Pemetrexed

Product NDC
72603-425
11-digit product format
726030425
Labeler code
72603
Product ID
72603-425_c754c764-7f07-480c-b130-c5ce64cf0b80
Type
HUMAN PRESCRIPTION DRUG
Nonproprietary name
Pemetrexed disodium
Dosage form
INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION
Route
INTRAVENOUS
Labeler
NorthStar RxLLC
Application
ANDA208696
Marketing category
ANDA
Marketing start
2024-10-01
Substance
PEMETREXED DISODIUM HEMIPENTAHYDRATE
Active strength
500 mg/50mL
Pharmacologic classes
Folate Analog Metabolic Inhibitor [EPC], Folic Acid Metabolism Inhibitors [MoA]
NDC exclude flag
No
Listing certified through
2026-12-31
Current FDA listing
Yes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 42.

Orange Book products#

Current product rows page 1 of 1 · 2 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
A208696-001PEMETREXED DISODIUMPEMETREXED DISODIUMEQ 100MG BASE/VIALPOWDER / INTRAVENOUSAP2022-05-25
A208696-002PEMETREXED DISODIUMPEMETREXED DISODIUMEQ 500MG BASE/VIALPOWDER / INTRAVENOUSAP2022-05-25

Therapeutic equivalence codes#

Current TE-code rows page 1 of 1 · 2 matching rows.

Application-product, TE code table
Application-productTE code
A208696-001AP
A208696-002AP

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Product history page 1 of 2 · 60 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-08-18 06:07:402026-07A208696-001PEMETREXED DISODIUMEQ 100MG BASE/VIALPOWDER / INTRAVENOUSAP2022-05-25caaa826d4ba7…
2026-08-18 06:07:402026-07A208696-002PEMETREXED DISODIUMEQ 500MG BASE/VIALPOWDER / INTRAVENOUSAP2022-05-25caaa826d4ba7…
2026-02-19 14:30 UTC2026-02A208696-001PEMETREXED DISODIUMEQ 100MG BASE/VIALPOWDER / INTRAVENOUSAP2022-05-25011fe1cb6892…
2026-02-19 14:30 UTC2026-02A208696-002PEMETREXED DISODIUMEQ 500MG BASE/VIALPOWDER / INTRAVENOUSAP2022-05-25011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A208696-001PEMETREXED DISODIUMEQ 100MG BASE/VIALPOWDER / INTRAVENOUSAP2022-05-2531067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A208696-002PEMETREXED DISODIUMEQ 500MG BASE/VIALPOWDER / INTRAVENOUSAP2022-05-2531067a03dcf5…
2025-08-23 18:47 UTC2025-08A208696-001PEMETREXED DISODIUMEQ 100MG BASE/VIALPOWDER / INTRAVENOUSAP2022-05-256a471c1ec25d…
2025-08-23 18:47 UTC2025-08A208696-002PEMETREXED DISODIUMEQ 500MG BASE/VIALPOWDER / INTRAVENOUSAP2022-05-256a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A208696-001PEMETREXED DISODIUMEQ 100MG BASE/VIALPOWDER / INTRAVENOUSAP2022-05-25fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A208696-002PEMETREXED DISODIUMEQ 500MG BASE/VIALPOWDER / INTRAVENOUSAP2022-05-25fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A208696-001PEMETREXED DISODIUMEQ 100MG BASE/VIALPOWDER / INTRAVENOUSAP2022-05-25b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A208696-002PEMETREXED DISODIUMEQ 500MG BASE/VIALPOWDER / INTRAVENOUSAP2022-05-25b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A208696-001PEMETREXED DISODIUMEQ 100MG BASE/VIALPOWDER / INTRAVENOUSAP2022-05-2503ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A208696-002PEMETREXED DISODIUMEQ 500MG BASE/VIALPOWDER / INTRAVENOUSAP2022-05-2503ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A208696-001PEMETREXED DISODIUMEQ 100MG BASE/VIALPOWDER / INTRAVENOUSAP2022-05-252680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A208696-002PEMETREXED DISODIUMEQ 500MG BASE/VIALPOWDER / INTRAVENOUSAP2022-05-252680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A208696-001PEMETREXED DISODIUMEQ 100MG BASE/VIALPOWDER / INTRAVENOUSAP2022-05-255bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A208696-002PEMETREXED DISODIUMEQ 500MG BASE/VIALPOWDER / INTRAVENOUSAP2022-05-255bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A208696-001PEMETREXED DISODIUMEQ 100MG BASE/VIALPOWDER / INTRAVENOUSAP2022-05-25d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A208696-002PEMETREXED DISODIUMEQ 500MG BASE/VIALPOWDER / INTRAVENOUSAP2022-05-25d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A208696-001PEMETREXED DISODIUMEQ 100MG BASE/VIALPOWDER / INTRAVENOUSAP2022-05-25d06236e962d9…
2024-10-29 15:01 UTC2024-10A208696-002PEMETREXED DISODIUMEQ 500MG BASE/VIALPOWDER / INTRAVENOUSAP2022-05-25d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A208696-001PEMETREXED DISODIUMEQ 100MG BASE/VIALPOWDER / INTRAVENOUSAP2022-05-2579d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A208696-002PEMETREXED DISODIUMEQ 500MG BASE/VIALPOWDER / INTRAVENOUSAP2022-05-2579d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A208696-001PEMETREXED DISODIUMEQ 100MG BASE/VIALPOWDER / INTRAVENOUSAP2022-05-25301d65b070ca…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A208696-002PEMETREXED DISODIUMEQ 500MG BASE/VIALPOWDER / INTRAVENOUSAP2022-05-25301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A208696-001PEMETREXED DISODIUMEQ 100MG BASE/VIALPOWDER / INTRAVENOUSAP2022-05-251e350fbaab3a…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A208696-002PEMETREXED DISODIUMEQ 500MG BASE/VIALPOWDER / INTRAVENOUSAP2022-05-251e350fbaab3a…
2024-05-31 18:47 UTC2024-05A208696-001PEMETREXED DISODIUMEQ 100MG BASE/VIALPOWDER / INTRAVENOUSAP2022-05-258072bd15b7f6…
2024-05-31 18:47 UTC2024-05A208696-002PEMETREXED DISODIUMEQ 500MG BASE/VIALPOWDER / INTRAVENOUSAP2022-05-258072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06A208696-001PEMETREXED DISODIUMEQ 100MG BASE/VIALPOWDER / INTRAVENOUSAP2022-05-255c6f7cd8ea54…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06A208696-002PEMETREXED DISODIUMEQ 500MG BASE/VIALPOWDER / INTRAVENOUSAP2022-05-255c6f7cd8ea54…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A208696-001PEMETREXED DISODIUMEQ 100MG BASE/VIALPOWDER / INTRAVENOUSAP2022-05-256a51e52b5d6a…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A208696-002PEMETREXED DISODIUMEQ 500MG BASE/VIALPOWDER / INTRAVENOUSAP2022-05-256a51e52b5d6a…
2024-02-18 07:12 UTC2024-02A208696-001PEMETREXED DISODIUMEQ 100MG BASE/VIALPOWDER / INTRAVENOUSAP2022-05-251c564ffb4f44…
2024-02-18 07:12 UTC2024-02A208696-002PEMETREXED DISODIUMEQ 500MG BASE/VIALPOWDER / INTRAVENOUSAP2022-05-251c564ffb4f44…
2023-12-20 04:57 UTC2023-12A208696-001PEMETREXED DISODIUMEQ 100MG BASE/VIALPOWDER / INTRAVENOUSAP2022-05-25ea1830bbd6c7…
2023-12-20 04:57 UTC2023-12A208696-002PEMETREXED DISODIUMEQ 500MG BASE/VIALPOWDER / INTRAVENOUSAP2022-05-25ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11A208696-001PEMETREXED DISODIUMEQ 100MG BASE/VIALPOWDER / INTRAVENOUSAP2022-05-25a72a2bbeb626…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11A208696-002PEMETREXED DISODIUMEQ 500MG BASE/VIALPOWDER / INTRAVENOUSAP2022-05-25a72a2bbeb626…

