acetaminophen 21.7 MG/ML / dextromethorphan hydrobromide 0.667 MG/ML / guaifenesin 13.3 MG/ML Oral Solution

RxCUI: 1042695
RxNorm name: acetaminophen 21.7 MG/ML / dextromethorphan hydrobromide 0.667 MG/ML / guaifenesin 13.3 MG/ML Oral Solution
Display name: Acetaminophen/Dextromethorphan/guaiFENesin (Oral Liquid)
Full name: acetaminophen 21.7 MG/ML / dextromethorphan hydrobromide 0.667 MG/ML / guaifenesin 13.3 MG/ML Oral Solution
Term type: SCD
Status: Active
Strength: 325-10-200 mg/15ml
Dose form: Sol
Route: Oral Liquid
Updated: 2026-06-12 07:02:22

RxNorm Status History#

Status: Active
Source: RXNORM
Current: YES
Release start: 122010
Active start: 122010
Multiple ingredient: YES
Branded: NO

Ingredients And Strength#

Ingredient, Strength, Base table
Ingredient	Strength	Base	Basis of strength
acetaminophen	21.7 MG / 1 ML	acetaminophen	acetaminophen
dextromethorphan hydrobromide	0.667 MG / 1 ML	dextromethorphan	dextromethorphan hydrobromide
guaifenesin	13.3 MG / 1 ML	guaifenesin	guaifenesin

Dose Form Concepts#

Dose form, RxCUI table
Dose form	RxCUI
Oral Solution	316968

Derived Ingredient Concepts#

Ingredient, RxCUI table
Ingredient	RxCUI
acetaminophen	161
dextromethorphan	3289
guaifenesin	5032

Source Vocabulary Codes#

Code type, Value, Category table
Code type	Value	Category
PRESCRIBABLE	Y	ATTRIBUTES
RXNAV_STR	acetaminophen 21.7 MG/ML / dextromethorphan hydrobromide 0.667 MG/ML / guaiFENesin 13.3 MG/ML Oral Solution	NAMES
RxNorm Name	acetaminophen 21.7 MG/ML / dextromethorphan hydrobromide 0.667 MG/ML / guaifenesin 13.3 MG/ML Oral Solution	NAMES
RxNorm Synonym	acetaminophen 325 MG / dextromethorphan HBr 10 MG / guaiFENesin 200 MG in 15 mL Oral Solution	NAMES
RxNorm Synonym	acetaminophen 650 MG / dextromethorphan HBr 20 MG / guaiFENesin 400 MG in 30 mL Oral Solution	NAMES
RxNorm Synonym	APAP 21.7 MG/ML / Dextromethorphan Hydrobromide 0.667 MG/ML / Guaifenesin 13.3 MG/ML Oral Solution	NAMES
TTY	SCD	ATTRIBUTES
SPL_SET_ID	09286d15-b63f-a9de-e063-6294a90ab948	CODES
SPL_SET_ID	0bf915af-a016-0a46-e063-6394a90aacf5	CODES
SPL_SET_ID	279e309c-040d-4001-808d-b7d986a9a1d8	CODES
SPL_SET_ID	8c821671-dc68-4e27-aa87-b4e45ade9817	CODES
SPL_SET_ID	b01cc9f5-53f2-40d8-acf1-6de180b3d0bf	CODES
RxCUI	1042695	CODES
MMSL_CODE	BD24791	CODES
MMSL_CODE	CD24791	CODES

FDA NDC Products And Packages#

Package NDC, Product NDC, Name table
Package NDC	Product NDC	Name	Labeler	Application
0067-0104-08	0067-0104	Theraflu Acetaminophen, Dextromethorphan HBr, Guaifenesin	Haleon US Holdings LLC	M012
55505-217-36	55505-217	Safetussin High Blood Pressure and diabetes Acetaminophen, Dextromethorphan Hydrobromide, and Guaifenesin	KRAMER LABORATORIES	M012

