acetaminophen 325 MG / chlorpheniramine maleate 2 MG / dextromethorphan hydrobromide 10 MG / phenylephrine hydrochloride 5 MG Oral Capsule
- RxCUI
- 1042688
- RxNorm name
- acetaminophen 325 MG / chlorpheniramine maleate 2 MG / dextromethorphan hydrobromide 10 MG / phenylephrine hydrochloride 5 MG Oral Capsule
- Display name
- Acetaminophen/Chlorpheniramine/Dextromethorphan/Phenylephrine (Oral Pill)
- Full name
- acetaminophen 325 MG / chlorpheniramine maleate 2 MG / dextromethorphan hydrobromide 10 MG / phenylephrine hydrochloride 5 MG Oral Capsule
- Term type
- SCD
- Status
- Active
- Strength
- 325-2-10-5 mg
- Dose form
- Cap
- Route
- Oral Pill
- Updated
- 2026-06-12 07:02:19
RxNorm Status History#
- Status
- Active
- Source
- RXNORM
- Current
- YES
- Release start
- 122010
- Active start
- 122010
- Multiple ingredient
- YES
- Branded
- NO
Ingredients And Strength#
| Ingredient | Strength | Base | Basis of strength |
|---|---|---|---|
| acetaminophen | 325 MG / 1 EACH | acetaminophen | acetaminophen |
| chlorpheniramine maleate | 2 MG / 1 EACH | chlorpheniramine | chlorpheniramine maleate |
| dextromethorphan hydrobromide | 10 MG / 1 EACH | dextromethorphan | dextromethorphan hydrobromide |
| phenylephrine hydrochloride | 5 MG / 1 EACH | phenylephrine | phenylephrine hydrochloride |
Dose Form Concepts#
| Dose form | RxCUI |
|---|---|
| Oral Capsule | 316965 |
Derived Ingredient Concepts#
| Ingredient | RxCUI |
|---|---|
| acetaminophen | 161 |
| chlorpheniramine | 2400 |
| dextromethorphan | 3289 |
| phenylephrine | 8163 |
Source Vocabulary Codes#
| Code type | Value | Category |
|---|---|---|
| PRESCRIBABLE | Y | ATTRIBUTES |
| RXNAV_STR | acetaminophen 325 MG / chlorpheniramine maleate 2 MG / dextromethorphan hydrobromide 10 MG / phenylephrine hydrochloride 5 MG Oral Capsule | NAMES |
| RxNorm Name | acetaminophen 325 MG / chlorpheniramine maleate 2 MG / dextromethorphan hydrobromide 10 MG / phenylephrine hydrochloride 5 MG Oral Capsule | NAMES |
| RxNorm Synonym | APAP 325 MG / chlorpheniramine maleate 2 MG / dextromethorphan hydrobromide 10 MG / phenylephrine hydrochloride 5 MG Oral Capsule | NAMES |
| TTY | SCD | ATTRIBUTES |
| SPL_SET_ID | 20ae92d9-fbc6-5b7a-e063-6294a90a15c3 | CODES |
| SPL_SET_ID | 51dec468-fbb2-3489-e054-00144ff88e88 | CODES |
| SPL_SET_ID | c483d88f-cb0a-4dd6-b3ae-559521782ba6 | CODES |
| RxCUI | 1042688 | CODES |
| MMSL_CODE | BD39449 | CODES |
| MMSL_CODE | CD39449 | CODES |
FDA NDC Products And Packages#
| Package NDC | Product NDC | Name | Labeler | Application |
|---|---|---|---|---|
| 0280-0092-01 | 0280-0092 | Alka-Seltzer Plus Maximum Strength Cold and Cough Power Max Gels Acetaminophen, Chlorpheniramine malaeate, Dextromethorphan hydrobromide, Phenylephrine hydrochloride | Bayer HealthCare LLC. | M012 |
| 0280-0092-02 | 0280-0092 | Alka-Seltzer Plus Maximum Strength Cold and Cough Power Max Gels Acetaminophen, Chlorpheniramine malaeate, Dextromethorphan hydrobromide, Phenylephrine hydrochloride | Bayer HealthCare LLC. | M012 |
