FDA.reportPublic FDA data

diphenhydramine hydrochloride 20 MG/ML / zinc acetate 1 MG/ML Topical Solution

RxCUI
1294589
RxNorm name
diphenhydramine hydrochloride 20 MG/ML / zinc acetate 1 MG/ML Topical Solution
Display name
diphenhydrAMINE/Zinc acetate (Topical)
Full name
diphenhydramine hydrochloride 20 MG/ML / zinc acetate 1 MG/ML Topical Solution
Term type
SCD
Status
Active
Strength
2-0.1%
Dose form
Sol
Route
Topical
Updated
2026-07-20 06:53:40

RxNorm Status History#

Status
Active
Source
RXNORM
Current
YES
Release start
062012
Active start
062012
Multiple ingredient
YES
Branded
NO

Ingredients And Strength#

Ingredient, Strength, Base table
IngredientStrengthBaseBasis of strength
diphenhydramine hydrochloride20 MG / 1 MLdiphenhydraminediphenhydramine hydrochloride
zinc acetate1 MG / 1 MLzinc acetatezinc acetate

Dose Form Concepts#

Dose form, RxCUI table
Dose formRxCUI
Topical Solution316986

Derived Ingredient Concepts#

Ingredient, RxCUI table
IngredientRxCUI
diphenhydramine3498
zinc acetate58295

Source Vocabulary Codes#

Code type, Values, Count table
Code typeValuesCountCategory
PRESCRIBABLEY1ATTRIBUTES
RXNAV_STRdiphenhydrAMINE hydrochloride 20 MG/ML / zinc acetate 1 MG/ML Topical Solution1NAMES
RxNorm Namediphenhydramine hydrochloride 20 MG/ML / zinc acetate 1 MG/ML Topical Solution1NAMES
RxNorm Synonymdiphenhydramine hydrochloride 2 % / zinc acetate 0.1 % Topical Solution1NAMES
TTYSCD1ATTRIBUTES
SPL_SET_ID236415fc-f923-4a82-b54a-ecaf666dd2e01CODES
RxCUI12945891CODES
MMSL_CODECD113601CODES

FDA NDC Products And Packages#

Package NDC, Product NDC, Name table
Package NDCProduct NDCNameLabelerApplication
59555-002-1859555-002Industrial Itch and Pain Relief DIPHENHYDRAMINE HYDROCHLORIDE and Zinc AcetateR & R Lotion, IncM017
59555-002-1959555-002Industrial Itch and Pain Relief DIPHENHYDRAMINE HYDROCHLORIDE and Zinc AcetateR & R Lotion, IncM017

Drugs@FDA Applications#

Application, NDC, Name table
ApplicationNDCNameMarketing categoryLabeler
M01759555-002Industrial Itch and Pain Relief DIPHENHYDRAMINE HYDROCHLORIDE and Zinc AcetateOTC MONOGRAPH DRUGR & R Lotion, Inc

RxNav Current And Historical NDCs#

RxNav current and historical NDC rows page 1 of 1 · 14 matching rows.

NDC11, Source, Active table
NDC11SourceActive
59555000218rxnav_ndcsyes
59555000219rxnav_ndcsyes
11822039230rxnav_historical
11822372310rxnav_historical
11822928120rxnav_historical
49348092530rxnav_historical_indirect
50428237741rxnav_historical
50428460403rxnav_historical
59555001018rxnav_historical
59555001019rxnav_historical
59555023004rxnav_historical
59555023007rxnav_historical
59555023018rxnav_historical
59555023019rxnav_historical

UNII Substances#

UNII substance links page 1 of 1 · 0 matching rows.

No records found.