Drugs@FDA Applications#

Application, NDC, Name table
Application	NDC	Name	Marketing category	Labeler
M012	0067-0104	Theraflu Acetaminophen, Dextromethorphan HBr, Guaifenesin	OTC MONOGRAPH DRUG	Haleon US Holdings LLC

RxNav Current And Historical NDCs#

NDC11, Source, Active table
NDC11	Source	Active
00067000712	rxnav_ndcs	yes
00067010408	rxnav_ndcs	yes
11523007601	rxnav_ndcs	yes
55505021736	rxnav_ndcs	yes
62750002210	rxnav_historical

DailyMed RxNorm Mappings#

Set ID, RxNorm string, TTY table
Set ID	RxNorm string	TTY	SPL version	Label	Effective
8c821671-dc68-4e27-aa87-b4e45ade9817	acetaminophen 21.7 MG/ML / dextromethorphan hydrobromide 0.667 MG/ML / guaifenesin 13.3 MG/ML Oral Solution	SCD	5	Drug Facts	20251113
8c821671-dc68-4e27-aa87-b4e45ade9817	acetaminophen 650 MG / dextromethorphan HBr 20 MG / guaiFENesin 400 MG in 30 mL Oral Solution	PSN	5	Drug Facts	20251113
8c821671-dc68-4e27-aa87-b4e45ade9817	APAP 21.7 MG/ML / Dextromethorphan Hydrobromide 0.667 MG/ML / Guaifenesin 13.3 MG/ML Oral Solution	SY	5	Drug Facts	20251113
8c821671-dc68-4e27-aa87-b4e45ade9817	acetaminophen 650 MG / dextromethorphan HBr 20 MG / guaiFENesin 400 MG in 30 mL Oral Solution	SY	5	Drug Facts	20251113
8c821671-dc68-4e27-aa87-b4e45ade9817	acetaminophen 325 MG / dextromethorphan HBr 10 MG / guaiFENesin 200 MG in 15 mL Oral Solution	SY	5	Drug Facts	20251113
279e309c-040d-4001-808d-b7d986a9a1d8	acetaminophen 21.7 MG/ML / dextromethorphan hydrobromide 0.667 MG/ML / guaifenesin 13.3 MG/ML Oral Solution	SCD	4	SAFETUSSIN High Blood Pressure Nighttime COLD & FLU	20251223
279e309c-040d-4001-808d-b7d986a9a1d8	acetaminophen 325 MG / dextromethorphan HBr 10 MG / guaiFENesin 200 MG in 15 mL Oral Solution	SY	4	SAFETUSSIN High Blood Pressure Nighttime COLD & FLU	20251223
279e309c-040d-4001-808d-b7d986a9a1d8	APAP 21.7 MG/ML / Dextromethorphan Hydrobromide 0.667 MG/ML / Guaifenesin 13.3 MG/ML Oral Solution	SY	4	SAFETUSSIN High Blood Pressure Nighttime COLD & FLU	20251223
279e309c-040d-4001-808d-b7d986a9a1d8	acetaminophen 650 MG / dextromethorphan HBr 20 MG / guaiFENesin 400 MG in 30 mL Oral Solution	PSN	4	SAFETUSSIN High Blood Pressure Nighttime COLD & FLU	20251223
279e309c-040d-4001-808d-b7d986a9a1d8	acetaminophen 650 MG / dextromethorphan HBr 20 MG / guaiFENesin 400 MG in 30 mL Oral Solution	SY	4	SAFETUSSIN High Blood Pressure Nighttime COLD & FLU	20251223
b01cc9f5-53f2-40d8-acf1-6de180b3d0bf	acetaminophen 21.7 MG/ML / dextromethorphan hydrobromide 0.667 MG/ML / guaifenesin 13.3 MG/ML Oral Solution	SCD	1	Drug Facts	20241014
b01cc9f5-53f2-40d8-acf1-6de180b3d0bf	acetaminophen 325 MG / dextromethorphan HBr 10 MG / guaiFENesin 200 MG in 15 mL Oral Solution	SY	1	Drug Facts	20241014
