Bivalirudin

Product NDC
83634-400
11-digit product format
836340400
Labeler code
83634
Product ID
83634-400_f893cc33-8b26-4b98-848d-61daf2e93a2c
Type
HUMAN PRESCRIPTION DRUG
Nonproprietary name
bivalirudin
Dosage form
INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION
Route
INTRAVENOUS
Labeler
Avenacy, Inc.
Application
ANDA210031
Marketing category
ANDA
Marketing start
2023-12-18
Substance
BIVALIRUDIN
Active strength
250 mg/1
Pharmacologic classes
Anti-coagulant [EPC], Direct Thrombin Inhibitor [EPC], Thrombin Inhibitors [MoA]
NDC exclude flag
No
Listing certified through
2026-12-31
Current FDA listing
Yes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 1.

Orange Book products#

Current product rows page 1 of 1 · 1 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
A210031-001BIVALIRUDINBIVALIRUDIN250MG/VIALINJECTABLE / INTRAVENOUSAP2019-10-23

Therapeutic equivalence codes#

Current TE-code rows page 1 of 1 · 1 matching rows.

Application-product, TE code table
Application-productTE code
A210031-001AP

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-02-19 14:30 UTC2026-02A210031-001BIVALIRUDIN250MG/VIALINJECTABLE / INTRAVENOUSAP2019-10-23011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A210031-001BIVALIRUDIN250MG/VIALINJECTABLE / INTRAVENOUSAP2019-10-2331067a03dcf5…
2025-08-23 18:47 UTC2025-08A210031-001BIVALIRUDIN250MG/VIALINJECTABLE / INTRAVENOUSAP2019-10-236a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A210031-001BIVALIRUDIN250MG/VIALINJECTABLE / INTRAVENOUSAP2019-10-23fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A210031-001BIVALIRUDIN250MG/VIALINJECTABLE / INTRAVENOUSAP2019-10-23b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A210031-001BIVALIRUDIN250MG/VIALINJECTABLE / INTRAVENOUSAP2019-10-2303ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A210031-001BIVALIRUDIN250MG/VIALINJECTABLE / INTRAVENOUSAP2019-10-232680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A210031-001BIVALIRUDIN250MG/VIALINJECTABLE / INTRAVENOUSAP2019-10-235bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A210031-001BIVALIRUDIN250MG/VIALINJECTABLE / INTRAVENOUSAP2019-10-23d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A210031-001BIVALIRUDIN250MG/VIALINJECTABLE / INTRAVENOUSAP2019-10-23d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A210031-001BIVALIRUDIN250MG/VIALINJECTABLE / INTRAVENOUSAP2019-10-2379d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A210031-001BIVALIRUDIN250MG/VIALINJECTABLE / INTRAVENOUSAP2019-10-23301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A210031-001BIVALIRUDIN250MG/VIALINJECTABLE / INTRAVENOUSAP2019-10-231e350fbaab3a…
2024-05-31 18:47 UTC2024-05A210031-001BIVALIRUDIN250MG/VIALINJECTABLE / INTRAVENOUSAP2019-10-238072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06A210031-001BIVALIRUDIN250MG/VIALINJECTABLE / INTRAVENOUSAP2019-10-235c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04A210031-001BIVALIRUDIN250MG/VIALINJECTABLE / INTRAVENOUSAP2019-10-235d02ea3f76ae…
2022-04-04 05:41 UTC2022-04A210031-001BIVALIRUDIN250MG/VIALINJECTABLE / INTRAVENOUSAP2019-10-234b0b4de00fa7…
2019-12-13 00:20 UTC2019-12A210031-001BIVALIRUDIN250MG/VIALINJECTABLE / INTRAVENOUSAP2019-10-2374a2ff9319b5…
2022-03-09 01:35 UTC2022-03A210031-001BIVALIRUDIN250MG/VIALINJECTABLE / INTRAVENOUSAP2019-10-23bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12A210031-001BIVALIRUDIN250MG/VIALINJECTABLE / INTRAVENOUSAP2019-10-23782e0a99824c…
2021-05-05 16:15 UTC · 3 captures of this ZIP2021-05A210031-001BIVALIRUDIN250MG/VIALINJECTABLE / INTRAVENOUSAP2019-10-2387673890dc5c…
2021-03-12 10:30 UTC2021-03A210031-001BIVALIRUDIN250MG/VIALINJECTABLE / INTRAVENOUSAP2019-10-235aa47cf7b7d7…
2020-12-22 03:56 UTC2020-12A210031-001BIVALIRUDIN250MG/VIALINJECTABLE / INTRAVENOUSAP2019-10-238869cabd3fbd…
2020-11-12 02:37 UTC2020-11A210031-001BIVALIRUDIN250MG/VIALINJECTABLE / INTRAVENOUSAP2019-10-23c0c555d07b60…
2019-12-14 00:12 UTC2019-12A210031-001BIVALIRUDIN250MG/VIALINJECTABLE / INTRAVENOUSAP2019-10-233f01610625f2…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A210031-001BIVALIRUDIN250MG/VIALINJECTABLE / INTRAVENOUSAP2019-10-236a51e52b5d6a…
2024-02-18 07:12 UTC2024-02A210031-001BIVALIRUDIN250MG/VIALINJECTABLE / INTRAVENOUSAP2019-10-231c564ffb4f44…
2023-12-20 04:57 UTC2023-12A210031-001BIVALIRUDIN250MG/VIALINJECTABLE / INTRAVENOUSAP2019-10-23ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11A210031-001BIVALIRUDIN250MG/VIALINJECTABLE / INTRAVENOUSAP2019-10-23a72a2bbeb626…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10A210031-001BIVALIRUDIN250MG/VIALINJECTABLE / INTRAVENOUSAP2019-10-239b2671bbb829…
2023-07-15 15:27 UTC · 2 captures of this ZIP2023-07A210031-001BIVALIRUDIN250MG/VIALINJECTABLE / INTRAVENOUSAP2019-10-23a67488948f0b…
2023-06-13 01:57 UTC · 3 captures of this ZIP2023-06A210031-001BIVALIRUDIN250MG/VIALINJECTABLE / INTRAVENOUSAP2019-10-233f0d92c62455…
2023-05-13 08:27 UTC2023-05A210031-001BIVALIRUDIN250MG/VIALINJECTABLE / INTRAVENOUSAP2019-10-23053a50430f4f…
2023-01-26 05:58 UTC2023-01A210031-001BIVALIRUDIN250MG/VIALINJECTABLE / INTRAVENOUSAP2019-10-233bdfa0b2c4d7…
2022-11-12 20:34 UTC · 5 captures of this ZIP2022-11A210031-001BIVALIRUDIN250MG/VIALINJECTABLE / INTRAVENOUSAP2019-10-233a93d1ddd44b…
2022-10-28 04:53 UTC2022-10A210031-001BIVALIRUDIN250MG/VIALINJECTABLE / INTRAVENOUSAP2019-10-23f41ea6bd6efb…
2022-09-29 23:25 UTC2022-09A210031-001BIVALIRUDIN250MG/VIALINJECTABLE / INTRAVENOUSAP2019-10-23e64feba35796…
2022-07-09 03:26 UTC · 3 captures of this ZIP2022-07A210031-001BIVALIRUDIN250MG/VIALINJECTABLE / INTRAVENOUSAP2019-10-23cb3db0bc1861…
2026-07-26 02:55 UTC · 3 captures of this ZIP2026-06A210031-001BIVALIRUDIN250MG/VIALINJECTABLE / INTRAVENOUSAP2019-10-23a50c72e98297…