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 2 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
Industrial Itch and Pain ReliefDIPHENHYDRAMINE HYDROCHLORIDE AND ZINC ACETATER & R Lotion, Inc236415fc-f923-4a82-b54a-ecaf666dd2e02025-09-11WarningsExact identifier
ndc (package): 59555-002-19
ndc (package): 59555-002-18
ndc (product): 59555-002
ndc11 (package): 59555000218
ndc11 (package): 59555000219
rxcui: 1294589
Benadryl Extra Strength Itch ReliefDIPHENHYDRAMINE HYDROCHLORIDE AND ZINC ACETATEKenvue Brands LLC309d9be0-e367-429a-a1fa-ab7855477c8a2025-07-10WarningsExact identifier
rxcui: 1294589

Reported adverse events (FAERS/openFDA)#

Adverse event summaries are temporarily unavailable. Other product information remains available.

DailyMed RxNorm Mappings#

unique DailyMed labels mapped to this RxNorm concept page 1 of 1 · 4 matching rows.

Set ID, RxNorm mappings, Terms table
Set IDRxNorm mappingsTermsSPL versionLabelEffective
309d9be0-e367-429a-a1fa-ab7855477c8adiphenhydrAMINE HCl 2 % / zinc acetate 0.1 % Topical Solution [PSN] · diphenhydramine hydrochloride 20 MG/ML / zinc acetate 1 MG/ML Topical Solution [SCD] · diphenhydramine hydrochloride 2 % / zinc acetate 0.1 % Topical Solution [SY]38Benadryl ® EXTRA STRENGTH ITCH RELIEF STICK20250710
236415fc-f923-4a82-b54a-ecaf666dd2e0diphenhydrAMINE HCl 2 % / zinc acetate 0.1 % Topical Solution [PSN] · diphenhydramine hydrochloride 20 MG/ML / zinc acetate 1 MG/ML Topical Solution [SCD] · diphenhydramine hydrochloride 2 % / zinc acetate 0.1 % Topical Solution [SY]33Industrial Itch and Pain Relief20250911
9cc4543c-12f9-46c8-864b-bc1f5705569adiphenhydrAMINE HCl 2 % / zinc acetate 0.1 % Topical Solution [PSN] · diphenhydramine hydrochloride 20 MG/ML / zinc acetate 1 MG/ML Topical Solution [SCD] · diphenhydramine hydrochloride 2 % / zinc acetate 0.1 % Topical Solution [SY]32Rugid Itch and Pain Relief20210114
7661cbc8-6b2e-4144-9085-3a58040446f2diphenhydrAMINE HCl 2 % / zinc acetate 0.1 % Topical Solution [PSN] · diphenhydramine hydrochloride 20 MG/ML / zinc acetate 1 MG/ML Topical Solution [SCD] · diphenhydramine hydrochloride 2 % / zinc acetate 0.1 % Topical Solution [SY]31IC ® Ivy Relief20210924

Recently Linked DailyMed Labels#

Set ID, Title, Manufacturer table
Set IDTitleManufacturerEffective
236415fc-f923-4a82-b54a-ecaf666dd2e0Industrial Itch and Pain ReliefR & R Lotion, Inc20250911
7661cbc8-6b2e-4144-9085-3a58040446f2IC ® Ivy ReliefR & R Lotion, Inc20210924
9cc4543c-12f9-46c8-864b-bc1f5705569aRugid Itch and Pain ReliefR & R Lotion, Inc20210114

