acetaminophen 21.7 MG/ML / chlorpheniramine maleate 0.133 MG/ML / dextromethorphan hydrobromide 1 MG/ML Oral Solution

RxCUI: 1046384
RxNorm name: acetaminophen 21.7 MG/ML / chlorpheniramine maleate 0.133 MG/ML / dextromethorphan hydrobromide 1 MG/ML Oral Solution
Display name: Acetaminophen/Chlorpheniramine/Dextromethorphan (Oral Liquid)
Full name: acetaminophen 21.7 MG/ML / chlorpheniramine maleate 0.133 MG/ML / dextromethorphan hydrobromide 1 MG/ML Oral Solution
Term type: SCD
Status: Active
Strength: 650-4.0-30 mg/30ml
Dose form: Sol
Route: Oral Liquid
Updated: 2026-06-12 07:03:09

RxNorm Status History#

Status: Active
Source: RXNORM
Current: YES
Release start: 122010
Active start: 122010
Multiple ingredient: YES
Branded: NO

Ingredients And Strength#

Ingredient, Strength, Base table
Ingredient	Strength	Base	Basis of strength
acetaminophen	21.7 MG / 1 ML	acetaminophen	acetaminophen
chlorpheniramine maleate	0.133 MG / 1 ML	chlorpheniramine	chlorpheniramine maleate
dextromethorphan hydrobromide	1 MG / 1 ML	dextromethorphan	dextromethorphan hydrobromide

Dose Form Concepts#

Dose form, RxCUI table
Dose form	RxCUI
Oral Solution	316968

Derived Ingredient Concepts#

Ingredient, RxCUI table
Ingredient	RxCUI
acetaminophen	161
chlorpheniramine	2400
dextromethorphan	3289

Source Vocabulary Codes#

Code type, Value, Category table
Code type	Value	Category
PRESCRIBABLE	Y	ATTRIBUTES
RXNAV_STR	acetaminophen 21.7 MG/ML / chlorpheniramine maleate 0.133 MG/ML / dextromethorphan hydrobromide 1 MG/ML Oral Solution	NAMES
RxNorm Name	acetaminophen 21.7 MG/ML / chlorpheniramine maleate 0.133 MG/ML / dextromethorphan hydrobromide 1 MG/ML Oral Solution	NAMES
RxNorm Synonym	acetaminophen 325 MG / chlorpheniramine maleate 2 MG / dextromethorphan hydrobromide 15 MG per 15 ML Oral Solution	NAMES
RxNorm Synonym	acetaminophen 650 MG / chlorpheniramine maleate 4 MG / dextromethorphan hydrobromide 30 MG per 30 ML Oral Solution	NAMES
RxNorm Synonym	APAP 21.7 MG/ML / Chlorpheniramine Maleate 0.133 MG/ML / Dextromethorphan Hydrobromide 1 MG/ML Oral Solution	NAMES
TTY	SCD	ATTRIBUTES
SPL_SET_ID	ec57c15e-cb6d-44a9-e053-2a95a90ae774	CODES
RxCUI	1046384	CODES
MMSL_CODE	BD28704	CODES
MMSL_CODE	CD28704	CODES

FDA NDC Products And Packages#

Package NDC, Product NDC, Name table
Package NDC	Product NDC	Name	Labeler	Application
69423-899-12	69423-899	Vicks NyQuil Alcohol Free Acetaminophen, Chlorpheniramine maleate, and Dextromethorphan Hydrobromide	The Procter & Gamble Manufacturing Company	M012

Drugs@FDA Applications#

Application, NDC, Name table
Application	NDC	Name	Marketing category	Labeler
M012	69423-899	Vicks NyQuil Alcohol Free Acetaminophen, Chlorpheniramine maleate, and Dextromethorphan Hydrobromide	OTC MONOGRAPH DRUG	The Procter & Gamble Manufacturing Company

RxNav Current And Historical NDCs#

NDC11, Source, Active table
NDC11	Source	Active
37000069912	rxnav_ndcs	yes
69423089912	rxnav_ndcs	yes
23900001434	rxnav_historical_indirect
37000069906	rxnav_historical
37000069908	rxnav_historical
37000069910	rxnav_historical
69842010002	rxnav_historical

