Home RxNorm 1294607 acetaminophen 21.7 MG/ML / diphenhydramine hydrochloride 0.833 MG/ML Oral Solution Drug identity information. FDA.report links public drug records from RxNav, DailyMed, FDA NDC, Drugs@FDA, and related public sources where available. This page is informational only and is not medical, prescribing, or regulatory advice.
RxCUI 1294607
RxNorm name acetaminophen 21.7 MG/ML / diphenhydramine hydrochloride 0.833 MG/ML Oral Solution
Display name Acetaminophen/diphenhydrAMINE (Oral Liquid)
Full name acetaminophen 21.7 MG/ML / diphenhydramine hydrochloride 0.833 MG/ML Oral Solution
Term type SCD
Status Active
Strength 325-12.495 mg/15ml
Dose form Sol
Route Oral Liquid
Updated 2026-07-22 07:07:35 RxNorm Status History#
Status Active
Source RXNORM
Current YES
Release start 062012
Active start 062012
Multiple ingredient YES
Branded NO Ingredients And Strength# Ingredient, Strength, Base table Ingredient Strength Base Basis of strength acetaminophen 21.7 MG / 1 ML acetaminophen acetaminophen diphenhydramine hydrochloride 0.833 MG / 1 ML diphenhydramine diphenhydramine hydrochloride
Derived Ingredient Concepts# FDA NDC Products And Packages# Package NDC, Product NDC, Name table Package NDC Product NDC Name Labeler Application 0067-0105-08 0067-0105 Theraflu Acetaminophen, Diphenhydramine HCl Haleon US Holdings LLC M012
Drugs@FDA Applications# Application, NDC, Name table Application NDC Name Marketing category Labeler M012 0067-0105 Theraflu Acetaminophen, Diphenhydramine HCl OTC MONOGRAPH DRUG Haleon US Holdings LLC
RxNav Current And Historical NDCs# RxNav current and historical NDC rows page 1 of 1 · 2 matching rows.
NDC11, Source, Active table NDC11 Source Active 00067010508 rxnav_ndcs yes 00085111701 rxnav_historical_indirect
UNII Substances# UNII substance links page 1 of 1 · 0 matching rows.
No records found.
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Matched openFDA labels page 1 of 1 · 2 matching rows.
DailyMed RxNorm Mappings# Drug Classes# Source, Class ID, Class table Source Class ID Class Type Relationship Drug concept ATC R06AA Aminoalkyl ethers ATC1-4 diphenhydramine ATC N02BE Anilides ATC1-4 acetaminophen ATC D04AA Antihistamines for topical use ATC1-4 diphenhydramine FDASPL N0000175587 Histamine-1 Receptor Antagonist EPC has_epc diphenhydramine FDASPL N0000000190 Histamine H1 Receptor Antagonists MOA has_moa diphenhydramine MEDRT D000082 Acetaminophen CHEM has_ingredient acetaminophen MEDRT D004155 Diphenhydramine CHEM has_ingredient diphenhydramine hydrochloride MEDRT D004155 Diphenhydramine CHEM has_ingredient diphenhydramine MEDRT D001008 Anxiety Disorders DISEASE may_treat diphenhydramine MEDRT D001008 Anxiety Disorders DISEASE may_treat diphenhydramine hydrochloride MEDRT D004342 Drug Hypersensitivity DISEASE ci_with diphenhydramine hydrochloride MEDRT D004342 Drug Hypersensitivity DISEASE ci_with acetaminophen MEDRT D004342 Drug Hypersensitivity DISEASE ci_with diphenhydramine MEDRT D005334 Fever DISEASE may_prevent acetaminophen MEDRT D005334 Fever DISEASE may_treat acetaminophen MEDRT D005955 Glucosephosphate Dehydrogenase Deficiency DISEASE ci_with acetaminophen MEDRT D007231 Infant, Newborn DISEASE ci_with diphenhydramine hydrochloride MEDRT D007231 Infant, Newborn DISEASE ci_with diphenhydramine MEDRT D007234 Infant, Premature DISEASE ci_with diphenhydramine hydrochloride MEDRT D007234 Infant, Premature DISEASE ci_with diphenhydramine MEDRT D007774 Lactation DISEASE ci_with