acetaminophen 325 MG / diphenhydramine hydrochloride 25 MG / phenylephrine hydrochloride 5 MG Oral Tablet

RxCUI
1046751
RxNorm name
acetaminophen 325 MG / diphenhydramine hydrochloride 25 MG / phenylephrine hydrochloride 5 MG Oral Tablet
Display name
Acetaminophen/diphenhydrAMINE/Phenylephrine (Oral Pill)
Full name
acetaminophen 325 MG / diphenhydramine hydrochloride 25 MG / phenylephrine hydrochloride 5 MG Oral Tablet
Term type
SCD
Status
Active
Strength
325-25-5 mg
Dose form
Tab
Route
Oral Pill
Updated
2026-06-13 07:09:09

RxNorm Status History#

Status
Active
Source
RXNORM
Current
YES
Release start
122010
Active start
122010
Multiple ingredient
YES
Branded
NO

Ingredients And Strength#

Ingredient, Strength, Base table
IngredientStrengthBaseBasis of strength
acetaminophen325 MG / 1 EACHacetaminophenacetaminophen
diphenhydramine hydrochloride25 MG / 1 EACHdiphenhydraminediphenhydramine hydrochloride
phenylephrine hydrochloride5 MG / 1 EACHphenylephrinephenylephrine hydrochloride

Dose Form Concepts#

Dose form, RxCUI table
Dose formRxCUI
Oral Tablet317541

Derived Ingredient Concepts#

Ingredient, RxCUI table
IngredientRxCUI
acetaminophen161
diphenhydramine3498
phenylephrine8163

Source Vocabulary Codes#

FDA NDC Products And Packages#

Package NDC, Product NDC, Name table
Package NDCProduct NDCNameLabelerApplication
0363-5430-090363-5430Allergy Relief ACETAMINOPHEN, DIPHENHYDRAMINE HCl, PHENYLEPHRINE HClWalgreen CompanyM012
49035-543-0949035-543Severe Allergy Plus Sinus Headache Acetaminophen, Diphenhydramine HCl, Phenylephrine HClWal-Mart Stores IncM012
49035-543-4149035-543Severe Allergy Plus Sinus Headache Acetaminophen, Diphenhydramine HCl, Phenylephrine HClWal-Mart Stores IncM012
59779-543-0959779-543Severe Allergy And Sinus Headache Acetaminophen, Diphenhydramine HCl, Phenylephrine HClCVS PharmacyM012

Drugs@FDA Applications#

Application, NDC, Name table
ApplicationNDCNameMarketing categoryLabeler
M0120363-5430Allergy Relief ACETAMINOPHEN, DIPHENHYDRAMINE HCl, PHENYLEPHRINE HClOTC MONOGRAPH DRUGWalgreen Company

RxNav Current And Historical NDCs#

RxNav current and historical NDC rows page 1 of 1 · 45 matching rows.

NDC11, Source, Active table
NDC11SourceActive
00363054309rxnav_ndcsyes
00363054409rxnav_ndcsyes
00363054508rxnav_ndcsyes
00363543009rxnav_ndcsyes
46122005360rxnav_ndcsyes
46122026860rxnav_ndcsyes
49035054309rxnav_ndcsyes
49035054341rxnav_ndcsyes
59779054309rxnav_ndcsyes
68016002590rxnav_ndcsyes
00045028324rxnav_historical
00363544009rxnav_historical
00501290720rxnav_historical_indirect
00501290820rxnav_historical_indirect
11822052602rxnav_historical
11822054301rxnav_historical
11822054309rxnav_historical
11822071400rxnav_historical
11822548050rxnav_historical
11917007644rxnav_historical
12547017584rxnav_historical
12547022736rxnav_historical
36800050002rxnav_historical
36800099901rxnav_historical
41250012602rxnav_historical
41250054309rxnav_historical
42507094201rxnav_historical
46122005262rxnav_historical
49781012320rxnav_historical
50580028312rxnav_historical_indirect
50580028324rxnav_historical_indirect
50580034020rxnav_historical
50580067120rxnav_historical_indirect
50804047302rxnav_historical
54473013936rxnav_historical_indirect
54473018401rxnav_historical
54473018436rxnav_historical
55312094201rxnav_historical
57344012602rxnav_historical
57344012702rxnav_historical
57344015602rxnav_historical
61715014420rxnav_historical
63824055020rxnav_historical
63868079220rxnav_historical
68016002012rxnav_historical

UNII Substances#

UNII substance links page 1 of 1 · 0 matching rows.