Observed Orange Book normalized TE history#

Normalized TE history page 1 of 2 · 60 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTE codeOrderSource SHA-256
2026-08-18 06:07:402026-07A208696-001AP1caaa826d4ba7…
2026-08-18 06:07:402026-07A208696-002AP1caaa826d4ba7…
2026-02-19 14:30 UTC2026-02A208696-001AP1011fe1cb6892…
2026-02-19 14:30 UTC2026-02A208696-002AP1011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A208696-001AP131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A208696-002AP131067a03dcf5…
2025-08-23 18:47 UTC2025-08A208696-001AP16a471c1ec25d…
2025-08-23 18:47 UTC2025-08A208696-002AP16a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A208696-001AP1fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A208696-002AP1fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A208696-001AP1b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A208696-002AP1b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A208696-001AP103ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A208696-002AP103ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A208696-001AP12680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A208696-002AP12680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A208696-001AP15bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A208696-002AP15bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A208696-001AP1d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A208696-002AP1d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A208696-001AP1d06236e962d9…
2024-10-29 15:01 UTC2024-10A208696-002AP1d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A208696-001AP179d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A208696-002AP179d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A208696-001AP1301d65b070ca…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A208696-002AP1301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A208696-001AP11e350fbaab3a…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A208696-002AP11e350fbaab3a…
2024-05-31 18:47 UTC2024-05A208696-001AP18072bd15b7f6…
2024-05-31 18:47 UTC2024-05A208696-002AP18072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06A208696-001AP15c6f7cd8ea54…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06A208696-002AP15c6f7cd8ea54…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A208696-001AP16a51e52b5d6a…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A208696-002AP16a51e52b5d6a…
2024-02-18 07:12 UTC2024-02A208696-001AP11c564ffb4f44…
2024-02-18 07:12 UTC2024-02A208696-002AP11c564ffb4f44…
2023-12-20 04:57 UTC2023-12A208696-001AP1ea1830bbd6c7…
2023-12-20 04:57 UTC2023-12A208696-002AP1ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11A208696-001AP1a72a2bbeb626…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11A208696-002AP1a72a2bbeb626…

