Bupivacaine Hydrochloride

Product NDC
84549-162
11-digit product format
845490162
Labeler code
84549
Product ID
84549-162_463e0e03-4f19-1b80-e063-6394a90a4da7
Type
HUMAN PRESCRIPTION DRUG
Nonproprietary name
BUPIVACAINE HYDROCHLORIDE
Dosage form
INJECTION, SOLUTION
Route
EPIDURAL; INTRACAUDAL; PERINEURAL
Labeler
ProPharma Distribution
Application
ANDA070584
Marketing category
ANDA
Marketing start
2005-11-22
Substance
BUPIVACAINE HYDROCHLORIDE
Active strength
5 mg/mL
Pharmacologic classes
Amide Local Anesthetic [EPC], Amides [CS], Local Anesthesia [PE]
NDC exclude flag
No
Listing certified through
2026-12-31
Current FDA listing
Yes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 1.

Orange Book products#

Current product rows page 1 of 1 · 1 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
A070584-001BUPIVACAINE HYDROCHLORIDEBUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1986-02-17

Therapeutic equivalence codes#

Current TE-code rows page 1 of 1 · 1 matching rows.

Application-product, TE code table
Application-productTE code
A070584-001AP

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Product history page 1 of 2 · 41 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-02-19 14:30 UTC2026-02A070584-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1986-02-17011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A070584-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1986-02-1731067a03dcf5…
2025-08-23 18:47 UTC2025-08A070584-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1986-02-176a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A070584-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1986-02-17fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A070584-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1986-02-17b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A070584-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1986-02-1703ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A070584-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1986-02-172680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A070584-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1986-02-175bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A070584-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1986-02-17d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A070584-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1986-02-17d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A070584-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1986-02-1779d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A070584-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1986-02-17301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A070584-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1986-02-171e350fbaab3a…
2024-05-31 18:47 UTC2024-05A070584-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1986-02-178072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06A070584-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1986-02-175c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04A070584-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1986-02-175d02ea3f76ae…
2022-04-04 05:41 UTC2022-04A070584-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1986-02-174b0b4de00fa7…
2019-12-13 00:20 UTC2019-12A070584-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1986-02-1774a2ff9319b5…
2022-03-09 01:35 UTC2022-03A070584-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1986-02-17bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12A070584-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1986-02-17782e0a99824c…
2021-05-05 16:15 UTC · 3 captures of this ZIP2021-05A070584-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1986-02-1787673890dc5c…
2021-03-12 10:30 UTC2021-03A070584-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1986-02-175aa47cf7b7d7…
2020-12-22 03:56 UTC2020-12A070584-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1986-02-178869cabd3fbd…
2020-11-12 02:37 UTC2020-11A070584-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1986-02-17c0c555d07b60…
2019-12-14 00:12 UTC2019-12A070584-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1986-02-173f01610625f2…
2019-09-15 20:21 UTC2019-09A070584-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1986-02-17b00525d2431f…
2019-07-19 19:46 UTC2019-07A070584-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1986-02-17ea99ee380514…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A070584-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1986-02-176a51e52b5d6a…
2024-02-18 07:12 UTC2024-02A070584-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1986-02-171c564ffb4f44…
2023-12-20 04:57 UTC2023-12A070584-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1986-02-17ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11A070584-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1986-02-17a72a2bbeb626…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10A070584-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1986-02-179b2671bbb829…
2023-07-15 15:27 UTC · 2 captures of this ZIP2023-07A070584-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1986-02-17a67488948f0b…
2023-06-13 01:57 UTC · 3 captures of this ZIP2023-06A070584-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1986-02-173f0d92c62455…
2023-05-13 08:27 UTC2023-05A070584-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1986-02-17053a50430f4f…
2023-01-26 05:58 UTC2023-01A070584-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1986-02-173bdfa0b2c4d7…
2022-11-12 20:34 UTC · 5 captures of this ZIP2022-11A070584-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1986-02-173a93d1ddd44b…
2022-10-28 04:53 UTC2022-10A070584-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1986-02-17f41ea6bd6efb…
2022-09-29 23:25 UTC2022-09A070584-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1986-02-17e64feba35796…
2022-07-09 03:26 UTC · 3 captures of this ZIP2022-07A070584-001BUPIVACAINE HYDROCHLORIDE0.5%INJECTABLE / INJECTIONAP1986-02-17cb3db0bc1861…