| 0280-1570-10 | 0280-1570 | Alka-Seltzer Plus Maximum Strength Cold and Cough Liquid Gels Acetaminophen, Chlorpheniramine maleate, Dextromethorphan hydrobromide, Phenylephrine hydrochloride | Bayer HealthCare LLC. | M012 |
| 0280-1570-20 | 0280-1570 | Alka-Seltzer Plus Maximum Strength Cold and Cough Liquid Gels Acetaminophen, Chlorpheniramine maleate, Dextromethorphan hydrobromide, Phenylephrine hydrochloride | Bayer HealthCare LLC. | M012 |
| 0280-1570-40 | 0280-1570 | Alka-Seltzer Plus Maximum Strength Cold and Cough Liquid Gels Acetaminophen, Chlorpheniramine maleate, Dextromethorphan hydrobromide, Phenylephrine hydrochloride | Bayer HealthCare LLC. | M012 |
| 53345-045-01 | 53345-045 | Cough and Cold plus Acetaminophen, Phenylephrine HCl, Chlorpheniramine Maleate, Dextromethorphan HBr | Humanwell PuraCap Pharmaceutical (Wuhan) Co., Ltd | M012 |
Drugs@FDA Applications#
DailyMed RxNorm Mappings#
| Set ID | RxNorm string | TTY | SPL version | Label | Effective |
|---|---|---|---|---|---|
| 51dec468-fbb2-3489-e054-00144ff88e88 | APAP 325 MG / chlorpheniramine maleate 2 MG / dextromethorphan hydrobromide 10 MG / phenylephrine hydrochloride 5 MG Oral Capsule | SY | 9 | Alka-Seltzer Plus® Maximum Strength Cold & Cough PowerMax Gels | 20251204 |
| 51dec468-fbb2-3489-e054-00144ff88e88 | acetaminophen 325 MG / chlorpheniramine maleate 2 MG / dextromethorphan hydrobromide 10 MG / phenylephrine hydrochloride 5 MG Oral Capsule | SCD | 9 | Alka-Seltzer Plus® Maximum Strength Cold & Cough PowerMax Gels | 20251204 |
| 51dec468-fbb2-3489-e054-00144ff88e88 | acetaminophen 325 MG / chlorpheniramine maleate 2 MG / dextromethorphan HBr 10 MG / phenylephrine HCl 5 MG Oral Capsule | PSN | 9 | Alka-Seltzer Plus® Maximum Strength Cold & Cough PowerMax Gels | 20251204 |
| c483d88f-cb0a-4dd6-b3ae-559521782ba6 | acetaminophen 325 MG / chlorpheniramine maleate 2 MG / dextromethorphan HBr 10 MG / phenylephrine HCl 5 MG Oral Capsule | PSN | 3 | Cough and Cold plus | 20241125 |
| c483d88f-cb0a-4dd6-b3ae-559521782ba6 | APAP 325 MG / chlorpheniramine maleate 2 MG / dextromethorphan hydrobromide 10 MG / phenylephrine hydrochloride 5 MG Oral Capsule | SY | 3 | Cough and Cold plus | 20241125 |
| c483d88f-cb0a-4dd6-b3ae-559521782ba6 | acetaminophen 325 MG / chlorpheniramine maleate 2 MG / dextromethorphan hydrobromide 10 MG / phenylephrine hydrochloride 5 MG Oral Capsule | SCD | 3 | Cough and Cold plus | 20241125 |
| 20ae92d9-fbc6-5b7a-e063-6294a90a15c3 | acetaminophen 325 MG / chlorpheniramine maleate 2 MG / dextromethorphan HBr 10 MG / phenylephrine HCl 5 MG Oral Capsule | PSN | 2 | Alka-Seltzer Plus® Maximum Strength Cold & Cough Liquid Gels | 20251204 |
| 20ae92d9-fbc6-5b7a-e063-6294a90a15c3 | APAP 325 MG / chlorpheniramine maleate 2 MG / dextromethorphan hydrobromide 10 MG / phenylephrine hydrochloride 5 MG Oral Capsule | SY | 2 | Alka-Seltzer Plus® Maximum Strength Cold & Cough Liquid Gels | 20251204 |
