acetaminophen 21.7 MG/ML / dextromethorphan hydrobromide 0.667 MG/ML / guaifenesin 13.3 MG/ML Oral Solution

RxCUI
1042695
RxNorm name
acetaminophen 21.7 MG/ML / dextromethorphan hydrobromide 0.667 MG/ML / guaifenesin 13.3 MG/ML Oral Solution
Display name
Acetaminophen/Dextromethorphan/guaiFENesin (Oral Liquid)
Full name
acetaminophen 21.7 MG/ML / dextromethorphan hydrobromide 0.667 MG/ML / guaifenesin 13.3 MG/ML Oral Solution
Term type
SCD
Status
Active
Strength
325-10-200 mg/15ml
Dose form
Sol
Route
Oral Liquid
Updated
2026-06-12 07:02:22

RxNorm Status History#

Status
Active
Source
RXNORM
Current
YES
Release start
122010
Active start
122010
Multiple ingredient
YES
Branded
NO

Ingredients And Strength#

Ingredient, Strength, Base table
IngredientStrengthBaseBasis of strength
acetaminophen21.7 MG / 1 MLacetaminophenacetaminophen
dextromethorphan hydrobromide0.667 MG / 1 MLdextromethorphandextromethorphan hydrobromide
guaifenesin13.3 MG / 1 MLguaifenesinguaifenesin

Dose Form Concepts#

Dose form, RxCUI table
Dose formRxCUI
Oral Solution316968

Derived Ingredient Concepts#

Ingredient, RxCUI table
IngredientRxCUI
acetaminophen161
dextromethorphan3289
guaifenesin5032

Source Vocabulary Codes#

FDA NDC Products And Packages#

Package NDC, Product NDC, Name table
Package NDCProduct NDCNameLabelerApplication
0067-0104-080067-0104Theraflu Acetaminophen, Dextromethorphan HBr, GuaifenesinHaleon US Holdings LLCM012
55505-217-3655505-217Safetussin High Blood Pressure and diabetes Acetaminophen, Dextromethorphan Hydrobromide, and GuaifenesinKRAMER LABORATORIESM012

Drugs@FDA Applications#

Application, NDC, Name table
ApplicationNDCNameMarketing categoryLabeler
M0120067-0104Theraflu Acetaminophen, Dextromethorphan HBr, GuaifenesinOTC MONOGRAPH DRUGHaleon US Holdings LLC

RxNav Current And Historical NDCs#

RxNav current and historical NDC rows page 1 of 1 · 5 matching rows.

NDC11, Source, Active table
NDC11SourceActive
00067000712rxnav_ndcsyes
00067010408rxnav_ndcsyes
11523007601rxnav_ndcsyes
55505021736rxnav_ndcsyes
62750002210rxnav_historical

UNII Substances#

UNII substance links page 1 of 1 · 0 matching rows.

No records found.

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 5 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
Safetussin High Blood Pressure and diabetes Cough, Cold and FluACETAMINOPHEN, DEXTROMETHORPHAN HYDROBROMIDE, AND GUAIFENESINKRAMER LABORATORIES279e309c-040d-4001-808d-b7d986a9a1d82025-12-23WarningsExact identifier
ndc (package): 55505-217-36
ndc (product): 55505-217
ndc11 (package): 55505021736
rxcui: 1042695
Theraflu Severe Cold Relief Chest Congestion DaytimeACETAMINOPHEN, DEXTROMETHORPHAN HBR, GUAIFENESINHaleon US Holdings LLC8c821671-dc68-4e27-aa87-b4e45ade98172025-11-13WarningsExact identifier
ndc (package): 0067-0104-08
ndc (product): 0067-0104
ndc11 (package): 00067010408
rxcui: 1042695
Theraflu Severe Cold ReliefACETAMINOPHEN, DEXTROMETHORPHAN HBR, DIPHENPHYDRAMINE HCL, GUAIFENESINHaleon US Holdings LLCb01cc9f5-53f2-40d8-acf1-6de180b3d0bf2024-10-14WarningsExact identifier
ndc (package): 0067-0104-08
ndc11 (package): 00067010408
rxcui: 1042695
Daytime and Nighttime Severe Honey Cold and FluDAYTIME - ACETAMINOPHEN, DEXTROMETHORPHAN HBR, GUAIFENESIN AND NIGHTTIME - ACETAMINOPHEN, DEXTROMETHORPHAN HBR, DOXYLAMINE SUCCINATETARGET CORPORATION0bf915af-a016-0a46-e063-6394a90aacf52023-12-08WarningsExact identifier
rxcui: 1042695
Daytime Severe and Nighttime Severe cold and fluDAYTIME SEVERE - ACETAMINOPHEN, DEXTROMETHORPHAN HBR, GUAIFENESIN AND NIGHTTIME SEVERE-ACETAMINOPHEN, DEXTROMETHORPHAN HBR, DOXYLAMINE SUCCINATETARGET CORPORATION09286d15-b63f-a9de-e063-6294a90ab9482023-11-02WarningsExact identifier
rxcui: 1042695

