Home RxNorm 1052462 acetaminophen 325 MG / diphenhydramine hydrochloride 12.5 MG Oral Tablet Drug identity information. FDA.report links public drug records from RxNav, DailyMed, FDA NDC, Drugs@FDA, and related public sources where available. This page is informational only and is not medical, prescribing, or regulatory advice.
RxCUI 1052462
RxNorm name acetaminophen 325 MG / diphenhydramine hydrochloride 12.5 MG Oral Tablet
Display name Acetaminophen/diphenhydrAMINE (Oral Pill)
Full name acetaminophen 325 MG / diphenhydramine hydrochloride 12.5 MG Oral Tablet
Term type SCD
Status Active
Strength 325-12.5 mg
Dose form Tab
Route Oral Pill
Updated 2026-07-25 06:53:13 RxNorm Status History#
Status Active
Source RXNORM
Current YES
Release start 022011
Active start 022011
Multiple ingredient YES
Branded NO Ingredients And Strength# Ingredient, Strength, Base table Ingredient Strength Base Basis of strength acetaminophen 325 MG / 1 EACH acetaminophen acetaminophen diphenhydramine hydrochloride 12.5 MG / 1 EACH diphenhydramine diphenhydramine hydrochloride
Derived Ingredient Concepts# RxNav Current And Historical NDCs# RxNav current and historical NDC rows page 1 of 1 · 5 matching rows.
NDC11, Source, Active table NDC11 Source Active 00536100301 rxnav_historical 00536360501 rxnav_historical 49483035600 rxnav_historical 49483035609 rxnav_historical 61786000202 rxnav_historical
UNII Substances# UNII substance links page 1 of 1 · 0 matching rows.
No records found.
openFDA label cross-check# OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.
Matched openFDA labels page 1 of 1 · 1 matching rows.
DailyMed RxNorm Mappings# Drug Classes# Source, Class ID, Class table Source Class ID Class Type Relationship Drug concept ATC R06AA Aminoalkyl ethers ATC1-4 diphenhydramine ATC N02BE Anilides ATC1-4 acetaminophen ATC D04AA Antihistamines for topical use ATC1-4 diphenhydramine FDASPL N0000175587 Histamine-1 Receptor Antagonist EPC has_epc diphenhydramine FDASPL N0000000190 Histamine H1 Receptor Antagonists MOA has_moa diphenhydramine MEDRT D000082 Acetaminophen CHEM has_ingredient acetaminophen MEDRT D004155 Diphenhydramine CHEM has_ingredient diphenhydramine hydrochloride MEDRT D004155 Diphenhydramine CHEM has_ingredient diphenhydramine MEDRT D001008 Anxiety Disorders DISEASE may_treat diphenhydramine MEDRT D001008 Anxiety Disorders DISEASE may_treat diphenhydramine hydrochloride MEDRT D004342 Drug Hypersensitivity DISEASE ci_with diphenhydramine hydrochloride MEDRT D004342 Drug Hypersensitivity DISEASE ci_with acetaminophen MEDRT D004342 Drug Hypersensitivity DISEASE ci_with diphenhydramine MEDRT D005334 Fever DISEASE may_prevent acetaminophen MEDRT D005334 Fever DISEASE may_treat acetaminophen MEDRT D005955 Glucosephosphate Dehydrogenase Deficiency DISEASE ci_with acetaminophen MEDRT D007231 Infant, Newborn DISEASE ci_with diphenhydramine hydrochloride MEDRT D007231 Infant, Newborn DISEASE ci_with diphenhydramine MEDRT D007234 Infant, Premature DISEASE ci_with diphenhydramine hydrochloride MEDRT D007234 Infant, Premature DISEASE ci_with diphenhydramine MEDRT D007774 