acetaminophen 325 MG / diphenhydramine hydrochloride 25 MG / phenylephrine hydrochloride 5 MG Oral Tablet
- RxCUI
- 1046751
- RxNorm name
- acetaminophen 325 MG / diphenhydramine hydrochloride 25 MG / phenylephrine hydrochloride 5 MG Oral Tablet
- Display name
- Acetaminophen/diphenhydrAMINE/Phenylephrine (Oral Pill)
- Full name
- acetaminophen 325 MG / diphenhydramine hydrochloride 25 MG / phenylephrine hydrochloride 5 MG Oral Tablet
- Term type
- SCD
- Status
- Active
- Strength
- 325-25-5 mg
- Dose form
- Tab
- Route
- Oral Pill
- Updated
- 2026-06-13 07:09:09
RxNorm Status History#
- Status
- Active
- Source
- RXNORM
- Current
- YES
- Release start
- 122010
- Active start
- 122010
- Multiple ingredient
- YES
- Branded
- NO
Ingredients And Strength#
| Ingredient | Strength | Base | Basis of strength |
|---|---|---|---|
| acetaminophen | 325 MG / 1 EACH | acetaminophen | acetaminophen |
| diphenhydramine hydrochloride | 25 MG / 1 EACH | diphenhydramine | diphenhydramine hydrochloride |
| phenylephrine hydrochloride | 5 MG / 1 EACH | phenylephrine | phenylephrine hydrochloride |
Dose Form Concepts#
| Dose form | RxCUI |
|---|---|
| Oral Tablet | 317541 |
Derived Ingredient Concepts#
| Ingredient | RxCUI |
|---|---|
| acetaminophen | 161 |
| diphenhydramine | 3498 |
| phenylephrine | 8163 |
Source Vocabulary Codes#
| Code type | Value | Category |
|---|---|---|
| PRESCRIBABLE | Y | ATTRIBUTES |
| RXNAV_STR | acetaminophen 325 MG / diphenhydrAMINE hydrochloride 25 MG / phenylephrine hydrochloride 5 MG Oral Tablet | NAMES |
| RxNorm Name | acetaminophen 325 MG / diphenhydramine hydrochloride 25 MG / phenylephrine hydrochloride 5 MG Oral Tablet | NAMES |
| RxNorm Synonym | APAP 325 MG / diphenhydramine hydrochloride 25 MG / phenylephrine hydrochloride 5 MG Oral Tablet | NAMES |
| TTY | SCD | ATTRIBUTES |
| SPL_SET_ID | 0a6e3251-02e0-42c1-bdf3-51c77f88c17f | CODES |
| SPL_SET_ID | 1a1f41c4-5430-4cff-873e-6547dadc8779 | CODES |
| SPL_SET_ID | b3c744b8-aa93-505d-f8cf-07995da4283d | CODES |
| RxCUI | 1046751 | CODES |
| MMSL_CODE | BD17154 | CODES |
| MMSL_CODE | CD17154 | CODES |
FDA NDC Products And Packages#
| Package NDC | Product NDC | Name | Labeler | Application |
|---|---|---|---|---|
| 0363-5430-09 | 0363-5430 | Allergy Relief ACETAMINOPHEN, DIPHENHYDRAMINE HCl, PHENYLEPHRINE HCl | Walgreen Company | M012 |
| 49035-543-09 | 49035-543 | Severe Allergy Plus Sinus Headache Acetaminophen, Diphenhydramine HCl, Phenylephrine HCl | Wal-Mart Stores Inc | M012 |
| 49035-543-41 | 49035-543 | Severe Allergy Plus Sinus Headache Acetaminophen, Diphenhydramine HCl, Phenylephrine HCl | Wal-Mart Stores Inc | M012 |
| 59779-543-09 | 59779-543 | Severe Allergy And Sinus Headache Acetaminophen, Diphenhydramine HCl, Phenylephrine HCl | CVS Pharmacy | M012 |
Drugs@FDA Applications#
UNII Substances#
No records found.