| 20ae92d9-fbc6-5b7a-e063-6294a90a15c3 | acetaminophen 325 MG / chlorpheniramine maleate 2 MG / dextromethorphan hydrobromide 10 MG / phenylephrine hydrochloride 5 MG Oral Capsule | SCD | 2 | Alka-Seltzer Plus® Maximum Strength Cold & Cough Liquid Gels | 20251204 |
DailyMed Labels#
| Set ID | Title | Manufacturer | Effective |
|---|---|---|---|
| 51dec468-fbb2-3489-e054-00144ff88e88 | Alka-Seltzer Plus® Maximum Strength Cold & Cough PowerMax Gels | Bayer HealthCare LLC. | Bayer Healthcare LLC | 20251204 |
| 20ae92d9-fbc6-5b7a-e063-6294a90a15c3 | Alka-Seltzer Plus® Maximum Strength Cold & Cough Liquid Gels | Bayer HealthCare LLC. | 20251204 |
| c483d88f-cb0a-4dd6-b3ae-559521782ba6 | Cough and Cold plus | Humanwell PuraCap Pharmaceutical (Wuhan) Co., Ltd | Humanwell PuraCap Pharmaceutical (Wuhan) Co., Ltd. | 20241125 |
Drug Classes#
| Source | Class ID | Class | Type | Relationship | Drug concept |
|---|---|---|---|---|---|
| ATC | C01CA | Adrenergic and dopaminergic agents | ATC1-4 | phenylephrine | |
| ATC | N02BE | Anilides | ATC1-4 | acetaminophen | |
| ATC | R05DA | Opium alkaloids and derivatives | ATC1-4 | dextromethorphan | |
| ATC | C05AX | Other agents for treatment of hemorrhoids and anal fissures for topical use | ATC1-4 | phenylephrine | |
| ATC | R06AB | Substituted alkylamines | ATC1-4 | chlorpheniramine | |
| ATC | R01BA | Sympathomimetics | ATC1-4 | phenylephrine | |
| ATC | S01FB | Sympathomimetics excl. antiglaucoma preparations | ATC1-4 | phenylephrine | |
| ATC | S01GA | Sympathomimetics used as decongestants | ATC1-4 | phenylephrine | |
| ATC | R01AB | Sympathomimetics, combinations excl. corticosteroids | ATC1-4 | phenylephrine | |
| ATC | R01AA | Sympathomimetics, plain | ATC1-4 | phenylephrine | |
| FDASPL | N0000186105 | alpha-1 Adrenergic Agonist | EPC | has_epc | phenylephrine |
| FDASPL | N0000175587 | Histamine-1 Receptor Antagonist | EPC | has_epc | chlorpheniramine |
| FDASPL | N0000182149 | Sigma-1 Agonist | EPC | has_epc | dextromethorphan |
| FDASPL | N0000181821 | Uncompetitive N-methyl-D-aspartate Receptor Antagonist | EPC | has_epc | dextromethorphan |
| FDASPL | N0000182147 | Sigma-1 Receptor Agonists | MOA | has_moa | dextromethorphan |
| FDASPL | N0000181819 | Uncompetitive NMDA Receptor Antagonists | MOA | has_moa | dextromethorphan |
| MEDRT | D000082 | Acetaminophen | CHEM | has_ingredient | acetaminophen |
| MEDRT | D002744 | Chlorpheniramine | CHEM | has_ingredient | chlorpheniramine maleate |
| MEDRT | D002744 | Chlorpheniramine | CHEM | has_ingredient | chlorpheniramine |
| MEDRT | D003915 | Dextromethorphan | CHEM | has_ingredient | dextromethorphan |
| MEDRT | D003915 | Dextromethorphan | CHEM | has_ingredient | dextromethorphan hydrobromide |
| MEDRT | D010656 | Phenylephrine | CHEM | has_ingredient | phenylephrine |
| MEDRT | D010656 | Phenylephrine | CHEM | has_ingredient | phenylephrine hydrochloride |
| MEDRT | D013447 | Sulfites | CHEM | ci_chemclass | phenylephrine |
| MEDRT | D013447 | Sulfites | CHEM | ci_chemclass | phenylephrine hydrochloride |
