acetaminophen 65 MG/ML / dextromethorphan hydrobromide 2 MG/ML / diphenhydramine hydrochloride 2.5 MG/ML Oral Solution

RxCUI: 1094131
RxNorm name: acetaminophen 65 MG/ML / dextromethorphan hydrobromide 2 MG/ML / diphenhydramine hydrochloride 2.5 MG/ML Oral Solution
Display name: Acetaminophen/Dextromethorphan/diphenhydrAMINE (Oral Liquid)
Full name: acetaminophen 65 MG/ML / dextromethorphan hydrobromide 2 MG/ML / diphenhydramine hydrochloride 2.5 MG/ML Oral Solution
Term type: SCD
Status: Active
Strength: 325-10-12.5 mg/5ml
Dose form: Sol
Route: Oral Liquid
Updated: 2026-06-15 07:01:25

RxNorm Status History#

Status: Active
Source: RXNORM
Current: YES
Release start: 042011
Active start: 042011
Multiple ingredient: YES
Branded: NO

Ingredients And Strength#

Ingredient, Strength, Base table
Ingredient	Strength	Base	Basis of strength
acetaminophen	65 MG / 1 ML	acetaminophen	acetaminophen
dextromethorphan hydrobromide	2 MG / 1 ML	dextromethorphan	dextromethorphan hydrobromide
diphenhydramine hydrochloride	2.5 MG / 1 ML	diphenhydramine	diphenhydramine hydrochloride

Dose Form Concepts#

Dose form, RxCUI table
Dose form	RxCUI
Oral Solution	316968

Derived Ingredient Concepts#

Ingredient, RxCUI table
Ingredient	RxCUI
acetaminophen	161
dextromethorphan	3289
diphenhydramine	3498

Source Vocabulary Codes#

Code type, Value, Category table
Code type	Value	Category
PRESCRIBABLE	Y	ATTRIBUTES
RXNAV_STR	acetaminophen 65 MG/ML / dextromethorphan hydrobromide 2 MG/ML / diphenhydrAMINE hydrochloride 2.5 MG/ML Oral Solution	NAMES
RxNorm Name	acetaminophen 65 MG/ML / dextromethorphan hydrobromide 2 MG/ML / diphenhydramine hydrochloride 2.5 MG/ML Oral Solution	NAMES
RxNorm Synonym	APAP 325 MG / dextromethorphan hydrobromide 10 MG / diphenhydramine hydrochloride 12.5 MG per 5 ML Oral Solution	NAMES
RxNorm Synonym	APAP 65 MG/ML / Dextromethorphan Hydrobromide 2 MG/ML / Diphenhydramine Hydrochloride 2.5 MG/ML Oral Solution	NAMES
TTY	SCD	ATTRIBUTES
RxCUI	1094131	CODES
MMSL_CODE	BD14679	CODES
MMSL_CODE	CD14679	CODES

RxNav Current And Historical NDCs#

NDC11, Source, Active table
NDC11	Source	Active
61787045204	rxnav_ndcs	yes
61787045208	rxnav_ndcs	yes
61787047104	rxnav_ndcs	yes
60569047104	rxnav_historical_indirect
61787051604	rxnav_historical

DailyMed RxNorm Mappings#

Set ID, RxNorm string, TTY table
Set ID	RxNorm string	TTY	SPL version	Label	Effective
4d5e317f-0e32-4cdc-b56e-b792efa972f5	acetaminophen 325 MG / dextromethorphan HBr 10 MG / diphenhydrAMINE HCl 12.5 MG in 5 mL Oral Solution	PSN	3	Diabetic Tussin Nighttime Cold and Flu 61787-516	20220303
4d5e317f-0e32-4cdc-b56e-b792efa972f5	APAP 65 MG/ML / Dextromethorphan Hydrobromide 2 MG/ML / Diphenhydramine Hydrochloride 2.5 MG/ML Oral Solution	SY	3	Diabetic Tussin Nighttime Cold and Flu 61787-516	20220303
4d5e317f-0e32-4cdc-b56e-b792efa972f5	acetaminophen 65 MG/ML / dextromethorphan hydrobromide 2 MG/ML / diphenhydramine hydrochloride 2.5 MG/ML Oral Solution	SCD	3	Diabetic Tussin Nighttime Cold and Flu 61787-516	20220303
4d5e317f-0e32-4cdc-b56e-b792efa972f5	APAP 325 MG / dextromethorphan hydrobromide 10 MG / diphenhydramine hydrochloride 12.5 MG per 5 ML Oral Solution	SY	3	Diabetic Tussin Nighttime Cold and Flu 61787-516	20220303
96ef6c88-ce06-4d7a-ab7b-42af64ba3149	acetaminophen 325 MG / dextromethorphan HBr 10 MG / diphenhydrAMINE HCl 12.5 MG in 5 mL Oral Solution	PSN	3	Drug Facts	20191217
96ef6c88-ce06-4d7a-ab7b-42af64ba3149	APAP 65 MG/ML / Dextromethorphan Hydrobromide 2 MG/ML / Diphenhydramine Hydrochloride 2.5 MG/ML Oral Solution	SY	3	Drug Facts	20191217
96ef6c88-ce06-4d7a-ab7b-42af64ba3149	APAP 325 MG / dextromethorphan hydrobromide 10 MG / diphenhydramine hydrochloride 12.5 MG per 5 ML Oral Solution	SY	3	Drug Facts	20191217
96ef6c88-ce06-4d7a-ab7b-42af64ba3149	acetaminophen 65 MG/ML / dextromethorphan hydrobromide 2 MG/ML / diphenhydramine hydrochloride 2.5 MG/ML Oral Solution	SCD	3	Drug Facts	20191217