No records found.

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 3 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
Severe Allergy And Sinus Headache Maximum StrengthACETAMINOPHEN, DIPHENHYDRAMINE HCL, PHENYLEPHRINE HCLCVS Pharmacyb3c744b8-aa93-505d-f8cf-07995da4283d2026-02-06WarningsExact identifier
ndc (package): 59779-543-09
ndc (product): 59779-543
ndc11 (package): 59779054309
rxcui: 1046751
Allergy ReliefACETAMINOPHEN, DIPHENHYDRAMINE HCL, PHENYLEPHRINE HCLWalgreen Company0a6e3251-02e0-42c1-bdf3-51c77f88c17f2025-12-11WarningsExact identifier
ndc (package): 0363-5430-09
ndc (product): 0363-5430
ndc11 (package): 00363543009
rxcui: 1046751
Severe Allergy Plus Sinus HeadacheACETAMINOPHEN, DIPHENHYDRAMINE HCL, PHENYLEPHRINE HCLWal-Mart Stores Inc1a1f41c4-5430-4cff-873e-6547dadc87792025-11-06WarningsExact identifier
ndc (package): 49035-543-09
ndc (package): 49035-543-41
ndc (product): 49035-543
ndc11 (package): 49035054309
ndc11 (package): 49035054341
rxcui: 1046751

DailyMed RxNorm Mappings#

Set ID, RxNorm string, TTY table
Set IDRxNorm stringTTYSPL versionLabelEffective
b3c744b8-aa93-505d-f8cf-07995da4283dAPAP 325 MG / diphenhydramine hydrochloride 25 MG / phenylephrine hydrochloride 5 MG Oral TabletSY18CVS 44-543-Delisted20260206
b3c744b8-aa93-505d-f8cf-07995da4283dacetaminophen 325 MG / diphenhydramine hydrochloride 25 MG / phenylephrine hydrochloride 5 MG Oral TabletSCD18CVS 44-543-Delisted20260206
b3c744b8-aa93-505d-f8cf-07995da4283dacetaminophen 325 MG / diphenhydrAMINE HCl 25 MG / phenylephrine HCl 5 MG Oral TabletPSN18CVS 44-543-Delisted20260206
1a1f41c4-5430-4cff-873e-6547dadc8779APAP 325 MG / diphenhydramine hydrochloride 25 MG / phenylephrine hydrochloride 5 MG Oral TabletSY13Equate 44-54320251106
1a1f41c4-5430-4cff-873e-6547dadc8779acetaminophen 325 MG / diphenhydrAMINE HCl 25 MG / phenylephrine HCl 5 MG Oral TabletPSN13Equate 44-54320251106
1a1f41c4-5430-4cff-873e-6547dadc8779acetaminophen 325 MG / diphenhydramine hydrochloride 25 MG / phenylephrine hydrochloride 5 MG Oral TabletSCD13Equate 44-54320251106
0a6e3251-02e0-42c1-bdf3-51c77f88c17facetaminophen 325 MG / diphenhydramine hydrochloride 25 MG / phenylephrine hydrochloride 5 MG Oral TabletSCD6Walgreens 44-543 AR20251211
0a6e3251-02e0-42c1-bdf3-51c77f88c17facetaminophen 325 MG / diphenhydrAMINE HCl 25 MG / phenylephrine HCl 5 MG Oral TabletPSN6Walgreens 44-543 AR20251211
0a6e3251-02e0-42c1-bdf3-51c77f88c17fAPAP 325 MG / diphenhydramine hydrochloride 25 MG / phenylephrine hydrochloride 5 MG Oral TabletSY6Walgreens 44-543 AR20251211

