acetaminophen 33.3 MG/ML / dextromethorphan hydrobromide 1 MG/ML / doxylamine succinate 0.417 MG/ML Oral Solution
- RxCUI
- 1042684
- RxNorm name
- acetaminophen 33.3 MG/ML / dextromethorphan hydrobromide 1 MG/ML / doxylamine succinate 0.417 MG/ML Oral Solution
- Display name
- Acetaminophen/Dextromethorphan/Doxylamine (Oral Liquid)
- Full name
- acetaminophen 33.3 MG/ML / dextromethorphan hydrobromide 1 MG/ML / doxylamine succinate 0.417 MG/ML Oral Solution
- Term type
- SCD
- Status
- Active
- Strength
- 500-15-6.255 mg/15ml
- Dose form
- Sol
- Route
- Oral Liquid
- Updated
- 2026-06-12 07:02:17
RxNorm Status History#
- Status
- Active
- Source
- RXNORM
- Current
- YES
- Release start
- 122010
- Active start
- 122010
- Multiple ingredient
- YES
- Branded
- NO
Ingredients And Strength#
| Ingredient | Strength | Base | Basis of strength |
|---|---|---|---|
| acetaminophen | 33.3 MG / 1 ML | acetaminophen | acetaminophen |
| dextromethorphan hydrobromide | 1 MG / 1 ML | dextromethorphan | dextromethorphan hydrobromide |
| doxylamine succinate | 0.417 MG / 1 ML | doxylamine | doxylamine succinate |
Dose Form Concepts#
| Dose form | RxCUI |
|---|---|
| Oral Solution | 316968 |
Derived Ingredient Concepts#
| Ingredient | RxCUI |
|---|---|
| acetaminophen | 161 |
| dextromethorphan | 3289 |
| doxylamine | 3642 |
Source Vocabulary Codes#
| Code type | Value | Category |
|---|---|---|
| PRESCRIBABLE | Y | ATTRIBUTES |
| RXNAV_STR | acetaminophen 33.3 MG/ML / dextromethorphan hydrobromide 1 MG/ML / doxylamine succinate 0.417 MG/ML Oral Solution | NAMES |
| RxNorm Name | acetaminophen 33.3 MG/ML / dextromethorphan hydrobromide 1 MG/ML / doxylamine succinate 0.417 MG/ML Oral Solution | NAMES |
| RxNorm Synonym | acetaminophen 1000 MG / dextromethorphan hydrobromide 30 MG / doxylamine succinate 12.5 MG per 30 ML Oral Solution | NAMES |
| RxNorm Synonym | acetaminophen 500 MG / dextromethorphan hydrobromide 15 MG / doxylamine succinate 6.25 MG per 15 ML Oral Solution | NAMES |
| RxNorm Synonym | APAP 33.3 MG/ML / Dextromethorphan Hydrobromide 1 MG/ML / doxylamine succinate 0.417 MG/ML Oral Solution | NAMES |
| TTY | SCD | ATTRIBUTES |
| SPL_SET_ID | 326e3a20-7bcb-0e24-e063-6394a90af327 | CODES |
| SPL_SET_ID | 32bea3dc-9889-22dd-e063-6394a90afa1b | CODES |
| SPL_SET_ID | f81d924e-10e9-0e9d-e053-6294a90a2ddf | CODES |
| RxCUI | 1042684 | CODES |
| MMSL_CODE | BD12767 | CODES |
| MMSL_CODE | BD27137 | CODES |
| MMSL_CODE | CD12767 | CODES |
| MMSL_CODE | CD27137 | CODES |
FDA NDC Products And Packages#
| Package NDC | Product NDC | Name | Labeler | Application |
|---|---|---|---|---|
| 50580-243-01 | 50580-243 | Extra Strength TYLENOL Severe Cough Plus Sore Throat Night Acetaminophen, Dextromethorphan Hydrobromide and Doxylamine Succinate. | Kenvue Brands LLC | M012 |
| 84126-357-08 | 84126-357 | Vicks NyQuil Acetaminophen, Dextromethorphan Hydrobromide, Doxylamine succinate | The Procter & Gamble Manufacturing Company | M012 |
| 84126-357-12 | 84126-357 | Vicks NyQuil Acetaminophen, Dextromethorphan Hydrobromide, Doxylamine succinate | The Procter & Gamble Manufacturing Company | M012 |
Drugs@FDA Applications#
DailyMed RxNorm Mappings#
| Set ID | RxNorm string | TTY | SPL version | Label | Effective |
|---|---|---|---|---|---|
| f81d924e-10e9-0e9d-e053-6294a90a2ddf | acetaminophen 1000 MG / dextromethorphan hydrobromide 30 MG / doxylamine succinate 12.5 MG per 30 ML Oral Solution | SY | 4 | Extra Strength TYLENOL® Severe Cough + Sore Throat Night | 20241107 |
| f81d924e-10e9-0e9d-e053-6294a90a2ddf | acetaminophen 33.3 MG/ML / dextromethorphan hydrobromide 1 MG/ML / doxylamine succinate 0.417 MG/ML Oral Solution | SCD | 4 | Extra Strength TYLENOL® Severe Cough + Sore Throat Night | 20241107 |
| f81d924e-10e9-0e9d-e053-6294a90a2ddf | acetaminophen 500 MG / dextromethorphan hydrobromide 15 MG / doxylamine succinate 6.25 MG per 15 ML Oral Solution | SY | 4 | Extra Strength TYLENOL® Severe Cough + Sore Throat Night | 20241107 |
| f81d924e-10e9-0e9d-e053-6294a90a2ddf | APAP 33.3 MG/ML / Dextromethorphan Hydrobromide 1 MG/ML / doxylamine succinate 0.417 MG/ML Oral Solution | SY | 4 | Extra Strength TYLENOL® Severe Cough + Sore Throat Night | 20241107 |
| f81d924e-10e9-0e9d-e053-6294a90a2ddf | acetaminophen 500 MG / dextromethorphan HBr 15 MG / doxylamine succinate 6.25 MG in 15 mL Oral Solution | PSN | 4 | Extra Strength TYLENOL® Severe Cough + Sore Throat Night | 20241107 |
| 326e3a20-7bcb-0e24-e063-6394a90af327 | acetaminophen 500 MG / dextromethorphan HBr 15 MG / doxylamine succinate 6.25 MG in 15 mL Oral Solution | PSN | 2 | Vicks ® NyQuil™ INTENSE FLU MULTI-SYMPTOM Liquid | 20260324 |
| 326e3a20-7bcb-0e24-e063-6394a90af327 | APAP 33.3 MG/ML / Dextromethorphan Hydrobromide 1 MG/ML / doxylamine succinate 0.417 MG/ML Oral Solution | SY | 2 | Vicks ® NyQuil™ INTENSE FLU MULTI-SYMPTOM Liquid | 20260324 |
| 326e3a20-7bcb-0e24-e063-6394a90af327 | acetaminophen 500 MG / dextromethorphan hydrobromide 15 MG / doxylamine succinate 6.25 MG per 15 ML Oral Solution | SY | 2 | Vicks ® NyQuil™ INTENSE FLU MULTI-SYMPTOM Liquid | 20260324 |
| 326e3a20-7bcb-0e24-e063-6394a90af327 | acetaminophen 33.3 MG/ML / dextromethorphan hydrobromide 1 MG/ML / doxylamine succinate 0.417 MG/ML Oral Solution | SCD | 2 | Vicks ® NyQuil™ INTENSE FLU MULTI-SYMPTOM Liquid | 20260324 |
| 326e3a20-7bcb-0e24-e063-6394a90af327 | acetaminophen 1000 MG / dextromethorphan hydrobromide 30 MG / doxylamine succinate 12.5 MG per 30 ML Oral Solution | SY | 2 | Vicks ® NyQuil™ INTENSE FLU MULTI-SYMPTOM Liquid | 20260324 |
| 8816ec3c-2a26-4bd5-9ba6-8f7fce999470 | acetaminophen 500 MG / dextromethorphan HBr 15 MG / doxylamine succinate 6.25 MG in 15 mL Oral Solution | PSN | 2 | Drug Facts | 20100909 |