DailyMed Labels#

Set ID, Title, Manufacturer table
Set ID	Title	Manufacturer	Effective
4d5e317f-0e32-4cdc-b56e-b792efa972f5	Diabetic Tussin Nighttime Cold and Flu 61787-516	MEDTECH PRODUCTS INC \| Akorn Operating Company LLC (dba Akorn)	20220303
96ef6c88-ce06-4d7a-ab7b-42af64ba3149	Drug Facts	Health Care Products \| Hi-Tech Pharmacal Co., Inc.	20191217

Drug Classes#

Source, Class ID, Class table
Source	Class ID	Class	Type	Relationship	Drug concept
ATC	R06AA	Aminoalkyl ethers	ATC1-4		diphenhydramine
ATC	N02BE	Anilides	ATC1-4		acetaminophen
ATC	D04AA	Antihistamines for topical use	ATC1-4		diphenhydramine
ATC	R05DA	Opium alkaloids and derivatives	ATC1-4		dextromethorphan
FDASPL	N0000175587	Histamine-1 Receptor Antagonist	EPC	has_epc	diphenhydramine
FDASPL	N0000182149	Sigma-1 Agonist	EPC	has_epc	dextromethorphan
FDASPL	N0000181821	Uncompetitive N-methyl-D-aspartate Receptor Antagonist	EPC	has_epc	dextromethorphan
FDASPL	N0000000190	Histamine H1 Receptor Antagonists	MOA	has_moa	diphenhydramine
FDASPL	N0000182147	Sigma-1 Receptor Agonists	MOA	has_moa	dextromethorphan
FDASPL	N0000181819	Uncompetitive NMDA Receptor Antagonists	MOA	has_moa	dextromethorphan
MEDRT	D000082	Acetaminophen	CHEM	has_ingredient	acetaminophen
MEDRT	D003915	Dextromethorphan	CHEM	has_ingredient	dextromethorphan
MEDRT	D003915	Dextromethorphan	CHEM	has_ingredient	dextromethorphan hydrobromide
MEDRT	D004155	Diphenhydramine	CHEM	has_ingredient	diphenhydramine hydrochloride
MEDRT	D004155	Diphenhydramine	CHEM	has_ingredient	diphenhydramine
MEDRT	D001008	Anxiety Disorders	DISEASE	may_treat	diphenhydramine hydrochloride
MEDRT	D001008	Anxiety Disorders	DISEASE	may_treat	diphenhydramine
MEDRT	D003371	Cough	DISEASE	may_treat	dextromethorphan
MEDRT	D003371	Cough	DISEASE	may_prevent	dextromethorphan
MEDRT	D003371	Cough	DISEASE	may_treat	dextromethorphan hydrobromide
MEDRT	D003371	Cough	DISEASE	may_prevent	dextromethorphan hydrobromide
MEDRT	D004342	Drug Hypersensitivity	DISEASE	ci_with	diphenhydramine hydrochloride
MEDRT	D004342	Drug Hypersensitivity	DISEASE	ci_with	diphenhydramine
MEDRT	D004342	Drug Hypersensitivity	DISEASE	ci_with	acetaminophen
MEDRT	D004342	Drug Hypersensitivity	DISEASE	ci_with	dextromethorphan
MEDRT	D004342	Drug Hypersensitivity	DISEASE	ci_with	dextromethorphan hydrobromide
MEDRT	D005334	Fever	DISEASE	may_prevent	acetaminophen
MEDRT	D005334	Fever	DISEASE	may_treat	acetaminophen
MEDRT	D005955	Glucosephosphate Dehydrogenase Deficiency	DISEASE	ci_with	acetaminophen
MEDRT	D007231	Infant, Newborn	DISEASE	ci_with	diphenhydramine hydrochloride
MEDRT	D007231	Infant, Newborn	DISEASE	ci_with	diphenhydramine
MEDRT	D007234	Infant, Premature	DISEASE	ci_with	diphenhydramine hydrochloride
MEDRT	D007234	Infant, Premature	DISEASE	ci_with	diphenhydramine
MEDRT	D007774	Lactation	DISEASE	ci_with	diphenhydramine
MEDRT	D007774	Lactation	DISEASE	ci_with	diphenhydramine hydrochloride
MEDRT	D008107	Liver Diseases	DISEASE	ci_with	acetaminophen
MEDRT	D009041	Motion Sickness	DISEASE	may_treat	diphenhydramine
MEDRT	D009041	Motion Sickness	DISEASE	may_treat	diphenhydramine hydrochloride
MEDRT	D009325	Nausea	DISEASE	may_treat	diphenhydramine
MEDRT	D009325	Nausea	DISEASE	may_treat	diphenhydramine hydrochloride
MEDRT	D010146	Pain	DISEASE	may_treat	acetaminophen
MEDRT	D010146	Pain	DISEASE	may_prevent	acetaminophen
MEDRT	D012221	Rhinitis, Allergic, Perennial	DISEASE	may_treat	diphenhydramine hydrochloride
MEDRT	D012221	Rhinitis, Allergic, Perennial	DISEASE	may_treat	diphenhydramine
MEDRT	D007319	Sleep Initiation and Maintenance Disorders	DISEASE	may_treat	diphenhydramine
MEDRT	D007319	Sleep Initiation and Maintenance Disorders	DISEASE	may_treat	diphenhydramine hydrochloride
MEDRT	D012912	Sneezing	DISEASE	may_treat	diphenhydramine
MEDRT	D012912	Sneezing	DISEASE	may_treat	diphenhydramine hydrochloride
MEDRT	D013224	Status Asthmaticus	DISEASE	ci_with	diphenhydramine
MEDRT	D013224	Status Asthmaticus	DISEASE	ci_with	diphenhydramine hydrochloride
MEDRT	D014581	Urticaria	DISEASE	may_treat	diphenhydramine hydrochloride
MEDRT	D014581	Urticaria	DISEASE	may_treat	diphenhydramine
MEDRT	N0000000190	Histamine H1 Receptor Antagonists	MOA	has_moa	diphenhydramine hydrochloride
MEDRT	N0000000190	Histamine H1 Receptor Antagonists	MOA	has_moa	diphenhydramine
MEDRT	N0000000184	Monoamine Oxidase Inhibitors	MOA	ci_moa	dextromethorphan
MEDRT	N0000000184	Monoamine Oxidase Inhibitors	MOA	ci_moa	dextromethorphan hydrobromide
MEDRT	N0000000108	Prostaglandin Receptor Antagonists	MOA	has_moa	acetaminophen
MEDRT	N0000000109	Serotonin Uptake Inhibitors	MOA	has_moa	dextromethorphan hydrobromide
MEDRT	N0000000109	Serotonin Uptake Inhibitors	MOA	has_moa	dextromethorphan
MEDRT	N0000182147	Sigma-1 Receptor Agonists	MOA	has_moa	dextromethorphan hydrobromide
MEDRT	N0000182147	Sigma-1 Receptor Agonists	MOA	has_moa	dextromethorphan
MEDRT	N0000181819	Uncompetitive NMDA Receptor Antagonists	MOA	has_moa	dextromethorphan hydrobromide
MEDRT	N0000181819	Uncompetitive NMDA Receptor Antagonists	MOA	has_moa	dextromethorphan
MEDRT	N0000175724	Central Nervous System Activity Alteration	PE	has_pe	acetaminophen
MEDRT	N0000008701	Decreased Medullary Respiratory Drive	PE	has_pe	dextromethorphan
MEDRT	N0000008701	Decreased Medullary Respiratory Drive	PE	has_pe	dextromethorphan hydrobromide
MEDRT	N0000008836	Decreased Prostaglandin Production	PE	has_pe	acetaminophen
MEDRT	N0000009072	Hypothalamic Endocrine Activity Alteration	PE	has_pe	acetaminophen
MEDRT	N0000175725	Peripheral Nervous System Activity Alteration	PE	has_pe	acetaminophen
MEDRT	N0000000026	Hepatic Metabolism	PK	has_pk	acetaminophen
MEDRT	N0000000042	Renal Excretion	PK	has_pk	acetaminophen

