717d7…`	`303034d00443…`

Reported adverse events (FAERS/openFDA)#

Adverse event summaries are temporarily unavailable. Other product information remains available.

Additional Listing Data#

Finished product: Yes
Brand name base: Allergy Relief
Listing expiration: 2026-12-31

Active Ingredients#

Ingredient, Strength table
Ingredient	Strength
DIPHENHYDRAMINE HYDROCHLORIDE	25 mg/1

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
TC2D6JAD40	Internal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
1049630	Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
ab45ae97-7951-4058-e053-2995a90a7b2e	Available on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product concept	Relation	Version	Effective
0e2e0f88-b076-afe1-4bdd-32bca4375bec	Product name	3	20250127
3e48c9c4-918d-5d23-2f0b-d2398b06be54	Product name	1	20140508
865c72dd-0d94-daac-f728-ddd4ded2a79e	Product name	1	20140508

FDA-Initiated Inactive NDC Indexing#

NDC, Effective, Indexing SPL table
NDC	Effective	Indexing SPL	Related label
72090-021-10	2024-05-13	d6a99b39-de89-a426-e053-dadaa90af4c2	ab45ed16-86bb-3faf-e053-2995a90acfbc
72090-021-60	2023-10-25	d6a99b39-ac04-a426-e053-dadaa90af4c2	ab45ae97-7951-4058-e053-2995a90a7b2e
72090-021-10	2022-01-28	d6a99b39-de89-a426-e053-dadaa90af4c2	ab45ed16-86bb-3faf-e053-2995a90acfbc
72090-021-24	2022-01-28	d6a99b39-8fca-a426-e053-dadaa90af4c2	a824b04e-1654-28f4-e053-2a95a90ab8bb
72090-021-26	2022-01-28	d6a99b39-418b-a426-e053-dadaa90af4c2	a96484ba-c618-ee52-e053-2a95a90a3344
72090-021-60	2022-01-28	d6a99b39-ac04-a426-e053-dadaa90af4c2	ab45ae97-7951-4058-e053-2995a90a7b2e
72090-021-25	2021-01-29	ba0f9c33-1a66-a910-e053-dadaa90a0b85	Diphenhydramine HCl 25 mg

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDC	Product	Description	Form	Quantity	SPL version
72090-021-60	Allergy Relief	600 in 1 BOTTLE	TABLET	600	6
72090-021-10	Allergy Relief	1000 in 1 BOTTLE	TABLET	1000	3
72090-021-24	Allergy Relief	24 in 1 BOTTLE	TABLET	24	1
72090-021-25	Allergy Relief	250 in 1 BOTTLE	TABLET	250	1
72090-021-26	Allergy Relief	1 in 1 CARTON	TABLET	1	1
72090-021-26	Allergy Relief	24 in 1 BOTTLE	TABLET	24	1

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDC	Dashboard title	SPL version	Validation	Dashboard ZIP
72090-021	ALLERGY RELIEF (DIPHENHYDRAMINE HCL 25 MG) TABLET [PIONEER LIFE SCIENCES, LLC]	5	Current NDC, Legacy NDC, 1 package rows	20240522_ab45ae97-7951-4058-e053-2995a90a7b2e.zip
72090-021	ALLERGY RELIEF (DIPHENHYDRAMINE HCL 25 MG) TABLET [PIONEER LIFE SCIENCES, LLC]	2	Current NDC, Legacy NDC, 1 package rows	20240514_ab45ed16-86bb-3faf-e053-2995a90acfbc.zip
72090-021	ALLERGY RELIEF (DIPHENHYDRAMINE HCL 25 MG) TABLET [PIONEER LIFE SCIENCES, LLC]	1	Current NDC, Legacy NDC, 1 package rows	20190220_7c1a38de-555f-46e6-91c5-2d14aa9ab5d1.zip
72090-021	ALLERGY RELIEF (DIPHENHYDRAMINE HCL 25 MG) TABLET [PIONEER LIFE SCIENCES, LLC]	1	Current NDC, Legacy NDC, 2 package rows	20200702_a96484ba-c618-ee52-e053-2a95a90a3344.zip
72090-021	ALLERGY RELIEF (DIPHENHYDRAMINE HCL 25 MG) TABLET [PIONEER LIFE SCIENCES, LLC]	1	Current NDC, Legacy NDC, 1 package rows	20200629_a824b04e-1654-28f4-e053-2a95a90ab8bb.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 22 of 180 · 3,583 matching rows.

