acetaminophen 21.7 MG/ML / diphenhydramine hydrochloride 0.833 MG/ML / phenylephrine hydrochloride 0.333 MG/ML Oral Solution
- RxCUI
- 1298348
- RxNorm name
- acetaminophen 21.7 MG/ML / diphenhydramine hydrochloride 0.833 MG/ML / phenylephrine hydrochloride 0.333 MG/ML Oral Solution
- Display name
- Acetaminophen/diphenhydrAMINE/Phenylephrine (Oral Liquid)
- Full name
- acetaminophen 21.7 MG/ML / diphenhydramine hydrochloride 0.833 MG/ML / phenylephrine hydrochloride 0.333 MG/ML Oral Solution
- Term type
- SCD
- Status
- Active
- Strength
- 325-12.495-5 mg/15ml
- Dose form
- Sol
- Route
- Oral Liquid
- Updated
- 2026-07-20 06:54:14
RxNorm Status History#
- Status
- Active
- Source
- RXNORM
- Current
- YES
- Release start
- 072012
- Active start
- 072012
- Multiple ingredient
- YES
- Branded
- NO
Ingredients And Strength#
| Ingredient | Strength | Base | Basis of strength |
|---|---|---|---|
| acetaminophen | 21.7 MG / 1 ML | acetaminophen | acetaminophen |
| diphenhydramine hydrochloride | 0.833 MG / 1 ML | diphenhydramine | diphenhydramine hydrochloride |
| phenylephrine hydrochloride | 0.333 MG / 1 ML | phenylephrine | phenylephrine hydrochloride |
Dose Form Concepts#
| Dose form | RxCUI |
|---|---|
| Oral Solution | 316968 |
Derived Ingredient Concepts#
| Ingredient | RxCUI |
|---|---|
| acetaminophen | 161 |
| diphenhydramine | 3498 |
| phenylephrine | 8163 |
Source Vocabulary Codes#
FDA NDC Products And Packages#
| Package NDC | Product NDC | Name | Labeler | Application |
|---|---|---|---|---|
| 0067-8129-08 | 0067-8129 | Theraflu ExpressMax Acetaminophen, Diphenhydramine HCl, Phenylephrine HCl | Haleon US Holdings LLC | M012 |
| 49580-0502-8 | 49580-0502 | Nighttime Severe Cold and Cough Acetaminophen, Diphenhydramine HCl, Phenylephrine HCl | P & L Development, LLC | M012 |
| 68016-154-08 | 68016-154 | Night Time Severe Cold and Cough Relief ACETAMINOPHEN, DIPHENHYDRAMINE HCL, PHENYLEPHRINE HCL | Chain Drug Consortium, LLC | M013 |
Drugs@FDA Applications#
| Application | NDC | Name | Marketing category | Labeler |
|---|---|---|---|---|
| M012 | 0067-8129 | Theraflu ExpressMax Acetaminophen, Diphenhydramine HCl, Phenylephrine HCl | OTC MONOGRAPH DRUG | Haleon US Holdings LLC |
| M013 | 68016-154 | Night Time Severe Cold and Cough Relief ACETAMINOPHEN, DIPHENHYDRAMINE HCL, PHENYLEPHRINE HCL | OTC MONOGRAPH DRUG | Chain Drug Consortium, LLC |
DailyMed RxNorm Mappings#
| Set ID | RxNorm string | TTY | SPL version | Label | Effective |
|---|---|---|---|---|---|
| f5a66541-1b15-4dfe-91e0-d8d5f8fdc7fb | APAP 21.7 MG/ML / Diphenhydramine Hydrochloride 0.833 MG/ML / Phenylephrine Hydrochloride 0.333 MG/ML Oral Solution | SY | 7 | Drug Facts | 20240307 |
| f5a66541-1b15-4dfe-91e0-d8d5f8fdc7fb | acetaminophen 325 MG / diphenhydrAMINE HCl 12.5 MG / phenylephrine HCl 5 MG in 15 mL Oral Solution | PSN | 7 | Drug Facts | 20240307 |
| f5a66541-1b15-4dfe-91e0-d8d5f8fdc7fb | acetaminophen 650 MG / diphenhydramine HCl 25 MG / phenylephrine HCl 10 MG per 30 ML Oral Solution | SY | 7 | Drug Facts | 20240307 |
| f5a66541-1b15-4dfe-91e0-d8d5f8fdc7fb | acetaminophen 21.7 MG/ML / diphenhydramine hydrochloride 0.833 MG/ML / phenylephrine hydrochloride 0.333 MG/ML Oral Solution | SCD | 7 | Drug Facts | 20240307 |
| f5a66541-1b15-4dfe-91e0-d8d5f8fdc7fb | acetaminophen 325 MG / diphenhydramine HCl 12.5 MG / phenylephrine HCl 5 MG per 15 ML Oral Solution | SY | 7 | Drug Facts | 20240307 |
| c8e9b57b-83e9-46c5-9791-02c4c2b94004 | APAP 21.7 MG/ML / Diphenhydramine Hydrochloride 0.833 MG/ML / Phenylephrine Hydrochloride 0.333 MG/ML Oral Solution | SY | 5 | 20241229 | |
| c8e9b57b-83e9-46c5-9791-02c4c2b94004 | acetaminophen 325 MG / diphenhydrAMINE HCl 12.5 MG / phenylephrine HCl 5 MG in 15 mL Oral Solution | PSN | 5 | 20241229 | |
| c8e9b57b-83e9-46c5-9791-02c4c2b94004 | acetaminophen 325 MG / diphenhydramine HCl 12.5 MG / phenylephrine HCl 5 MG per 15 ML Oral Solution | SY | 5 | 20241229 | |
| c8e9b57b-83e9-46c5-9791-02c4c2b94004 | acetaminophen 21.7 MG/ML / diphenhydramine hydrochloride 0.833 MG/ML / phenylephrine hydrochloride 0.333 MG/ML Oral Solution | SCD | 5 | 20241229 | |
| c8e9b57b-83e9-46c5-9791-02c4c2b94004 | acetaminophen 650 MG / diphenhydramine HCl 25 MG / phenylephrine HCl 10 MG per 30 ML Oral Solution | SY | 5 | 20241229 | |
| 9736ad4c-8c2e-421f-b023-f91b72d2828b | acetaminophen 650 MG / diphenhydramine HCl 25 MG / phenylephrine HCl 10 MG per 30 ML Oral Solution | SY | 5 | Drug Facts | 20240410 |
| 9736ad4c-8c2e-421f-b023-f91b72d2828b | APAP 21.7 MG/ML / Diphenhydramine Hydrochloride 0.833 MG/ML / Phenylephrine Hydrochloride 0.333 MG/ML Oral Solution | SY | 5 | Drug Facts | 20240410 |
| 9736ad4c-8c2e-421f-b023-f91b72d2828b | acetaminophen 325 MG / diphenhydrAMINE HCl 12.5 MG / phenylephrine HCl 5 MG in 15 mL Oral Solution | PSN | 5 | Drug Facts | 20240410 |
| 9736ad4c-8c2e-421f-b023-f91b72d2828b | acetaminophen 21.7 MG/ML / diphenhydramine hydrochloride 0.833 MG/ML / phenylephrine hydrochloride 0.333 MG/ML Oral Solution | SCD | 5 | Drug Facts | 20240410 |
| 9736ad4c-8c2e-421f-b023-f91b72d2828b | acetaminophen 325 MG / diphenhydramine HCl 12.5 MG / phenylephrine HCl 5 MG per 15 ML Oral Solution | SY | 5 | Drug Facts | 20240410 |
| 8d27b94d-23a1-4e6c-a064-79e2580f7e2e | APAP 21.7 MG/ML / Diphenhydramine Hydrochloride 0.833 MG/ML / Phenylephrine Hydrochloride 0.333 MG/ML Oral Solution | SY | 3 | Drug Facts | 20240415 |
| 8d27b94d-23a1-4e6c-a064-79e2580f7e2e | acetaminophen 650 MG / diphenhydramine HCl 25 MG / phenylephrine HCl 10 MG per 30 ML Oral Solution | SY | 3 | Drug Facts | 20240415 |
| 8d27b94d-23a1-4e6c-a064-79e2580f7e2e | acetaminophen 21.7 MG/ML / diphenhydramine hydrochloride 0.833 MG/ML / phenylephrine hydrochloride 0.333 MG/ML Oral Solution | SCD | 3 | Drug Facts | 20240415 |
| 8d27b94d-23a1-4e6c-a064-79e2580f7e2e | acetaminophen 325 MG / diphenhydrAMINE HCl 12.5 MG / phenylephrine HCl 5 MG in 15 mL Oral Solution | PSN | 3 | Drug Facts | 20240415 |
| 8d27b94d-23a1-4e6c-a064-79e2580f7e2e | acetaminophen 325 MG / diphenhydramine HCl 12.5 MG / phenylephrine HCl 5 MG per 15 ML Oral Solution | SY | 3 | Drug Facts | 20240415 |
DailyMed Labels#
| Set ID | Title | Manufacturer | Effective |
|---|---|---|---|
| c8e9b57b-83e9-46c5-9791-02c4c2b94004 | Chain Drug Consortium, LLC | AptaPharma Inc. | 20241229 | |
| 8d27b94d-23a1-4e6c-a064-79e2580f7e2e | Drug Facts | P & L Development, LLC | 20240415 |
| 9736ad4c-8c2e-421f-b023-f91b72d2828b | Drug Facts | Haleon US Holdings LLC | 20240410 |
| f5a66541-1b15-4dfe-91e0-d8d5f8fdc7fb | Drug Facts | Haleon US Holdings LLC | 20240307 |
| ed063755-6bdc-479a-92ab-04120350434d | Drug Facts | TOP CARE (Topco Associates LLC) | 20231013 |
| fcb23436-7a62-4338-83b1-7b3755b58616 | Drug Facts | H E B | 20230211 |
Drug Classes#
| Source | Class ID | Class | Type | Relationship | Drug concept |
|---|---|---|---|---|---|
| ATC | C01CA | Adrenergic and dopaminergic agents | ATC1-4 | phenylephrine | |
| ATC | R06AA | Aminoalkyl ethers | ATC1-4 | diphenhydramine | |
| ATC | N02BE | Anilides | ATC1-4 | acetaminophen | |
| ATC | D04AA | Antihistamines for topical use | ATC1-4 | diphenhydramine | |
| ATC | C05AX | Other agents for treatment of hemorrhoids and anal fissures for topical use | ATC1-4 | phenylephrine | |
| ATC | R01BA | Sympathomimetics | ATC1-4 | phenylephrine | |
| ATC | S01FB | Sympathomimetics excl. antiglaucoma preparations | ATC1-4 | phenylephrine | |
| ATC | S01GA | Sympathomimetics used as decongestants | ATC1-4 | phenylephrine | |
| ATC | R01AB | Sympathomimetics, combinations excl. corticosteroids | ATC1-4 | phenylephrine | |
| ATC | R01AA | Sympathomimetics, plain | ATC1-4 | phenylephrine | |
| FDASPL | N0000186105 | alpha-1 Adrenergic Agonist | EPC | has_epc | phenylephrine |
| FDASPL | N0000175587 | Histamine-1 Receptor Antagonist | EPC | has_epc | diphenhydramine |
| FDASPL | N0000000190 | Histamine H1 Receptor Antagonists | MOA | has_moa | diphenhydramine |
| MEDRT | D000082 | Acetaminophen | CHEM | has_ingredient | acetaminophen |
| MEDRT | D004155 | Diphenhydramine | CHEM | has_ingredient | diphenhydramine hydrochloride |
| MEDRT | D004155 | Diphenhydramine | CHEM | has_ingredient | diphenhydramine |
| MEDRT | D010656 | Phenylephrine | CHEM | has_ingredient | phenylephrine |
| MEDRT | D010656 | Phenylephrine | CHEM | has_ingredient | phenylephrine hydrochloride |
| MEDRT | D013447 | Sulfites | CHEM | ci_chemclass | phenylephrine |
| MEDRT | D013447 | Sulfites | CHEM | ci_chemclass | phenylephrine hydrochloride |
| MEDRT | D001008 | Anxiety Disorders | DISEASE | may_treat | diphenhydramine hydrochloride |
| MEDRT | D001008 | Anxiety Disorders | DISEASE | may_treat | diphenhydramine |
| MEDRT | D004342 | Drug Hypersensitivity | DISEASE | ci_with | diphenhydramine |
| MEDRT | D004342 | Drug Hypersensitivity | DISEASE | ci_with | diphenhydramine hydrochloride |
| MEDRT | D004342 | Drug Hypersensitivity | DISEASE | ci_with | phenylephrine hydrochloride |
| MEDRT | D004342 | Drug Hypersensitivity | DISEASE | ci_with | acetaminophen |
| MEDRT | D004342 | Drug Hypersensitivity | DISEASE | ci_with | phenylephrine |
| MEDRT | D005334 | Fever | DISEASE | may_treat | acetaminophen |
| MEDRT | D005334 | Fever | DISEASE | may_prevent | acetaminophen |
| MEDRT | D005401 | Fissure in Ano | DISEASE | may_treat | phenylephrine |
| MEDRT | D005401 | Fissure in Ano | DISEASE | may_treat | phenylephrine hydrochloride |
| MEDRT | D005902 | Glaucoma, Open-Angle | DISEASE | may_treat | phenylephrine hydrochloride |
| MEDRT | D005902 | Glaucoma, Open-Angle | DISEASE | may_treat | phenylephrine |
| MEDRT | D005955 | Glucosephosphate Dehydrogenase Deficiency | DISEASE | ci_with | acetaminophen |
| MEDRT | D006484 | Hemorrhoids | DISEASE | may_treat | phenylephrine hydrochloride |
| MEDRT | D006484 | Hemorrhoids | DISEASE | may_treat | phenylephrine |
| MEDRT | D006973 | Hypertension | DISEASE | ci_with | phenylephrine |
| MEDRT | D006973 | Hypertension | DISEASE | ci_with | phenylephrine hydrochloride |
| MEDRT | D007022 | Hypotension | DISEASE | may_treat | phenylephrine hydrochloride |
| MEDRT | D007022 | Hypotension | DISEASE | may_treat | phenylephrine |
| MEDRT | D007231 | Infant, Newborn | DISEASE | ci_with | diphenhydramine hydrochloride |
| MEDRT | D007231 | Infant, Newborn | DISEASE | ci_with | diphenhydramine |
| MEDRT | D007234 | Infant, Premature | DISEASE | ci_with | diphenhydramine hydrochloride |
| MEDRT | D007234 | Infant, Premature | DISEASE | ci_with | diphenhydramine |
| MEDRT | D007774 | Lactation | DISEASE | ci_with | diphenhydramine |
| MEDRT | D007774 | Lactation | DISEASE | ci_with | diphenhydramine hydrochloride |
| MEDRT | D008107 | Liver Diseases | DISEASE | ci_with | acetaminophen |
| MEDRT | D009041 | Motion Sickness | DISEASE | may_treat | diphenhydramine hydrochloride |
| MEDRT | D009041 | Motion Sickness | DISEASE | may_treat | diphenhydramine |
| MEDRT | D015878 | Mydriasis | DISEASE | induces | phenylephrine |
| MEDRT | D015878 | Mydriasis | DISEASE | induces | phenylephrine hydrochloride |
| MEDRT | D009325 | Nausea | DISEASE | may_treat | diphenhydramine hydrochloride |
| MEDRT | D009325 | Nausea | DISEASE | may_treat | diphenhydramine |
| MEDRT | D010146 | Pain | DISEASE | may_treat | acetaminophen |
| MEDRT | D010146 | Pain | DISEASE | may_prevent | acetaminophen |
| MEDRT | D011538 | Pruritus Ani | DISEASE | may_treat | phenylephrine |
| MEDRT | D011538 | Pruritus Ani | DISEASE | may_treat | phenylephrine hydrochloride |
| MEDRT | D012221 | Rhinitis, Allergic, Perennial | DISEASE | may_treat | diphenhydramine |
| MEDRT | D012221 | Rhinitis, Allergic, Perennial | DISEASE | may_treat | diphenhydramine hydrochloride |
| MEDRT | D012223 | Rhinitis, Vasomotor | DISEASE | may_treat | phenylephrine |
| MEDRT | D012223 | Rhinitis, Vasomotor | DISEASE | may_treat | phenylephrine hydrochloride |
| MEDRT | D012772 | Shock, Septic | DISEASE | may_treat | phenylephrine hydrochloride |
| MEDRT | D012772 | Shock, Septic | DISEASE | may_treat | phenylephrine |
| MEDRT | D007319 | Sleep Initiation and Maintenance Disorders | DISEASE | may_treat | diphenhydramine hydrochloride |
| MEDRT | D007319 | Sleep Initiation and Maintenance Disorders | DISEASE | may_treat | diphenhydramine |
| MEDRT | D012912 | Sneezing | DISEASE | may_treat | diphenhydramine |
| MEDRT | D012912 | Sneezing | DISEASE | may_treat | diphenhydramine hydrochloride |
| MEDRT | D013224 | Status Asthmaticus | DISEASE | ci_with | diphenhydramine |
| MEDRT | D013224 | Status Asthmaticus | DISEASE | ci_with | diphenhydramine hydrochloride |
| MEDRT | D013617 | Tachycardia, Supraventricular | DISEASE | may_treat | phenylephrine |
| MEDRT | D013617 | Tachycardia, Supraventricular | DISEASE | may_treat | phenylephrine hydrochloride |
| MEDRT | D017180 | Tachycardia, Ventricular | DISEASE | ci_with | phenylephrine hydrochloride |
| MEDRT | D017180 | Tachycardia, Ventricular | DISEASE | ci_with | phenylephrine |
| MEDRT | D014581 | Urticaria | DISEASE | may_treat | diphenhydramine |
| MEDRT | D014581 | Urticaria | DISEASE | may_treat | diphenhydramine hydrochloride |
| MEDRT | N0000000209 | Adrenergic alpha-Agonists | MOA | has_moa | phenylephrine |
| MEDRT | N0000000209 | Adrenergic alpha-Agonists | MOA | has_moa | phenylephrine hydrochloride |
| MEDRT | N0000000190 | Histamine H1 Receptor Antagonists | MOA | has_moa | diphenhydramine hydrochloride |
| MEDRT | N0000000190 | Histamine H1 Receptor Antagonists | MOA | has_moa | diphenhydramine |
| MEDRT | N0000000108 | Prostaglandin Receptor Antagonists | MOA | has_moa | acetaminophen |
| MEDRT | N0000175724 | Central Nervous System Activity Alteration | PE | has_pe | acetaminophen |
| MEDRT | N0000008371 | Conjunctival Arterial Vasoconstriction | PE | has_pe | phenylephrine |
| MEDRT | N0000008371 | Conjunctival Arterial Vasoconstriction | PE | has_pe | phenylephrine hydrochloride |
| MEDRT | N0000008896 | Decreased Nasal and Sinus Secretions | PE | has_pe | phenylephrine hydrochloride |
| MEDRT | N0000008896 | Decreased Nasal and Sinus Secretions | PE | has_pe | phenylephrine |
| MEDRT | N0000008836 | Decreased Prostaglandin Production | PE | has_pe | acetaminophen |
| MEDRT | N0000009072 | Hypothalamic Endocrine Activity Alteration | PE | has_pe | acetaminophen |
| MEDRT | N0000175725 | Peripheral Nervous System Activity Alteration | PE | has_pe | acetaminophen |
| MEDRT | N0000000026 | Hepatic Metabolism | PK | has_pk | acetaminophen |
| MEDRT | N0000000042 | Renal Excretion | PK | has_pk | acetaminophen |
Properties#
| Category | Property | Value |
|---|---|---|
| ATTRIBUTES | AVAILABLE_STRENGTH | 21.7 MG/ML / 0.833 MG/ML / 0.333 MG/ML |
| ATTRIBUTES | GENERAL_CARDINALITY | MULTI |
| ATTRIBUTES | HUMAN_DRUG | US |
| ATTRIBUTES | PRESCRIBABLE | Y |
| ATTRIBUTES | RXNAV_HUMAN_DRUG | US |
| ATTRIBUTES | SCHEDULE | 0 |
| ATTRIBUTES | TTY | SCD |
| CODES | MMSL_CODE | BD17167 |
| CODES | MMSL_CODE | BD19702 |
| CODES | MMSL_CODE | CD17167 |
| CODES | MMSL_CODE | CD19702 |
| CODES | RxCUI | 1298348 |
| CODES | SPL_SET_ID | 8d27b94d-23a1-4e6c-a064-79e2580f7e2e |
| CODES | SPL_SET_ID | 9736ad4c-8c2e-421f-b023-f91b72d2828b |
| CODES | SPL_SET_ID | c8e9b57b-83e9-46c5-9791-02c4c2b94004 |
| CODES | SPL_SET_ID | f5a66541-1b15-4dfe-91e0-d8d5f8fdc7fb |
| CODES | VUID | 4035417 |
| NAMES | Prescribable Synonym | acetaminophen 325 MG / diphenhydrAMINE HCl 12.5 MG / phenylephrine HCl 5 MG in 15 mL Oral Solution |
| NAMES | RXNAV_STR | acetaminophen 21.7 MG/ML / diphenhydrAMINE hydrochloride 0.833 MG/ML / phenylephrine hydrochloride 0.333 MG/ML Oral Solution |
| NAMES | RxNorm Name | acetaminophen 21.7 MG/ML / diphenhydramine hydrochloride 0.833 MG/ML / phenylephrine hydrochloride 0.333 MG/ML Oral Solution |
| NAMES | RxNorm Synonym | acetaminophen 325 MG / diphenhydramine HCl 12.5 MG / phenylephrine HCl 5 MG per 15 ML Oral Solution |
| NAMES | RxNorm Synonym | acetaminophen 650 MG / diphenhydramine HCl 25 MG / phenylephrine HCl 10 MG per 30 ML Oral Solution |
| NAMES | RxNorm Synonym | APAP 21.7 MG/ML / Diphenhydramine Hydrochloride 0.833 MG/ML / Phenylephrine Hydrochloride 0.333 MG/ML Oral Solution |
| NAMES | Tallman Synonym | acetaminophen 21.7 MG/ML / diphenhydrAMINE hydrochloride 0.833 MG/ML / phenylephrine hydrochloride 0.333 MG/ML Oral Solution |
| NAMES | Tallman Synonym | acetaminophen 325 MG / diphenhydrAMINE HCl 12.5 MG / phenylephrine HCl 5 MG per 15 ML Oral Solution |
| NAMES | Tallman Synonym | acetaminophen 650 MG / diphenhydrAMINE HCl 25 MG / phenylephrine HCl 10 MG per 30 ML Oral Solution |
| NAMES | Tallman Synonym | APAP 21.7 MG/ML / diphenhydrAMINE Hydrochloride 0.833 MG/ML / Phenylephrine Hydrochloride 0.333 MG/ML Oral Solution |
| SOURCES | Source | Gold Standard Alchemy |
| SOURCES | Source | Metathesaurus FDA Structured Product Labels |
| SOURCES | Source | Micromedex RED BOOK |
| SOURCES | Source | Multum MediSource Lexicon |
| SOURCES | Source | National Drug Data File Plus Source Vocabulary |
| SOURCES | