Naproxen and esomeprazole magnesium

Product NDC
85509-1438
11-digit product format
855091438
Labeler code
85509
Product ID
85509-1438_4c25c053-eadd-e346-e063-6394a90afe42
Type
HUMAN PRESCRIPTION DRUG
Nonproprietary name
Naproxen and esomeprazole magnesium
Dosage form
TABLET, DELAYED RELEASE
Route
ORAL
Labeler
PHOENIX RX LLC
Application
ANDA217738
Marketing category
ANDA
Marketing start
2023-10-11
Substance
ESOMEPRAZOLE MAGNESIUM; NAPROXEN
Active strength
20; 500 mg/1; mg/1
Pharmacologic classes
Anti-Inflammatory Agents, Non-Steroidal [CS], Cyclooxygenase Inhibitors [MoA], Cytochrome P450 2C19 Inhibitors [MoA], Nonsteroidal Anti-inflammatory Drug [EPC], Proton Pump Inhibitor [EPC], Proton Pump Inhibitors [MoA]
NDC exclude flag
No
Listing certified through
2027-12-31
Current FDA listing
Yes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 1.

Orange Book products#

Current product rows page 1 of 1 · 2 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
A217738-001NAPROXEN AND ESOMEPRAZOLE MAGNESIUMESOMEPRAZOLE MAGNESIUM; NAPROXENEQ 20MG BASE;375MGTABLET, DELAYED RELEASE / ORALAB2023-10-11
A217738-002NAPROXEN AND ESOMEPRAZOLE MAGNESIUMESOMEPRAZOLE MAGNESIUM; NAPROXENEQ 20MG BASE;500MGTABLET, DELAYED RELEASE / ORALAB2023-10-11

Therapeutic equivalence codes#

Current TE-code rows page 1 of 1 · 2 matching rows.

Application-product, TE code table
Application-productTE code
A217738-001AB
A217738-002AB