DailyMed Labels#

Set ID, Title, Manufacturer table
Set IDTitleManufacturerEffective
b3c744b8-aa93-505d-f8cf-07995da4283dCVS 44-543-DelistedCVS Pharmacy | LNK International, Inc.20260206
0a6e3251-02e0-42c1-bdf3-51c77f88c17fWalgreens 44-543 ARWalgreen Company | LNK International, Inc.20251211
0a6e3251-02e0-42c1-bdf3-51c77f88c17fWalgreens 44-543 ARWalgreen Company | LNK International, Inc.20251115
1a1f41c4-5430-4cff-873e-6547dadc8779Equate 44-543Wal-Mart Stores Inc | LNK International, Inc.20251106
1a1f41c4-5430-4cff-873e-6547dadc8779Equate 44-543Wal-Mart Stores Inc | LNK International, Inc.20241025
09bb548f-f833-4eec-bacc-e4f1e71f5cf2Walgreens 44-543 DelistedWalgreen Company | LNK International, Inc.20221119
8722c9e2-21bb-4772-bdb7-de8687de0a7bTCR - 1126 - 2019-1007TopCare20211116
940dd12a-bd92-4f55-898c-a4e8cd3474561126 - QCH - 2014-1030Chain Drug Marketing Association20211112
a2fe2e33-c3ae-4c9a-bc0d-a02da11fb238GDS - 1126 - 2016-0523GoodSense20211112
c500f07b-1a07-4afb-a98c-4a8ee9e16675CounterAct Night Content of LabelMelaleuca, Inc.20191209
a909785f-53dc-4714-af2b-4264c373afbaTopco Associates LLC. Cold & Flu Night Time Drug FactsTopco Associates LLC20191203
8d7ecd9c-3823-403b-9a2d-050879432663Amerisource Bergen Cold & Flu Night Time Drug FactsAmerisource Bergen20191203
27ef0b8a-ef92-41e3-8b60-7207132d7b0d1125 - GNP - 2019-1001 Old NDCAmeriSource Bergen20191001
4f9ff74d-b8b1-4532-af6b-b92a0a4bd2ceMeijer 44-543-DiscontinuedMeijer Distribution Inc | LNK International, Inc.20170607
7b4b309b-3726-4a14-b7e6-64469b994322Mucinex ® Fast-Max ® Night Time Cold and FluReckitt Benckiser LLC20141205
8a998d94-5f3a-4a2e-878e-db9eec94dfbfNational Council for Prescription Drug Programs20130213
acf476e9-a7bd-42f4-a0f4-80497baf18a3National Council for Prescription Drug Programs20120724