Observed Orange Book normalized TE history#

Captured, Edition, Application-product table
CapturedEditionApplication-productTE codeOrderSource SHA-256
2026-02-19 14:30 UTC2026-02A210031-001AP1011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A210031-001AP131067a03dcf5…
2025-08-23 18:47 UTC2025-08A210031-001AP16a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A210031-001AP1fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A210031-001AP1b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A210031-001AP103ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A210031-001AP12680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A210031-001AP15bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A210031-001AP1d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A210031-001AP1d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A210031-001AP179d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A210031-001AP1301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A210031-001AP11e350fbaab3a…
2024-05-31 18:47 UTC2024-05A210031-001AP18072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06A210031-001AP15c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04A210031-001AP15d02ea3f76ae…
2022-04-04 05:41 UTC2022-04A210031-001AP14b0b4de00fa7…
2019-12-13 00:20 UTC2019-12A210031-001AP174a2ff9319b5…
2022-03-09 01:35 UTC2022-03A210031-001AP1bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12A210031-001AP1782e0a99824c…
2021-05-05 16:15 UTC · 3 captures of this ZIP2021-05A210031-001AP187673890dc5c…
2021-03-12 10:30 UTC2021-03A210031-001AP15aa47cf7b7d7…
2020-12-22 03:56 UTC2020-12A210031-001AP18869cabd3fbd…
2020-11-12 02:37 UTC2020-11A210031-001AP1c0c555d07b60…
2019-12-14 00:12 UTC2019-12A210031-001AP13f01610625f2…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A210031-001AP16a51e52b5d6a…
2024-02-18 07:12 UTC2024-02A210031-001AP11c564ffb4f44…
2023-12-20 04:57 UTC2023-12A210031-001AP1ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11A210031-001AP1a72a2bbeb626…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10A210031-001AP19b2671bbb829…
2023-07-15 15:27 UTC · 2 captures of this ZIP2023-07A210031-001AP1a67488948f0b…
2023-06-13 01:57 UTC · 3 captures of this ZIP2023-06A210031-001AP13f0d92c62455…
2023-05-13 08:27 UTC2023-05A210031-001AP1053a50430f4f…
2023-01-26 05:58 UTC2023-01A210031-001AP13bdfa0b2c4d7…
2022-11-12 20:34 UTC · 5 captures of this ZIP2022-11A210031-001AP13a93d1ddd44b…
2022-10-28 04:53 UTC2022-10A210031-001AP1f41ea6bd6efb…
2022-09-29 23:25 UTC2022-09A210031-001AP1e64feba35796…
2022-07-09 03:26 UTC · 3 captures of this ZIP2022-07A210031-001AP1cb3db0bc1861…
2026-07-26 02:55 UTC · 3 captures of this ZIP2026-06A210031-001AP1a50c72e98297…