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-02-19 14:30 UTC2026-02A217738-001NAPROXEN AND ESOMEPRAZOLE MAGNESIUMEQ 20MG BASE;375MGTABLET, DELAYED RELEASE / ORALAB2023-10-11011fe1cb6892…
2026-02-19 14:30 UTC2026-02A217738-002NAPROXEN AND ESOMEPRAZOLE MAGNESIUMEQ 20MG BASE;500MGTABLET, DELAYED RELEASE / ORALAB2023-10-11011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A217738-001NAPROXEN AND ESOMEPRAZOLE MAGNESIUMEQ 20MG BASE;375MGTABLET, DELAYED RELEASE / ORALAB2023-10-1131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A217738-002NAPROXEN AND ESOMEPRAZOLE MAGNESIUMEQ 20MG BASE;500MGTABLET, DELAYED RELEASE / ORALAB2023-10-1131067a03dcf5…
2025-08-23 18:47 UTC2025-08A217738-001NAPROXEN AND ESOMEPRAZOLE MAGNESIUMEQ 20MG BASE;375MGTABLET, DELAYED RELEASE / ORALAB2023-10-116a471c1ec25d…
2025-08-23 18:47 UTC2025-08A217738-002NAPROXEN AND ESOMEPRAZOLE MAGNESIUMEQ 20MG BASE;500MGTABLET, DELAYED RELEASE / ORALAB2023-10-116a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A217738-001NAPROXEN AND ESOMEPRAZOLE MAGNESIUMEQ 20MG BASE;375MGTABLET, DELAYED RELEASE / ORALAB2023-10-11fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A217738-002NAPROXEN AND ESOMEPRAZOLE MAGNESIUMEQ 20MG BASE;500MGTABLET, DELAYED RELEASE / ORALAB2023-10-11fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A217738-001NAPROXEN AND ESOMEPRAZOLE MAGNESIUMEQ 20MG BASE;375MGTABLET, DELAYED RELEASE / ORALAB2023-10-11b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A217738-002NAPROXEN AND ESOMEPRAZOLE MAGNESIUMEQ 20MG BASE;500MGTABLET, DELAYED RELEASE / ORALAB2023-10-11b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A217738-001NAPROXEN AND ESOMEPRAZOLE MAGNESIUMEQ 20MG BASE;375MGTABLET, DELAYED RELEASE / ORALAB2023-10-1103ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A217738-002NAPROXEN AND ESOMEPRAZOLE MAGNESIUMEQ 20MG BASE;500MGTABLET, DELAYED RELEASE / ORALAB2023-10-1103ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A217738-001NAPROXEN AND ESOMEPRAZOLE MAGNESIUMEQ 20MG BASE;375MGTABLET, DELAYED RELEASE / ORALAB2023-10-112680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A217738-002NAPROXEN AND ESOMEPRAZOLE MAGNESIUMEQ 20MG BASE;500MGTABLET, DELAYED RELEASE / ORALAB2023-10-112680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A217738-001NAPROXEN AND ESOMEPRAZOLE MAGNESIUMEQ 20MG BASE;375MGTABLET, DELAYED RELEASE / ORALAB2023-10-115bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A217738-002NAPROXEN AND ESOMEPRAZOLE MAGNESIUMEQ 20MG BASE;500MGTABLET, DELAYED RELEASE / ORALAB2023-10-115bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A217738-001NAPROXEN AND ESOMEPRAZOLE MAGNESIUMEQ 20MG BASE;375MGTABLET, DELAYED RELEASE / ORALAB2023-10-11d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A217738-002NAPROXEN AND ESOMEPRAZOLE MAGNESIUMEQ 20MG BASE;500MGTABLET, DELAYED RELEASE / ORALAB2023-10-11d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A217738-001NAPROXEN AND ESOMEPRAZOLE MAGNESIUMEQ 20MG BASE;375MGTABLET, DELAYED RELEASE / ORALAB2023-10-11d06236e962d9…
2024-10-29 15:01 UTC2024-10A217738-002NAPROXEN AND ESOMEPRAZOLE MAGNESIUMEQ 20MG BASE;500MGTABLET, DELAYED RELEASE / ORALAB2023-10-11d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A217738-001NAPROXEN AND ESOMEPRAZOLE MAGNESIUMEQ 20MG BASE;375MGTABLET, DELAYED RELEASE / ORALAB2023-10-1179d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A217738-002NAPROXEN AND ESOMEPRAZOLE MAGNESIUMEQ 20MG BASE;500MGTABLET, DELAYED RELEASE / ORALAB2023-10-1179d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A217738-001NAPROXEN AND ESOMEPRAZOLE MAGNESIUMEQ 20MG BASE;375MGTABLET, DELAYED RELEASE / ORALAB2023-10-11301d65b070ca…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A217738-002NAPROXEN AND ESOMEPRAZOLE MAGNESIUMEQ 20MG BASE;500MGTABLET, DELAYED RELEASE / ORALAB2023-10-11301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A217738-001NAPROXEN AND ESOMEPRAZOLE MAGNESIUMEQ 20MG BASE;375MGTABLET, DELAYED RELEASE / ORALAB2023-10-111e350fbaab3a…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A217738-002NAPROXEN AND ESOMEPRAZOLE MAGNESIUMEQ 20MG BASE;500MGTABLET, DELAYED RELEASE / ORALAB2023-10-111e350fbaab3a…
2024-05-31 18:47 UTC2024-05A217738-001NAPROXEN AND ESOMEPRAZOLE MAGNESIUMEQ 20MG BASE;375MGTABLET, DELAYED RELEASE / ORALAB2023-10-118072bd15b7f6…
2024-05-31 18:47 UTC2024-05A217738-002NAPROXEN AND ESOMEPRAZOLE MAGNESIUMEQ 20MG BASE;500MGTABLET, DELAYED RELEASE / ORALAB2023-10-118072bd15b7f6…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A217738-001NAPROXEN AND ESOMEPRAZOLE MAGNESIUMEQ 20MG BASE;375MGTABLET, DELAYED RELEASE / ORALAB2023-10-116a51e52b5d6a…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A217738-002NAPROXEN AND ESOMEPRAZOLE MAGNESIUMEQ 20MG BASE;500MGTABLET, DELAYED RELEASE / ORALAB2023-10-116a51e52b5d6a…
2024-02-18 07:12 UTC2024-02A217738-001NAPROXEN AND ESOMEPRAZOLE MAGNESIUMEQ 20MG BASE;375MGTABLET, DELAYED RELEASE / ORALAB2023-10-111c564ffb4f44…
2024-02-18 07:12 UTC2024-02A217738-002NAPROXEN AND ESOMEPRAZOLE MAGNESIUMEQ 20MG BASE;500MGTABLET, DELAYED RELEASE / ORALAB2023-10-111c564ffb4f44…
2023-12-20 04:57 UTC2023-12A217738-001NAPROXEN AND ESOMEPRAZOLE MAGNESIUMEQ 20MG BASE;375MGTABLET, DELAYED RELEASE / ORALAB2023-10-11ea1830bbd6c7…
2023-12-20 04:57 UTC2023-12A217738-002NAPROXEN AND ESOMEPRAZOLE MAGNESIUMEQ 20MG BASE;500MGTABLET, DELAYED RELEASE / ORALAB2023-10-11ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11A217738-001NAPROXEN AND ESOMEPRAZOLE MAGNESIUMEQ 20MG BASE;375MGTABLET, DELAYED RELEASE / ORALAB2023-10-11a72a2bbeb626…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11A217738-002NAPROXEN AND ESOMEPRAZOLE MAGNESIUMEQ 20MG BASE;500MGTABLET, DELAYED RELEASE / ORALAB2023-10-11a72a2bbeb626…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10A217738-001NAPROXEN AND ESOMEPRAZOLE MAGNESIUMEQ 20MG BASE;375MGTABLET, DELAYED RELEASE / ORALAB2023-10-119b2671bbb829…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10A217738-002NAPROXEN AND ESOMEPRAZOLE MAGNESIUMEQ 20MG BASE;500MGTABLET, DELAYED RELEASE / ORALAB2023-10-119b2671bbb829…
2026-07-26 02:55 UTC · 3 captures of this ZIP2026-06A217738-001NAPROXEN AND ESOMEPRAZOLE MAGNESIUMEQ 20MG BASE;375MGTABLET, DELAYED RELEASE / ORALAB2023-10-11a50c72e98297…
2026-07-26 02:55 UTC · 3 captures of this ZIP2026-06A217738-002NAPROXEN AND ESOMEPRAZOLE MAGNESIUMEQ 20MG BASE;500MGTABLET, DELAYED RELEASE / ORALAB2023-10-11a50c72e98297…