Lactation DISEASE ci_with diphenhydramine hydrochloride MEDRT D007774 Lactation DISEASE ci_with diphenhydramine MEDRT D008107 Liver Diseases DISEASE ci_with acetaminophen MEDRT D009041 Motion Sickness DISEASE may_treat diphenhydramine MEDRT D009041 Motion Sickness DISEASE may_treat diphenhydramine hydrochloride MEDRT D009325 Nausea DISEASE may_treat diphenhydramine MEDRT D009325 Nausea DISEASE may_treat diphenhydramine hydrochloride MEDRT D010146 Pain DISEASE may_treat acetaminophen MEDRT D010146 Pain DISEASE may_prevent acetaminophen MEDRT D012221 Rhinitis, Allergic, Perennial DISEASE may_treat diphenhydramine MEDRT D012221 Rhinitis, Allergic, Perennial DISEASE may_treat diphenhydramine hydrochloride MEDRT D007319 Sleep Initiation and Maintenance Disorders DISEASE may_treat diphenhydramine hydrochloride MEDRT D007319 Sleep Initiation and Maintenance Disorders DISEASE may_treat diphenhydramine MEDRT D012912 Sneezing DISEASE may_treat diphenhydramine hydrochloride MEDRT D012912 Sneezing DISEASE may_treat diphenhydramine MEDRT D013224 Status Asthmaticus DISEASE ci_with diphenhydramine hydrochloride MEDRT D013224 Status Asthmaticus DISEASE ci_with diphenhydramine MEDRT D014581 Urticaria DISEASE may_treat diphenhydramine MEDRT D014581 Urticaria DISEASE may_treat diphenhydramine hydrochloride MEDRT N0000000190 Histamine H1 Receptor Antagonists MOA has_moa diphenhydramine hydrochloride MEDRT N0000000190 Histamine H1 Receptor Antagonists MOA has_moa diphenhydramine MEDRT N0000000108 Prostaglandin Receptor Antagonists MOA has_moa acetaminophen MEDRT N0000175724 Central Nervous System Activity Alteration PE has_pe acetaminophen MEDRT N0000008836 Decreased Prostaglandin Production PE has_pe acetaminophen MEDRT N0000009072 Hypothalamic Endocrine Activity Alteration PE has_pe acetaminophen MEDRT N0000175725 Peripheral Nervous System Activity Alteration PE has_pe acetaminophen MEDRT N0000000026 Hepatic Metabolism PK has_pk acetaminophen MEDRT N0000000042 Renal Excretion PK has_pk acetaminophen
Properties# Category, Property, Value table Category Property Value ATTRIBUTES AVAILABLE_STRENGTH 325 MG / 12.5 MG ATTRIBUTES GENERAL_CARDINALITY MULTI ATTRIBUTES HUMAN_DRUG US ATTRIBUTES PRESCRIBABLE Y ATTRIBUTES RXNAV_HUMAN_DRUG US ATTRIBUTES SCHEDULE 0 ATTRIBUTES TTY SCD CODES MMSL_CODE BD26905 CODES MMSL_CODE CD26905 CODES RxCUI 1052462 CODES VUID 4030503 NAMES Prescribable Synonym acetaminophen 325 MG / diphenhydrAMINE HCl 12.5 MG Oral Tablet NAMES RXNAV_STR acetaminophen 325 MG / diphenhydrAMINE hydrochloride 12.5 MG Oral Tablet NAMES RxNorm Name acetaminophen 325 MG / diphenhydramine hydrochloride 12.5 MG Oral Tablet NAMES RxNorm Synonym APAP 325 MG / diphenhydramine hydrochloride 12.5 MG Oral Tablet NAMES Tallman Synonym acetaminophen 325 MG / diphenhydrAMINE hydrochloride 12.5 MG Oral Tablet NAMES Tallman Synonym APAP 325 MG / diphenhydrAMINE hydrochloride 12.5 MG Oral Tablet SOURCES Source Micromedex RED BOOK SOURCES Source Multum MediSource Lexicon SOURCES Source National Drug Data File Plus Source Vocabulary SOURCES Source Veterans Health Administration National Drug File