Additional Listing Data#

Finished product
Yes
Brand name base
Bivalirudin
Listing expiration
2026-12-31

Active Ingredients#

Ingredient, Strength table
IngredientStrength
BIVALIRUDIN250 mg/1

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
TN9BEX005GInternal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
308769Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
42aa2630-83d6-433d-8277-0f672cf8d71dAvailable on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product conceptRelationVersionEffective
1c25cd48-e81c-4683-ac07-71f9a642e2bfProduct name920211217
a62a50ac-1535-4461-9768-8ae703e2e9fbProduct name120210525
325b79a5-b460-45d7-abfc-c4784f5b0531Product name120191120
c3370853-5a7f-4c73-a273-26ef0162f2f3Product name120180308
9514609b-a2a9-f8ec-6ba6-3f8e5ee89877Product name120140508
bc07ef78-e82d-0c19-31f4-31f263780582Product name120140508

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDCProductDescriptionFormQuantityStrengthSPL version
83634-400-10Bivalirudin10 in 1 CARTONINJECTION, POWDER, LYOPHILIZED,101
83634-400-41Bivalirudin1 in 1 VIAL, SINGLE-DOSEINJECTION, POWDER, LYOPHILIZED,11

DailyMed Billing Units#

Package NDC, Billing unit, Product NDC table
Package NDCBilling unitProduct NDCDailyMed indexing SPLSPL versionEffective
83634-400-10EA - Each83634-4003bc0676f-cda0-4e46-9e6c-27a8eea070eb12024-03-12

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDCDashboard titleSPL versionValidationDashboard ZIP
83634-400BIVALIRUDIN INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION [AVENACY, INC.]1Current NDC, 2 package rows20231218_42aa2630-83d6-433d-8277-0f672cf8d71d.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 2 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
BivalirudinBIVALIRUDINHainan Shuangcheng Pharmaceuticals Co., Ltd.61de12ff-e280-4bab-9804-43869ec45fa72024-12-23Warnings, Adverse reactionsExact identifier
application applno (ANDA): 210031
application number: ANDA210031
BivalirudinBIVALIRUDINAvenacy, Inc.42aa2630-83d6-433d-8277-0f672cf8d71d2023-10-20Warnings, Adverse reactionsExact identifier
application applno (ANDA): 210031
application number: ANDA210031
ndc (product): 83634-400

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUIRxNorm stringTTYDailyMedSPL version
308769bivalirudin 250 MG InjectionPSN42aa2630-83d6-433d-8277-0f672cf8d71d1
308769bivalirudin 250 MG InjectionSCD42aa2630-83d6-433d-8277-0f672cf8d71d1
308769bivalirudin 250 MG (as bivalirudin trifluoroacetate 275 MG) per 5 ML InjectionSY42aa2630-83d6-433d-8277-0f672cf8d71d1
308769bivalirudin 50 MG/ML InjectionSY42aa2630-83d6-433d-8277-0f672cf8d71d1

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionMarketing startSampleExclude flagStatus
83634-400-108363404001010 VIAL, SINGLE-DOSE in 1 CARTON (83634-400-10) / 1 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION in 1 VIAL, SINGLE-DOSE (83634-400-41) 2023-12-18NoNoCurrent
83634-400-41836340400411 in 1 VIAL, SINGLE-DOSEHistorical