Drug Classes#

Source, Class ID, Class table
SourceClass IDClassTypeRelationshipDrug concept
ATCR06AAAminoalkyl ethersATC1-4diphenhydramine
ATCD04AAAntihistamines for topical useATC1-4diphenhydramine
ATCA16AXVarious alimentary tract and metabolism productsATC1-4zinc acetate
FDASPLN0000175587Histamine-1 Receptor AntagonistEPChas_epcdiphenhydramine
FDASPLN0000000190Histamine H1 Receptor AntagonistsMOAhas_moadiphenhydramine
MEDRTD004155DiphenhydramineCHEMhas_ingredientdiphenhydramine hydrochloride
MEDRTD004155DiphenhydramineCHEMhas_ingredientdiphenhydramine
MEDRTD019345Zinc AcetateCHEMhas_ingredientzinc acetate
MEDRTD001008Anxiety DisordersDISEASEmay_treatdiphenhydramine hydrochloride
MEDRTD001008Anxiety DisordersDISEASEmay_treatdiphenhydramine
MEDRTD003139Common ColdDISEASEmay_treatzinc acetate
MEDRTD004342Drug HypersensitivityDISEASEci_withdiphenhydramine hydrochloride
MEDRTD004342Drug HypersensitivityDISEASEci_withdiphenhydramine
MEDRTD007231Infant, NewbornDISEASEci_withdiphenhydramine hydrochloride
MEDRTD007231Infant, NewbornDISEASEci_withdiphenhydramine
MEDRTD007234Infant, PrematureDISEASEci_withdiphenhydramine hydrochloride
MEDRTD007234Infant, PrematureDISEASEci_withdiphenhydramine
MEDRTD007774LactationDISEASEci_withdiphenhydramine
MEDRTD007774LactationDISEASEci_withdiphenhydramine hydrochloride
MEDRTD009041Motion SicknessDISEASEmay_treatdiphenhydramine
MEDRTD009041Motion SicknessDISEASEmay_treatdiphenhydramine hydrochloride
MEDRTD009325NauseaDISEASEmay_treatdiphenhydramine
MEDRTD009325NauseaDISEASEmay_treatdiphenhydramine hydrochloride
MEDRTD012221Rhinitis, Allergic, PerennialDISEASEmay_treatdiphenhydramine
MEDRTD012221Rhinitis, Allergic, PerennialDISEASEmay_treatdiphenhydramine hydrochloride
MEDRTD012883Skin UlcerDISEASEmay_treatzinc acetate
MEDRTD007319Sleep Initiation and Maintenance DisordersDISEASEmay_treatdiphenhydramine
MEDRTD007319Sleep Initiation and Maintenance DisordersDISEASEmay_treatdiphenhydramine hydrochloride
MEDRTD012912SneezingDISEASEmay_treatdiphenhydramine
MEDRTD012912SneezingDISEASEmay_treatdiphenhydramine hydrochloride
MEDRTD013224Status AsthmaticusDISEASEci_withdiphenhydramine hydrochloride
MEDRTD013224Status AsthmaticusDISEASEci_withdiphenhydramine
MEDRTD014581UrticariaDISEASEmay_treatdiphenhydramine
MEDRTD014581UrticariaDISEASEmay_treatdiphenhydramine hydrochloride
MEDRTD014947Wounds and InjuriesDISEASEmay_treatzinc acetate
MEDRTN0000000226Acid-Base ActivityMOAhas_moazinc acetate
MEDRTN0000000220Electrolyte ActivityMOAhas_moazinc acetate
MEDRTN0000000163Enzyme InteractionsMOAhas_moazinc acetate
MEDRTN0000000190Histamine H1 Receptor AntagonistsMOAhas_moadiphenhydramine
MEDRTN0000000190Histamine H1 Receptor AntagonistsMOAhas_moadiphenhydramine hydrochloride

Properties#

Category, Property, Value table
CategoryPropertyValue
ATTRIBUTESAVAILABLE_STRENGTH20 MG/ML / 1 MG/ML
ATTRIBUTESGENERAL_CARDINALITYMULTI
ATTRIBUTESHUMAN_DRUGUS
ATTRIBUTESRXNAV_HUMAN_DRUGUS
ATTRIBUTESSCHEDULE0
NAMESPrescribable SynonymdiphenhydrAMINE HCl 2 % / zinc acetate 0.1 % Topical Solution
NAMESTallman SynonymdiphenhydrAMINE hydrochloride 2 % / zinc acetate 0.1 % Topical Solution
NAMESTallman SynonymdiphenhydrAMINE hydrochloride 20 MG/ML / zinc acetate 1 MG/ML Topical Solution
SOURCESSourceMetathesaurus FDA Structured Product Labels
SOURCESSourceMicromedex RED BOOK
SOURCESSourceMultum MediSource Lexicon
SOURCESSourceNational Drug Data File Plus Source Vocabulary