| 8816ec3c-2a26-4bd5-9ba6-8f7fce999470 | acetaminophen 1000 MG / dextromethorphan hydrobromide 30 MG / doxylamine succinate 12.5 MG per 30 ML Oral Solution | SY | 2 | Drug Facts | 20100909 |
| 8816ec3c-2a26-4bd5-9ba6-8f7fce999470 | acetaminophen 500 MG / dextromethorphan hydrobromide 15 MG / doxylamine succinate 6.25 MG per 15 ML Oral Solution | SY | 2 | Drug Facts | 20100909 |
| 8816ec3c-2a26-4bd5-9ba6-8f7fce999470 | APAP 33.3 MG/ML / Dextromethorphan Hydrobromide 1 MG/ML / doxylamine succinate 0.417 MG/ML Oral Solution | SY | 2 | Drug Facts | 20100909 |
| 8816ec3c-2a26-4bd5-9ba6-8f7fce999470 | acetaminophen 33.3 MG/ML / dextromethorphan hydrobromide 1 MG/ML / doxylamine succinate 0.417 MG/ML Oral Solution | SCD | 2 | Drug Facts | 20100909 |
| 32bea3dc-9889-22dd-e063-6394a90afa1b | acetaminophen 500 MG / dextromethorphan HBr 15 MG / doxylamine succinate 6.25 MG in 15 mL Oral Solution | PSN | 1 | Vicks ® DayQuil™ and NyQuil™ INTENSE FLU MULTI-SYMPTOM Liquid Convenience Pack | 20250414 |
| 32bea3dc-9889-22dd-e063-6394a90afa1b | acetaminophen 1000 MG / dextromethorphan hydrobromide 30 MG / doxylamine succinate 12.5 MG per 30 ML Oral Solution | SY | 1 | Vicks ® DayQuil™ and NyQuil™ INTENSE FLU MULTI-SYMPTOM Liquid Convenience Pack | 20250414 |
| 32bea3dc-9889-22dd-e063-6394a90afa1b | acetaminophen 500 MG / dextromethorphan hydrobromide 15 MG / doxylamine succinate 6.25 MG per 15 ML Oral Solution | SY | 1 | Vicks ® DayQuil™ and NyQuil™ INTENSE FLU MULTI-SYMPTOM Liquid Convenience Pack | 20250414 |
| 32bea3dc-9889-22dd-e063-6394a90afa1b | APAP 33.3 MG/ML / Dextromethorphan Hydrobromide 1 MG/ML / doxylamine succinate 0.417 MG/ML Oral Solution | SY | 1 | Vicks ® DayQuil™ and NyQuil™ INTENSE FLU MULTI-SYMPTOM Liquid Convenience Pack | 20250414 |
| 32bea3dc-9889-22dd-e063-6394a90afa1b | acetaminophen 33.3 MG/ML / dextromethorphan hydrobromide 1 MG/ML / doxylamine succinate 0.417 MG/ML Oral Solution | SCD | 1 | Vicks ® DayQuil™ and NyQuil™ INTENSE FLU MULTI-SYMPTOM Liquid Convenience Pack | 20250414 |
| 015d6dbd-d537-4c14-80c3-a7d4ed077fbf | acetaminophen 1000 MG / dextromethorphan hydrobromide 30 MG / doxylamine succinate 12.5 MG per 30 ML Oral Solution | SY | 1 | Drug Facts | 20110826 |
| 015d6dbd-d537-4c14-80c3-a7d4ed077fbf | acetaminophen 500 MG / dextromethorphan hydrobromide 15 MG / doxylamine succinate 6.25 MG per 15 ML Oral Solution | SY | 1 | Drug Facts | 20110826 |
| 015d6dbd-d537-4c14-80c3-a7d4ed077fbf | acetaminophen 33.3 MG/ML / dextromethorphan hydrobromide 1 MG/ML / doxylamine succinate 0.417 MG/ML Oral Solution | SCD | 1 | Drug Facts | 20110826 |
| 015d6dbd-d537-4c14-80c3-a7d4ed077fbf | APAP 33.3 MG/ML / Dextromethorphan Hydrobromide 1 MG/ML / doxylamine succinate 0.417 MG/ML Oral Solution | SY | 1 | Drug Facts | 20110826 |
| 015d6dbd-d537-4c14-80c3-a7d4ed077fbf | acetaminophen 500 MG / dextromethorphan HBr 15 MG / doxylamine succinate 6.25 MG in 15 mL Oral Solution | PSN | 1 | Drug Facts | 20110826 |