openFDA label cross-check#
OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.
| Brand | Generic | Manufacturer | SPL set ID | Effective date | Available safety fields | Join |
|---|---|---|---|---|---|---|
| Severe Allergy And Sinus Headache Maximum Strength | ACETAMINOPHEN, DIPHENHYDRAMINE HCL, PHENYLEPHRINE HCL | CVS Pharmacy | b3c744b8-aa93-505d-f8cf-07995da4283d | 2026-02-06 | Warnings | 59779-543-09 59779-543 59779054309 1046751 |
| Allergy Relief | ACETAMINOPHEN, DIPHENHYDRAMINE HCL, PHENYLEPHRINE HCL | Walgreen Company | 0a6e3251-02e0-42c1-bdf3-51c77f88c17f | 2025-12-11 | Warnings | 0363-5430-09 0363-5430 00363543009 1046751 |
| Severe Allergy Plus Sinus Headache | ACETAMINOPHEN, DIPHENHYDRAMINE HCL, PHENYLEPHRINE HCL | Wal-Mart Stores Inc | 1a1f41c4-5430-4cff-873e-6547dadc8779 | 2025-11-06 | Warnings | 49035-543-09 49035-543-41 49035-543 49035054309 49035054341 1046751 |
DailyMed RxNorm Mappings#
| Set ID | RxNorm string | TTY | SPL version | Label | Effective |
|---|---|---|---|---|---|
| b3c744b8-aa93-505d-f8cf-07995da4283d | APAP 325 MG / diphenhydramine hydrochloride 25 MG / phenylephrine hydrochloride 5 MG Oral Tablet | SY | 18 | CVS 44-543-Delisted | 20260206 |
| b3c744b8-aa93-505d-f8cf-07995da4283d | acetaminophen 325 MG / diphenhydramine hydrochloride 25 MG / phenylephrine hydrochloride 5 MG Oral Tablet | SCD | 18 | CVS 44-543-Delisted | 20260206 |
| b3c744b8-aa93-505d-f8cf-07995da4283d | acetaminophen 325 MG / diphenhydrAMINE HCl 25 MG / phenylephrine HCl 5 MG Oral Tablet | PSN | 18 | CVS 44-543-Delisted | 20260206 |
| 1a1f41c4-5430-4cff-873e-6547dadc8779 | APAP 325 MG / diphenhydramine hydrochloride 25 MG / phenylephrine hydrochloride 5 MG Oral Tablet | SY | 13 | Equate 44-543 | 20251106 |
| 1a1f41c4-5430-4cff-873e-6547dadc8779 | acetaminophen 325 MG / diphenhydrAMINE HCl 25 MG / phenylephrine HCl 5 MG Oral Tablet | PSN | 13 | Equate 44-543 | 20251106 |
| 1a1f41c4-5430-4cff-873e-6547dadc8779 | acetaminophen 325 MG / diphenhydramine hydrochloride 25 MG / phenylephrine hydrochloride 5 MG Oral Tablet | SCD | 13 | Equate 44-543 | 20251106 |
| 0a6e3251-02e0-42c1-bdf3-51c77f88c17f | acetaminophen 325 MG / diphenhydramine hydrochloride 25 MG / phenylephrine hydrochloride 5 MG Oral Tablet | SCD | 6 | Walgreens 44-543 AR | 20251211 |
| 0a6e3251-02e0-42c1-bdf3-51c77f88c17f | acetaminophen 325 MG / diphenhydrAMINE HCl 25 MG / phenylephrine HCl 5 MG Oral Tablet | PSN | 6 | Walgreens 44-543 AR | 20251211 |
| 0a6e3251-02e0-42c1-bdf3-51c77f88c17f | APAP 325 MG / diphenhydramine hydrochloride 25 MG / phenylephrine hydrochloride 5 MG Oral Tablet | SY | 6 | Walgreens 44-543 AR | 20251211 |
DailyMed Labels#
| Set ID | Title | Manufacturer | Effective |
|---|---|---|---|
| b3c744b8-aa93-505d-f8cf-07995da4283d | CVS 44-543-Delisted | CVS Pharmacy | LNK International, Inc. | 20260206 |