b01cc9f5-53f2-40d8-acf1-6de180b3d0bf	acetaminophen 650 MG / dextromethorphan HBr 20 MG / guaiFENesin 400 MG in 30 mL Oral Solution	PSN	1	Drug Facts	20241014
b01cc9f5-53f2-40d8-acf1-6de180b3d0bf	acetaminophen 650 MG / dextromethorphan HBr 20 MG / guaiFENesin 400 MG in 30 mL Oral Solution	SY	1	Drug Facts	20241014
b01cc9f5-53f2-40d8-acf1-6de180b3d0bf	APAP 21.7 MG/ML / Dextromethorphan Hydrobromide 0.667 MG/ML / Guaifenesin 13.3 MG/ML Oral Solution	SY	1	Drug Facts	20241014
0bf915af-a016-0a46-e063-6394a90aacf5	acetaminophen 650 MG / dextromethorphan HBr 20 MG / guaiFENesin 400 MG in 30 mL Oral Solution	PSN	1	745L Target Daytime Severe Honey and Nighttime Severe Honey Cold & Flu Combo Pack (Without PE)	20231208
0bf915af-a016-0a46-e063-6394a90aacf5	APAP 21.7 MG/ML / Dextromethorphan Hydrobromide 0.667 MG/ML / Guaifenesin 13.3 MG/ML Oral Solution	SY	1	745L Target Daytime Severe Honey and Nighttime Severe Honey Cold & Flu Combo Pack (Without PE)	20231208
0bf915af-a016-0a46-e063-6394a90aacf5	acetaminophen 21.7 MG/ML / dextromethorphan hydrobromide 0.667 MG/ML / guaifenesin 13.3 MG/ML Oral Solution	SCD	1	745L Target Daytime Severe Honey and Nighttime Severe Honey Cold & Flu Combo Pack (Without PE)	20231208
0bf915af-a016-0a46-e063-6394a90aacf5	acetaminophen 325 MG / dextromethorphan HBr 10 MG / guaiFENesin 200 MG in 15 mL Oral Solution	SY	1	745L Target Daytime Severe Honey and Nighttime Severe Honey Cold & Flu Combo Pack (Without PE)	20231208
0bf915af-a016-0a46-e063-6394a90aacf5	acetaminophen 650 MG / dextromethorphan HBr 20 MG / guaiFENesin 400 MG in 30 mL Oral Solution	SY	1	745L Target Daytime Severe Honey and Nighttime Severe Honey Cold & Flu Combo Pack (Without PE)	20231208
09286d15-b63f-a9de-e063-6294a90ab948	acetaminophen 21.7 MG/ML / dextromethorphan hydrobromide 0.667 MG/ML / guaifenesin 13.3 MG/ML Oral Solution	SCD	1	754L Target Daytime Severe and Nighttime Severe Cold and Flu	20231102
09286d15-b63f-a9de-e063-6294a90ab948	acetaminophen 650 MG / dextromethorphan HBr 20 MG / guaiFENesin 400 MG in 30 mL Oral Solution	SY	1	754L Target Daytime Severe and Nighttime Severe Cold and Flu	20231102
09286d15-b63f-a9de-e063-6294a90ab948	acetaminophen 650 MG / dextromethorphan HBr 20 MG / guaiFENesin 400 MG in 30 mL Oral Solution	PSN	1	754L Target Daytime Severe and Nighttime Severe Cold and Flu	20231102
09286d15-b63f-a9de-e063-6294a90ab948	APAP 21.7 MG/ML / Dextromethorphan Hydrobromide 0.667 MG/ML / Guaifenesin 13.3 MG/ML Oral Solution	SY	1	754L Target Daytime Severe and Nighttime Severe Cold and Flu	20231102
09286d15-b63f-a9de-e063-6294a90ab948	acetaminophen 325 MG / dextromethorphan HBr 10 MG / guaiFENesin 200 MG in 15 mL Oral Solution	SY	1	754L Target Daytime Severe and Nighttime Severe Cold and Flu	20231102

