Home RxNorm 1052641 acetaminophen 500 MG / pamabrom 25 MG / pyrilamine maleate 15 MG Oral Tablet [Premsyn PMS] Drug identity information. FDA.report links public drug records from RxNav, DailyMed, FDA NDC, Drugs@FDA, and related public sources where available. This page is informational only and is not medical, prescribing, or regulatory advice.
RxCUI 1052641
RxNorm name acetaminophen 500 MG / pamabrom 25 MG / pyrilamine maleate 15 MG Oral Tablet [Premsyn PMS]
Display name PREMSYN PMS (Oral Pill)
Full name acetaminophen 500 MG / pamabrom 25 MG / pyrilamine maleate 15 MG Oral Tablet [Premsyn PMS]
Term type SBD
Status Active
Strength 500-25-15 mg
Dose form Tab
Route Oral Pill
Updated 2026-10-17 23:44:43 RxNorm Status History#
Status Active
Source RXNORM
Current YES
Release start 022011
Active start 022011
Multiple ingredient YES
Branded YES Ingredients And Strength# Ingredient, Strength, Base table Ingredient Strength Base Basis of strength acetaminophen 500 MG / 1 EACH acetaminophen acetaminophen pamabrom 25 MG / 1 EACH pamabrom pamabrom pyrilamine maleate 15 MG / 1 EACH pyrilamine pyrilamine maleate
Derived Ingredient Concepts# FDA NDC Products And Packages# Package NDC, Product NDC, Name table Package NDC Product NDC Name Labeler Application 71687-3102-4 71687-3102 Premsyn pms Premenstrual Pain Relief Acetaminophen and Pamabrom and Pyrilamine maleate Focus Consumer Healthcare, LLC M013
Drugs@FDA Applications# Application, NDC, Name table Application NDC Name Marketing category Labeler M013 71687-3102 Premsyn pms Premenstrual Pain Relief Acetaminophen and Pamabrom and Pyrilamine maleate OTC MONOGRAPH DRUG Focus Consumer Healthcare, LLC
RxNav Current And Historical NDCs# RxNav current and historical NDC rows page 1 of 1 · 7 matching rows.
NDC11, Source, Active table NDC11 Source Active 41167031023 rxnav_ndcs yes 41167310201 rxnav_ndcs yes 71687310204 rxnav_ndcs yes 41167031021 rxnav_historical 41167310203 rxnav_historical 41167310210 rxnav_historical_indirect 41167310230 rxnav_historical_indirect
UNII Substances# UNII substance links page 1 of 1 · 0 matching rows.
No records found.
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Matched openFDA labels page 1 of 1 · 1 matching rows.
Reported adverse events (FAERS/openFDA)# Adverse event summaries are temporarily unavailable. Other product information remains available.
DailyMed RxNorm Mappings# unique DailyMed labels mapped to this RxNorm concept page 1 of 1 · 1 matching rows.