DailyMed RxNorm Mappings#

Set ID, RxNorm string, TTY table
Set ID	RxNorm string	TTY	SPL version	Label	Effective
ec57c15e-cb6d-44a9-e053-2a95a90ae774	APAP 21.7 MG/ML / Chlorpheniramine Maleate 0.133 MG/ML / Dextromethorphan Hydrobromide 1 MG/ML Oral Solution	SY	7	VICKS ® NyQuil Alcohol Free COLD & FLU	20251201
ec57c15e-cb6d-44a9-e053-2a95a90ae774	acetaminophen 650 MG / chlorpheniramine maleate 4 MG / dextromethorphan HBr 30 MG in 30 mL Oral Solution	PSN	7	VICKS ® NyQuil Alcohol Free COLD & FLU	20251201
ec57c15e-cb6d-44a9-e053-2a95a90ae774	acetaminophen 21.7 MG/ML / chlorpheniramine maleate 0.133 MG/ML / dextromethorphan hydrobromide 1 MG/ML Oral Solution	SCD	7	VICKS ® NyQuil Alcohol Free COLD & FLU	20251201
ec57c15e-cb6d-44a9-e053-2a95a90ae774	acetaminophen 650 MG / chlorpheniramine maleate 4 MG / dextromethorphan hydrobromide 30 MG per 30 ML Oral Solution	SY	7	VICKS ® NyQuil Alcohol Free COLD & FLU	20251201
ec57c15e-cb6d-44a9-e053-2a95a90ae774	acetaminophen 325 MG / chlorpheniramine maleate 2 MG / dextromethorphan hydrobromide 15 MG per 15 ML Oral Solution	SY	7	VICKS ® NyQuil Alcohol Free COLD & FLU	20251201

DailyMed Labels#

Set ID, Title, Manufacturer table
Set ID	Title	Manufacturer	Effective
ec57c15e-cb6d-44a9-e053-2a95a90ae774	VICKS ® NyQuil Alcohol Free COLD & FLU	The Procter & Gamble Manufacturing Company	20251201