DailyMed RxNorm Mappings#

Set ID, RxNorm string, TTY table
Set IDRxNorm stringTTYSPL versionLabelEffective
8c821671-dc68-4e27-aa87-b4e45ade9817acetaminophen 21.7 MG/ML / dextromethorphan hydrobromide 0.667 MG/ML / guaifenesin 13.3 MG/ML Oral SolutionSCD5Drug Facts20251113
8c821671-dc68-4e27-aa87-b4e45ade9817acetaminophen 650 MG / dextromethorphan HBr 20 MG / guaiFENesin 400 MG in 30 mL Oral SolutionPSN5Drug Facts20251113
8c821671-dc68-4e27-aa87-b4e45ade9817APAP 21.7 MG/ML / Dextromethorphan Hydrobromide 0.667 MG/ML / Guaifenesin 13.3 MG/ML Oral SolutionSY5Drug Facts20251113
8c821671-dc68-4e27-aa87-b4e45ade9817acetaminophen 650 MG / dextromethorphan HBr 20 MG / guaiFENesin 400 MG in 30 mL Oral SolutionSY5Drug Facts20251113
8c821671-dc68-4e27-aa87-b4e45ade9817acetaminophen 325 MG / dextromethorphan HBr 10 MG / guaiFENesin 200 MG in 15 mL Oral SolutionSY5Drug Facts20251113
279e309c-040d-4001-808d-b7d986a9a1d8acetaminophen 21.7 MG/ML / dextromethorphan hydrobromide 0.667 MG/ML / guaifenesin 13.3 MG/ML Oral SolutionSCD4SAFETUSSIN High Blood Pressure Nighttime COLD & FLU20251223
279e309c-040d-4001-808d-b7d986a9a1d8acetaminophen 325 MG / dextromethorphan HBr 10 MG / guaiFENesin 200 MG in 15 mL Oral SolutionSY4SAFETUSSIN High Blood Pressure Nighttime COLD & FLU20251223
279e309c-040d-4001-808d-b7d986a9a1d8APAP 21.7 MG/ML / Dextromethorphan Hydrobromide 0.667 MG/ML / Guaifenesin 13.3 MG/ML Oral SolutionSY4SAFETUSSIN High Blood Pressure Nighttime COLD & FLU20251223
279e309c-040d-4001-808d-b7d986a9a1d8acetaminophen 650 MG / dextromethorphan HBr 20 MG / guaiFENesin 400 MG in 30 mL Oral SolutionPSN4SAFETUSSIN High Blood Pressure Nighttime COLD & FLU20251223
279e309c-040d-4001-808d-b7d986a9a1d8acetaminophen 650 MG / dextromethorphan HBr 20 MG / guaiFENesin 400 MG in 30 mL Oral SolutionSY4SAFETUSSIN High Blood Pressure Nighttime COLD & FLU20251223
b01cc9f5-53f2-40d8-acf1-6de180b3d0bfacetaminophen 21.7 MG/ML / dextromethorphan hydrobromide 0.667 MG/ML / guaifenesin 13.3 MG/ML Oral SolutionSCD1Drug Facts20241014
b01cc9f5-53f2-40d8-acf1-6de180b3d0bfacetaminophen 325 MG / dextromethorphan HBr 10 MG / guaiFENesin 200 MG in 15 mL Oral SolutionSY1Drug Facts20241014
b01cc9f5-53f2-40d8-acf1-6de180b3d0bfacetaminophen 650 MG / dextromethorphan HBr 20 MG / guaiFENesin 400 MG in 30 mL Oral SolutionPSN1Drug Facts20241014
b01cc9f5-53f2-40d8-acf1-6de180b3d0bfacetaminophen 650 MG / dextromethorphan HBr 20 MG / guaiFENesin 400 MG in 30 mL Oral SolutionSY1Drug Facts20241014
b01cc9f5-53f2-40d8-acf1-6de180b3d0bfAPAP 21.7 MG/ML / Dextromethorphan Hydrobromide 0.667 MG/ML / Guaifenesin 13.3 MG/ML Oral SolutionSY1Drug Facts20241014