Observed Orange Book normalized TE history#

Normalized TE history page 1 of 2 · 41 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTE codeOrderSource SHA-256
2026-02-19 14:30 UTC2026-02A070584-001AP1011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A070584-001AP131067a03dcf5…
2025-08-23 18:47 UTC2025-08A070584-001AP16a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A070584-001AP1fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A070584-001AP1b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A070584-001AP103ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A070584-001AP12680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A070584-001AP15bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A070584-001AP1d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A070584-001AP1d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A070584-001AP179d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A070584-001AP1301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A070584-001AP11e350fbaab3a…
2024-05-31 18:47 UTC2024-05A070584-001AP18072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06A070584-001AP15c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04A070584-001AP15d02ea3f76ae…
2022-04-04 05:41 UTC2022-04A070584-001AP14b0b4de00fa7…
2019-12-13 00:20 UTC2019-12A070584-001AP174a2ff9319b5…
2022-03-09 01:35 UTC2022-03A070584-001AP1bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12A070584-001AP1782e0a99824c…
2021-05-05 16:15 UTC · 3 captures of this ZIP2021-05A070584-001AP187673890dc5c…
2021-03-12 10:30 UTC2021-03A070584-001AP15aa47cf7b7d7…
2020-12-22 03:56 UTC2020-12A070584-001AP18869cabd3fbd…
2020-11-12 02:37 UTC2020-11A070584-001AP1c0c555d07b60…
2019-12-14 00:12 UTC2019-12A070584-001AP13f01610625f2…
2019-09-15 20:21 UTC2019-09A070584-001AP1b00525d2431f…
2019-07-19 19:46 UTC2019-07A070584-001AP1ea99ee380514…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A070584-001AP16a51e52b5d6a…
2024-02-18 07:12 UTC2024-02A070584-001AP11c564ffb4f44…
2023-12-20 04:57 UTC2023-12A070584-001AP1ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11A070584-001AP1a72a2bbeb626…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10A070584-001AP19b2671bbb829…
2023-07-15 15:27 UTC · 2 captures of this ZIP2023-07A070584-001AP1a67488948f0b…
2023-06-13 01:57 UTC · 3 captures of this ZIP2023-06A070584-001AP13f0d92c62455…
2023-05-13 08:27 UTC2023-05A070584-001AP1053a50430f4f…
2023-01-26 05:58 UTC2023-01A070584-001AP13bdfa0b2c4d7…
2022-11-12 20:34 UTC · 5 captures of this ZIP2022-11A070584-001AP13a93d1ddd44b…
2022-10-28 04:53 UTC2022-10A070584-001AP1f41ea6bd6efb…
2022-09-29 23:25 UTC2022-09A070584-001AP1e64feba35796…
2022-07-09 03:26 UTC · 3 captures of this ZIP2022-07A070584-001AP1cb3db0bc1861…

Additional Listing Data#

Finished product
Yes
Brand name base
Bupivacaine Hydrochloride
Listing expiration
2026-12-31

Active Ingredients#

Ingredient, Strength table
IngredientStrength
BUPIVACAINE HYDROCHLORIDE5 mg/mL

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
7TQO7W3VT8Internal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
1724884Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
42c973e2-307b-924c-e063-6394a90a737aAvailable on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product conceptRelationVersionEffective
cbf85893-59ef-423f-87d4-a573c000a8b9Product name820250731
5dad6767-dcd1-b0da-8727-7f3f7bc3a435Product name220250303
e3a99641-4540-4894-9108-00cab3c57b7eProduct name120211207
5da98533-f072-406b-9e1b-6ac19eca9926Product name120210622
306b993e-3140-4823-ad5e-88b708f9d2acProduct name120210510
a831e694-3663-4a83-82be-6c309429f750Product name220200608

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDCProductDescriptionFormQuantityStrengthSPL version
84549-162-02Bupivacaine Hydrochloride30 mL in 1 VIAL, SINGLE-DOSEINJECTION, SOLUTION302

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 4 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
Bupivacaine HydrochlorideBUPIVACAINE HYDROCHLORIDEHospira, Inc.02a845c3-4521-4926-e397-25ab536e7cf62026-03-09Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 070584
application number: ANDA070584
Bupivacaine HydrochlorideBUPIVACAINE HYDROCHLORIDESportpharm LLC0e6a55f0-5107-4ea9-9ee1-5c6c09bbe4a62026-02-03Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 070584
application number: ANDA070584
Bupivacaine HydrochlorideBUPIVACAINE HYDROCHLORIDEProPharma Distribution42c973e2-307b-924c-e063-6394a90a737a2025-12-18Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 070584
application number: ANDA070584
ndc (product): 84549-162
Bupivacaine HydrochlorideBUPIVACAINE HYDROCHLORIDEAsclemed USA, Inc.8759cac8-d977-4c2a-814c-5b59f2f0c9102023-08-09Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 070584
application number: ANDA070584

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUIRxNorm stringTTYDailyMedSPL version
1724884BUPivacaine HCl 0.5 % in 30 ML InjectionPSN42c973e2-307b-924c-e063-6394a90a737a2
172488430 ML bupivacaine hydrochloride 5 MG/ML InjectionSCD42c973e2-307b-924c-e063-6394a90a737a2
1724884bupivacaine HCl 0.5 % in 30 ML InjectionSY42c973e2-307b-924c-e063-6394a90a737a2

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionUnitsMarketing startSampleExclude flagStatus
84549-162-028454901620230 mL in 1 VIAL, SINGLE-DOSE (84549-162-02) 30 ml2025-10-10NoNoCurrent