| 0a6e3251-02e0-42c1-bdf3-51c77f88c17f | Walgreens 44-543 AR | Walgreen Company | LNK International, Inc. | 20251211 |
| 0a6e3251-02e0-42c1-bdf3-51c77f88c17f | Walgreens 44-543 AR | Walgreen Company | LNK International, Inc. | 20251115 |
| 1a1f41c4-5430-4cff-873e-6547dadc8779 | Equate 44-543 | Wal-Mart Stores Inc | LNK International, Inc. | 20251106 |
| 1a1f41c4-5430-4cff-873e-6547dadc8779 | Equate 44-543 | Wal-Mart Stores Inc | LNK International, Inc. | 20241025 |
| 09bb548f-f833-4eec-bacc-e4f1e71f5cf2 | Walgreens 44-543 Delisted | Walgreen Company | LNK International, Inc. | 20221119 |
| 8722c9e2-21bb-4772-bdb7-de8687de0a7b | TCR - 1126 - 2019-1007 | TopCare | 20211116 |
| 940dd12a-bd92-4f55-898c-a4e8cd347456 | 1126 - QCH - 2014-1030 | Chain Drug Marketing Association | 20211112 |
| a2fe2e33-c3ae-4c9a-bc0d-a02da11fb238 | GDS - 1126 - 2016-0523 | GoodSense | 20211112 |
| c500f07b-1a07-4afb-a98c-4a8ee9e16675 | CounterAct Night Content of Label | Melaleuca, Inc. | 20191209 |
| a909785f-53dc-4714-af2b-4264c373afba | Topco Associates LLC. Cold & Flu Night Time Drug Facts | Topco Associates LLC | 20191203 |
| 8d7ecd9c-3823-403b-9a2d-050879432663 | Amerisource Bergen Cold & Flu Night Time Drug Facts | Amerisource Bergen | 20191203 |
| 27ef0b8a-ef92-41e3-8b60-7207132d7b0d | 1125 - GNP - 2019-1001 Old NDC | AmeriSource Bergen | 20191001 |
| 4f9ff74d-b8b1-4532-af6b-b92a0a4bd2ce | Meijer 44-543-Discontinued | Meijer Distribution Inc | LNK International, Inc. | 20170607 |
| 7b4b309b-3726-4a14-b7e6-64469b994322 | Mucinex ® Fast-Max ® Night Time Cold and Flu | Reckitt Benckiser LLC | 20141205 |
| 8a998d94-5f3a-4a2e-878e-db9eec94dfbf | National Council for Prescription Drug Programs | 20130213 | |
| acf476e9-a7bd-42f4-a0f4-80497baf18a3 | National Council for Prescription Drug Programs | 20120724 |
Drug Classes#
| Source | Class ID | Class | Type | Relationship | Drug concept |
|---|---|---|---|---|---|
| ATC | C01CA | Adrenergic and dopaminergic agents | ATC1-4 | phenylephrine | |
| ATC | R06AA | Aminoalkyl ethers | ATC1-4 | diphenhydramine | |
| ATC | N02BE | Anilides | ATC1-4 | acetaminophen | |
| ATC | D04AA | Antihistamines for topical use | ATC1-4 | diphenhydramine | |
| ATC | C05AX | Other agents for treatment of hemorrhoids and anal fissures for topical use | ATC1-4 | phenylephrine | |
| ATC | R01BA | Sympathomimetics | ATC1-4 | phenylephrine | |
| ATC | S01FB | Sympathomimetics excl. antiglaucoma preparations | ATC1-4 | phenylephrine | |
| ATC | S01GA | Sympathomimetics used as decongestants | ATC1-4 | phenylephrine | |
| ATC | R01AB | Sympathomimetics, combinations excl. corticosteroids | ATC1-4 | phenylephrine | |
| ATC | R01AA | Sympathomimetics, plain | ATC1-4 | phenylephrine | |
