FDA.reportPublic FDA data

diphenhydramine hydrochloride 20 MG/ML / zinc acetate 1 MG/ML Topical Spray [Benadryl Itch Stopping]

RxCUI
1294592
RxNorm name
diphenhydramine hydrochloride 20 MG/ML / zinc acetate 1 MG/ML Topical Spray [Benadryl Itch Stopping]
Display name
BENADRYL ITCH STOPPING (Topical)
Full name
diphenhydramine hydrochloride 20 MG/ML / zinc acetate 1 MG/ML Topical Spray [Benadryl Itch Stopping]
Term type
SBD
Status
Active
Strength
2-0.1%
Dose form
Spray
Route
Topical
Updated
2026-07-20 06:53:46

RxNorm Status History#

Status
Active
Source
RXNORM
Current
YES
Release start
062012
Active start
062012
Multiple ingredient
YES
Branded
YES

Ingredients And Strength#

Ingredient, Strength, Base table
IngredientStrengthBaseBasis of strength
diphenhydramine hydrochloride20 MG / 1 MLdiphenhydraminediphenhydramine hydrochloride
zinc acetate1 MG / 1 MLzinc acetatezinc acetate

Dose Form Concepts#

Dose form, RxCUI table
Dose formRxCUI
Topical Spray346165

Derived Ingredient Concepts#

Ingredient, RxCUI table
IngredientRxCUI
diphenhydramine3498
zinc acetate58295

Source Vocabulary Codes#

Code type, Value, Category table
Code typeValueCategory
PRESCRIBABLEYATTRIBUTES
RXNAV_STRBenadryl Itch Cooling (diphenhydrAMINE hydrochloride 2 % / zinc acetate 0.1 % ) Topical SprayNAMES
RxNorm Namediphenhydramine hydrochloride 20 MG/ML / zinc acetate 1 MG/ML Topical Spray [Benadryl Itch Stopping]NAMES
RxNorm SynonymBenadryl Extra Strength (diphenhydramine hydrochloride 2 % / zinc acetate 0.1 % ) Topical SprayNAMES
RxNorm SynonymBenadryl Extra Strength Itch Relief (diphenhydramine hydrochloride 2 % / zinc acetate 0.1 % ) Topical SprayNAMES
RxNorm SynonymBenadryl Itch Cooling (diphenhydramine hydrochloride 2 % / zinc acetate 0.1 % ) Topical SprayNAMES
RxNorm SynonymBenadryl ReadyMist Itch Stopping (diphenhydramine hydrochloride 2 % / zinc acetate 0.1 % ) Topical SprayNAMES
TTYSBDATTRIBUTES
SPL_SET_IDa7eae5dc-9db6-4bdf-9179-76060e75e044CODES
RxCUI1294592CODES
MMSL_CODEBD19730CODES

FDA NDC Products And Packages#

Package NDC, Product NDC, Name table
Package NDCProduct NDCNameLabelerApplication
69968-0270-269968-0270Benadryl Extra Strength Itch Cooling Diphenhydramine Hydrochloride and Zinc AcetateKenvue Brands LLCM017

Drugs@FDA Applications#

Application, NDC, Name table
ApplicationNDCNameMarketing categoryLabeler
M01769968-0270Benadryl Extra Strength Itch Cooling Diphenhydramine Hydrochloride and Zinc AcetateOTC MONOGRAPH DRUGKenvue Brands LLC

RxNav Current And Historical NDCs#

NDC11, Source, Active table
NDC11SourceActive
00501320302rxnav_ndcsyes
69968027002rxnav_ndcsyes
12547017004rxnav_historical
12547017126rxnav_historical
58232074502rxnav_historical
58232075002rxnav_historical
58232075402rxnav_historical