0bf915af-a016-0a46-e063-6394a90aacf5acetaminophen 650 MG / dextromethorphan HBr 20 MG / guaiFENesin 400 MG in 30 mL Oral SolutionPSN1745L Target Daytime Severe Honey and Nighttime Severe Honey Cold & Flu Combo Pack (Without PE)20231208
0bf915af-a016-0a46-e063-6394a90aacf5APAP 21.7 MG/ML / Dextromethorphan Hydrobromide 0.667 MG/ML / Guaifenesin 13.3 MG/ML Oral SolutionSY1745L Target Daytime Severe Honey and Nighttime Severe Honey Cold & Flu Combo Pack (Without PE)20231208
0bf915af-a016-0a46-e063-6394a90aacf5acetaminophen 21.7 MG/ML / dextromethorphan hydrobromide 0.667 MG/ML / guaifenesin 13.3 MG/ML Oral SolutionSCD1745L Target Daytime Severe Honey and Nighttime Severe Honey Cold & Flu Combo Pack (Without PE)20231208
0bf915af-a016-0a46-e063-6394a90aacf5acetaminophen 325 MG / dextromethorphan HBr 10 MG / guaiFENesin 200 MG in 15 mL Oral SolutionSY1745L Target Daytime Severe Honey and Nighttime Severe Honey Cold & Flu Combo Pack (Without PE)20231208
0bf915af-a016-0a46-e063-6394a90aacf5acetaminophen 650 MG / dextromethorphan HBr 20 MG / guaiFENesin 400 MG in 30 mL Oral SolutionSY1745L Target Daytime Severe Honey and Nighttime Severe Honey Cold & Flu Combo Pack (Without PE)20231208
09286d15-b63f-a9de-e063-6294a90ab948acetaminophen 21.7 MG/ML / dextromethorphan hydrobromide 0.667 MG/ML / guaifenesin 13.3 MG/ML Oral SolutionSCD1754L Target Daytime Severe and Nighttime Severe Cold and Flu20231102
09286d15-b63f-a9de-e063-6294a90ab948acetaminophen 650 MG / dextromethorphan HBr 20 MG / guaiFENesin 400 MG in 30 mL Oral SolutionSY1754L Target Daytime Severe and Nighttime Severe Cold and Flu20231102
09286d15-b63f-a9de-e063-6294a90ab948acetaminophen 650 MG / dextromethorphan HBr 20 MG / guaiFENesin 400 MG in 30 mL Oral SolutionPSN1754L Target Daytime Severe and Nighttime Severe Cold and Flu20231102
09286d15-b63f-a9de-e063-6294a90ab948APAP 21.7 MG/ML / Dextromethorphan Hydrobromide 0.667 MG/ML / Guaifenesin 13.3 MG/ML Oral SolutionSY1754L Target Daytime Severe and Nighttime Severe Cold and Flu20231102
09286d15-b63f-a9de-e063-6294a90ab948acetaminophen 325 MG / dextromethorphan HBr 10 MG / guaiFENesin 200 MG in 15 mL Oral SolutionSY1754L Target Daytime Severe and Nighttime Severe Cold and Flu20231102

DailyMed Labels#

Set ID, Title, Manufacturer table
Set IDTitleManufacturerEffective
279e309c-040d-4001-808d-b7d986a9a1d8SAFETUSSIN High Blood Pressure Nighttime COLD & FLUKRAMER LABORATORIES20251223
8c821671-dc68-4e27-aa87-b4e45ade9817Drug FactsHaleon US Holdings LLC20251113
b01cc9f5-53f2-40d8-acf1-6de180b3d0bfDrug FactsHaleon US Holdings LLC20241014
c4ba51b8-e86f-4227-e053-2995a90a853eCoricidin HBP Maximum Strength Cold Cough and Flu (Liquid) UI 1614784Bayer HealthCare LLC.20231130