| FDASPL | N0000186105 | alpha-1 Adrenergic Agonist | EPC | has_epc | phenylephrine |
| FDASPL | N0000175587 | Histamine-1 Receptor Antagonist | EPC | has_epc | diphenhydramine |
| FDASPL | N0000000190 | Histamine H1 Receptor Antagonists | MOA | has_moa | diphenhydramine |
| MEDRT | D000082 | Acetaminophen | CHEM | has_ingredient | acetaminophen |
| MEDRT | D004155 | Diphenhydramine | CHEM | has_ingredient | diphenhydramine hydrochloride |
| MEDRT | D004155 | Diphenhydramine | CHEM | has_ingredient | diphenhydramine |
| MEDRT | D010656 | Phenylephrine | CHEM | has_ingredient | phenylephrine |
| MEDRT | D010656 | Phenylephrine | CHEM | has_ingredient | phenylephrine hydrochloride |
| MEDRT | D013447 | Sulfites | CHEM | ci_chemclass | phenylephrine |
| MEDRT | D013447 | Sulfites | CHEM | ci_chemclass | phenylephrine hydrochloride |
| MEDRT | D001008 | Anxiety Disorders | DISEASE | may_treat | diphenhydramine hydrochloride |
| MEDRT | D001008 | Anxiety Disorders | DISEASE | may_treat | diphenhydramine |
| MEDRT | D004342 | Drug Hypersensitivity | DISEASE | ci_with | diphenhydramine |
| MEDRT | D004342 | Drug Hypersensitivity | DISEASE | ci_with | diphenhydramine hydrochloride |
| MEDRT | D004342 | Drug Hypersensitivity | DISEASE | ci_with | phenylephrine hydrochloride |
| MEDRT | D004342 | Drug Hypersensitivity | DISEASE | ci_with | acetaminophen |
| MEDRT | D004342 | Drug Hypersensitivity | DISEASE | ci_with | phenylephrine |
| MEDRT | D005334 | Fever | DISEASE | may_treat | acetaminophen |
| MEDRT | D005334 | Fever | DISEASE | may_prevent | acetaminophen |
| MEDRT | D005401 | Fissure in Ano | DISEASE | may_treat | phenylephrine |
| MEDRT | D005401 | Fissure in Ano | DISEASE | may_treat | phenylephrine hydrochloride |
| MEDRT | D005902 | Glaucoma, Open-Angle | DISEASE | may_treat | phenylephrine hydrochloride |
| MEDRT | D005902 | Glaucoma, Open-Angle | DISEASE | may_treat | phenylephrine |
| MEDRT | D005955 | Glucosephosphate Dehydrogenase Deficiency | DISEASE | ci_with | acetaminophen |
| MEDRT | D006484 | Hemorrhoids | DISEASE | may_treat | phenylephrine hydrochloride |
| MEDRT | D006484 | Hemorrhoids | DISEASE | may_treat | phenylephrine |
| MEDRT | D006973 | Hypertension | DISEASE | ci_with | phenylephrine |
| MEDRT | D006973 | Hypertension | DISEASE | ci_with | phenylephrine hydrochloride |
| MEDRT | D007022 | Hypotension | DISEASE | may_treat | phenylephrine hydrochloride |
| MEDRT | D007022 | Hypotension | DISEASE | may_treat | phenylephrine |
| MEDRT | D007231 | Infant, Newborn | DISEASE | ci_with | diphenhydramine hydrochloride |
| MEDRT | D007231 | Infant, Newborn | DISEASE | ci_with | diphenhydramine |
| MEDRT | D007234 | Infant, Premature | DISEASE | ci_with | diphenhydramine hydrochloride |
| MEDRT | D007234 | Infant, Premature | DISEASE | ci_with | diphenhydramine |