DailyMed RxNorm Mappings#

Set ID, RxNorm string, TTY table
Set IDRxNorm stringTTYSPL versionLabelEffective
a7eae5dc-9db6-4bdf-9179-76060e75e044Benadryl Extra Strength Itch Relief (diphenhydramine hydrochloride 2 % / zinc acetate 0.1 % ) Topical SpraySY7Benadryl ® EXTRA STRENGTH ITCH COOLING SPRAY20250718
a7eae5dc-9db6-4bdf-9179-76060e75e044Benadryl ReadyMist Itch Stopping (diphenhydramine hydrochloride 2 % / zinc acetate 0.1 % ) Topical SpraySY7Benadryl ® EXTRA STRENGTH ITCH COOLING SPRAY20250718
a7eae5dc-9db6-4bdf-9179-76060e75e044diphenhydramine hydrochloride 20 MG/ML / zinc acetate 1 MG/ML Topical Spray [Benadryl Itch Stopping]SBD7Benadryl ® EXTRA STRENGTH ITCH COOLING SPRAY20250718
a7eae5dc-9db6-4bdf-9179-76060e75e044Benadryl Itch Cooling (diphenhydramine hydrochloride 2 % / zinc acetate 0.1 % ) Topical SpraySY7Benadryl ® EXTRA STRENGTH ITCH COOLING SPRAY20250718
a7eae5dc-9db6-4bdf-9179-76060e75e044Benadryl Extra Strength (diphenhydramine hydrochloride 2 % / zinc acetate 0.1 % ) Topical SpraySY7Benadryl ® EXTRA STRENGTH ITCH COOLING SPRAY20250718
a7eae5dc-9db6-4bdf-9179-76060e75e044Benadryl ITCH COOLING 2 % / 0.1 % Topical SprayPSN7Benadryl ® EXTRA STRENGTH ITCH COOLING SPRAY20250718

DailyMed Labels#

Set ID, Title, Manufacturer table
Set IDTitleManufacturerEffective
a7eae5dc-9db6-4bdf-9179-76060e75e044Benadryl ® EXTRA STRENGTH ITCH COOLING SPRAYKenvue Brands LLC20250718

Drug Classes#

Source, Class ID, Class table
SourceClass IDClassTypeRelationshipDrug concept
ATCR06AAAminoalkyl ethersATC1-4diphenhydramine
ATCD04AAAntihistamines for topical useATC1-4diphenhydramine
ATCA16AXVarious alimentary tract and metabolism productsATC1-4zinc acetate
FDASPLN0000175587Histamine-1 Receptor AntagonistEPChas_epcdiphenhydramine
FDASPLN0000000190Histamine H1 Receptor AntagonistsMOAhas_moadiphenhydramine
MEDRTD004155DiphenhydramineCHEMhas_ingredientdiphenhydramine hydrochloride
MEDRTD004155DiphenhydramineCHEMhas_ingredientdiphenhydramine
MEDRTD019345Zinc AcetateCHEMhas_ingredientzinc acetate
MEDRTD001008Anxiety DisordersDISEASEmay_treatdiphenhydramine hydrochloride
MEDRTD001008Anxiety DisordersDISEASEmay_treatdiphenhydramine
MEDRTD003139Common ColdDISEASEmay_treatzinc acetate
MEDRTD004342Drug HypersensitivityDISEASEci_withdiphenhydramine hydrochloride
MEDRTD004342Drug HypersensitivityDISEASEci_withdiphenhydramine
MEDRTD007231Infant, NewbornDISEASEci_withdiphenhydramine hydrochloride
MEDRTD007231Infant, NewbornDISEASEci_withdiphenhydramine
MEDRTD007234Infant, PrematureDISEASEci_withdiphenhydramine hydrochloride
MEDRTD007234Infant, PrematureDISEASEci_withdiphenhydramine
MEDRTD007774LactationDISEASEci_withdiphenhydramine
MEDRTD007774LactationDISEASEci_withdiphenhydramine hydrochloride
MEDRTD009041Motion SicknessDISEASEmay_treatdiphenhydramine
MEDRTD009041Motion SicknessDISEASEmay_treatdiphenhydramine hydrochloride
MEDRTD009325NauseaDISEASEmay_treatdiphenhydramine
MEDRTD009325NauseaDISEASEmay_treatdiphenhydramine hydrochloride
MEDRTD012221Rhinitis, Allergic, PerennialDISEASEmay_treatdiphenhydramine
MEDRTD012221Rhinitis, Allergic, PerennialDISEASEmay_treatdiphenhydramine hydrochloride
MEDRTD012883Skin UlcerDISEASEmay_treatzinc acetate
MEDRTD007319Sleep Initiation and Maintenance DisordersDISEASEmay_treatdiphenhydramine
MEDRTD007319Sleep Initiation and Maintenance DisordersDISEASEmay_treatdiphenhydramine hydrochloride
MEDRTD012912SneezingDISEASEmay_treatdiphenhydramine
MEDRTD012912SneezingDISEASEmay_treatdiphenhydramine hydrochloride
MEDRTD013224Status AsthmaticusDISEASEci_withdiphenhydramine hydrochloride
MEDRTD013224Status AsthmaticusDISEASEci_withdiphenhydramine
MEDRTD014581UrticariaDISEASEmay_treatdiphenhydramine
MEDRTD014581UrticariaDISEASEmay_treatdiphenhydramine hydrochloride
MEDRTD014947Wounds and InjuriesDISEASEmay_treatzinc acetate
MEDRTN0000000226Acid-Base ActivityMOAhas_moazinc acetate
MEDRTN0000000220Electrolyte ActivityMOAhas_moazinc acetate
MEDRTN0000000163Enzyme InteractionsMOAhas_moazinc acetate
MEDRTN0000000190Histamine H1 Receptor AntagonistsMOAhas_moadiphenhydramine
MEDRTN0000000190Histamine H1 Receptor AntagonistsMOAhas_moadiphenhydramine hydrochloride