Drug Classes#

Source, Class ID, Class table
Source	Class ID	Class	Type	Relationship	Drug concept
ATC	N02BE	Anilides	ATC1-4		acetaminophen
ATC	R05DA	Opium alkaloids and derivatives	ATC1-4		dextromethorphan
ATC	R06AB	Substituted alkylamines	ATC1-4		chlorpheniramine
FDASPL	N0000175587	Histamine-1 Receptor Antagonist	EPC	has_epc	chlorpheniramine
FDASPL	N0000182149	Sigma-1 Agonist	EPC	has_epc	dextromethorphan
FDASPL	N0000181821	Uncompetitive N-methyl-D-aspartate Receptor Antagonist	EPC	has_epc	dextromethorphan
FDASPL	N0000182147	Sigma-1 Receptor Agonists	MOA	has_moa	dextromethorphan
FDASPL	N0000181819	Uncompetitive NMDA Receptor Antagonists	MOA	has_moa	dextromethorphan
MEDRT	D000082	Acetaminophen	CHEM	has_ingredient	acetaminophen
MEDRT	D002744	Chlorpheniramine	CHEM	has_ingredient	chlorpheniramine maleate
MEDRT	D002744	Chlorpheniramine	CHEM	has_ingredient	chlorpheniramine
MEDRT	D003915	Dextromethorphan	CHEM	has_ingredient	dextromethorphan hydrobromide
MEDRT	D003915	Dextromethorphan	CHEM	has_ingredient	dextromethorphan
MEDRT	D003371	Cough	DISEASE	may_treat	dextromethorphan hydrobromide
MEDRT	D003371	Cough	DISEASE	may_treat	dextromethorphan
MEDRT	D003371	Cough	DISEASE	may_prevent	dextromethorphan
MEDRT	D003371	Cough	DISEASE	may_prevent	dextromethorphan hydrobromide
MEDRT	D004342	Drug Hypersensitivity	DISEASE	ci_with	dextromethorphan hydrobromide
MEDRT	D004342	Drug Hypersensitivity	DISEASE	ci_with	dextromethorphan
MEDRT	D004342	Drug Hypersensitivity	DISEASE	ci_with	chlorpheniramine maleate
MEDRT	D004342	Drug Hypersensitivity	DISEASE	ci_with	chlorpheniramine
MEDRT	D004342	Drug Hypersensitivity	DISEASE	ci_with	acetaminophen
MEDRT	D004380	Duodenal Obstruction	DISEASE	ci_with	chlorpheniramine
MEDRT	D004380	Duodenal Obstruction	DISEASE	ci_with	chlorpheniramine maleate
MEDRT	D005334	Fever	DISEASE	may_prevent	acetaminophen
MEDRT	D005334	Fever	DISEASE	may_treat	acetaminophen
MEDRT	D015812	Glaucoma, Angle-Closure	DISEASE	ci_with	chlorpheniramine maleate
MEDRT	D015812	Glaucoma, Angle-Closure	DISEASE	ci_with	chlorpheniramine
MEDRT	D005955	Glucosephosphate Dehydrogenase Deficiency	DISEASE	ci_with	acetaminophen
MEDRT	D007231	Infant, Newborn	DISEASE	ci_with	chlorpheniramine
MEDRT	D007231	Infant, Newborn	DISEASE	ci_with	chlorpheniramine maleate
MEDRT	D007234	Infant, Premature	DISEASE	ci_with	chlorpheniramine
MEDRT	D007234	Infant, Premature	DISEASE	ci_with	chlorpheniramine maleate
MEDRT	D008107	Liver Diseases	DISEASE	ci_with	acetaminophen
MEDRT	D010146	Pain	DISEASE	may_prevent	acetaminophen
MEDRT	D010146	Pain	DISEASE	may_treat	acetaminophen
MEDRT	D010437	Peptic Ulcer	DISEASE	ci_with	chlorpheniramine maleate
MEDRT	D010437	Peptic Ulcer	DISEASE	ci_with	chlorpheniramine
MEDRT	D011470	Prostatic Hyperplasia	DISEASE	ci_with	chlorpheniramine
MEDRT	D011470	Prostatic Hyperplasia	DISEASE	ci_with	chlorpheniramine maleate
MEDRT	D012221	Rhinitis, Allergic, Perennial	DISEASE	may_treat	chlorpheniramine maleate
MEDRT	D012221	Rhinitis, Allergic, Perennial	DISEASE	may_treat	chlorpheniramine
MEDRT	D013224	Status Asthmaticus	DISEASE	ci_with	chlorpheniramine maleate
MEDRT	D013224	Status Asthmaticus	DISEASE	ci_with	chlorpheniramine
MEDRT	D001748	Urinary Bladder Neck Obstruction	DISEASE	ci_with	chlorpheniramine
MEDRT	D001748	Urinary Bladder Neck Obstruction	DISEASE	ci_with	chlorpheniramine maleate
MEDRT	D014581	Urticaria	DISEASE	may_treat	chlorpheniramine maleate
MEDRT	D014581	Urticaria	DISEASE	may_treat	chlorpheniramine
MEDRT	N0000000190	Histamine H1 Receptor Antagonists	MOA	has_moa	chlorpheniramine maleate
MEDRT	N0000000190	Histamine H1 Receptor Antagonists	MOA	has_moa	chlorpheniramine
MEDRT	N0000000184	Monoamine Oxidase Inhibitors	MOA	ci_moa	dextromethorphan
MEDRT	N0000000184	Monoamine Oxidase Inhibitors	MOA	ci_moa	dextromethorphan hydrobromide
MEDRT	N0000000108	Prostaglandin Receptor Antagonists	MOA	has_moa	acetaminophen
MEDRT	N0000000109	Serotonin Uptake Inhibitors	MOA	has_moa	dextromethorphan hydrobromide
MEDRT	N0000000109	Serotonin Uptake Inhibitors	MOA	has_moa	dextromethorphan
MEDRT	N0000182147	Sigma-1 Receptor Agonists	MOA	has_moa	dextromethorphan
MEDRT	N0000182147	Sigma-1 Receptor Agonists	MOA	has_moa	dextromethorphan hydrobromide
MEDRT	N0000181819	Uncompetitive NMDA Receptor Antagonists	MOA	has_moa	dextromethorphan
MEDRT	N0000181819	Uncompetitive NMDA Receptor Antagonists	MOA	has_moa	dextromethorphan hydrobromide
MEDRT	N0000175724	Central Nervous System Activity Alteration	PE	has_pe	acetaminophen
MEDRT	N0000008657	Decreased Histamine Activity	PE	has_pe	chlorpheniramine maleate
MEDRT	N0000008657	Decreased Histamine Activity	PE	has_pe	chlorpheniramine
MEDRT	N0000008701	Decreased Medullary Respiratory Drive	PE	has_pe	dextromethorphan
MEDRT	N0000008701	Decreased Medullary Respiratory Drive	PE	has_pe	dextromethorphan hydrobromide
MEDRT	N0000008836	Decreased Prostaglandin Production	PE	has_pe	acetaminophen
MEDRT	N0000009072	Hypothalamic Endocrine Activity Alteration	PE	has_pe	acetaminophen
MEDRT	N0000175725	Peripheral Nervous System Activity Alteration	PE	has_pe	acetaminophen
MEDRT	N0000000026	Hepatic Metabolism	PK	has_pk	acetaminophen
MEDRT	N0000000042	Renal Excretion	PK	has_pk	acetaminophen

