FDA.reportPublic FDA data

Acetaminophen

Product NDC
76420-914
Requested package NDC
76420-914-40
11-digit product format
764200914
Labeler code
76420
Product ID
76420-914_2ef14964-4fa1-9fb6-e063-6294a90aff36
Type
HUMAN OTC DRUG
Nonproprietary name
Acetaminophen tablet extended release
Dosage form
TABLET, EXTENDED RELEASE
Route
ORAL
Labeler
Asclemed USA, Inc.
Application
ANDA215486
Marketing category
ANDA
Marketing start
2021-10-04
Substance
ACETAMINOPHEN
Active strength
650 mg/1
NDC exclude flag
No
Listing certified through
2026-12-31
Current FDA listing
Yes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 1.

Orange Book products#

Current product rows page 1 of 1 · 1 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
A215486-001ACETAMINOPHENACETAMINOPHEN650MGTABLET, EXTENDED RELEASE / ORAL2021-08-25

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-02-19 14:30 UTC2026-02A215486-001ACETAMINOPHEN650MGTABLET, EXTENDED RELEASE / ORAL2021-08-25011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A215486-001ACETAMINOPHEN650MGTABLET, EXTENDED RELEASE / ORAL2021-08-2531067a03dcf5…
2025-08-23 18:47 UTC2025-08A215486-001ACETAMINOPHEN650MGTABLET, EXTENDED RELEASE / ORAL2021-08-256a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A215486-001ACETAMINOPHEN650MGTABLET, EXTENDED RELEASE / ORAL2021-08-25fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A215486-001ACETAMINOPHEN650MGTABLET, EXTENDED RELEASE / ORAL2021-08-25b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A215486-001ACETAMINOPHEN650MGTABLET, EXTENDED RELEASE / ORAL2021-08-2503ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A215486-001ACETAMINOPHEN650MGTABLET, EXTENDED RELEASE / ORAL2021-08-252680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A215486-001ACETAMINOPHEN650MGTABLET, EXTENDED RELEASE / ORAL2021-08-255bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A215486-001ACETAMINOPHEN650MGTABLET, EXTENDED RELEASE / ORAL2021-08-25d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A215486-001ACETAMINOPHEN650MGTABLET, EXTENDED RELEASE / ORAL2021-08-25d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A215486-001ACETAMINOPHEN650MGTABLET, EXTENDED RELEASE / ORAL2021-08-2579d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A215486-001ACETAMINOPHEN650MGTABLET, EXTENDED RELEASE / ORAL2021-08-25301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A215486-001ACETAMINOPHEN650MGTABLET, EXTENDED RELEASE / ORAL2021-08-251e350fbaab3a…
2024-05-31 18:47 UTC2024-05A215486-001ACETAMINOPHEN650MGTABLET, EXTENDED RELEASE / ORAL2021-08-258072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06A215486-001ACETAMINOPHEN650MGTABLET, EXTENDED RELEASE / ORAL2021-08-255c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04A215486-001ACETAMINOPHEN650MGTABLET, EXTENDED RELEASE / ORAL2021-08-255d02ea3f76ae…
2022-04-04 05:41 UTC2022-04A215486-001ACETAMINOPHEN650MGTABLET, EXTENDED RELEASE / ORAL2021-08-254b0b4de00fa7…
2022-03-09 01:35 UTC2022-03A215486-001ACETAMINOPHEN650MGTABLET, EXTENDED RELEASE / ORAL2021-08-25bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12A215486-001ACETAMINOPHEN650MGTABLET, EXTENDED RELEASE / ORAL2021-08-25782e0a99824c…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A215486-001ACETAMINOPHEN650MGTABLET, EXTENDED RELEASE / ORAL2021-08-256a51e52b5d6a…
2024-02-18 07:12 UTC2024-02A215486-001ACETAMINOPHEN650MGTABLET, EXTENDED RELEASE / ORAL2021-08-251c564ffb4f44…
2023-12-20 04:57 UTC2023-12A215486-001ACETAMINOPHEN650MGTABLET, EXTENDED RELEASE / ORAL2021-08-25ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11A215486-001ACETAMINOPHEN650MGTABLET, EXTENDED RELEASE / ORAL2021-08-25a72a2bbeb626…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10A215486-001ACETAMINOPHEN650MGTABLET, EXTENDED RELEASE / ORAL2021-08-259b2671bbb829…
2023-07-15 15:27 UTC · 2 captures of this ZIP2023-07A215486-001ACETAMINOPHEN650MGTABLET, EXTENDED RELEASE / ORAL2021-08-25a67488948f0b…
2023-06-13 01:57 UTC · 3 captures of this ZIP2023-06A215486-001ACETAMINOPHEN650MGTABLET, EXTENDED RELEASE / ORAL2021-08-253f0d92c62455…
2023-05-13 08:27 UTC2023-05A215486-001ACETAMINOPHEN650MGTABLET, EXTENDED RELEASE / ORAL2021-08-25053a50430f4f…
2023-01-26 05:58 UTC2023-01A215486-001ACETAMINOPHEN650MGTABLET, EXTENDED RELEASE / ORAL2021-08-253bdfa0b2c4d7…
2022-11-12 20:34 UTC · 5 captures of this ZIP2022-11A215486-001ACETAMINOPHEN650MGTABLET, EXTENDED RELEASE / ORAL2021-08-253a93d1ddd44b…
2022-10-28 04:53 UTC2022-10A215486-001ACETAMINOPHEN650MGTABLET, EXTENDED RELEASE / ORAL2021-08-25f41ea6bd6efb…
2022-09-29 23:25 UTC2022-09A215486-001ACETAMINOPHEN650MGTABLET, EXTENDED RELEASE / ORAL2021-08-25e64feba35796…
2022-07-09 03:26 UTC · 3 captures of this ZIP2022-07A215486-001ACETAMINOPHEN650MGTABLET, EXTENDED RELEASE / ORAL2021-08-25cb3db0bc1861…
2026-07-26 02:55 UTC · 3 captures of this ZIP2026-06A215486-001ACETAMINOPHEN650MGTABLET, EXTENDED RELEASE / ORAL2021-08-25a50c72e98297…