DailyMed Labels#

Set ID, Title, Manufacturer table
Set ID	Title	Manufacturer	Effective
279e309c-040d-4001-808d-b7d986a9a1d8	SAFETUSSIN High Blood Pressure Nighttime COLD & FLU	KRAMER LABORATORIES	20251223
8c821671-dc68-4e27-aa87-b4e45ade9817	Drug Facts	Haleon US Holdings LLC	20251113
b01cc9f5-53f2-40d8-acf1-6de180b3d0bf	Drug Facts	Haleon US Holdings LLC	20241014

Drug Classes#

Source, Class ID, Class table
Source	Class ID	Class	Type	Relationship	Drug concept
ATC	N02BE	Anilides	ATC1-4		acetaminophen
ATC	R05CA	Expectorants	ATC1-4		guaifenesin
ATC	R05DA	Opium alkaloids and derivatives	ATC1-4		dextromethorphan
FDASPL	N0000193956	Expectorant	EPC	has_epc	guaifenesin
FDASPL	N0000182149	Sigma-1 Agonist	EPC	has_epc	dextromethorphan
FDASPL	N0000181821	Uncompetitive N-methyl-D-aspartate Receptor Antagonist	EPC	has_epc	dextromethorphan
FDASPL	N0000182147	Sigma-1 Receptor Agonists	MOA	has_moa	dextromethorphan
FDASPL	N0000181819	Uncompetitive NMDA Receptor Antagonists	MOA	has_moa	dextromethorphan
MEDRT	D000082	Acetaminophen	CHEM	has_ingredient	acetaminophen
MEDRT	D003915	Dextromethorphan	CHEM	has_ingredient	dextromethorphan hydrobromide
MEDRT	D003915	Dextromethorphan	CHEM	has_ingredient	dextromethorphan
MEDRT	D006140	Guaifenesin	CHEM	has_ingredient	guaifenesin
MEDRT	D001991	Bronchitis	DISEASE	may_treat	guaifenesin
MEDRT	D003139	Common Cold	DISEASE	may_treat	guaifenesin
MEDRT	D003371	Cough	DISEASE	may_treat	guaifenesin
MEDRT	D003371	Cough	DISEASE	may_prevent	dextromethorphan hydrobromide
MEDRT	D003371	Cough	DISEASE	may_prevent	dextromethorphan
MEDRT	D003371	Cough	DISEASE	may_treat	dextromethorphan
MEDRT	D003371	Cough	DISEASE	may_treat	dextromethorphan hydrobromide
MEDRT	D004342	Drug Hypersensitivity	DISEASE	ci_with	dextromethorphan hydrobromide
MEDRT	D004342	Drug Hypersensitivity	DISEASE	ci_with	guaifenesin
MEDRT	D004342	Drug Hypersensitivity	DISEASE	ci_with	acetaminophen
MEDRT	D004342	Drug Hypersensitivity	DISEASE	ci_with	dextromethorphan
MEDRT	D005334	Fever	DISEASE	may_prevent	acetaminophen
MEDRT	D005334	Fever	DISEASE	may_treat	acetaminophen
MEDRT	D005955	Glucosephosphate Dehydrogenase Deficiency	DISEASE	ci_with	acetaminophen
MEDRT	D007827	Laryngitis	DISEASE	may_treat	guaifenesin
MEDRT	D008107	Liver Diseases	DISEASE	ci_with	acetaminophen
MEDRT	D010146	Pain	DISEASE	may_prevent	acetaminophen
MEDRT	D010146	Pain	DISEASE	may_treat	acetaminophen
MEDRT	D010612	Pharyngitis	DISEASE	may_treat	guaifenesin
MEDRT	D012221	Rhinitis, Allergic, Perennial	DISEASE	may_treat	guaifenesin
MEDRT	D012852	Sinusitis	DISEASE	may_treat	guaifenesin
MEDRT	D014917	Whooping Cough	DISEASE	may_treat	guaifenesin
MEDRT	N0000000184	Monoamine Oxidase Inhibitors	MOA	ci_moa	dextromethorphan
MEDRT	N0000000184	Monoamine Oxidase Inhibitors	MOA	ci_moa	dextromethorphan hydrobromide
MEDRT	N0000000108	Prostaglandin Receptor Antagonists	MOA	has_moa	acetaminophen
MEDRT	N0000000109	Serotonin Uptake Inhibitors	MOA	has_moa	dextromethorphan hydrobromide
MEDRT	N0000000109	Serotonin Uptake Inhibitors	MOA	has_moa	dextromethorphan
MEDRT	N0000182147	Sigma-1 Receptor Agonists	MOA	has_moa	dextromethorphan hydrobromide
MEDRT	N0000182147	Sigma-1 Receptor Agonists	MOA	has_moa	dextromethorphan
MEDRT	N0000181819	Uncompetitive NMDA Receptor Antagonists	MOA	has_moa	dextromethorphan hydrobromide
MEDRT	N0000181819	Uncompetitive NMDA Receptor Antagonists	MOA	has_moa	dextromethorphan
MEDRT	N0000175724	Central Nervous System Activity Alteration	PE	has_pe	acetaminophen
MEDRT	N0000008701	Decreased Medullary Respiratory Drive	PE	has_pe	dextromethorphan hydrobromide
MEDRT	N0000008701	Decreased Medullary Respiratory Drive	PE	has_pe	dextromethorphan
MEDRT	N0000008836	Decreased Prostaglandin Production	PE	has_pe	acetaminophen
MEDRT	N0000008867	Decreased Respiratory Secretion Viscosity	PE	has_pe	guaifenesin
MEDRT	N0000009072	Hypothalamic Endocrine Activity Alteration	PE	has_pe	acetaminophen
MEDRT	N0000009560	Increased Respiratory Secretions	PE	has_pe	guaifenesin
MEDRT	N0000175725	Peripheral Nervous System Activity Alteration	PE	has_pe	acetaminophen
MEDRT	N0000000026	Hepatic Metabolism	PK	has_pk	acetaminophen
MEDRT	N0000000042	Renal Excretion	PK	has_pk	acetaminophen

