Motofen

Product NDC
83107-011
11-digit product format
831070011
Labeler code
83107
Product ID
83107-011_4db25dab-3394-5f06-e063-6294a90a9688
Type
HUMAN PRESCRIPTION DRUG
Nonproprietary name
difenoxin and atropine sulfate
Dosage form
TABLET
Route
ORAL
Labeler
Legacy Pharma USA Inc.
Application
NDA017744
Marketing category
NDA
Marketing start
2026-01-01
Substance
ATROPINE SULFATE; DIFENOXIN HYDROCHLORIDE
Active strength
.025; 1 mg/1; mg/1
Pharmacologic classes
Anticholinergic [EPC], Antidiarrheal [EPC], Cholinergic Antagonists [MoA], Cholinergic Muscarinic Antagonist [EPC], Cholinergic Muscarinic Antagonists [MoA]
DEA schedule
CIV
NDC exclude flag
No
Listing certified through
2027-12-31
Current FDA listing
Yes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 42.

Orange Book products#

Current product rows page 1 of 1 · 2 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
N017744-001MOTOFEN HALF-STRENGTHATROPINE SULFATE; DIFENOXIN HYDROCHLORIDE0.025MG;0.5MGTABLET / ORALApproved before 1982
N017744-002MOTOFENATROPINE SULFATE; DIFENOXIN HYDROCHLORIDE0.025MG;1MGTABLET / ORALRLD, RS, Approved before 1982

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Product history page 1 of 3 · 84 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-08-18 06:07:402026-07N017744-001MOTOFEN HALF-STRENGTH0.025MG;0.5MGTABLET / ORALApproved before 1982caaa826d4ba7…
2026-08-18 06:07:402026-07N017744-002MOTOFEN0.025MG;1MGTABLET / ORALRLD, RS, Approved before 1982caaa826d4ba7…
2026-02-19 14:30 UTC2026-02N017744-001MOTOFEN HALF-STRENGTH0.025MG;0.5MGTABLET / ORALApproved before 1982011fe1cb6892…
2026-02-19 14:30 UTC2026-02N017744-002MOTOFEN0.025MG;1MGTABLET / ORALRLD, RS, Approved before 1982011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N017744-001MOTOFEN HALF-STRENGTH0.025MG;0.5MGTABLET / ORALApproved before 198231067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N017744-002MOTOFEN0.025MG;1MGTABLET / ORALRLD, RS, Approved before 198231067a03dcf5…
2025-08-23 18:47 UTC2025-08N017744-001MOTOFEN HALF-STRENGTH0.025MG;0.5MGTABLET / ORALApproved before 19826a471c1ec25d…
2025-08-23 18:47 UTC2025-08N017744-002MOTOFEN0.025MG;1MGTABLET / ORALRLD, RS, Approved before 19826a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N017744-001MOTOFEN HALF-STRENGTH0.025MG;0.5MGTABLET / ORALApproved before 1982fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N017744-002MOTOFEN0.025MG;1MGTABLET / ORALRLD, RS, Approved before 1982fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N017744-001MOTOFEN HALF-STRENGTH0.025MG;0.5MGTABLET / ORALApproved before 1982b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N017744-002MOTOFEN0.025MG;1MGTABLET / ORALRLD, RS, Approved before 1982b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N017744-001MOTOFEN HALF-STRENGTH0.025MG;0.5MGTABLET / ORALApproved before 198203ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N017744-002MOTOFEN0.025MG;1MGTABLET / ORALRLD, RS, Approved before 198203ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N017744-001MOTOFEN HALF-STRENGTH0.025MG;0.5MGTABLET / ORALApproved before 19822680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N017744-002MOTOFEN0.025MG;1MGTABLET / ORALRLD, RS, Approved before 19822680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N017744-001MOTOFEN HALF-STRENGTH0.025MG;0.5MGTABLET / ORALApproved before 19825bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N017744-002MOTOFEN0.025MG;1MGTABLET / ORALRLD, RS, Approved before 19825bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N017744-001MOTOFEN HALF-STRENGTH0.025MG;0.5MGTABLET / ORALApproved before 1982d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N017744-002MOTOFEN0.025MG;1MGTABLET / ORALRLD, RS, Approved before 1982d8e5a09893c0…
2024-10-29 15:01 UTC2024-10N017744-001MOTOFEN HALF-STRENGTH0.025MG;0.5MGTABLET / ORALApproved before 1982d06236e962d9…
2024-10-29 15:01 UTC2024-10N017744-002MOTOFEN0.025MG;1MGTABLET / ORALRLD, RS, Approved before 1982d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08N017744-001MOTOFEN HALF-STRENGTH0.025MG;0.5MGTABLET / ORALApproved before 198279d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08N017744-002MOTOFEN0.025MG;1MGTABLET / ORALRLD, RS, Approved before 198279d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07N017744-001MOTOFEN HALF-STRENGTH0.025MG;0.5MGTABLET / ORALApproved before 1982301d65b070ca…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07N017744-002MOTOFEN0.025MG;1MGTABLET / ORALRLD, RS, Approved before 1982301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06N017744-001MOTOFEN HALF-STRENGTH0.025MG;0.5MGTABLET / ORALApproved before 19821e350fbaab3a…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06N017744-002MOTOFEN0.025MG;1MGTABLET / ORALRLD, RS, Approved before 19821e350fbaab3a…
2024-05-31 18:47 UTC2024-05N017744-001MOTOFEN HALF-STRENGTH0.025MG;0.5MGTABLET / ORALApproved before 19828072bd15b7f6…
2024-05-31 18:47 UTC2024-05N017744-002MOTOFEN0.025MG;1MGTABLET / ORALRLD, RS, Approved before 19828072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06N017744-001MOTOFEN HALF-STRENGTH0.025MG;0.5MGTABLET / ORALApproved before 19825c6f7cd8ea54…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06N017744-002MOTOFEN0.025MG;1MGTABLET / ORALRLD, RS, Approved before 19825c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04N017744-001MOTOFEN HALF-STRENGTH0.025MG;0.5MGTABLET / ORALApproved before 19825d02ea3f76ae…
2022-04-08 23:34 UTC2022-04N017744-002MOTOFEN0.025MG;1MGTABLET / ORALRLD, RS, Approved before 19825d02ea3f76ae…
2022-04-04 05:41 UTC2022-04N017744-001MOTOFEN HALF-STRENGTH0.025MG;0.5MGTABLET / ORALApproved before 19824b0b4de00fa7…
2022-04-04 05:41 UTC2022-04N017744-002MOTOFEN0.025MG;1MGTABLET / ORALRLD, RS, Approved before 19824b0b4de00fa7…
2019-12-13 00:20 UTC2019-12N017744-001MOTOFEN HALF-STRENGTH0.025MG;0.5MGTABLET / ORALApproved before 198274a2ff9319b5…
2019-12-13 00:20 UTC2019-12N017744-002MOTOFEN0.025MG;1MGTABLET / ORALRLD, RS, Approved before 198274a2ff9319b5…
2022-03-09 01:35 UTC2022-03N017744-001MOTOFEN HALF-STRENGTH0.025MG;0.5MGTABLET / ORALApproved before 1982bb7c543d1eb4…
2022-03-09 01:35 UTC2022-03N017744-002MOTOFEN0.025MG;1MGTABLET / ORALRLD, RS, Approved before 1982bb7c543d1eb4…

