Home RxNorm 1099872 acetaminophen 500 MG / diphenhydramine citrate 38 MG Oral Tablet Drug identity information. FDA.report links public drug records from RxNav, DailyMed, FDA NDC, Drugs@FDA, and related public sources where available. This page is informational only and is not medical, prescribing, or regulatory advice.
RxCUI 1099872
RxNorm name acetaminophen 500 MG / diphenhydramine citrate 38 MG Oral Tablet
Display name Acetaminophen/diphenhydrAMINE (Oral Pill)
Full name acetaminophen 500 MG / diphenhydramine citrate 38 MG Oral Tablet
Term type SCD
Status Active
Strength 500-38 mg
Dose form Tab
Route Oral Pill
Updated 2026-10-17 23:45:23 RxNorm Status History#
Status Active
Source RXNORM
Current YES
Release start 052011
Active start 052011
Multiple ingredient YES
Branded NO Ingredients And Strength# Ingredient, Strength, Base table Ingredient Strength Base Basis of strength acetaminophen 500 MG / 1 EACH acetaminophen acetaminophen diphenhydramine citrate 38 MG / 1 EACH diphenhydramine diphenhydramine citrate
Derived Ingredient Concepts# FDA NDC Products And Packages# Package NDC, Product NDC, Name table Package NDC Product NDC Name Labeler Application 57631-010-00 57631-010 Acetaminophen and Diphenhydramine citrate Acetaminophen and Diphenhydramine citrate InvaTech Pharma Solutions LLC M012
Drugs@FDA Applications# Application, NDC, Name table Application NDC Name Marketing category Labeler M012 57631-010 Acetaminophen and Diphenhydramine citrate Acetaminophen and Diphenhydramine citrate OTC MONOGRAPH DRUG InvaTech Pharma Solutions LLC
RxNav Current And Historical NDCs# RxNav current and historical NDC rows page 1 of 1 · 58 matching rows.
NDC11, Source, Active table NDC11 Source Active 00280807020 rxnav_ndcs yes 00363037312 rxnav_ndcs yes 12843053711 rxnav_ndcs yes 57631001000 rxnav_ndcs yes 00067205324 rxnav_historical_indirect 00067205350 rxnav_historical_indirect 00067205391 rxnav_historical_indirect 00067205524 rxnav_historical_indirect 00067205550 rxnav_historical_indirect 00067205591 rxnav_historical_indirect 01981000323 rxnav_historical_indirect 01981000325 rxnav_historical_indirect 01981000326 rxnav_historical_indirect 01981007634 rxnav_historical_indirect 01981007643 rxnav_historical_indirect 11673037312 rxnav_historical 11822037302 rxnav_historical 11822574290 rxnav_historical 11917007220 rxnav_historical 19810000183 rxnav_historical_indirect 19810000240 rxnav_historical_indirect 19810000322 rxnav_historical_indirect 19810000323 rxnav_historical_indirect 19810000326 rxnav_historical_indirect 19810001801 rxnav_historical_indirect 19810001802 rxnav_historical_indirect 19810001803 rxnav_historical_indirect 19810001804 rxnav_historical_indirect 19810003202 rxnav_historical_indirect 19810003203 rxnav_historical_indirect 19810003206 rxnav_historical_indirect 19810007067 rxnav_historical_indirect 19810007068 rxnav_historical_indirect 19810008401 rxnav_historical_indirect 19810008402 rxnav_historical_indirect 19810076303 rxnav_historical_indirect 19810076304 rxnav_historical_indirect 19810076305 rxnav_historical_indirect 19810076306 rxnav_historical_indirect 19810076309 rxnav_historical_indirect 21130037315 rxnav_historical 33992037300 rxnav_historical 33992037308 rxnav_historical 33992037309 rxnav_historical 41163037312 rxnav_historical 49348007209 rxnav_historical 50428322867 rxnav_historical 55301037315 rxnav_historical 55301097315 rxnav_historical 55910037315 rxnav_historical 59779037308 rxnav_historical 59779037312 rxnav_historical 63868015901 rxnav_historical 63868015912 rxnav_historical 63941037315 rxnav_historical 68210002003 rxnav_historical 68210200002 rxnav_historical 68210413502 rxnav_historical
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DailyMed RxNorm Mappings# unique DailyMed labels mapped to this RxNorm concept page 1 of 1 · 3 matching rows.