| MEDRT | D003371 | Cough | DISEASE | may_treat | dextromethorphan |
| MEDRT | D003371 | Cough | DISEASE | may_prevent | dextromethorphan |
| MEDRT | D003371 | Cough | DISEASE | may_treat | dextromethorphan hydrobromide |
| MEDRT | D003371 | Cough | DISEASE | may_prevent | dextromethorphan hydrobromide |
| MEDRT | D004342 | Drug Hypersensitivity | DISEASE | ci_with | phenylephrine |
| MEDRT | D004342 | Drug Hypersensitivity | DISEASE | ci_with | dextromethorphan hydrobromide |
| MEDRT | D004342 | Drug Hypersensitivity | DISEASE | ci_with | acetaminophen |
| MEDRT | D004342 | Drug Hypersensitivity | DISEASE | ci_with | dextromethorphan |
| MEDRT | D004342 | Drug Hypersensitivity | DISEASE | ci_with | chlorpheniramine maleate |
| MEDRT | D004342 | Drug Hypersensitivity | DISEASE | ci_with | chlorpheniramine |
| MEDRT | D004342 | Drug Hypersensitivity | DISEASE | ci_with | phenylephrine hydrochloride |
| MEDRT | D004380 | Duodenal Obstruction | DISEASE | ci_with | chlorpheniramine maleate |
| MEDRT | D004380 | Duodenal Obstruction | DISEASE | ci_with | chlorpheniramine |
| MEDRT | D005334 | Fever | DISEASE | may_prevent | acetaminophen |
| MEDRT | D005334 | Fever | DISEASE | may_treat | acetaminophen |
| MEDRT | D005401 | Fissure in Ano | DISEASE | may_treat | phenylephrine |
| MEDRT | D005401 | Fissure in Ano | DISEASE | may_treat | phenylephrine hydrochloride |
| MEDRT | D015812 | Glaucoma, Angle-Closure | DISEASE | ci_with | chlorpheniramine maleate |
| MEDRT | D015812 | Glaucoma, Angle-Closure | DISEASE | ci_with | chlorpheniramine |
| MEDRT | D005902 | Glaucoma, Open-Angle | DISEASE | may_treat | phenylephrine |
| MEDRT | D005902 | Glaucoma, Open-Angle | DISEASE | may_treat | phenylephrine hydrochloride |
| MEDRT | D005955 | Glucosephosphate Dehydrogenase Deficiency | DISEASE | ci_with | acetaminophen |
| MEDRT | D006484 | Hemorrhoids | DISEASE | may_treat | phenylephrine |
| MEDRT | D006484 | Hemorrhoids | DISEASE | may_treat | phenylephrine hydrochloride |
| MEDRT | D006973 | Hypertension | DISEASE | ci_with | phenylephrine hydrochloride |
| MEDRT | D006973 | Hypertension | DISEASE | ci_with | phenylephrine |
| MEDRT | D007022 | Hypotension | DISEASE | may_treat | phenylephrine |
| MEDRT | D007022 | Hypotension | DISEASE | may_treat | phenylephrine hydrochloride |
| MEDRT | D007231 | Infant, Newborn | DISEASE | ci_with | chlorpheniramine maleate |
| MEDRT | D007231 | Infant, Newborn | DISEASE | ci_with | chlorpheniramine |
| MEDRT | D007234 | Infant, Premature | DISEASE | ci_with | chlorpheniramine maleate |
| MEDRT | D007234 | Infant, Premature | DISEASE | ci_with | chlorpheniramine |
| MEDRT | D008107 | Liver Diseases | DISEASE | ci_with | acetaminophen |
| MEDRT | D015878 | Mydriasis | DISEASE | induces | phenylephrine hydrochloride |
| MEDRT | D015878 | Mydriasis | DISEASE | induces | phenylephrine |
| MEDRT | D010146 | Pain | DISEASE | may_treat | acetaminophen |
| MEDRT | D010146 | Pain | DISEASE | may_prevent | acetaminophen |