Additional Listing Data#

Finished product
Yes
Brand name base
Acetaminophen
Listing expiration
2026-12-31

Active Ingredients#

Ingredient, Strength table
IngredientStrength
ACETAMINOPHEN650 mg/1

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
362O9ITL9DInternal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
1148399Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
4ef6bc2b-03cf-474f-bb9e-dbb5792ec197Available on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product conceptRelationVersionEffective
75d4bef7-334c-4a95-abb5-bff9def24114Product name220260112
7dea7767-9f52-b60a-5435-33cb9cc28baeProduct name420250124
6338270f-96cb-0ecb-6fbb-0a9bc78001f4Product name720250116
11939cf5-0ea7-5df5-5127-00a7ce07fd7fProduct name520250115
0ca83774-3f79-b837-5d6f-c210102f3bc8Product name620250114
88300afc-e1c4-ad17-c80b-4957f1b809a5Product name520250113
4eddd6ca-259a-4c6c-a3a4-2025015ce043Product name720240611
16cde546-8deb-4df2-a072-dab5566ede95Product name120231003
20ab58de-c64a-4ec2-9210-3aa3fae2b66fProduct name120230808
a3631b20-02d1-41d7-8187-5e5e850b9e80Product name120230306
79e1734e-f721-4d46-978a-be382f771672Product name220230110
41b814f3-0166-1c53-c9ef-a0794c7daf9dProduct name320221110
a590be26-846c-8659-a5a1-fb25907965dcProduct name220221110
06cc817f-60e0-4473-8e6b-c44d11dc5af6Product name920220921
92ead9ae-674d-4eee-a492-c385d496891fProduct name320220308
103b151b-b17f-42ac-8624-3ef62f5e2975Product name220200507
b8497372-efe9-9dde-fa2d-59be9761aa64Product name920200428
20c8cafe-5cfc-44f8-a9be-a664f437f780Product name220200225
3a16d77a-e865-468a-aedf-6e58913c1c21Product name320190619
2a0c98e1-033f-4e0d-a0da-b5291ffbe880Product name120190320
00d531e4-b130-8c52-eaf9-826cbb6f15ddProduct name320190205
aa0f353d-f35e-62e4-4e1f-5b563f01c659Product name920190205
22d922aa-c443-d9f3-b23c-03b03a9ad31cProduct name720181220
377068df-225f-7318-a910-a1987cdfa361Product name320170608
23475c0b-a5b5-4fec-b97f-acca901eae6aProduct name120140718
105ef617-6fa4-6713-326f-72ec8a6b75a9Product name120140508
332e86c3-7875-ca6e-f934-2206d2b31996Product name120140508
3ed6b849-48b8-8899-c288-6eeb396123b6Product name120140508
47fd879b-91c5-e1e5-130f-29d082a871ecProduct name120140508
53855190-7124-8179-f018-e792f7c27f28Product name120140508
7dfac40f-a405-cd2e-7c06-3059ec0e1092Product name120140508
84fb0b3d-1d72-b672-bc70-2b676a23e7e0Product name120140508
96c5169b-5b9d-547d-bf22-d688d91866e4Product name120140508
b8e0daf1-fb81-290b-c0bf-873be19ef775Product name120140508
c35d1ac8-8885-2ee1-6c52-5a715b242c00Product name120140508
c8753a88-edde-8e17-a396-705537b52ceeProduct name120140508
cd4f9ae2-1343-ecd2-ce0f-97db0c2b51ceProduct name120140508
cf3a804d-0326-aa22-0142-c184b5657d85Product name120140508
d83c592c-dd97-4cbf-36ac-13da806684bdProduct name120140508
e01133ad-4dcd-c7f3-454b-2ff569ee160aProduct name120140508