Additional Listing Data#

Finished product
Yes
Brand name base
Pemetrexed
Listing expiration
2026-12-31

Active Ingredients#

Ingredient, Strength table
IngredientStrength
PEMETREXED DISODIUM HEMIPENTAHYDRATE500 mg/50mL

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
F4GSH45R4CInternal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 2 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
1728072Internal RxNorm lookup
1728077Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
64f4a9ed-26ff-4bc7-bef1-4faa98b35563Available on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product conceptRelationVersionEffective
6b7ab8f1-bb38-4c30-8b8b-003c0fe639eaProduct name120250303
0976ea44-ea26-403d-a39d-71fffc6a3d33Product name420250225
f15e8921-7cd5-4c00-9cde-9fa0c9eaca68Product name120231013
0bb393b5-af67-4798-84a7-b797956b02a5Product name120230830
7ea5dc07-b4d4-439d-8145-a10a534148e7Product name120230320
a620f3f0-1e13-41d6-a838-d5407971d39eProduct name120230313
8766e415-735a-4d2c-b173-894ecced3fd9Product name120230308

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDCProductDescriptionFormQuantityStrengthSPL version
72603-425-01Pemetrexed1 in 1 CARTONINJECTION, POWDER, LYOPHILIZED,11
72603-425-01Pemetrexed50 mL in 1 VIAL, SINGLE-DOSEINJECTION, POWDER, LYOPHILIZED,501

DailyMed Billing Units#

Package NDC, Billing unit, Product NDC table
Package NDCBilling unitProduct NDCDailyMed indexing SPLSPL versionEffective
72603-425-01EA - Each72603-4252c17c23d-7603-49fa-98b7-6dc22e26f7df12025-01-14

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDCDashboard titleSPL versionValidationDashboard ZIP
72603-425PEMETREXED (PEMETREXED DISODIUM) INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION [NORTHSTAR RXLLC]1Current NDC, 2 package rows20241001_64f4a9ed-26ff-4bc7-bef1-4faa98b35563.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 4 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
PemetrexedPEMETREXED DISODIUMMeitheal Pharmaceuticals Inc.e0d000a3-b9d2-4fa9-9591-f7acb077481d2025-11-17Warnings, Adverse reactionsExact identifier
application applno (ANDA): 208696
application number: ANDA208696
PemetrexedPEMETREXED DISODIUMNorthStar RxLLC64f4a9ed-26ff-4bc7-bef1-4faa98b355632024-09-10Warnings, Adverse reactionsExact identifier
application applno (ANDA): 208696
application number: ANDA208696
ndc (product): 72603-425
PemetrexedPEMETREXED DISODIUMMeitheal Pharmaceuticals Inc.1ceacc3e-f555-489b-8b16-2baa58b2f5a52024-04-19Warnings, Adverse reactionsExact identifier
application applno (ANDA): 208696
application number: ANDA208696
PemetrexedPEMETREXED DISODIUMMeitheal Pharmaceuticals Inc.5fb3a2d5-b9ec-4044-abb9-3e0d848a448e2024-04-19Warnings, Adverse reactionsExact identifier
application applno (ANDA): 208696
application number: ANDA208696

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUIRxNorm stringTTYDailyMedSPL version
1728077PEMEtrexed 100 MG InjectionPSN64f4a9ed-26ff-4bc7-bef1-4faa98b355631
1728072PEMEtrexed 500 MG InjectionPSN64f4a9ed-26ff-4bc7-bef1-4faa98b355631
1728077pemetrexed 100 MG InjectionSCD64f4a9ed-26ff-4bc7-bef1-4faa98b355631
1728072pemetrexed 500 MG InjectionSCD64f4a9ed-26ff-4bc7-bef1-4faa98b355631
1728077pemetrexed 100 MG InjectionSY64f4a9ed-26ff-4bc7-bef1-4faa98b355631
1728072pemetrexed 500 MG InjectionSY64f4a9ed-26ff-4bc7-bef1-4faa98b355631

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionMarketing startSampleExclude flagStatus
72603-425-01726030425011 VIAL, SINGLE-DOSE in 1 CARTON (72603-425-01) / 50 mL in 1 VIAL, SINGLE-DOSE2024-10-01NoNoCurrent