| MEDRT | D007774 | Lactation | DISEASE | ci_with | diphenhydramine |
| MEDRT | D007774 | Lactation | DISEASE | ci_with | diphenhydramine hydrochloride |
| MEDRT | D008107 | Liver Diseases | DISEASE | ci_with | acetaminophen |
| MEDRT | D009041 | Motion Sickness | DISEASE | may_treat | diphenhydramine hydrochloride |
| MEDRT | D009041 | Motion Sickness | DISEASE | may_treat | diphenhydramine |
| MEDRT | D015878 | Mydriasis | DISEASE | induces | phenylephrine |
| MEDRT | D015878 | Mydriasis | DISEASE | induces | phenylephrine hydrochloride |
| MEDRT | D009325 | Nausea | DISEASE | may_treat | diphenhydramine hydrochloride |
| MEDRT | D009325 | Nausea | DISEASE | may_treat | diphenhydramine |
| MEDRT | D010146 | Pain | DISEASE | may_treat | acetaminophen |
| MEDRT | D010146 | Pain | DISEASE | may_prevent | acetaminophen |
| MEDRT | D011538 | Pruritus Ani | DISEASE | may_treat | phenylephrine |
| MEDRT | D011538 | Pruritus Ani | DISEASE | may_treat | phenylephrine hydrochloride |
| MEDRT | D012221 | Rhinitis, Allergic, Perennial | DISEASE | may_treat | diphenhydramine |
| MEDRT | D012221 | Rhinitis, Allergic, Perennial | DISEASE | may_treat | diphenhydramine hydrochloride |
| MEDRT | D012223 | Rhinitis, Vasomotor | DISEASE | may_treat | phenylephrine |
| MEDRT | D012223 | Rhinitis, Vasomotor | DISEASE | may_treat | phenylephrine hydrochloride |
| MEDRT | D012772 | Shock, Septic | DISEASE | may_treat | phenylephrine hydrochloride |
| MEDRT | D012772 | Shock, Septic | DISEASE | may_treat | phenylephrine |
| MEDRT | D007319 | Sleep Initiation and Maintenance Disorders | DISEASE | may_treat | diphenhydramine hydrochloride |
| MEDRT | D007319 | Sleep Initiation and Maintenance Disorders | DISEASE | may_treat | diphenhydramine |
| MEDRT | D012912 | Sneezing | DISEASE | may_treat | diphenhydramine |
| MEDRT | D012912 | Sneezing | DISEASE | may_treat | diphenhydramine hydrochloride |
| MEDRT | D013224 | Status Asthmaticus | DISEASE | ci_with | diphenhydramine |
| MEDRT | D013224 | Status Asthmaticus | DISEASE | ci_with | diphenhydramine hydrochloride |
| MEDRT | D013617 | Tachycardia, Supraventricular | DISEASE | may_treat | phenylephrine |
| MEDRT | D013617 | Tachycardia, Supraventricular | DISEASE | may_treat | phenylephrine hydrochloride |
| MEDRT | D017180 | Tachycardia, Ventricular | DISEASE | ci_with | phenylephrine hydrochloride |
| MEDRT | D017180 | Tachycardia, Ventricular | DISEASE | ci_with | phenylephrine |
| MEDRT | D014581 | Urticaria | DISEASE | may_treat | diphenhydramine |
| MEDRT | D014581 | Urticaria | DISEASE | may_treat | diphenhydramine hydrochloride |
| MEDRT | N0000000209 | Adrenergic alpha-Agonists | MOA | has_moa | phenylephrine |
| MEDRT | N0000000209 | Adrenergic alpha-Agonists | MOA | has_moa | phenylephrine hydrochloride |