Additional Listing Data#

Finished product
Yes
Brand name base
Motofen
Listing expiration
2027-12-31

Active Ingredients#

Ingredient, Strength table
IngredientStrength
DIFENOXIN HYDROCHLORIDE1 mg/1
ATROPINE SULFATE.025 mg/1

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 2 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
VQZ63K01IWInternal UNII lookup
03J5ZE7KA5Internal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 2 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
1190738Internal RxNorm lookup
1190740Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
1fa11c67-5492-469c-9475-6bfa0e5e9ff8Available on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product conceptRelationVersionEffective
6c78bd43-efb4-4aeb-b7d8-eff1532f7822Product name420250801
41231c1e-8789-4da7-ac52-77fa90a85bf5Product name220250304
e77ab9a2-80cf-4832-bff0-469bbc7cbcd0Product name220250214
5f84b7a7-523a-f042-dffb-1dadcd9b2407Product name420240110
0cbc6fb2-78c0-4b88-98f0-a4cc76ff95caProduct name120230719
04cd5dc0-102f-46cb-8dbc-ca38dd2628d0Product name320230317
dfd25202-b8d2-4628-9213-f3e0f9eafce5Product name420210513
4199bf9b-4718-828a-6dd6-ac2fbbd61687Product name120140508
4edd8af5-cea7-ae42-8023-e91c5335db1dProduct name120140508
d3908afb-7784-440f-c406-88294732d36aProduct name120140508

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDCProductDescriptionFormQuantityStrengthSPL version
83107-011-10Motofen100 in 1 BOTTLETABLET1002

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 2 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
MotofenDIFENOXIN AND ATROPINE SULFATELegacy Pharma USA Inc.1fa11c67-5492-469c-9475-6bfa0e5e9ff82026-03-23Warnings, Adverse reactionsExact identifier
application applno (NDA): 017744
application number: NDA017744
ndc (product): 83107-011
MotofenDIFENOXIN AND ATROPINE SULFATESebela Pharmaceuticals Inc.4cd3f029-a5e3-5812-e054-00144ff8d46c2025-11-08Warnings, Adverse reactionsExact identifier
application applno (NDA): 017744
application number: NDA017744

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUIRxNorm stringTTYDailyMedSPL version
1190738difenoxin 1 MG / atropine sulfate 0.025 MG Oral TabletPSN1fa11c67-5492-469c-9475-6bfa0e5e9ff82
1190740Motofen 1 MG / 0.025 MG Oral TabletPSN1fa11c67-5492-469c-9475-6bfa0e5e9ff82
1190740atropine sulfate 0.025 MG / difenoxin hydrochloride 1 MG Oral Tablet [Motofen]SBD1fa11c67-5492-469c-9475-6bfa0e5e9ff82
1190738atropine sulfate 0.025 MG / difenoxin hydrochloride 1 MG Oral TabletSCD1fa11c67-5492-469c-9475-6bfa0e5e9ff82
1190740Motofen (atropine sulfate 0.025 MG / difenoxin hydrochloride 1 MG) Oral TabletSY1fa11c67-5492-469c-9475-6bfa0e5e9ff82

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionUnitsMarketing startSampleExclude flagStatus
83107-011-1083107001110100 TABLET in 1 BOTTLE (83107-011-10) 100 tablet2026-01-01NoNoCurrent