Group, Type, Concept table
Group	Type	Concept	Source
DF	DF	Oral Solution	rxnav_allrelated
DFG	DFG	Oral Liquid Product	rxnav_allrelated
DFG	DFG	Oral Product	rxnav_allrelated
GPCK	GPCK	{1 (acetaminophen 21.7 MG/ML / dextromethorphan hydrobromide 0.667 MG/ML / guaifenesin 13.3 MG/ML Oral Solution) / 1 (acetaminophen 21.7 MG/ML / diphenhydramine hydrochloride 0.833 MG/ML Oral Solution) } Pack	rxnav_allrelated
IN	IN	acetaminophen	rxnav_allrelated
IN	IN	dextromethorphan	rxnav_allrelated
IN	IN	guaifenesin	rxnav_allrelated
MIN	MIN	acetaminophen / dextromethorphan / guaifenesin	rxnav_allrelated
PIN	PIN	dextromethorphan hydrobromide	rxnav_allrelated
SCD	SCD	acetaminophen 21.7 MG/ML / dextromethorphan hydrobromide 0.667 MG/ML / guaifenesin 13.3 MG/ML Oral Solution	rxnav_allrelated
SCDC	SCDC	acetaminophen 21.7 MG/ML	rxnav_allrelated
SCDC	SCDC	dextromethorphan hydrobromide 0.667 MG/ML	rxnav_allrelated
SCDC	SCDC	guaifenesin 13.3 MG/ML	rxnav_allrelated
SCDF	SCDF	acetaminophen / dextromethorphan / guaifenesin Oral Solution	rxnav_allrelated
SCDFP	SCDFP	acetaminophen / dextromethorphan hydrobromide / guaifenesin Oral Solution	rxnav_allrelated
SCDG	SCDG	acetaminophen / dextromethorphan / guaifenesin Oral Liquid Product	rxnav_allrelated
SCDG	SCDG	acetaminophen / dextromethorphan / guaifenesin Oral Product	rxnav_allrelated
SCDGP	SCDGP	acetaminophen / dextromethorphan hydrobromide / guaifenesin Oral Liquid Product	rxnav_allrelated
SCDGP	SCDGP	acetaminophen / dextromethorphan hydrobromide / guaifenesin Oral Product	rxnav_allrelated