| MEDRT | D010437 | Peptic Ulcer | DISEASE | ci_with | chlorpheniramine maleate |
| MEDRT | D010437 | Peptic Ulcer | DISEASE | ci_with | chlorpheniramine |
| MEDRT | D011470 | Prostatic Hyperplasia | DISEASE | ci_with | chlorpheniramine |
| MEDRT | D011470 | Prostatic Hyperplasia | DISEASE | ci_with | chlorpheniramine maleate |
| MEDRT | D011538 | Pruritus Ani | DISEASE | may_treat | phenylephrine |
| MEDRT | D011538 | Pruritus Ani | DISEASE | may_treat | phenylephrine hydrochloride |
| MEDRT | D012221 | Rhinitis, Allergic, Perennial | DISEASE | may_treat | chlorpheniramine |
| MEDRT | D012221 | Rhinitis, Allergic, Perennial | DISEASE | may_treat | chlorpheniramine maleate |
| MEDRT | D012223 | Rhinitis, Vasomotor | DISEASE | may_treat | phenylephrine |
| MEDRT | D012223 | Rhinitis, Vasomotor | DISEASE | may_treat | phenylephrine hydrochloride |
| MEDRT | D012772 | Shock, Septic | DISEASE | may_treat | phenylephrine hydrochloride |
| MEDRT | D012772 | Shock, Septic | DISEASE | may_treat | phenylephrine |
| MEDRT | D013224 | Status Asthmaticus | DISEASE | ci_with | chlorpheniramine |
| MEDRT | D013224 | Status Asthmaticus | DISEASE | ci_with | chlorpheniramine maleate |
| MEDRT | D013617 | Tachycardia, Supraventricular | DISEASE | may_treat | phenylephrine hydrochloride |
| MEDRT | D013617 | Tachycardia, Supraventricular | DISEASE | may_treat | phenylephrine |
| MEDRT | D017180 | Tachycardia, Ventricular | DISEASE | ci_with | phenylephrine |
| MEDRT | D017180 | Tachycardia, Ventricular | DISEASE | ci_with | phenylephrine hydrochloride |
| MEDRT | D001748 | Urinary Bladder Neck Obstruction | DISEASE | ci_with | chlorpheniramine |
| MEDRT | D001748 | Urinary Bladder Neck Obstruction | DISEASE | ci_with | chlorpheniramine maleate |
| MEDRT | D014581 | Urticaria | DISEASE | may_treat | chlorpheniramine |
| MEDRT | D014581 | Urticaria | DISEASE | may_treat | chlorpheniramine maleate |
| MEDRT | N0000000209 | Adrenergic alpha-Agonists | MOA | has_moa | phenylephrine |
| MEDRT | N0000000209 | Adrenergic alpha-Agonists | MOA | has_moa | phenylephrine hydrochloride |
| MEDRT | N0000000190 | Histamine H1 Receptor Antagonists | MOA | has_moa | chlorpheniramine |
| MEDRT | N0000000190 | Histamine H1 Receptor Antagonists | MOA | has_moa | chlorpheniramine maleate |
| MEDRT | N0000000184 | Monoamine Oxidase Inhibitors | MOA | ci_moa | dextromethorphan |
| MEDRT | N0000000184 | Monoamine Oxidase Inhibitors | MOA | ci_moa | dextromethorphan hydrobromide |
| MEDRT | N0000000108 | Prostaglandin Receptor Antagonists | MOA | has_moa | acetaminophen |
| MEDRT | N0000000109 | Serotonin Uptake Inhibitors | MOA | has_moa | dextromethorphan hydrobromide |
| MEDRT | N0000000109 | Serotonin Uptake Inhibitors | MOA | has_moa | dextromethorphan |
| MEDRT | N0000182147 | Sigma-1 Receptor Agonists | MOA | has_moa | dextromethorphan |
| MEDRT | N0000182147 | Sigma-1 Receptor Agonists | MOA | has_moa | dextromethorphan hydrobromide |
| MEDRT | N0000181819 | Uncompetitive NMDA Receptor Antagonists | MOA | has_moa | dextromethorphan hydrobromide |