| 28b74efa-fbf4-4cc4-85e8-56807c773ee6 | acetaminophen 1000 MG / dextromethorphan hydrobromide 30 MG / doxylamine succinate 12.5 MG per 30 ML Oral Solution | SY | 1 | Drug Facts | 20110826 |
| 28b74efa-fbf4-4cc4-85e8-56807c773ee6 | acetaminophen 500 MG / dextromethorphan hydrobromide 15 MG / doxylamine succinate 6.25 MG per 15 ML Oral Solution | SY | 1 | Drug Facts | 20110826 |
| 28b74efa-fbf4-4cc4-85e8-56807c773ee6 | APAP 33.3 MG/ML / Dextromethorphan Hydrobromide 1 MG/ML / doxylamine succinate 0.417 MG/ML Oral Solution | SY | 1 | Drug Facts | 20110826 |
| 28b74efa-fbf4-4cc4-85e8-56807c773ee6 | acetaminophen 33.3 MG/ML / dextromethorphan hydrobromide 1 MG/ML / doxylamine succinate 0.417 MG/ML Oral Solution | SCD | 1 | Drug Facts | 20110826 |
| 28b74efa-fbf4-4cc4-85e8-56807c773ee6 | acetaminophen 500 MG / dextromethorphan HBr 15 MG / doxylamine succinate 6.25 MG in 15 mL Oral Solution | PSN | 1 | Drug Facts | 20110826 |
DailyMed Labels#
| Set ID | Title | Manufacturer | Effective |
|---|---|---|---|
| 326e3a20-7bcb-0e24-e063-6394a90af327 | Vicks ® NyQuil™ INTENSE FLU MULTI-SYMPTOM Liquid | The Procter & Gamble Manufacturing Company | 20260324 |
| d6b9fb27-3ef7-47ee-81f2-b9a3ccd6de25 | American Sales Company NIGHTTIME COLD & FLU Drug Facts | American Sales Company | 20260210 |
| 32bea3dc-9889-22dd-e063-6394a90afa1b | Vicks ® DayQuil™ and NyQuil™ INTENSE FLU MULTI-SYMPTOM Liquid Convenience Pack | The Procter & Gamble Manufacturing Company | 20250414 |
| f81d924e-10e9-0e9d-e053-6294a90a2ddf | Extra Strength TYLENOL® Severe Cough + Sore Throat Night | Kenvue Brands LLC | 20241107 |
| 015d6dbd-d537-4c14-80c3-a7d4ed077fbf | Drug Facts | Kareway Product, Inc. | 20110826 |
| 28b74efa-fbf4-4cc4-85e8-56807c773ee6 | Drug Facts | Kareway Product, Inc. | 20110826 |
| 8816ec3c-2a26-4bd5-9ba6-8f7fce999470 | Drug Facts | Pharmalab Enterprises Inc | 20100909 |
Drug Classes#
| Source | Class ID | Class | Type | Relationship | Drug concept |
|---|---|---|---|---|---|
| ATC | R06AA | Aminoalkyl ethers | ATC1-4 | doxylamine | |
| ATC | N02BE | Anilides | ATC1-4 | acetaminophen | |
| ATC | R05DA | Opium alkaloids and derivatives | ATC1-4 | dextromethorphan | |
| FDASPL | N0000175750 | Antihistamine | EPC | has_epc | doxylamine |
| FDASPL | N0000182149 | Sigma-1 Agonist | EPC | has_epc | dextromethorphan |
| FDASPL | N0000181821 | Uncompetitive N-methyl-D-aspartate Receptor Antagonist | EPC | has_epc | dextromethorphan |
| FDASPL | N0000000207 | Histamine Receptor Antagonists | MOA | has_moa | doxylamine |
| FDASPL | N0000182147 | Sigma-1 Receptor Agonists | MOA | has_moa | dextromethorphan |
| FDASPL | N0000181819 | Uncompetitive NMDA Receptor Antagonists | MOA | has_moa | dextromethorphan |
| MEDRT | D000082 | Acetaminophen | CHEM | has_ingredient | acetaminophen |
| MEDRT | D003915 | Dextromethorphan | CHEM | has_ingredient | dextromethorphan hydrobromide |
