Dihydroergotamine Mesylate

Product NDC
81284-411
11-digit product format
812840411
Labeler code
81284
Product ID
81284-411_c3c6ccb7-6054-426c-8a56-d3c29dac13e2
Type
HUMAN PRESCRIPTION DRUG
Nonproprietary name
Dihydroergotamine Mesylate
Dosage form
INJECTION, SOLUTION
Route
INTRAMUSCULAR; INTRAVENOUS; SUBCUTANEOUS
Labeler
Provepharm Inc.
Application
ANDA212046
Marketing category
ANDA
Marketing start
2021-09-30
Substance
DIHYDROERGOTAMINE MESYLATE
Active strength
1 mg/mL
Pharmacologic classes
Ergotamine Derivative [EPC], Ergotamines [CS]
NDC exclude flag
No
Listing certified through
2026-12-31
Current FDA listing
Yes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 1.

Orange Book products#

Current product rows page 1 of 1 · 1 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
A212046-001DIHYDROERGOTAMINE MESYLATEDIHYDROERGOTAMINE MESYLATE1MG/MLINJECTABLE / INJECTIONAP2020-01-07

Therapeutic equivalence codes#

Current TE-code rows page 1 of 1 · 1 matching rows.

Application-product, TE code table
Application-productTE code
A212046-001AP

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-02-19 14:30 UTC2026-02A212046-001DIHYDROERGOTAMINE MESYLATE1MG/MLINJECTABLE / INJECTIONAP2020-01-07011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A212046-001DIHYDROERGOTAMINE MESYLATE1MG/MLINJECTABLE / INJECTIONAP2020-01-0731067a03dcf5…
2025-08-23 18:47 UTC2025-08A212046-001DIHYDROERGOTAMINE MESYLATE1MG/MLINJECTABLE / INJECTIONAP2020-01-076a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A212046-001DIHYDROERGOTAMINE MESYLATE1MG/MLINJECTABLE / INJECTIONAP2020-01-07fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A212046-001DIHYDROERGOTAMINE MESYLATE1MG/MLINJECTABLE / INJECTIONAP2020-01-07b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A212046-001DIHYDROERGOTAMINE MESYLATE1MG/MLINJECTABLE / INJECTIONAP2020-01-0703ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A212046-001DIHYDROERGOTAMINE MESYLATE1MG/MLINJECTABLE / INJECTIONAP2020-01-072680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A212046-001DIHYDROERGOTAMINE MESYLATE1MG/MLINJECTABLE / INJECTIONAP2020-01-075bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A212046-001DIHYDROERGOTAMINE MESYLATE1MG/MLINJECTABLE / INJECTIONAP2020-01-07d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A212046-001DIHYDROERGOTAMINE MESYLATE1MG/MLINJECTABLE / INJECTIONAP2020-01-07d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A212046-001DIHYDROERGOTAMINE MESYLATE1MG/MLINJECTABLE / INJECTIONAP2020-01-0779d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A212046-001DIHYDROERGOTAMINE MESYLATE1MG/MLINJECTABLE / INJECTIONAP2020-01-07301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A212046-001DIHYDROERGOTAMINE MESYLATE1MG/MLINJECTABLE / INJECTIONAP2020-01-071e350fbaab3a…
2024-05-31 18:47 UTC2024-05A212046-001DIHYDROERGOTAMINE MESYLATE1MG/MLINJECTABLE / INJECTIONAP2020-01-078072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06A212046-001DIHYDROERGOTAMINE MESYLATE1MG/MLINJECTABLE / INJECTIONAP2020-01-075c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04A212046-001DIHYDROERGOTAMINE MESYLATE1MG/MLINJECTABLE / INJECTIONAP2020-01-075d02ea3f76ae…
2022-04-04 05:41 UTC2022-04A212046-001DIHYDROERGOTAMINE MESYLATE1MG/MLINJECTABLE / INJECTIONAP2020-01-074b0b4de00fa7…
2022-03-09 01:35 UTC2022-03A212046-001DIHYDROERGOTAMINE MESYLATE1MG/MLINJECTABLE / INJECTIONAP2020-01-07bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12A212046-001DIHYDROERGOTAMINE MESYLATE1MG/MLINJECTABLE / INJECTIONAP2020-01-07782e0a99824c…
2021-05-05 16:15 UTC · 3 captures of this ZIP2021-05A212046-001DIHYDROERGOTAMINE MESYLATE1MG/MLINJECTABLE / INJECTIONAP2020-01-0787673890dc5c…
2021-03-12 10:30 UTC2021-03A212046-001DIHYDROERGOTAMINE MESYLATE1MG/MLINJECTABLE / INJECTIONAP2020-01-075aa47cf7b7d7…
2020-12-22 03:56 UTC2020-12A212046-001DIHYDROERGOTAMINE MESYLATE1MG/MLINJECTABLE / INJECTIONAP2020-01-078869cabd3fbd…
2020-11-12 02:37 UTC2020-11A212046-001DIHYDROERGOTAMINE MESYLATE1MG/MLINJECTABLE / INJECTIONAP2020-01-07c0c555d07b60…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A212046-001DIHYDROERGOTAMINE MESYLATE1MG/MLINJECTABLE / INJECTIONAP2020-01-076a51e52b5d6a…
2024-02-18 07:12 UTC2024-02A212046-001DIHYDROERGOTAMINE MESYLATE1MG/MLINJECTABLE / INJECTIONAP2020-01-071c564ffb4f44…
2023-12-20 04:57 UTC2023-12A212046-001DIHYDROERGOTAMINE MESYLATE1MG/MLINJECTABLE / INJECTIONAP2020-01-07ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11A212046-001DIHYDROERGOTAMINE MESYLATE1MG/MLINJECTABLE / INJECTIONAP2020-01-07a72a2bbeb626…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10A212046-001DIHYDROERGOTAMINE MESYLATE1MG/MLINJECTABLE / INJECTIONAP2020-01-079b2671bbb829…
2023-07-15 15:27 UTC · 2 captures of this ZIP2023-07A212046-001DIHYDROERGOTAMINE MESYLATE1MG/MLINJECTABLE / INJECTIONAP2020-01-07a67488948f0b…
2023-06-13 01:57 UTC · 3 captures of this ZIP2023-06A212046-001DIHYDROERGOTAMINE MESYLATE1MG/MLINJECTABLE / INJECTIONAP2020-01-073f0d92c62455…
2023-05-13 08:27 UTC2023-05A212046-001DIHYDROERGOTAMINE MESYLATE1MG/MLINJECTABLE / INJECTIONAP2020-01-07053a50430f4f…
2023-01-26 05:58 UTC2023-01A212046-001DIHYDROERGOTAMINE MESYLATE1MG/MLINJECTABLE / INJECTIONAP2020-01-073bdfa0b2c4d7…
2022-11-12 20:34 UTC · 5 captures of this ZIP2022-11A212046-001DIHYDROERGOTAMINE MESYLATE1MG/MLINJECTABLE / INJECTIONAP2020-01-073a93d1ddd44b…
2022-10-28 04:53 UTC2022-10A212046-001DIHYDROERGOTAMINE MESYLATE1MG/MLINJECTABLE / INJECTIONAP2020-01-07f41ea6bd6efb…
2022-09-29 23:25 UTC2022-09A212046-001DIHYDROERGOTAMINE MESYLATE1MG/MLINJECTABLE / INJECTIONAP2020-01-07e64feba35796…
2022-07-09 03:26 UTC · 3 captures of this ZIP2022-07A212046-001DIHYDROERGOTAMINE MESYLATE1MG/MLINJECTABLE / INJECTIONAP2020-01-07cb3db0bc1861…
2026-07-26 02:55 UTC · 3 captures of this ZIP2026-06A212046-001DIHYDROERGOTAMINE MESYLATE1MG/MLINJECTABLE / INJECTIONAP2020-01-07a50c72e98297…