Set ID, RxNorm mappings, Terms table Set ID RxNorm mappings Terms SPL version Label Effective 5b6f6260-69ae-cfeb-e053-2a91aa0a6b49 Premsyn PMS 500 MG / 25 MG / 15 MG Oral Tablet [PSN] · acetaminophen 500 MG / pamabrom 25 MG / pyrilamine maleate 15 MG Oral Tablet [Premsyn PMS] [SBD] · APAP 500 MG / pamabrom 25 MG / Pyrilamine Maleate 15 MG Oral Tablet [Premsyn PMS] [SY] · Premsyn PMS (APAP 500 MG / pamabrom 25 MG / pyrilamine maleate 15 MG) Oral Tablet [SY] 4 8 Premsyn pms Premenstrual Pain Relief 20250414
Recently Linked DailyMed Labels# Drug Classes# Source, Class ID, Class table Source Class ID Class Type Relationship Drug concept ATC N02BE Anilides ATC1-4 acetaminophen ATC D04AA Antihistamines for topical use ATC1-4 pyrilamine ATC R06AC Substituted ethylene diamines ATC1-4 pyrilamine MEDRT D000082 Acetaminophen CHEM has_ingredient acetaminophen MEDRT D004338 Drug Combinations CHEM has_ingredient pamabrom MEDRT D011412 Propanolamines CHEM has_ingredient pamabrom MEDRT D011738 Pyrilamine CHEM has_ingredient pyrilamine MEDRT D011738 Pyrilamine CHEM has_ingredient pyrilamine maleate MEDRT D013806 Theophylline CHEM has_ingredient pamabrom MEDRT D003233 Conjunctivitis, Allergic DISEASE may_treat pyrilamine MEDRT D003233 Conjunctivitis, Allergic DISEASE may_treat pyrilamine maleate MEDRT D004342 Drug Hypersensitivity DISEASE ci_with acetaminophen MEDRT D004342 Drug Hypersensitivity DISEASE ci_with pyrilamine MEDRT D004342 Drug Hypersensitivity DISEASE ci_with pyrilamine maleate MEDRT D005334 Fever DISEASE may_prevent acetaminophen MEDRT D005334 Fever DISEASE may_treat acetaminophen MEDRT D005955 Glucosephosphate Dehydrogenase Deficiency DISEASE ci_with acetaminophen MEDRT D008107 Liver Diseases DISEASE ci_with acetaminophen MEDRT D010146 Pain DISEASE may_treat acetaminophen MEDRT D010146 Pain DISEASE may_prevent acetaminophen MEDRT D011293 Premenstrual Syndrome DISEASE may_treat pamabrom MEDRT D011537 Pruritus DISEASE may_treat pyrilamine maleate MEDRT D011537 Pruritus DISEASE may_treat pyrilamine MEDRT D012221 Rhinitis, Allergic, Perennial DISEASE may_treat pyrilamine MEDRT D012221 Rhinitis, Allergic, Perennial DISEASE may_treat pyrilamine maleate MEDRT D006255 Rhinitis, Allergic, Seasonal DISEASE may_treat pyrilamine maleate MEDRT D006255 Rhinitis, Allergic, Seasonal DISEASE may_treat pyrilamine MEDRT N0000000190 Histamine H1 Receptor Antagonists MOA has_moa pyrilamine MEDRT N0000000190 Histamine H1 Receptor Antagonists MOA has_moa pyrilamine maleate MEDRT N0000000108 Prostaglandin Receptor Antagonists MOA has_moa acetaminophen MEDRT N0000009915 Unknown Cellular or Molecular Interaction MOA has_moa pamabrom MEDRT N0000175724 Central Nervous System Activity Alteration PE has_pe acetaminophen MEDRT N0000008657 Decreased Histamine Activity PE has_pe pyrilamine maleate MEDRT N0000008657 Decreased Histamine Activity PE has_pe pyrilamine MEDRT N0000008836 Decreased Prostaglandin Production PE has_pe acetaminophen MEDRT N0000009072 Hypothalamic Endocrine Activity Alteration PE has_pe acetaminophen MEDRT N0000009263 Increased Collecting Duct Water Permeability PE has_pe pamabrom MEDRT N0000175359 Increased Diuresis PE has_pe pamabrom MEDRT N0000175725 Peripheral Nervous System Activity Alteration PE has_pe acetaminophen MEDRT N0000000026 Hepatic Metabolism PK has_pk acetaminophen MEDRT N0000000042 Renal Excretion PK has_pk acetaminophen
Properties# Category, Property, Value table Category Property Value ATTRIBUTES AVAILABLE_STRENGTH 500 MG / 25 MG / 15 MG ATTRIBUTES GENERAL_CARDINALITY MULTI ATTRIBUTES HUMAN_DRUG US ATTRIBUTES RXNAV_HUMAN_DRUG US NAMES Prescribable Synonym Premsyn PMS 500 MG / 25 MG / 15 MG Oral Tablet SOURCES Source Gold Standard Alchemy SOURCES Source Metathesaurus FDA Structured Product Labels