Drug Classes#

Source, Class ID, Class table
SourceClass IDClassTypeRelationshipDrug concept
ATCN02BEAnilidesATC1-4acetaminophen
ATCR05CAExpectorantsATC1-4guaifenesin
ATCR05DAOpium alkaloids and derivativesATC1-4dextromethorphan
FDASPLN0000193956ExpectorantEPChas_epcguaifenesin
FDASPLN0000182149Sigma-1 AgonistEPChas_epcdextromethorphan
FDASPLN0000181821Uncompetitive N-methyl-D-aspartate Receptor AntagonistEPChas_epcdextromethorphan
FDASPLN0000182147Sigma-1 Receptor AgonistsMOAhas_moadextromethorphan
FDASPLN0000181819Uncompetitive NMDA Receptor AntagonistsMOAhas_moadextromethorphan
MEDRTD000082AcetaminophenCHEMhas_ingredientacetaminophen
MEDRTD003915DextromethorphanCHEMhas_ingredientdextromethorphan hydrobromide
MEDRTD003915DextromethorphanCHEMhas_ingredientdextromethorphan
MEDRTD006140GuaifenesinCHEMhas_ingredientguaifenesin
MEDRTD001991BronchitisDISEASEmay_treatguaifenesin
MEDRTD003139Common ColdDISEASEmay_treatguaifenesin
MEDRTD003371CoughDISEASEmay_treatguaifenesin
MEDRTD003371CoughDISEASEmay_preventdextromethorphan hydrobromide
MEDRTD003371CoughDISEASEmay_preventdextromethorphan
MEDRTD003371CoughDISEASEmay_treatdextromethorphan
MEDRTD003371CoughDISEASEmay_treatdextromethorphan hydrobromide
MEDRTD004342Drug HypersensitivityDISEASEci_withdextromethorphan hydrobromide
MEDRTD004342Drug HypersensitivityDISEASEci_withguaifenesin
MEDRTD004342Drug HypersensitivityDISEASEci_withacetaminophen
MEDRTD004342Drug HypersensitivityDISEASEci_withdextromethorphan
MEDRTD005334FeverDISEASEmay_preventacetaminophen
MEDRTD005334FeverDISEASEmay_treatacetaminophen
MEDRTD005955Glucosephosphate Dehydrogenase DeficiencyDISEASEci_withacetaminophen
MEDRTD007827LaryngitisDISEASEmay_treatguaifenesin
MEDRTD008107Liver DiseasesDISEASEci_withacetaminophen
MEDRTD010146PainDISEASEmay_preventacetaminophen
MEDRTD010146PainDISEASEmay_treatacetaminophen
MEDRTD010612PharyngitisDISEASEmay_treatguaifenesin
MEDRTD012221Rhinitis, Allergic, PerennialDISEASEmay_treatguaifenesin
MEDRTD012852SinusitisDISEASEmay_treatguaifenesin
MEDRTD014917Whooping CoughDISEASEmay_treatguaifenesin
MEDRTN0000000184Monoamine Oxidase InhibitorsMOAci_moadextromethorphan
MEDRTN0000000184Monoamine Oxidase InhibitorsMOAci_moadextromethorphan hydrobromide
MEDRTN0000000108Prostaglandin Receptor AntagonistsMOAhas_moaacetaminophen
MEDRTN0000000109Serotonin Uptake InhibitorsMOAhas_moadextromethorphan hydrobromide
MEDRTN0000000109Serotonin Uptake InhibitorsMOAhas_moadextromethorphan
MEDRTN0000182147Sigma-1 Receptor AgonistsMOAhas_moadextromethorphan hydrobromide
MEDRTN0000182147Sigma-1 Receptor AgonistsMOAhas_moadextromethorphan
MEDRTN0000181819Uncompetitive NMDA Receptor AntagonistsMOAhas_moadextromethorphan hydrobromide
MEDRTN0000181819Uncompetitive NMDA Receptor AntagonistsMOAhas_moadextromethorphan
MEDRTN0000175724Central Nervous System Activity AlterationPEhas_peacetaminophen
MEDRTN0000008701Decreased Medullary Respiratory DrivePEhas_pedextromethorphan hydrobromide
MEDRTN0000008701Decreased Medullary Respiratory DrivePEhas_pedextromethorphan
MEDRTN0000008836Decreased Prostaglandin ProductionPEhas_peacetaminophen
MEDRTN0000008867Decreased Respiratory Secretion ViscosityPEhas_peguaifenesin
MEDRTN0000009072Hypothalamic Endocrine Activity AlterationPEhas_peacetaminophen
MEDRTN0000009560Increased Respiratory SecretionsPEhas_peguaifenesin
MEDRTN0000175725Peripheral Nervous System Activity AlterationPEhas_peacetaminophen
MEDRTN0000000026Hepatic MetabolismPKhas_pkacetaminophen
MEDRTN0000000042Renal ExcretionPKhas_pkacetaminophen