| MEDRT | D003915 | Dextromethorphan | CHEM | has_ingredient | dextromethorphan |
| MEDRT | D004319 | Doxylamine | CHEM | has_ingredient | doxylamine |
| MEDRT | D004319 | Doxylamine | CHEM | has_ingredient | doxylamine succinate |
| MEDRT | D003371 | Cough | DISEASE | may_treat | dextromethorphan |
| MEDRT | D003371 | Cough | DISEASE | may_prevent | dextromethorphan |
| MEDRT | D003371 | Cough | DISEASE | may_treat | dextromethorphan hydrobromide |
| MEDRT | D003371 | Cough | DISEASE | may_prevent | dextromethorphan hydrobromide |
| MEDRT | D004342 | Drug Hypersensitivity | DISEASE | ci_with | acetaminophen |
| MEDRT | D004342 | Drug Hypersensitivity | DISEASE | ci_with | doxylamine |
| MEDRT | D004342 | Drug Hypersensitivity | DISEASE | ci_with | dextromethorphan |
| MEDRT | D004342 | Drug Hypersensitivity | DISEASE | ci_with | doxylamine succinate |
| MEDRT | D004342 | Drug Hypersensitivity | DISEASE | ci_with | dextromethorphan hydrobromide |
| MEDRT | D005334 | Fever | DISEASE | may_prevent | acetaminophen |
| MEDRT | D005334 | Fever | DISEASE | may_treat | acetaminophen |
| MEDRT | D005955 | Glucosephosphate Dehydrogenase Deficiency | DISEASE | ci_with | acetaminophen |
| MEDRT | D006261 | Headache | DISEASE | may_treat | doxylamine |
| MEDRT | D006261 | Headache | DISEASE | may_treat | doxylamine succinate |
| MEDRT | D008107 | Liver Diseases | DISEASE | ci_with | acetaminophen |
| MEDRT | D010146 | Pain | DISEASE | may_treat | acetaminophen |
| MEDRT | D010146 | Pain | DISEASE | may_prevent | acetaminophen |
| MEDRT | D012221 | Rhinitis, Allergic, Perennial | DISEASE | may_treat | doxylamine |
| MEDRT | D012221 | Rhinitis, Allergic, Perennial | DISEASE | may_treat | doxylamine succinate |
| MEDRT | D007319 | Sleep Initiation and Maintenance Disorders | DISEASE | may_treat | doxylamine |
| MEDRT | D007319 | Sleep Initiation and Maintenance Disorders | DISEASE | may_treat | doxylamine succinate |
| MEDRT | N0000000190 | Histamine H1 Receptor Antagonists | MOA | has_moa | doxylamine succinate |
| MEDRT | N0000000190 | Histamine H1 Receptor Antagonists | MOA | has_moa | doxylamine |
| MEDRT | N0000000184 | Monoamine Oxidase Inhibitors | MOA | ci_moa | dextromethorphan |
| MEDRT | N0000000184 | Monoamine Oxidase Inhibitors | MOA | ci_moa | dextromethorphan hydrobromide |
| MEDRT | N0000000108 | Prostaglandin Receptor Antagonists | MOA | has_moa | acetaminophen |
| MEDRT | N0000000109 | Serotonin Uptake Inhibitors | MOA | has_moa | dextromethorphan hydrobromide |
| MEDRT | N0000000109 | Serotonin Uptake Inhibitors | MOA | has_moa | dextromethorphan |
| MEDRT | N0000182147 | Sigma-1 Receptor Agonists | MOA | has_moa | dextromethorphan hydrobromide |
| MEDRT | N0000182147 | Sigma-1 Receptor Agonists | MOA | has_moa | dextromethorphan |
| MEDRT | N0000181819 | Uncompetitive NMDA Receptor Antagonists | MOA | has_moa | dextromethorphan hydrobromide |