Observed Orange Book normalized TE history#

Captured, Edition, Application-product table
CapturedEditionApplication-productTE codeOrderSource SHA-256
2026-02-19 14:30 UTC2026-02A217738-001AB1011fe1cb6892…
2026-02-19 14:30 UTC2026-02A217738-002AB1011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A217738-001AB131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A217738-002AB131067a03dcf5…
2025-08-23 18:47 UTC2025-08A217738-001AB16a471c1ec25d…
2025-08-23 18:47 UTC2025-08A217738-002AB16a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A217738-001AB1fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A217738-002AB1fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A217738-001AB1b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A217738-002AB1b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A217738-001AB103ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A217738-002AB103ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A217738-001AB12680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A217738-002AB12680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A217738-001AB15bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A217738-002AB15bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A217738-001AB1d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A217738-002AB1d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A217738-001AB1d06236e962d9…
2024-10-29 15:01 UTC2024-10A217738-002AB1d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A217738-001AB179d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A217738-002AB179d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A217738-001AB1301d65b070ca…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A217738-002AB1301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A217738-001AB11e350fbaab3a…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A217738-002AB11e350fbaab3a…
2024-05-31 18:47 UTC2024-05A217738-001AB18072bd15b7f6…
2024-05-31 18:47 UTC2024-05A217738-002AB18072bd15b7f6…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A217738-001AB16a51e52b5d6a…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A217738-002AB16a51e52b5d6a…
2024-02-18 07:12 UTC2024-02A217738-001AB11c564ffb4f44…
2024-02-18 07:12 UTC2024-02A217738-002AB11c564ffb4f44…
2023-12-20 04:57 UTC2023-12A217738-001AB1ea1830bbd6c7…
2023-12-20 04:57 UTC2023-12A217738-002AB1ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11A217738-001AB1a72a2bbeb626…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11A217738-002AB1a72a2bbeb626…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10A217738-001AB19b2671bbb829…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10A217738-002AB19b2671bbb829…
2026-07-26 02:55 UTC · 3 captures of this ZIP2026-06A217738-001AB1a50c72e98297…
2026-07-26 02:55 UTC · 3 captures of this ZIP2026-06A217738-002AB1a50c72e98297…

Additional Listing Data#

Finished product
Yes
Brand name base
Naproxen and esomeprazole magnesium
Listing expiration
2027-12-31

Active Ingredients#

Ingredient, Strength table
IngredientStrength
NAPROXEN20 mg/1
ESOMEPRAZOLE MAGNESIUM500 mg/1