Set ID, RxNorm mappings, Terms table Set ID RxNorm mappings Terms SPL version Label Effective d9d22e45-1a13-4b45-910d-1183a8e6ed7d acetaminophen 500 MG / diphenhydrAMINE citrate 38 MG Oral Tablet [PSN] · acetaminophen 500 MG / diphenhydramine citrate 38 MG Oral Tablet [SCD] · APAP 500 MG / Diphenhydramine Citrate 38 MG Oral Tablet [SY] 3 6 Headache PM (Aspirin Free) 20241230 e5e73f9d-7927-4b7f-be6c-cb8aeda21bee acetaminophen 500 MG / diphenhydrAMINE citrate 38 MG Oral Tablet [PSN] · acetaminophen 500 MG / diphenhydramine citrate 38 MG Oral Tablet [SCD] · APAP 500 MG / Diphenhydramine Citrate 38 MG Oral Tablet [SY] 3 5 Assured™ Headache PM (Aspirin Free) 20220113 403a88fa-e06b-9b6e-e063-6394a90a97b8 acetaminophen 500 MG / diphenhydrAMINE citrate 38 MG Oral Tablet [PSN] · acetaminophen 500 MG / diphenhydramine citrate 38 MG Oral Tablet [SCD] · APAP 500 MG / Diphenhydramine Citrate 38 MG Oral Tablet [SY] 3 4 Acetaminophen and Diphenhydramine citrate 20251002
Recently Linked DailyMed Labels# Drug Classes# Source, Class ID, Class table Source Class ID Class Type Relationship Drug concept ATC R06AA Aminoalkyl ethers ATC1-4 diphenhydramine ATC N02BE Anilides ATC1-4 acetaminophen ATC D04AA Antihistamines for topical use ATC1-4 diphenhydramine FDASPL N0000175587 Histamine-1 Receptor Antagonist EPC has_epc diphenhydramine FDASPL N0000000190 Histamine H1 Receptor Antagonists MOA has_moa diphenhydramine MEDRT D000082 Acetaminophen CHEM has_ingredient acetaminophen MEDRT D004155 Diphenhydramine CHEM has_ingredient diphenhydramine MEDRT D004155 Diphenhydramine CHEM has_ingredient diphenhydramine citrate MEDRT D001008 Anxiety Disorders DISEASE may_treat diphenhydramine citrate MEDRT D001008 Anxiety Disorders DISEASE may_treat diphenhydramine MEDRT D004342 Drug Hypersensitivity DISEASE ci_with diphenhydramine MEDRT D004342 Drug Hypersensitivity DISEASE ci_with acetaminophen MEDRT D004342 Drug Hypersensitivity DISEASE ci_with diphenhydramine citrate MEDRT D005334 Fever DISEASE may_treat acetaminophen MEDRT D005334 Fever DISEASE may_prevent acetaminophen MEDRT D005955 Glucosephosphate Dehydrogenase Deficiency DISEASE ci_with acetaminophen MEDRT D007231 Infant, Newborn DISEASE ci_with diphenhydramine citrate MEDRT D007231 Infant, Newborn DISEASE ci_with diphenhydramine MEDRT D007234 Infant, Premature DISEASE ci_with diphenhydramine citrate MEDRT D007234 Infant, Premature DISEASE ci_with diphenhydramine MEDRT D007774 Lactation DISEASE ci_with diphenhydramine citrate MEDRT D007774 Lactation DISEASE ci_with diphenhydramine MEDRT D008107 Liver Diseases DISEASE ci_with acetaminophen MEDRT D009041 Motion Sickness DISEASE may_treat diphenhydramine citrate MEDRT D009041 Motion Sickness DISEASE may_treat diphenhydramine MEDRT D009325 Nausea DISEASE may_treat diphenhydramine MEDRT D009325 Nausea DISEASE may_treat diphenhydramine citrate MEDRT D010146 Pain DISEASE may_prevent acetaminophen MEDRT D010146 Pain DISEASE may_treat acetaminophen MEDRT D012221 Rhinitis, Allergic, Perennial DISEASE may_treat diphenhydramine MEDRT D012221 Rhinitis, Allergic, Perennial DISEASE may_treat diphenhydramine citrate MEDRT D007319 Sleep Initiation and Maintenance Disorders DISEASE may_treat diphenhydramine MEDRT D007319 Sleep Initiation and Maintenance Disorders DISEASE may_treat diphenhydramine citrate MEDRT D012912 Sneezing DISEASE may_treat diphenhydramine MEDRT D012912 Sneezing DISEASE may_treat diphenhydramine citrate MEDRT D013224 Status Asthmaticus DISEASE ci_with diphenhydramine MEDRT D013224 Status Asthmaticus DISEASE ci_with diphenhydramine citrate MEDRT D014581 Urticaria DISEASE may_treat diphenhydramine MEDRT D014581 Urticaria DISEASE may_treat diphenhydramine citrate MEDRT N0000000190 Histamine H1 Receptor Antagonists MOA has_moa diphenhydramine citrate MEDRT N0000000190 Histamine H1 Receptor Antagonists MOA has_moa diphenhydramine MEDRT N0000000108 Prostaglandin Receptor Antagonists MOA has_moa acetaminophen MEDRT N0000175724 Central Nervous System Activity Alteration PE has_pe acetaminophen MEDRT N0000008836 Decreased Prostaglandin Production PE has_pe acetaminophen MEDRT N0000009072 Hypothalamic Endocrine Activity Alteration PE has_pe acetaminophen MEDRT N0000175725 Peripheral Nervous System Activity Alteration PE has_pe acetaminophen MEDRT N0000000026 Hepatic Metabolism PK has_pk acetaminophen MEDRT N0000000042 Renal Excretion PK has_pk acetaminophen
Properties# Category, Property, Value table Category Property Value ATTRIBUTES AVAILABLE_STRENGTH 500 MG / 38 MG ATTRIBUTES GENERAL_CARDINALITY MULTI ATTRIBUTES HUMAN_DRUG US ATTRIBUTES RXNAV_HUMAN_DRUG US ATTRIBUTES SCHEDULE 0 CODES VUID 4010178 NAMES Prescribable Synonym acetaminophen 500 MG / diphenhydrAMINE citrate 38 MG Oral Tablet NAMES Tallman Synonym acetaminophen 500 MG / diphenhydrAMINE citrate 38 MG Oral Tablet NAMES Tallman Synonym APAP 500 MG / diphenhydrAMINE Citrate 38 MG Oral Tablet SOURCES Source Gold Standard Alchemy SOURCES Source Metathesaurus FDA Structured Product Labels SOURCES Source Multum MediSource Lexicon SOURCES Source National Drug Data File Plus Source Vocabulary SOURCES Source Veterans Health Administration National Drug File