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDCProductDescriptionFormQuantityStrengthSPL version
76420-914-01Acetaminophen100 in 1 BOTTLETABLET, EXTENDED RELEASE1002
76420-914-05Acetaminophen50 in 1 CARTONTABLET, EXTENDED RELEASE502
76420-914-05Acetaminophen1 in 1 BOTTLETABLET, EXTENDED RELEASE12
76420-914-26Acetaminophen225 in 1 BOTTLETABLET, EXTENDED RELEASE2252
76420-914-40Acetaminophen400 in 1 BOTTLETABLET, EXTENDED RELEASE4002
76420-914-42Acetaminophen24 in 1 BOTTLETABLET, EXTENDED RELEASE242
76420-914-42Acetaminophen1 in 1 CARTONTABLET, EXTENDED RELEASE12
76420-914-60Acetaminophen60 in 1 BOTTLETABLET, EXTENDED RELEASE602

DailyMed Billing Units#

Package NDC, Billing unit, Product NDC table
Package NDCBilling unitProduct NDCDailyMed indexing SPLSPL versionEffective
76420-914-01EA - Each76420-91492b7e6de-1e98-43f7-812e-87fd3f5c3b2012025-07-08
76420-914-05EA - Each76420-91433ff1f01-a8fe-41dc-84f0-1252e980536112025-07-08
76420-914-26EA - Each76420-91449b8b977-285e-4551-9402-4066271cb17412025-07-08
76420-914-40EA - Each76420-91416675aaf-0f63-43d1-9657-9b5e625ea74f12025-07-08
76420-914-42EA - Each76420-914ca0742f2-4420-4078-9e60-9faf67d0fc5012025-07-08
76420-914-60EA - Each76420-91411addeee-98ff-4849-ab7d-37b1c26c14ca12025-07-08