Observed Orange Book normalized TE history#

Captured, Edition, Application-product table
CapturedEditionApplication-productTE codeOrderSource SHA-256
2026-02-19 14:30 UTC2026-02A212046-001AP1011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A212046-001AP131067a03dcf5…
2025-08-23 18:47 UTC2025-08A212046-001AP16a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A212046-001AP1fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A212046-001AP1b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A212046-001AP103ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A212046-001AP12680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A212046-001AP15bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A212046-001AP1d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A212046-001AP1d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A212046-001AP179d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A212046-001AP1301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A212046-001AP11e350fbaab3a…
2024-05-31 18:47 UTC2024-05A212046-001AP18072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06A212046-001AP15c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04A212046-001AP15d02ea3f76ae…
2022-04-04 05:41 UTC2022-04A212046-001AP14b0b4de00fa7…
2022-03-09 01:35 UTC2022-03A212046-001AP1bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12A212046-001AP1782e0a99824c…
2021-05-05 16:15 UTC · 3 captures of this ZIP2021-05A212046-001AP187673890dc5c…
2021-03-12 10:30 UTC2021-03A212046-001AP15aa47cf7b7d7…
2020-12-22 03:56 UTC2020-12A212046-001AP18869cabd3fbd…
2020-11-12 02:37 UTC2020-11A212046-001AP1c0c555d07b60…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A212046-001AP16a51e52b5d6a…
2024-02-18 07:12 UTC2024-02A212046-001AP11c564ffb4f44…
2023-12-20 04:57 UTC2023-12A212046-001AP1ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11A212046-001AP1a72a2bbeb626…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10A212046-001AP19b2671bbb829…
2023-07-15 15:27 UTC · 2 captures of this ZIP2023-07A212046-001AP1a67488948f0b…
2023-06-13 01:57 UTC · 3 captures of this ZIP2023-06A212046-001AP13f0d92c62455…
2023-05-13 08:27 UTC2023-05A212046-001AP1053a50430f4f…
2023-01-26 05:58 UTC2023-01A212046-001AP13bdfa0b2c4d7…
2022-11-12 20:34 UTC · 5 captures of this ZIP2022-11A212046-001AP13a93d1ddd44b…
2022-10-28 04:53 UTC2022-10A212046-001AP1f41ea6bd6efb…
2022-09-29 23:25 UTC2022-09A212046-001AP1e64feba35796…
2022-07-09 03:26 UTC · 3 captures of this ZIP2022-07A212046-001AP1cb3db0bc1861…
2026-07-26 02:55 UTC · 3 captures of this ZIP2026-06A212046-001AP1a50c72e98297…