Group, Type, Concept table
Group	Type	Concept	Source
DF	DF	Oral Solution	rxnav_allrelated
DFG	DFG	Oral Liquid Product	rxnav_allrelated
DFG	DFG	Oral Product	rxnav_allrelated
IN	IN	acetaminophen	rxnav_allrelated
IN	IN	chlorpheniramine	rxnav_allrelated
IN	IN	dextromethorphan	rxnav_allrelated
MIN	MIN	acetaminophen / chlorpheniramine / dextromethorphan	rxnav_allrelated
PIN	PIN	chlorpheniramine maleate	rxnav_allrelated
PIN	PIN	dextromethorphan hydrobromide	rxnav_allrelated
SCD	SCD	acetaminophen 21.7 MG/ML / chlorpheniramine maleate 0.133 MG/ML / dextromethorphan hydrobromide 1 MG/ML Oral Solution	rxnav_allrelated
SCDC	SCDC	acetaminophen 21.7 MG/ML	rxnav_allrelated
SCDC	SCDC	chlorpheniramine maleate 0.133 MG/ML	rxnav_allrelated
SCDC	SCDC	dextromethorphan hydrobromide 1 MG/ML	rxnav_allrelated
SCDF	SCDF	acetaminophen / chlorpheniramine / dextromethorphan Oral Solution	rxnav_allrelated
SCDFP	SCDFP	acetaminophen / chlorpheniramine maleate / dextromethorphan hydrobromide Oral Solution	rxnav_allrelated
SCDG	SCDG	acetaminophen / chlorpheniramine / dextromethorphan Oral Liquid Product	rxnav_allrelated
SCDG	SCDG	acetaminophen / chlorpheniramine / dextromethorphan Oral Product	rxnav_allrelated
SCDGP	SCDGP	acetaminophen / chlorpheniramine maleate / dextromethorphan hydrobromide Oral Liquid Product	rxnav_allrelated
SCDGP	SCDGP	acetaminophen / chlorpheniramine maleate / dextromethorphan hydrobromide Oral Product	rxnav_allrelated

Properties#

Category, Property, Value table
Category	Property	Value
ATTRIBUTES	AVAILABLE_STRENGTH	21.7 MG/ML / 0.133 MG/ML / 1 MG/ML
ATTRIBUTES	GENERAL_CARDINALITY	MULTI
ATTRIBUTES	HUMAN_DRUG	US
ATTRIBUTES	PRESCRIBABLE	Y
ATTRIBUTES	RXNAV_HUMAN_DRUG	US
ATTRIBUTES	SCHEDULE	0
ATTRIBUTES	TTY	SCD
CODES	MMSL_CODE	BD28704
CODES	MMSL_CODE	CD28704
CODES	RxCUI	1046384
CODES	SPL_SET_ID	ec57c15e-cb6d-44a9-e053-2a95a90ae774
NAMES	Prescribable Synonym	acetaminophen 650 MG / chlorpheniramine maleate 4 MG / dextromethorphan HBr 30 MG in 30 mL Oral Solution
NAMES	RXNAV_STR	acetaminophen 21.7 MG/ML / chlorpheniramine maleate 0.133 MG/ML / dextromethorphan hydrobromide 1 MG/ML Oral Solution
NAMES	RxNorm Name	acetaminophen 21.7 MG/ML / chlorpheniramine maleate 0.133 MG/ML / dextromethorphan hydrobromide 1 MG/ML Oral Solution
NAMES	RxNorm Synonym	acetaminophen 325 MG / chlorpheniramine maleate 2 MG / dextromethorphan hydrobromide 15 MG per 15 ML Oral Solution
NAMES	RxNorm Synonym	acetaminophen 650 MG / chlorpheniramine maleate 4 MG / dextromethorphan hydrobromide 30 MG per 30 ML Oral Solution
NAMES	RxNorm Synonym	APAP 21.7 MG/ML / Chlorpheniramine Maleate 0.133 MG/ML / Dextromethorphan Hydrobromide 1 MG/ML Oral Solution
SOURCES	Source	Metathesaurus FDA Structured Product Labels
SOURCES	Source	Micromedex RED BOOK
SOURCES	Source	Multum MediSource Lexicon
SOURCES	Source	National Drug Data File Plus Source Vocabulary

acetaminophen 21.7 MG/ML / chlorpheniramine maleate 0.133 MG/ML / dextromethorphan hydrobromide 1 MG/ML Oral Solution

RxNorm Status History#

Ingredients And Strength#

Dose Form Concepts#

Derived Ingredient Concepts#

Source Vocabulary Codes#

FDA NDC Products And Packages#

Drugs@FDA Applications#

RxNav Current And Historical NDCs#

DailyMed RxNorm Mappings#

DailyMed Labels#

Drug Classes#

Related Concepts#

Properties#