Home RxNorm 1093077 acetaminophen 325 MG / diphenhydramine hydrochloride 50 MG Oral Tablet [Unisom with Pain Relief] Drug identity information. FDA.report links public drug records from RxNav, DailyMed, FDA NDC, Drugs@FDA, and related public sources where available. This page is informational only and is not medical, prescribing, or regulatory advice.
RxCUI 1093077
RxNorm name acetaminophen 325 MG / diphenhydramine hydrochloride 50 MG Oral Tablet [Unisom with Pain Relief]
Display name UNISOM WITH PAIN RELIEF (Oral Pill)
Full name acetaminophen 325 MG / diphenhydramine hydrochloride 50 MG Oral Tablet [Unisom with Pain Relief]
Term type SBD
Status Active
Strength 325-50 mg
Dose form Tab
Route Oral Pill
Updated 2026-07-22 07:07:11 RxNorm Status History#
Status Active
Source RXNORM
Current YES
Release start 042011
Active start 042011
Multiple ingredient YES
Branded YES Ingredients And Strength# Ingredient, Strength, Base table Ingredient Strength Base Basis of strength acetaminophen 325 MG / 1 EACH acetaminophen acetaminophen diphenhydramine hydrochloride 50 MG / 1 EACH diphenhydramine diphenhydramine hydrochloride
Derived Ingredient Concepts# FDA NDC Products And Packages# Package NDC, Product NDC, Name table Package NDC Product NDC Name Labeler Application 41167-0040-2 41167-0040 Unisom PM Pain Nighttime Sleep Aid and Pain Reliever Acetaminophen and Diphenhydramine Hydrochloride Chattem, Inc. M013 41167-0040-4 41167-0040 Unisom PM Pain Nighttime Sleep Aid and Pain Reliever Acetaminophen and Diphenhydramine Hydrochloride Chattem, Inc. M013
Drugs@FDA Applications# Application, NDC, Name table Application NDC Name Marketing category Labeler M013 41167-0040 Unisom PM Pain Nighttime Sleep Aid and Pain Reliever Acetaminophen and Diphenhydramine Hydrochloride OTC MONOGRAPH DRUG Chattem, Inc.
RxNav Current And Historical NDCs# RxNav current and historical NDC rows page 1 of 1 · 4 matching rows.
NDC11, Source, Active table NDC11 Source Active 41167000404 rxnav_ndcs yes 41167004002 rxnav_ndcs yes 41167004004 rxnav_ndcs yes 41167004003 rxnav_historical_indirect
UNII Substances# UNII substance links page 1 of 1 · 0 matching rows.
No records found.
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Matched openFDA labels page 1 of 1 · 1 matching rows.
DailyMed RxNorm Mappings# Set ID, RxNorm string, TTY table Set ID RxNorm string TTY SPL version Label Effective 451daeeb-88a9-44b1-9a2d-1ff0b0ec41cb Unisom with Pain Relief (APAP 325 MG / diphenhydramine hydrochloride 50 MG) Oral Tablet SY 9 Unisom PM Pain Nighttime Sleep-Aid and Pain Reliever 20260114 451daeeb-88a9-44b1-9a2d-1ff0b0ec41cb Unisom PM Pain SleepCaps 325 MG / 50 MG Oral Tablet PSN 9 Unisom PM Pain Nighttime Sleep-Aid and Pain Reliever 20260114 451daeeb-88a9-44b1-9a2d-1ff0b0ec41cb APAP 325 MG / Diphenhydramine Hydrochloride 50 MG Oral Tablet [Unisom with Pain Relief] SY 9 Unisom PM Pain Nighttime Sleep-Aid and Pain Reliever 20260114 451daeeb-88a9-44b1-9a2d-1ff0b0ec41cb acetaminophen 325 MG / diphenhydramine hydrochloride 50 MG Oral Tablet [Unisom with Pain Relief] SBD 9 Unisom PM Pain Nighttime Sleep-Aid and Pain Reliever 20260114
Drug Classes# Source, Class ID, Class table Source Class ID Class Type Relationship Drug concept ATC R06AA Aminoalkyl ethers ATC1-4 diphenhydramine ATC N02BE Anilides ATC1-4 acetaminophen ATC D04AA Antihistamines for topical use ATC1-4 diphenhydramine FDASPL N0000175587 Histamine-1 Receptor Antagonist EPC has_epc diphenhydramine FDASPL N0000000190 Histamine H1 Receptor Antagonists MOA has_moa diphenhydramine MEDRT D000082 Acetaminophen CHEM has_ingredient acetaminophen MEDRT D004155 Diphenhydramine CHEM has_ingredient diphenhydramine hydrochloride MEDRT D004155 Diphenhydramine CHEM has_ingredient diphenhydramine MEDRT D001008 Anxiety Disorders DISEASE may_treat diphenhydramine MEDRT D001008 Anxiety Disorders DISEASE may_treat diphenhydramine hydrochloride MEDRT D004342 Drug Hypersensitivity DISEASE ci_with diphenhydramine hydrochloride MEDRT D004342 Drug Hypersensitivity DISEASE ci_with acetaminophen MEDRT D004342 Drug Hypersensitivity DISEASE ci_with diphenhydramine MEDRT D005334 Fever DISEASE may_prevent acetaminophen MEDRT D005334 Fever DISEASE may_treat acetaminophen MEDRT D005955 Glucosephosphate Dehydrogenase Deficiency DISEASE ci_with acetaminophen MEDRT D007231 Infant, Newborn DISEASE ci_with diphenhydramine hydrochloride MEDRT D007231 Infant, Newborn DISEASE ci_with diphenhydramine MEDRT D007234 Infant, Premature DISEASE ci_with diphenhydramine hydrochloride MEDRT D007234 Infant, Premature DISEASE ci_with diphenhydramine MEDRT D007774 Lactation DISEASE ci_with diphenhydramine hydrochloride MEDRT D007774 Lactation DISEASE ci_with diphenhydramine MEDRT D008107 Liver Diseases DISEASE ci_with acetaminophen MEDRT D009041 Motion Sickness DISEASE may_treat diphenhydramine MEDRT D009041 Motion Sickness DISEASE may_treat diphenhydramine hydrochloride MEDRT D009325 Nausea DISEASE may_treat diphenhydramine MEDRT D009325 Nausea DISEASE may_treat diphenhydramine hydrochloride MEDRT D010146 Pain DISEASE may_treat acetaminophen MEDRT D010146 Pain DISEASE may_prevent acetaminophen MEDRT D012221 Rhinitis, Allergic, Perennial DISEASE may_treat diphenhydramine MEDRT D012221 Rhinitis, Allergic, Perennial DISEASE may_treat diphenhydramine hydrochloride MEDRT D007319 Sleep Initiation and Maintenance Disorders DISEASE may_treat diphenhydramine hydrochloride MEDRT D007319 Sleep Initiation and Maintenance Disorders DISEASE may_treat diphenhydramine MEDRT D012912 Sneezing DISEASE may_treat diphenhydramine hydrochloride MEDRT D012912 Sneezing DISEASE may_treat diphenhydramine MEDRT D013224 Status Asthmaticus DISEASE ci_with diphenhydramine hydrochloride MEDRT D013224 Status Asthmaticus DISEASE ci_with diphenhydramine MEDRT D014581 Urticaria DISEASE may_treat diphenhydramine MEDRT D014581 Urticaria DISEASE may_treat diphenhydramine hydrochloride MEDRT N0000000190 Histamine H1 Receptor Antagonists MOA has_moa diphenhydramine hydrochloride MEDRT N0000000190 Histamine H1 Receptor Antagonists MOA has_moa diphenhydramine MEDRT N0000000108 Prostaglandin Receptor Antagonists MOA has_moa acetaminophen MEDRT N0000175724 Central Nervous System Activity Alteration PE has_pe acetaminophen MEDRT N0000008836 Decreased Prostaglandin Production PE has_pe acetaminophen MEDRT N0000009072 Hypothalamic Endocrine Activity Alteration PE has_pe acetaminophen MEDRT N0000175725 Peripheral Nervous System Activity Alteration PE has_pe acetaminophen MEDRT N0000000026 Hepatic Metabolism PK has_pk acetaminophen MEDRT N0000000042 Renal Excretion PK has_pk acetaminophen
Properties# Category, Property, Value table Category Property Value ATTRIBUTES AVAILABLE_STRENGTH 325 MG / 50 MG ATTRIBUTES GENERAL_CARDINALITY MULTI ATTRIBUTES HUMAN_DRUG US ATTRIBUTES PRESCRIBABLE Y ATTRIBUTES RXNAV_HUMAN_DRUG US ATTRIBUTES SCHEDULE 0 ATTRIBUTES TTY SBD CODES MMSL_CODE BD39439 CODES RxCUI 1093077 CODES SPL_SET_ID 451daeeb-88a9-44b1-9a2d-1ff0b0ec41cb NAMES Prescribable Synonym Unisom PM Pain SleepCaps 325 MG / 50 MG Oral Tablet NAMES RXNAV_STR APAP 325 MG / diphenhydrAMINE Hydrochloride 50 MG Oral Tablet [Unisom with Pain Relief] NAMES RxNorm Name acetaminophen 325 MG / diphenhydramine hydrochloride 50 MG Oral Tablet [Unisom with Pain Relief] NAMES RxNorm Synonym APAP 325 MG / Diphenhydramine Hydrochloride 50 MG Oral Tablet [Unisom with Pain Relief] NAMES RxNorm Synonym Unisom with Pain Relief (APAP 325 MG / diphenhydramine hydrochloride 50 MG) Oral Tablet NAMES Tallman Synonym acetaminophen 325 MG / diphenhydrAMINE hydrochloride 50 MG Oral Tablet [Unisom with Pain Relief] NAMES Tallman Synonym APAP 325 MG / diphenhydrAMINE Hydrochloride 50 MG Oral Tablet [Unisom with Pain Relief] NAMES Tallman Synonym Unisom with Pain Relief (APAP 325 MG / diphenhydrAMINE hydrochloride 50 MG) Oral Tablet SOURCES Source Gold Standard Alchemy SOURCES Source Metathesaurus FDA Structured Product Labels SOURCES Source Micromedex RED BOOK SOURCES Source Multum MediSource Lexicon