Drug Classes#

Source, Class ID, Class table
SourceClass IDClassTypeRelationshipDrug concept
ATCC01CAAdrenergic and dopaminergic agentsATC1-4phenylephrine
ATCR06AAAminoalkyl ethersATC1-4diphenhydramine
ATCN02BEAnilidesATC1-4acetaminophen
ATCD04AAAntihistamines for topical useATC1-4diphenhydramine
ATCC05AXOther agents for treatment of hemorrhoids and anal fissures for topical useATC1-4phenylephrine
ATCR01BASympathomimeticsATC1-4phenylephrine
ATCS01FBSympathomimetics excl. antiglaucoma preparationsATC1-4phenylephrine
ATCS01GASympathomimetics used as decongestantsATC1-4phenylephrine
ATCR01ABSympathomimetics, combinations excl. corticosteroidsATC1-4phenylephrine
ATCR01AASympathomimetics, plainATC1-4phenylephrine
FDASPLN0000186105alpha-1 Adrenergic AgonistEPChas_epcphenylephrine
FDASPLN0000175587Histamine-1 Receptor AntagonistEPChas_epcdiphenhydramine
FDASPLN0000000190Histamine H1 Receptor AntagonistsMOAhas_moadiphenhydramine
MEDRTD000082AcetaminophenCHEMhas_ingredientacetaminophen
MEDRTD004155DiphenhydramineCHEMhas_ingredientdiphenhydramine hydrochloride
MEDRTD004155DiphenhydramineCHEMhas_ingredientdiphenhydramine
MEDRTD010656PhenylephrineCHEMhas_ingredientphenylephrine
MEDRTD010656PhenylephrineCHEMhas_ingredientphenylephrine hydrochloride
MEDRTD013447SulfitesCHEMci_chemclassphenylephrine
MEDRTD013447SulfitesCHEMci_chemclassphenylephrine hydrochloride
MEDRTD001008Anxiety DisordersDISEASEmay_treatdiphenhydramine hydrochloride
MEDRTD001008Anxiety DisordersDISEASEmay_treatdiphenhydramine
MEDRTD004342Drug HypersensitivityDISEASEci_withdiphenhydramine
MEDRTD004342Drug HypersensitivityDISEASEci_withdiphenhydramine hydrochloride
MEDRTD004342Drug HypersensitivityDISEASEci_withphenylephrine hydrochloride
MEDRTD004342Drug HypersensitivityDISEASEci_withacetaminophen
MEDRTD004342Drug HypersensitivityDISEASEci_withphenylephrine
MEDRTD005334FeverDISEASEmay_treatacetaminophen
MEDRTD005334FeverDISEASEmay_preventacetaminophen
MEDRTD005401Fissure in AnoDISEASEmay_treatphenylephrine
MEDRTD005401Fissure in AnoDISEASEmay_treatphenylephrine hydrochloride
MEDRTD005902Glaucoma, Open-AngleDISEASEmay_treatphenylephrine hydrochloride
MEDRTD005902Glaucoma, Open-AngleDISEASEmay_treatphenylephrine
MEDRTD005955Glucosephosphate Dehydrogenase DeficiencyDISEASEci_withacetaminophen
MEDRTD006484HemorrhoidsDISEASEmay_treatphenylephrine hydrochloride
MEDRTD006484HemorrhoidsDISEASEmay_treatphenylephrine
MEDRTD006973HypertensionDISEASEci_withphenylephrine
MEDRTD006973HypertensionDISEASEci_withphenylephrine hydrochloride
MEDRTD007022HypotensionDISEASEmay_treatphenylephrine hydrochloride
MEDRTD007022HypotensionDISEASEmay_treatphenylephrine
MEDRTD007231Infant, NewbornDISEASEci_withdiphenhydramine hydrochloride
MEDRTD007231Infant, NewbornDISEASEci_withdiphenhydramine
MEDRTD007234Infant, PrematureDISEASEci_withdiphenhydramine hydrochloride
MEDRTD007234Infant, PrematureDISEASEci_withdiphenhydramine
MEDRTD007774LactationDISEASEci_withdiphenhydramine
MEDRTD007774LactationDISEASEci_withdiphenhydramine hydrochloride
MEDRTD008107Liver DiseasesDISEASEci_withacetaminophen
MEDRTD009041Motion SicknessDISEASEmay_treatdiphenhydramine hydrochloride
MEDRTD009041Motion SicknessDISEASEmay_treatdiphenhydramine
MEDRTD015878MydriasisDISEASEinducesphenylephrine
MEDRTD015878MydriasisDISEASEinducesphenylephrine hydrochloride
MEDRTD009325NauseaDISEASEmay_treatdiphenhydramine hydrochloride
MEDRTD009325NauseaDISEASEmay_treatdiphenhydramine
MEDRTD010146PainDISEASEmay_treatacetaminophen
MEDRTD010146PainDISEASEmay_preventacetaminophen
MEDRTD011538Pruritus AniDISEASEmay_treatphenylephrine
MEDRTD011538Pruritus AniDISEASEmay_treatphenylephrine hydrochloride
MEDRTD012221Rhinitis, Allergic, PerennialDISEASEmay_treatdiphenhydramine
MEDRTD012221Rhinitis, Allergic, PerennialDISEASEmay_treatdiphenhydramine hydrochloride
MEDRTD012223Rhinitis, VasomotorDISEASEmay_treatphenylephrine
MEDRTD012223Rhinitis, VasomotorDISEASEmay_treatphenylephrine hydrochloride
MEDRTD012772Shock, SepticDISEASEmay_treatphenylephrine hydrochloride
MEDRTD012772Shock, SepticDISEASEmay_treatphenylephrine
MEDRTD007319Sleep Initiation and Maintenance DisordersDISEASEmay_treatdiphenhydramine hydrochloride
MEDRTD007319Sleep Initiation and Maintenance DisordersDISEASEmay_treatdiphenhydramine
MEDRTD012912SneezingDISEASEmay_treatdiphenhydramine
MEDRTD012912SneezingDISEASEmay_treatdiphenhydramine hydrochloride
MEDRTD013224Status AsthmaticusDISEASEci_withdiphenhydramine
MEDRTD013224Status AsthmaticusDISEASEci_withdiphenhydramine hydrochloride
MEDRTD013617Tachycardia, SupraventricularDISEASEmay_treatphenylephrine
MEDRTD013617Tachycardia, SupraventricularDISEASEmay_treatphenylephrine hydrochloride
MEDRTD017180Tachycardia, VentricularDISEASEci_withphenylephrine hydrochloride
MEDRTD017180Tachycardia, VentricularDISEASEci_withphenylephrine
MEDRTD014581UrticariaDISEASEmay_treatdiphenhydramine
MEDRTD014581UrticariaDISEASEmay_treatdiphenhydramine hydrochloride
MEDRTN0000000209Adrenergic alpha-AgonistsMOAhas_moaphenylephrine
MEDRTN0000000209Adrenergic alpha-AgonistsMOAhas_moaphenylephrine hydrochloride
MEDRTN0000000190Histamine H1 Receptor AntagonistsMOAhas_moadiphenhydramine hydrochloride
MEDRTN0000000190Histamine H1 Receptor AntagonistsMOAhas_moadiphenhydramine
MEDRTN0000000108Prostaglandin Receptor AntagonistsMOAhas_moaacetaminophen
MEDRTN0000175724Central Nervous System Activity AlterationPEhas_peacetaminophen
MEDRTN0000008371Conjunctival Arterial VasoconstrictionPEhas_pephenylephrine
MEDRTN0000008371Conjunctival Arterial VasoconstrictionPEhas_pephenylephrine hydrochloride
MEDRTN0000008896Decreased Nasal and Sinus SecretionsPEhas_pephenylephrine hydrochloride
MEDRTN0000008896Decreased Nasal and Sinus SecretionsPEhas_pephenylephrine
MEDRTN0000008836Decreased Prostaglandin ProductionPEhas_peacetaminophen
MEDRTN0000009072Hypothalamic Endocrine Activity AlterationPEhas_peacetaminophen
MEDRTN0000175725Peripheral Nervous System Activity AlterationPEhas_peacetaminophen
MEDRTN0000000026Hepatic MetabolismPKhas_pkacetaminophen
MEDRTN0000000042Renal ExcretionPKhas_pkacetaminophen