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDCDashboard titleSPL versionValidationDashboard ZIP
76420-914ACETAMINOPHEN (ACETAMINOPHEN TABLET EXTENDED RELEASE) TABLET, EXTENDED RELEASE [ASCLEMED USA, INC.]2Current NDC, 8 package rows20250227_4ef6bc2b-03cf-474f-bb9e-dbb5792ec197.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 18 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
8HR Arthritis Pain ReliefACETAMINOPHEN 650MGCVS Pharmacy2eb6eba1-46af-32a4-e063-6294a90a499c2026-04-28WarningsExact identifier
application applno (ANDA): 215486
application number: ANDA215486
Arthritis PainACETAMINOPHENSAM'S WEST INC3928090d-b45e-6948-e063-6394a90a47dd2025-08-11WarningsExact identifier
application applno (ANDA): 215486
application number: ANDA215486
8HR Arthritis Pain ReliefACETAMINOPHENLEADER/ Cardinal Health 110, Inc.331f907a-0fb6-e23d-e063-6394a90a2db12025-06-22WarningsExact identifier
application applno (ANDA): 215486
application number: ANDA215486
8HR Muscle Aches and Pain ReliefACETAMINOPHENLEADER/ Cardinal Health 110, Inc.331f4bd1-1303-cc48-e063-6394a90a74d32025-06-03WarningsExact identifier
application applno (ANDA): 215486
application number: ANDA215486
Arthritis Pain ReliefACETAMINOPHENKROGER COMPANY0fec22a3-aad0-8c28-e063-6394a90adc182025-05-10WarningsExact identifier
application applno (ANDA): 215486
application number: ANDA215486
8hr arthritis pain reliefACETAMINOPHENMajor Pharmaceuticals31b3aaa2-8af2-670a-e063-6394a90a80032025-05-03WarningsExact identifier
application applno (ANDA): 215486
application number: ANDA215486
8 HR MUSCLE ACHES AND PAINACETAMINOPHENCVS Pharmacy2eb6fc42-6ba4-8f58-e063-6294a90ac6a02025-04-28WarningsExact identifier
application applno (ANDA): 215486
application number: ANDA215486
AcetaminophenACETAMINOPHEN TABLET EXTENDED RELEASEAsclemed USA, Inc.4ef6bc2b-03cf-474f-bb9e-dbb5792ec1972025-02-24WarningsExact identifier
application applno (ANDA): 215486
application number: ANDA215486
ndc (package): 76420-914-40
ndc (product): 76420-914
ndc11 (package): 76420091440
8 Hour Pain ReliefACETAMINOPHENKROGER COMPANY0fec5c67-8d5d-8e45-e063-6394a90a982a2024-04-15WarningsExact identifier
application applno (ANDA): 215486
application number: ANDA215486
AcetaminophenACETAMINOPHEN TABLET EXTENDED RELEASEBryant Ranch Prepack61ea1796-b9c7-4cb9-9a36-60943f8848752024-04-05WarningsExact identifier
application applno (ANDA): 215486
application number: ANDA215486
AcetaminophenACETAMINOPHEN TABLET EXTENDED RELEASETIME CAP LABORATORIES, INC.cd4d0ad4-7206-94c8-e053-2a95a90aaa142024-03-19WarningsExact identifier
application applno (ANDA): 215486
application number: ANDA215486
Arthritis Pain AcetaminophenACETAMINOPHENTARGET CORPORATIONc8025c83-77a1-c0dd-e053-2995a90a838d2024-03-15WarningsExact identifier
application applno (ANDA): 215486
application number: ANDA215486
8HR Pain ReliefACETAMINOPHENTARGET CORPORATIONe8b48f37-6023-ba04-e053-2a95a90a0e6c2024-03-15WarningsExact identifier
application applno (ANDA): 215486
application number: ANDA215486
Arthritis Pain RelieverACETAMINOPHENWALGREENSe71f632f-37dd-49c0-e053-2a95a90a67d72024-03-15WarningsExact identifier
application applno (ANDA): 215486
application number: ANDA215486
Acetaminophen Extended-Release Tablets, 650 mgACETAMINOPHENMARKSANS PHARMA LIMITEDd973a910-5fe0-4a85-884d-2c39878366912023-10-17WarningsExact identifier
application applno (ANDA): 215486
application number: ANDA215486
Arthritis PainACETAMINOPHENBETTER LIVING BRANDS, LLCee84323a-b615-3ec6-e053-2995a90a5a262023-06-15WarningsExact identifier
application applno (ANDA): 215486
application number: ANDA215486
8 hr Arthritis Pain ReliefACETAMINOPHENDOLGENCORP, INC.ea2eae7c-e9bd-534c-e053-2a95a90a26c82023-04-20WarningsExact identifier
application applno (ANDA): 215486
application number: ANDA215486
8 hr Pain ReliefACETAMINOPHENDOLGENCORP, INC.ea2ebb7b-ceab-567a-e053-2995a90aa4022023-04-20WarningsExact identifier
application applno (ANDA): 215486
application number: ANDA215486

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUIRxNorm stringTTYDailyMedSPL version
1148399acetaminophen 650 MG 8HR Extended Release Oral TabletPSN4ef6bc2b-03cf-474f-bb9e-dbb5792ec1972
11483998 HR acetaminophen 650 MG Extended Release Oral TabletSCD4ef6bc2b-03cf-474f-bb9e-dbb5792ec1972
11483998 HR APAP 650 MG Extended Release Oral TabletSY4ef6bc2b-03cf-474f-bb9e-dbb5792ec1972
1148399acetaminophen 650 MG 8 HR Extended Release Oral TabletSY4ef6bc2b-03cf-474f-bb9e-dbb5792ec1972

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionMarketing startSampleExclude flagStatus
76420-914-4076420091440400 TABLET, EXTENDED RELEASE in 1 BOTTLE (76420-914-40) 2025-01-27NoNoCurrent