| MEDRT | N0000181819 | Uncompetitive NMDA Receptor Antagonists | MOA | has_moa | dextromethorphan |
| MEDRT | N0000175724 | Central Nervous System Activity Alteration | PE | has_pe | acetaminophen |
| MEDRT | N0000008371 | Conjunctival Arterial Vasoconstriction | PE | has_pe | phenylephrine |
| MEDRT | N0000008371 | Conjunctival Arterial Vasoconstriction | PE | has_pe | phenylephrine hydrochloride |
| MEDRT | N0000008657 | Decreased Histamine Activity | PE | has_pe | chlorpheniramine maleate |
| MEDRT | N0000008657 | Decreased Histamine Activity | PE | has_pe | chlorpheniramine |
| MEDRT | N0000008701 | Decreased Medullary Respiratory Drive | PE | has_pe | dextromethorphan hydrobromide |
| MEDRT | N0000008701 | Decreased Medullary Respiratory Drive | PE | has_pe | dextromethorphan |
| MEDRT | N0000008896 | Decreased Nasal and Sinus Secretions | PE | has_pe | phenylephrine |
| MEDRT | N0000008896 | Decreased Nasal and Sinus Secretions | PE | has_pe | phenylephrine hydrochloride |
| MEDRT | N0000008836 | Decreased Prostaglandin Production | PE | has_pe | acetaminophen |
| MEDRT | N0000009072 | Hypothalamic Endocrine Activity Alteration | PE | has_pe | acetaminophen |
| MEDRT | N0000175725 | Peripheral Nervous System Activity Alteration | PE | has_pe | acetaminophen |
| MEDRT | N0000000026 | Hepatic Metabolism | PK | has_pk | acetaminophen |
| MEDRT | N0000000042 | Renal Excretion | PK | has_pk | acetaminophen |
Properties#
| Category | Property | Value |
|---|---|---|
| ATTRIBUTES | AVAILABLE_STRENGTH | 325 MG / 2 MG / 10 MG / 5 MG |
| ATTRIBUTES | GENERAL_CARDINALITY | MULTI |
| ATTRIBUTES | HUMAN_DRUG | US |
| ATTRIBUTES | PRESCRIBABLE | Y |
| ATTRIBUTES | RXNAV_HUMAN_DRUG | US |
| ATTRIBUTES | SCHEDULE | 0 |
| ATTRIBUTES | TTY | SCD |
| CODES | MMSL_CODE | BD39449 |
| CODES | MMSL_CODE | CD39449 |
| CODES | RxCUI | 1042688 |
| CODES | SPL_SET_ID | 20ae92d9-fbc6-5b7a-e063-6294a90a15c3 |
| CODES | SPL_SET_ID | 51dec468-fbb2-3489-e054-00144ff88e88 |
| CODES | SPL_SET_ID | c483d88f-cb0a-4dd6-b3ae-559521782ba6 |
| NAMES | Prescribable Synonym | acetaminophen 325 MG / chlorpheniramine maleate 2 MG / dextromethorphan HBr 10 MG / phenylephrine HCl 5 MG Oral Capsule |
| NAMES | RXNAV_STR | acetaminophen 325 MG / chlorpheniramine maleate 2 MG / dextromethorphan hydrobromide 10 MG / phenylephrine hydrochloride 5 MG Oral Capsule |
| NAMES | RxNorm Name | acetaminophen 325 MG / chlorpheniramine maleate 2 MG / dextromethorphan hydrobromide 10 MG / phenylephrine hydrochloride 5 MG Oral Capsule |
| NAMES | RxNorm Synonym | APAP 325 MG / chlorpheniramine maleate 2 MG / dextromethorphan hydrobromide 10 MG / phenylephrine hydrochloride 5 MG Oral Capsule |
| SOURCES | Source | Gold Standard Alchemy |
| SOURCES | Source | Metathesaurus FDA Structured Product Labels |
| SOURCES | Source | Micromedex RED BOOK |
| SOURCES | Source | Multum MediSource Lexicon |
| SOURCES | Source | National Drug Data File Plus Source Vocabulary |