Additional Listing Data#

Finished product
Yes
Brand name base
Dihydroergotamine Mesylate
Listing expiration
2026-12-31

Active Ingredients#

Ingredient, Strength table
IngredientStrength
DIHYDROERGOTAMINE MESYLATE1 mg/mL

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
81AXN7R2QTInternal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
861672Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
40b9ba9e-436e-444e-b078-01b12bb57ea7Available on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product conceptRelationVersionEffective
45c9a995-456f-4920-9be6-19f388510405Product name120260303
0dc20644-8d0b-4adf-9269-872bb65fd7fbProduct name320251205
803e1b3a-35b6-0bc8-229b-d2f7e8a7ffd4Product name520250516
2053edd2-6ad3-4897-ba63-817235bdab3cProduct name220220309

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDCProductDescriptionFormQuantityStrengthSPL version
81284-411-00Dihydroergotamine Mesylate1 mL in 1 AMPULEINJECTION, SOLUTION15
81284-411-05Dihydroergotamine Mesylate5 in 1 CARTONINJECTION, SOLUTION55
81284-411-10Dihydroergotamine Mesylate10 in 1 CARTONINJECTION, SOLUTION105

DailyMed Billing Units#

Package NDC, Billing unit, Product NDC table
Package NDCBilling unitProduct NDCDailyMed indexing SPLSPL versionEffective
81284-411-00ML - Milliliter81284-411808c7794-961a-4579-8994-9c7648f1975a12022-06-06
81284-411-05ML - Milliliter81284-4119f5c28eb-c0c4-4cfe-aa58-fe92298d3b7212022-11-07
81284-411-10ML - Milliliter81284-411f78fdc46-fb48-493d-8b42-538ed279fe4512022-06-06

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDCDashboard titleSPL versionValidationDashboard ZIP
81284-411DIHYDROERGOTAMINE MESYLATE INJECTION, SOLUTION [PROVEPHARM INC.]5Current NDC, Legacy NDC, 3 package rows20250227_40b9ba9e-436e-444e-b078-01b12bb57ea7.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 2 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
Dihydroergotamine MesylateDIHYDROERGOTAMINE MESYLATEMilla Pharmaceuticals Inc.b464a64d-b150-4f6b-b3df-e486a41294d72026-05-26Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 212046
application number: ANDA212046
Dihydroergotamine MesylateDIHYDROERGOTAMINE MESYLATEProvepharm Inc.40b9ba9e-436e-444e-b078-01b12bb57ea72025-02-25Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 212046
application number: ANDA212046
ndc (product): 81284-411

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUIRxNorm stringTTYDailyMedSPL version
861672dihydroergotamine mesylate 1 MG in 1 ML InjectionPSN40b9ba9e-436e-444e-b078-01b12bb57ea75
8616721 ML dihydroergotamine mesylate 1 MG/ML InjectionSCD40b9ba9e-436e-444e-b078-01b12bb57ea75
8616721 ML DHE Mesylate 1 MG/ML InjectionSY40b9ba9e-436e-444e-b078-01b12bb57ea75
861672dihydroergotamine mesylate 1 MG per 1 ML InjectionSY40b9ba9e-436e-444e-b078-01b12bb57ea75

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionUnitsMarketing startMarketing endSampleExclude flagStatus
81284-411-00812840411001 mL in 1 AMPULE1 mlHistorical
81284-411-05812840411055 AMPULE in 1 CARTON (81284-411-05) / 1 mL in 1 AMPULE (81284-411-00) 5 ampule2021-09-300000-00-00NoNoCurrent
81284-411-108128404111010 AMPULE in 1 CARTON (81284-411-10) / 1 mL in 1 AMPULE (81284-411-00) 10 ampule2021-09-300000-00-00NoNoCurrent