| MEDRT | N0000000190 | Histamine H1 Receptor Antagonists | MOA | has_moa | diphenhydramine hydrochloride |
| MEDRT | N0000000190 | Histamine H1 Receptor Antagonists | MOA | has_moa | diphenhydramine |
| MEDRT | N0000000108 | Prostaglandin Receptor Antagonists | MOA | has_moa | acetaminophen |
| MEDRT | N0000175724 | Central Nervous System Activity Alteration | PE | has_pe | acetaminophen |
| MEDRT | N0000008371 | Conjunctival Arterial Vasoconstriction | PE | has_pe | phenylephrine |
| MEDRT | N0000008371 | Conjunctival Arterial Vasoconstriction | PE | has_pe | phenylephrine hydrochloride |
| MEDRT | N0000008896 | Decreased Nasal and Sinus Secretions | PE | has_pe | phenylephrine hydrochloride |
| MEDRT | N0000008896 | Decreased Nasal and Sinus Secretions | PE | has_pe | phenylephrine |
| MEDRT | N0000008836 | Decreased Prostaglandin Production | PE | has_pe | acetaminophen |
| MEDRT | N0000009072 | Hypothalamic Endocrine Activity Alteration | PE | has_pe | acetaminophen |
| MEDRT | N0000175725 | Peripheral Nervous System Activity Alteration | PE | has_pe | acetaminophen |
| MEDRT | N0000000026 | Hepatic Metabolism | PK | has_pk | acetaminophen |
| MEDRT | N0000000042 | Renal Excretion | PK | has_pk | acetaminophen |
Properties#
| Category | Property | Value |
|---|---|---|
| ATTRIBUTES | AVAILABLE_STRENGTH | 325 MG / 25 MG / 5 MG |
| ATTRIBUTES | GENERAL_CARDINALITY | MULTI |
| ATTRIBUTES | HUMAN_DRUG | US |
| ATTRIBUTES | PRESCRIBABLE | Y |
| ATTRIBUTES | RXNAV_HUMAN_DRUG | US |
| ATTRIBUTES | TTY | SCD |
| CODES | MMSL_CODE | BD17154 |
| CODES | MMSL_CODE | CD17154 |
| CODES | RxCUI | 1046751 |
| CODES | SPL_SET_ID | 0a6e3251-02e0-42c1-bdf3-51c77f88c17f |
| CODES | SPL_SET_ID | 1a1f41c4-5430-4cff-873e-6547dadc8779 |
| CODES | SPL_SET_ID | b3c744b8-aa93-505d-f8cf-07995da4283d |
| NAMES | Prescribable Synonym | acetaminophen 325 MG / diphenhydrAMINE HCl 25 MG / phenylephrine HCl 5 MG Oral Tablet |
| NAMES | RXNAV_STR | acetaminophen 325 MG / diphenhydrAMINE hydrochloride 25 MG / phenylephrine hydrochloride 5 MG Oral Tablet |
| NAMES | RxNorm Name | acetaminophen 325 MG / diphenhydramine hydrochloride 25 MG / phenylephrine hydrochloride 5 MG Oral Tablet |
| NAMES | RxNorm Synonym | APAP 325 MG / diphenhydramine hydrochloride 25 MG / phenylephrine hydrochloride 5 MG Oral Tablet |
| NAMES | Tallman Synonym | acetaminophen 325 MG / diphenhydrAMINE hydrochloride 25 MG / phenylephrine hydrochloride 5 MG Oral Tablet |
| NAMES | Tallman Synonym | APAP 325 MG / diphenhydrAMINE hydrochloride 25 MG / phenylephrine hydrochloride 5 MG Oral Tablet |
| SOURCES | Source | Gold Standard Alchemy |
| SOURCES | Source | Metathesaurus FDA Structured Product Labels |
| SOURCES | Source | Micromedex RED BOOK |
| SOURCES | Source | National Drug Data File Plus Source Vocabulary |