Properties#

Category, Property, Value table
CategoryPropertyValue
ATTRIBUTESAVAILABLE_STRENGTH325 MG / 25 MG / 5 MG
ATTRIBUTESGENERAL_CARDINALITYMULTI
ATTRIBUTESHUMAN_DRUGUS
ATTRIBUTESPRESCRIBABLEY
ATTRIBUTESRXNAV_HUMAN_DRUGUS
ATTRIBUTESTTYSCD
CODESMMSL_CODEBD17154
CODESMMSL_CODECD17154
CODESRxCUI1046751
CODESSPL_SET_ID0a6e3251-02e0-42c1-bdf3-51c77f88c17f
CODESSPL_SET_ID1a1f41c4-5430-4cff-873e-6547dadc8779
CODESSPL_SET_IDb3c744b8-aa93-505d-f8cf-07995da4283d
NAMESPrescribable Synonymacetaminophen 325 MG / diphenhydrAMINE HCl 25 MG / phenylephrine HCl 5 MG Oral Tablet
NAMESRXNAV_STRacetaminophen 325 MG / diphenhydrAMINE hydrochloride 25 MG / phenylephrine hydrochloride 5 MG Oral Tablet
NAMESRxNorm Nameacetaminophen 325 MG / diphenhydramine hydrochloride 25 MG / phenylephrine hydrochloride 5 MG Oral Tablet
NAMESRxNorm SynonymAPAP 325 MG / diphenhydramine hydrochloride 25 MG / phenylephrine hydrochloride 5 MG Oral Tablet
NAMESTallman Synonymacetaminophen 325 MG / diphenhydrAMINE hydrochloride 25 MG / phenylephrine hydrochloride 5 MG Oral Tablet
NAMESTallman SynonymAPAP 325 MG / diphenhydrAMINE hydrochloride 25 MG / phenylephrine hydrochloride 5 MG Oral Tablet
SOURCESSourceGold Standard Alchemy
SOURCESSourceMetathesaurus FDA Structured Product Labels
SOURCESSourceMicromedex RED BOOK
SOURCESSourceNational Drug Data File Plus Source Vocabulary