Properties#

Category, Property, Value table
Category	Property	Value
ATTRIBUTES	ACTIVATED	12/01/2021
ATTRIBUTES	AVAILABLE_STRENGTH	21.7 MG/ML / 0.667 MG/ML / 13.3 MG/ML
ATTRIBUTES	GENERAL_CARDINALITY	MULTI
ATTRIBUTES	HUMAN_DRUG	US
ATTRIBUTES	PRESCRIBABLE	Y
ATTRIBUTES	RXNAV_HUMAN_DRUG	US
ATTRIBUTES	SCHEDULE	0
ATTRIBUTES	TTY	SCD
CODES	MMSL_CODE	BD24791
CODES	MMSL_CODE	CD24791
CODES	RxCUI	1042695
CODES	SPL_SET_ID	09286d15-b63f-a9de-e063-6294a90ab948
CODES	SPL_SET_ID	0bf915af-a016-0a46-e063-6394a90aacf5
CODES	SPL_SET_ID	279e309c-040d-4001-808d-b7d986a9a1d8
CODES	SPL_SET_ID	8c821671-dc68-4e27-aa87-b4e45ade9817
CODES	SPL_SET_ID	b01cc9f5-53f2-40d8-acf1-6de180b3d0bf
NAMES	Prescribable Synonym	acetaminophen 650 MG / dextromethorphan HBr 20 MG / guaiFENesin 400 MG in 30 mL Oral Solution
NAMES	RXNAV_STR	acetaminophen 21.7 MG/ML / dextromethorphan hydrobromide 0.667 MG/ML / guaiFENesin 13.3 MG/ML Oral Solution
NAMES	RxNorm Name	acetaminophen 21.7 MG/ML / dextromethorphan hydrobromide 0.667 MG/ML / guaifenesin 13.3 MG/ML Oral Solution
NAMES	RxNorm Synonym	acetaminophen 325 MG / dextromethorphan HBr 10 MG / guaiFENesin 200 MG in 15 mL Oral Solution
NAMES	RxNorm Synonym	acetaminophen 650 MG / dextromethorphan HBr 20 MG / guaiFENesin 400 MG in 30 mL Oral Solution
NAMES	RxNorm Synonym	APAP 21.7 MG/ML / Dextromethorphan Hydrobromide 0.667 MG/ML / Guaifenesin 13.3 MG/ML Oral Solution
NAMES	Tallman Synonym	acetaminophen 21.7 MG/ML / dextromethorphan hydrobromide 0.667 MG/ML / guaiFENesin 13.3 MG/ML Oral Solution
NAMES	Tallman Synonym	acetaminophen 325 MG / dextromethorphan HBr 10 MG / guaiFENesin 200 MG in 15 mL Oral Solution
NAMES	Tallman Synonym	acetaminophen 650 MG / dextromethorphan HBr 20 MG / guaiFENesin 400 MG in 30 mL Oral Solution
NAMES	Tallman Synonym	APAP 21.7 MG/ML / Dextromethorphan Hydrobromide 0.667 MG/ML / guaiFENesin 13.3 MG/ML Oral Solution
SOURCES	Source	Metathesaurus FDA Structured Product Labels
SOURCES	Source	Micromedex RED BOOK
SOURCES	Source	Multum MediSource Lexicon
SOURCES	Source	National Drug Data File Plus Source Vocabulary

acetaminophen 21.7 MG/ML / dextromethorphan hydrobromide 0.667 MG/ML / guaifenesin 13.3 MG/ML Oral Solution

RxNorm Status History#

Ingredients And Strength#

Dose Form Concepts#

Derived Ingredient Concepts#

Source Vocabulary Codes#

FDA NDC Products And Packages#

Drugs@FDA Applications#

RxNav Current And Historical NDCs#

DailyMed RxNorm Mappings#

DailyMed Labels#

Drug Classes#

Related Concepts#

Properties#