diphenhydramine hydrochloride MEDRT D007774 Lactation DISEASE ci_with diphenhydramine MEDRT D008107 Liver Diseases DISEASE ci_with acetaminophen MEDRT D009041 Motion Sickness DISEASE may_treat diphenhydramine MEDRT D009041 Motion Sickness DISEASE may_treat diphenhydramine hydrochloride MEDRT D009325 Nausea DISEASE may_treat diphenhydramine MEDRT D009325 Nausea DISEASE may_treat diphenhydramine hydrochloride MEDRT D010146 Pain DISEASE may_treat acetaminophen MEDRT D010146 Pain DISEASE may_prevent acetaminophen MEDRT D012221 Rhinitis, Allergic, Perennial DISEASE may_treat diphenhydramine MEDRT D012221 Rhinitis, Allergic, Perennial DISEASE may_treat diphenhydramine hydrochloride MEDRT D007319 Sleep Initiation and Maintenance Disorders DISEASE may_treat diphenhydramine hydrochloride MEDRT D007319 Sleep Initiation and Maintenance Disorders DISEASE may_treat diphenhydramine MEDRT D012912 Sneezing DISEASE may_treat diphenhydramine hydrochloride MEDRT D012912 Sneezing DISEASE may_treat diphenhydramine MEDRT D013224 Status Asthmaticus DISEASE ci_with diphenhydramine hydrochloride MEDRT D013224 Status Asthmaticus DISEASE ci_with diphenhydramine MEDRT D014581 Urticaria DISEASE may_treat diphenhydramine MEDRT D014581 Urticaria DISEASE may_treat diphenhydramine hydrochloride MEDRT N0000000190 Histamine H1 Receptor Antagonists MOA has_moa diphenhydramine hydrochloride MEDRT N0000000190 Histamine H1 Receptor Antagonists MOA has_moa diphenhydramine MEDRT N0000000108 Prostaglandin Receptor Antagonists MOA has_moa acetaminophen MEDRT N0000175724 Central Nervous System Activity Alteration PE has_pe acetaminophen MEDRT N0000008836 Decreased Prostaglandin Production PE has_pe acetaminophen MEDRT N0000009072 Hypothalamic Endocrine Activity Alteration PE has_pe acetaminophen MEDRT N0000175725 Peripheral Nervous System Activity Alteration PE has_pe acetaminophen MEDRT N0000000026 Hepatic Metabolism PK has_pk acetaminophen MEDRT N0000000042 Renal Excretion PK has_pk acetaminophen
Properties# Category, Property, Value table Category Property Value ATTRIBUTES ACTIVATED 01/30/2024 ATTRIBUTES AVAILABLE_STRENGTH 21.7 MG/ML / 0.833 MG/ML ATTRIBUTES GENERAL_CARDINALITY MULTI ATTRIBUTES HUMAN_DRUG US ATTRIBUTES PRESCRIBABLE Y ATTRIBUTES RXNAV_HUMAN_DRUG US ATTRIBUTES SCHEDULE 0 ATTRIBUTES TTY SCD CODES MMSL_CODE BD41068 CODES MMSL_CODE BD6258 CODES MMSL_CODE CD6258 CODES RxCUI 1294607 CODES SPL_SET_ID b01cc9f5-53f2-40d8-acf1-6de180b3d0bf CODES SPL_SET_ID c24b9489-208c-472b-8ae5-c6e86c12e04d NAMES Prescribable Synonym acetaminophen 650 MG / diphenhydrAMINE HCl 25 MG in 30 mL Oral Solution NAMES RXNAV_STR acetaminophen 21.7 MG/ML / diphenhydrAMINE hydrochloride 0.833 MG/ML Oral Solution NAMES RxNorm Name acetaminophen 21.7 MG/ML / diphenhydramine hydrochloride 0.833 MG/ML Oral Solution NAMES RxNorm Synonym APAP 21.7 MG/ML / Diphenhydramine Hydrochloride 0.833 MG/ML Oral Solution NAMES RxNorm Synonym APAP 325 MG / diphenhydramine hydrochloride 12.5 MG per 15 ML Oral Solution NAMES Tallman Synonym acetaminophen 21.7 MG/ML / diphenhydrAMINE hydrochloride 0.833 MG/ML Oral Solution NAMES Tallman Synonym APAP 21.7 MG/ML / diphenhydrAMINE Hydrochloride 0.833 MG/ML Oral Solution NAMES Tallman Synonym APAP 325 MG / diphenhydrAMINE hydrochloride 12.5 MG per 15 ML Oral Solution SOURCES Source Metathesaurus FDA Structured Product Labels SOURCES Source Micromedex RED BOOK SOURCES Source Multum MediSource Lexicon SOURCES Source National Drug Data File Plus Source Vocabulary