| MEDRT | N0000181819 | Uncompetitive NMDA Receptor Antagonists | MOA | has_moa | dextromethorphan |
| MEDRT | N0000175724 | Central Nervous System Activity Alteration | PE | has_pe | acetaminophen |
| MEDRT | N0000008657 | Decreased Histamine Activity | PE | has_pe | doxylamine succinate |
| MEDRT | N0000008657 | Decreased Histamine Activity | PE | has_pe | doxylamine |
| MEDRT | N0000008701 | Decreased Medullary Respiratory Drive | PE | has_pe | dextromethorphan hydrobromide |
| MEDRT | N0000008701 | Decreased Medullary Respiratory Drive | PE | has_pe | dextromethorphan |
| MEDRT | N0000008836 | Decreased Prostaglandin Production | PE | has_pe | acetaminophen |
| MEDRT | N0000009072 | Hypothalamic Endocrine Activity Alteration | PE | has_pe | acetaminophen |
| MEDRT | N0000175725 | Peripheral Nervous System Activity Alteration | PE | has_pe | acetaminophen |
| MEDRT | N0000000026 | Hepatic Metabolism | PK | has_pk | acetaminophen |
| MEDRT | N0000000042 | Renal Excretion | PK | has_pk | acetaminophen |
Properties#
| Category | Property | Value |
|---|---|---|
| ATTRIBUTES | AVAILABLE_STRENGTH | 33.3 MG/ML / 1 MG/ML / 0.417 MG/ML (expressed as doxylamine succinate) |
| ATTRIBUTES | GENERAL_CARDINALITY | MULTI |
| ATTRIBUTES | HUMAN_DRUG | US |
| ATTRIBUTES | PRESCRIBABLE | Y |
| ATTRIBUTES | RXNAV_HUMAN_DRUG | US |
| ATTRIBUTES | SCHEDULE | 0 |
| ATTRIBUTES | TTY | SCD |
| CODES | MMSL_CODE | BD12767 |
| CODES | MMSL_CODE | BD27137 |
| CODES | MMSL_CODE | CD12767 |
| CODES | MMSL_CODE | CD27137 |
| CODES | RxCUI | 1042684 |
| CODES | SPL_SET_ID | 326e3a20-7bcb-0e24-e063-6394a90af327 |
| CODES | SPL_SET_ID | 32bea3dc-9889-22dd-e063-6394a90afa1b |
| CODES | SPL_SET_ID | f81d924e-10e9-0e9d-e053-6294a90a2ddf |
| CODES | VUID | 4026000 |
| NAMES | Prescribable Synonym | acetaminophen 500 MG / dextromethorphan HBr 15 MG / doxylamine succinate 6.25 MG in 15 mL Oral Solution |
| NAMES | RXNAV_STR | acetaminophen 33.3 MG/ML / dextromethorphan hydrobromide 1 MG/ML / doxylamine succinate 0.417 MG/ML Oral Solution |
| NAMES | RxNorm Name | acetaminophen 33.3 MG/ML / dextromethorphan hydrobromide 1 MG/ML / doxylamine succinate 0.417 MG/ML Oral Solution |
| NAMES | RxNorm Synonym | acetaminophen 1000 MG / dextromethorphan hydrobromide 30 MG / doxylamine succinate 12.5 MG per 30 ML Oral Solution |
| NAMES | RxNorm Synonym | acetaminophen 500 MG / dextromethorphan hydrobromide 15 MG / doxylamine succinate 6.25 MG per 15 ML Oral Solution |
| NAMES | RxNorm Synonym | APAP 33.3 MG/ML / Dextromethorphan Hydrobromide 1 MG/ML / doxylamine succinate 0.417 MG/ML Oral Solution |
| SOURCES | Source | Gold Standard Alchemy |
| SOURCES | Source | Metathesaurus FDA Structured Product Labels |
| SOURCES | Source | Micromedex RED BOOK |
| SOURCES | Source | Multum MediSource Lexicon |
| SOURCES | Source | National Drug Data File Plus Source Vocabulary |