Properties#

Category, Property, Value table
CategoryPropertyValue
ATTRIBUTESAVAILABLE_STRENGTH20 MG/ML / 1 MG/ML
ATTRIBUTESGENERAL_CARDINALITYMULTI
ATTRIBUTESHUMAN_DRUGUS
ATTRIBUTESPRESCRIBABLEY
ATTRIBUTESRXNAV_HUMAN_DRUGUS
ATTRIBUTESSCHEDULE0
ATTRIBUTESTTYSBD
CODESMMSL_CODEBD19730
CODESRxCUI1294592
CODESSPL_SET_IDa7eae5dc-9db6-4bdf-9179-76060e75e044
NAMESPrescribable SynonymBenadryl ITCH COOLING 2 % / 0.1 % Topical Spray
NAMESRXNAV_STRBenadryl Itch Cooling (diphenhydrAMINE hydrochloride 2 % / zinc acetate 0.1 % ) Topical Spray
NAMESRxNorm Namediphenhydramine hydrochloride 20 MG/ML / zinc acetate 1 MG/ML Topical Spray [Benadryl Itch Stopping]
NAMESRxNorm SynonymBenadryl Extra Strength (diphenhydramine hydrochloride 2 % / zinc acetate 0.1 % ) Topical Spray
NAMESRxNorm SynonymBenadryl Extra Strength Itch Relief (diphenhydramine hydrochloride 2 % / zinc acetate 0.1 % ) Topical Spray
NAMESRxNorm SynonymBenadryl Itch Cooling (diphenhydramine hydrochloride 2 % / zinc acetate 0.1 % ) Topical Spray
NAMESRxNorm SynonymBenadryl ReadyMist Itch Stopping (diphenhydramine hydrochloride 2 % / zinc acetate 0.1 % ) Topical Spray
NAMESTallman SynonymBenadryl Extra Strength (diphenhydrAMINE hydrochloride 2 % / zinc acetate 0.1 % ) Topical Spray
NAMESTallman SynonymBenadryl Extra Strength Itch Relief (diphenhydrAMINE hydrochloride 2 % / zinc acetate 0.1 % ) Topical Spray
NAMESTallman SynonymBenadryl Itch Cooling (diphenhydrAMINE hydrochloride 2 % / zinc acetate 0.1 % ) Topical Spray
NAMESTallman SynonymBenadryl ReadyMist Itch Stopping (diphenhydrAMINE hydrochloride 2 % / zinc acetate 0.1 % ) Topical Spray
NAMESTallman SynonymdiphenhydrAMINE hydrochloride 20 MG/ML / zinc acetate 1 MG/ML Topical Spray [Benadryl Itch Stopping]
SOURCESSourceGold Standard Alchemy
SOURCESSourceMetathesaurus FDA Structured Product Labels
SOURCESSourceMicromedex RED BOOK
SOURCESSourceMultum MediSource Lexicon