Properties#

Category, Property, Value table
CategoryPropertyValue
ATTRIBUTESACTIVATED12/01/2021
ATTRIBUTESAVAILABLE_STRENGTH21.7 MG/ML / 0.667 MG/ML / 13.3 MG/ML
ATTRIBUTESGENERAL_CARDINALITYMULTI
ATTRIBUTESHUMAN_DRUGUS
ATTRIBUTESPRESCRIBABLEY
ATTRIBUTESRXNAV_HUMAN_DRUGUS
ATTRIBUTESSCHEDULE0
ATTRIBUTESTTYSCD
CODESMMSL_CODEBD24791
CODESMMSL_CODECD24791
CODESRxCUI1042695
CODESSPL_SET_ID09286d15-b63f-a9de-e063-6294a90ab948
CODESSPL_SET_ID0bf915af-a016-0a46-e063-6394a90aacf5
CODESSPL_SET_ID279e309c-040d-4001-808d-b7d986a9a1d8
CODESSPL_SET_ID8c821671-dc68-4e27-aa87-b4e45ade9817
CODESSPL_SET_IDb01cc9f5-53f2-40d8-acf1-6de180b3d0bf
NAMESPrescribable Synonymacetaminophen 650 MG / dextromethorphan HBr 20 MG / guaiFENesin 400 MG in 30 mL Oral Solution
NAMESRXNAV_STRacetaminophen 21.7 MG/ML / dextromethorphan hydrobromide 0.667 MG/ML / guaiFENesin 13.3 MG/ML Oral Solution
NAMESRxNorm Nameacetaminophen 21.7 MG/ML / dextromethorphan hydrobromide 0.667 MG/ML / guaifenesin 13.3 MG/ML Oral Solution
NAMESRxNorm Synonymacetaminophen 325 MG / dextromethorphan HBr 10 MG / guaiFENesin 200 MG in 15 mL Oral Solution
NAMESRxNorm Synonymacetaminophen 650 MG / dextromethorphan HBr 20 MG / guaiFENesin 400 MG in 30 mL Oral Solution
NAMESRxNorm SynonymAPAP 21.7 MG/ML / Dextromethorphan Hydrobromide 0.667 MG/ML / Guaifenesin 13.3 MG/ML Oral Solution
NAMESTallman Synonymacetaminophen 21.7 MG/ML / dextromethorphan hydrobromide 0.667 MG/ML / guaiFENesin 13.3 MG/ML Oral Solution
NAMESTallman Synonymacetaminophen 325 MG / dextromethorphan HBr 10 MG / guaiFENesin 200 MG in 15 mL Oral Solution
NAMESTallman Synonymacetaminophen 650 MG / dextromethorphan HBr 20 MG / guaiFENesin 400 MG in 30 mL Oral Solution
NAMESTallman SynonymAPAP 21.7 MG/ML / Dextromethorphan Hydrobromide 0.667 MG/ML / guaiFENesin 13.3 MG/ML Oral Solution
SOURCESSourceMetathesaurus FDA Structured Product Labels
SOURCESSourceMicromedex RED BOOK
SOURCESSourceMultum MediSource Lexicon
SOURCESSourceNational Drug Data File Plus Source Vocabulary