Brand, Generic, Manufacturer table
Brand	Generic	Manufacturer	SPL set ID	Effective date	Available safety fields	Join
foster and thrive daytime cold and flu relief	ACETAMINOPHEN, DEXTROMETHORPHAN HBR, PHENYLEPHRINE HCL	Strategic Sourcing Services LLC	067ce5de-dbb4-4b65-8ec0-f4aacbe5e0a6	2026-06-16	Warnings	Exact identifier application number: M012
Equate Severe Cold Cough and Flu	ACETAMINOPHEN, DIPHENHYDRAMINE HYDROCHLORIDE	WALMART INC.	a35531d7-1a96-45cb-922f-61db085cde1f	2026-06-16	Warnings	Exact identifier application number: M012
Cold and Flu Daytime, Nighttime, Maximum Strength	ACETAMINOPHEN, DEXTROMETHORPHAN HBR, DOXYLAMINE SUCCINATE, GUAIFENESIN, PHENYLEPHRINE HCL	Walgreen Company	5fe9f313-d6e7-41f5-abfc-e4c72b708961	2026-06-15	Warnings	Exact identifier application number: M012
Pain Relief Sinus Congestion	ACETAMINOPHEN, PHENYLEPHRINE HCL	Better Living Brands, LLC	1d3d6397-0d92-4145-9a70-8bcc45bd0322	2026-06-15	Warnings	Exact identifier application number: M012
Goodmeds Allergy Relief Diphenhydramine HCl	DIPHENHYDRAMINE HYDROCHLORIDE	Cabinet Health P.B.C.	c1cc40f4-9bbb-47f2-ba3b-a5c46ec10f11	2026-06-15	Warnings	Exact identifier application number: M012
Allergy Relief	DIPHENHYDRAMINE HCL	Rite Aid Corporation	d5d9334d-3db6-4f45-ab84-3e1ec5a752c6	2026-06-15	Warnings	Exact identifier application number: M012
Allergy Relief	DIPHENHYDRAMINE HCL	Geiss, Destin & Dunn Inc.	fac64ddc-a89b-4d73-b9e5-edc4e5cc3c4b	2026-06-15	Warnings	Exact identifier application number: M012
equate daytime cold and flu nighttime cold and flu	ACETAMINOPHEN, DEXTROMETHORPHAN HBR, DOXYLAMINE SUCCINATE, PHENYLEPHRINE HCL	Wal-Mart Stores Inc	983a4783-d826-41b6-8087-ca66bcd5b6ca	2026-06-12	Warnings	Exact identifier application number: M012
Equate Daytime Nighttime Cold and Flu	ACETAMINOPHEN, DEXTROMETHORPHAN HYDROBROMIDE, DOXYLAMINE SUCCINATE, GUAIFENESIN, PHENYLEPHRINE HYDROCHLORIDE	Wal-Mart Stores Inc	4173ecde-a2d7-4836-a6e9-fef2270d1b4e	2026-06-12	Warnings	Exact identifier application number: M012
PAIN RELIEVER PM Extra Strength	ACETAMINOPHEN, DIPHENHYDRAMINE HCL	Best Choice (Valu Merchandisers Company)	cf370a59-42d5-42fe-882f-09885c55f570	2026-06-11	Warnings	Exact identifier application number: M012
Sudafed Sinus Congestion Plus Cold Severe Day	ACETAMINOPHEN, PSEUDOEPHEDRINE	Kenvue Brands LLC	537e1a0d-820d-c3f7-e063-6294a90a56ea	2026-06-10	Warnings	Exact identifier application number: M012
Sudafed Sinus Congestion plus Cold Severe Day and Night	ACETAMINOPHEN, DIPHENHYDRAMINE, PSEUDOEPHEDRINE	Kenvue Brands LLC	5382dcad-0337-4440-e063-6394a90a706e	2026-06-10	Warnings	Exact identifier application number: M012
good neighbor pharmacy nasal	OXYMETAZOLINE HYDROCHLORIDE	Preferred Pharmaceuticals Inc.	21cfa71c-7a8f-4100-a42e-9190260653d1	2026-06-09	Warnings	Exact identifier application number: M012
Daytime Nighttime	ACETAMINOPHEN DEXTROMETHORPHAN HBR, ACETAMINOPHEN DEXTROMETHORPHAN HBR TRIPROLIDINE HCL	WALGREENS	47f1d92f-cb4b-1635-e063-6294a90a2c71	2026-06-09	Warnings	Exact identifier application number: M012
HALLS Honey	MENTHOL	Mondelez Global LLC	837f5ded-8efb-402b-a1bc-b5c142755660	2026-06-09	Warnings	Exact identifier application number: M012
Daytime Cold and Flu	ACETAMINOPHEN, DEXTROMETHORPHAN HBR, GUAIFENESIN, PHENYLEPHRINE HCL	Meijer Distribution Inc	932b11b1-f4a0-417a-bfa1-05261a172155	2026-06-08	Warnings	Exact identifier application number: M012
NO DRIP NASAL MIST	OXYMETAZOLINE HYDROCHLORIDE	Kroger Company	957efbcf-b6d3-4793-bb6e-27e99c9be905	2026-06-08	Warnings	Exact identifier application number: M012
DAYTIME SEVERE COLD AND FLU	ACETAMINOPHEN, DEXTROMETHORPHAN HYDROBROMIDE, GUAIFENESIN, PHENYLEPHRINE HYDROCHLORIDE	CVS WOONSOCKET PRESCRIPTION CENTER, INCORPORATED	493caecb-e687-49ea-b7a1-2a5b9376896d	2026-06-08	Warnings	Exact identifier application number: M012
Severe Cold and Flu Relief	ACETAMINOPHEN, DEXTROMETHORPHAN HBR, GUAIFENESIN, PHENYLEPHRINE HCL	CVS PHARMACY	4ad10fd7-c088-4356-9d34-a95cfe3a4133	2026-06-08	Warnings	Exact identifier application number: M012
Theraflu Severe Congestion Relief Nasal Mist	OXYMETAZOLINE HCL	Haleon US Holdings LLC	4ec42064-7390-4137-a93e-57343c3c76a7	2026-06-08	Warnings	Exact identifier application number: M012

UNII, Preferred term, Registry number table
UNII	Preferred term	Registry number	Matched term
TC2D6JAD40	DIPHENHYDRAMINE HYDROCHLORIDE	147-24-0	DIPHENHYDRAMINE HYDROCHLORIDE

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUI	RxNorm string	TTY	DailyMed	SPL version
1049630	diphenhydrAMINE HCl 25 MG Oral Tablet	PSN	ab45ae97-7951-4058-e053-2995a90a7b2e	6
1049630	diphenhydramine hydrochloride 25 MG Oral Tablet	SCD	ab45ae97-7951-4058-e053-2995a90a7b2e	6
1049630	diphenhydrAMINE HCl 25 MG Oral Tablet	PSN	ab45ed16-86bb-3faf-e053-2995a90acfbc	3
1049630	diphenhydramine hydrochloride 25 MG Oral Tablet	SCD	ab45ed16-86bb-3faf-e053-2995a90acfbc	3
1049630	diphenhydrAMINE HCl 25 MG Oral Tablet	PSN	7c1a38de-555f-46e6-91c5-2d14aa9ab5d1	1
1049630	diphenhydrAMINE HCl 25 MG Oral Tablet	PSN	a824b04e-1654-28f4-e053-2a95a90ab8bb	1
1049630	diphenhydrAMINE HCl 25 MG Oral Tablet	PSN	a96484ba-c618-ee52-e053-2a95a90a3344	1
1049630	diphenhydramine hydrochloride 25 MG Oral Tablet	SCD	7c1a38de-555f-46e6-91c5-2d14aa9ab5d1	1
1049630	diphenhydramine hydrochloride 25 MG Oral Tablet	SCD	a824b04e-1654-28f4-e053-2a95a90ab8bb	1
1049630	diphenhydramine hydrochloride 25 MG Oral Tablet	SCD	a96484ba-c618-ee52-e053-2a95a90a3344	1

Packages#

Package NDC, 11-digit format, Description table
Package NDC	11-digit format	Description	Units	Marketing start	Marketing end	Sample	Exclude flag	Status
72090-021-10	72090002110	1000 TABLET in 1 BOTTLE (72090-021-10)	1000 tablet	2024-05-13	0000-00-00	No	No	Current

Title, Manufacturer, Effective date table
Title	Manufacturer	Effective date	Type	Version
Allergy Relief - Pioneer Life Sciences, LLC	Pioneer Life Sciences, LLC	2025-12-23	HUMAN OTC DRUG LABEL	6
Allergy Relief - Pioneer Life Sciences, LLC	Pioneer Life Sciences, LLC	2025-12-23	HUMAN OTC DRUG LABEL	3
Allergy Relief - Pioneer Life Sciences, LLC	Pioneer Life Sciences, LLC	2020-07-01	HUMAN OTC DRUG LABEL	1
Allergy Relief - Pioneer Life Sciences, LLC	Pioneer Life Sciences, LLC	2020-06-15	HUMAN OTC DRUG LABEL	1
Diphenhydramine HCl 25 mg	Pioneer Life Sciences, LLC	2018-10-01	HUMAN OTC DRUG LABEL	1