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 2 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
57Y76R9ATQInternal UNII lookup
R6DXU4WAY9Internal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
994008Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
4c25c106-b5ca-079f-e063-6394a90a4978Available on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product conceptRelationVersionEffective
d7006a36-e68d-42e2-8cd3-d725cb2e47b1Product name620251027
fef6ad89-235f-4274-ba49-a8e53642473eProduct name220250225
e2db08c6-133f-4f4f-afb4-e90a2418d6f6Product name120230320
87fed3e6-8fba-48ef-96b0-3a7fb54b96ffProduct name320230306
b5fdaaec-7251-4da6-9cb2-4e9e76939ec8Product name120200623
11ed6f83-cdd2-4637-8379-b1a1d3ae3cdeProduct name120181101
e76dbbc1-775d-722c-08ff-ed45e8a80defProduct name320181002
d71865e8-5c35-4d76-8ecd-a7adda982240Product name920180628
86c45a79-b9f0-4476-a27c-6e10db098497Product name120180125
d71865e8-5c35-4d76-8ecd-a7adda982240Product name820171212
094c6751-235c-4d12-acee-2baf94f676f4Product name120151116
6f4f4521-fd56-1ae6-888b-3b021bd75c7cProduct name120140508
ce67e27d-1d21-5465-4409-b0662dd99d4dProduct name120140508

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDCProductDescriptionFormQuantityStrengthSPL version
85509-1438-1Naproxen and esomeprazole magnesium100 in 1 BOTTLETABLET, DELAYED RELEASE1001
85509-1438-3Naproxen and esomeprazole magnesium30 in 1 BOTTLETABLET, DELAYED RELEASE301
85509-1438-6Naproxen and esomeprazole magnesium60 in 1 BOTTLETABLET, DELAYED RELEASE601
85509-1438-9Naproxen and esomeprazole magnesium90 in 1 BOTTLETABLET, DELAYED RELEASE901

DailyMed Billing Units#

Package NDC, Billing unit, Product NDC table
Package NDCBilling unitProduct NDCDailyMed indexing SPLSPL versionEffective
85509-1438-1EA - Each85509-14384f3708dc-ecfb-408b-b1dc-dcaaf5d8625712026-04-20
85509-1438-3EA - Each85509-14386bc8b8b4-9705-4a2d-b269-408b459c10d512026-04-20
85509-1438-6EA - Each85509-14384c7c450d-359c-4e15-a85f-79cb9c79a20912026-04-20
85509-1438-9EA - Each85509-1438eb7c1ff3-c208-4169-ad16-0b166c303a1212026-04-20

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 5 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
Naproxen and esomeprazole magnesiumNAPROXEN AND ESOMEPRAZOLE MAGNESIUMProficient Rx LPcfd4ef00-cfc4-4794-99fe-faa45eb2f6172026-07-01Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 217738
application number: ANDA217738
Naproxen and esomeprazole magnesiumNAPROXEN AND ESOMEPRAZOLE MAGNESIUMPHOENIX RX LLC4c25c106-b5ca-079f-e063-6394a90a49782026-03-03Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 217738
application number: ANDA217738
ndc (product): 85509-1438
Naproxen and esomeprazole magnesiumNAPROXEN AND ESOMEPRAZOLE MAGNESIUMPreferred Pharmaceuticals Inc470496f5-a71d-40b2-bf11-3a8d3d7909622025-07-31Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 217738
application number: ANDA217738
Naproxen and esomeprazole magnesiumNAPROXEN AND ESOMEPRAZOLE MAGNESIUMScieGen Pharmaceuticals, Inc167340c2-1234-4d00-b4e2-cccf3d270fda2025-03-06Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 217738
application number: ANDA217738
Naproxen and esomeprazole magnesiumNAPROXEN AND ESOMEPRAZOLE MAGNESIUMBryant Ranch Prepackf3a3eea2-f6b3-4559-8536-26c1125df3e12025-01-21Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 217738
application number: ANDA217738

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUIRxNorm stringTTYDailyMedSPL version
994008naproxen 500 MG / esomeprazole magnesium 20 MG Delayed Release Oral TabletPSN4c25c106-b5ca-079f-e063-6394a90a49781
994008esomeprazole 20 MG / naproxen 500 MG Delayed Release Oral TabletSCD4c25c106-b5ca-079f-e063-6394a90a49781

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionMarketing startSampleExclude flagStatus
85509-1438-185509143801100 TABLET, DELAYED RELEASE in 1 BOTTLE (85509-1438-1) 2026-03-03NoNoCurrent
85509-1438-38550914380330 TABLET, DELAYED RELEASE in 1 BOTTLE (85509-1438-3) 2026-03-03NoNoCurrent
85509-1438-68550914380660 TABLET, DELAYED RELEASE in 1 BOTTLE (85509-1438-6) 2026-03-03NoNoCurrent
85509-1438-98550914380990 TABLET, DELAYED RELEASE in 1 BOTTLE (85509-1438-9) 2026-03-03NoNoCurrent