Group, Type, Concept table
Group	Type	Concept	Source
DF	DF	Oral Solution	rxnav_allrelated
DFG	DFG	Oral Liquid Product	rxnav_allrelated
DFG	DFG	Oral Product	rxnav_allrelated
IN	IN	acetaminophen	rxnav_allrelated
IN	IN	dextromethorphan	rxnav_allrelated
IN	IN	diphenhydramine	rxnav_allrelated
MIN	MIN	acetaminophen / dextromethorphan / diphenhydramine	rxnav_allrelated
PIN	PIN	dextromethorphan hydrobromide	rxnav_allrelated
PIN	PIN	diphenhydramine hydrochloride	rxnav_allrelated
SCD	SCD	acetaminophen 65 MG/ML / dextromethorphan hydrobromide 2 MG/ML / diphenhydramine hydrochloride 2.5 MG/ML Oral Solution	rxnav_allrelated
SCDC	SCDC	acetaminophen 65 MG/ML	rxnav_allrelated
SCDC	SCDC	dextromethorphan hydrobromide 2 MG/ML	rxnav_allrelated
SCDC	SCDC	diphenhydramine hydrochloride 2.5 MG/ML	rxnav_allrelated
SCDF	SCDF	acetaminophen / dextromethorphan / diphenhydramine Oral Solution	rxnav_allrelated
SCDFP	SCDFP	acetaminophen / dextromethorphan hydrobromide / diphenhydramine hydrochloride Oral Solution	rxnav_allrelated
SCDG	SCDG	acetaminophen / dextromethorphan / diphenhydramine Oral Liquid Product	rxnav_allrelated
SCDG	SCDG	acetaminophen / dextromethorphan / diphenhydramine Oral Product	rxnav_allrelated
SCDGP	SCDGP	acetaminophen / dextromethorphan hydrobromide / diphenhydramine hydrochloride Oral Liquid Product	rxnav_allrelated
SCDGP	SCDGP	acetaminophen / dextromethorphan hydrobromide / diphenhydramine hydrochloride Oral Product	rxnav_allrelated

Properties#

Category, Property, Value table
Category	Property	Value
ATTRIBUTES	AVAILABLE_STRENGTH	65 MG/ML / 2 MG/ML / 2.5 MG/ML
ATTRIBUTES	GENERAL_CARDINALITY	MULTI
ATTRIBUTES	HUMAN_DRUG	US
ATTRIBUTES	PRESCRIBABLE	Y
ATTRIBUTES	RXNAV_HUMAN_DRUG	US
ATTRIBUTES	SCHEDULE	0
ATTRIBUTES	TTY	SCD
CODES	MMSL_CODE	BD14679
CODES	MMSL_CODE	CD14679
CODES	RxCUI	1094131
CODES	VUID	4033952
CODES	VUID	4034031
NAMES	Prescribable Synonym	acetaminophen 325 MG / dextromethorphan HBr 10 MG / diphenhydrAMINE HCl 12.5 MG in 5 mL Oral Solution
NAMES	RXNAV_STR	acetaminophen 65 MG/ML / dextromethorphan hydrobromide 2 MG/ML / diphenhydrAMINE hydrochloride 2.5 MG/ML Oral Solution
NAMES	RxNorm Name	acetaminophen 65 MG/ML / dextromethorphan hydrobromide 2 MG/ML / diphenhydramine hydrochloride 2.5 MG/ML Oral Solution
NAMES	RxNorm Synonym	APAP 325 MG / dextromethorphan hydrobromide 10 MG / diphenhydramine hydrochloride 12.5 MG per 5 ML Oral Solution
NAMES	RxNorm Synonym	APAP 65 MG/ML / Dextromethorphan Hydrobromide 2 MG/ML / Diphenhydramine Hydrochloride 2.5 MG/ML Oral Solution
NAMES	Tallman Synonym	acetaminophen 65 MG/ML / dextromethorphan hydrobromide 2 MG/ML / diphenhydrAMINE hydrochloride 2.5 MG/ML Oral Solution
NAMES	Tallman Synonym	APAP 325 MG / dextromethorphan hydrobromide 10 MG / diphenhydrAMINE hydrochloride 12.5 MG per 5 ML Oral Solution
NAMES	Tallman Synonym	APAP 65 MG/ML / Dextromethorphan Hydrobromide 2 MG/ML / diphenhydrAMINE Hydrochloride 2.5 MG/ML Oral Solution
SOURCES	Source	Gold Standard Alchemy
SOURCES	Source	Micromedex RED BOOK
SOURCES	Source	Multum MediSource Lexicon
SOURCES	Source	National Drug Data File Plus Source Vocabulary
SOURCES	Source	Veterans Health Administration National Drug File

acetaminophen 65 MG/ML / dextromethorphan hydrobromide 2 MG/ML / diphenhydramine hydrochloride 2.5 MG/ML Oral Solution

RxNorm Status History#

Ingredients And Strength#

Dose Form Concepts#

Derived Ingredient Concepts#

Source Vocabulary Codes#

RxNav Current And Historical NDCs#

DailyMed RxNorm Mappings#

DailyMed Labels#

Drug Classes#

Related Concepts#

Properties#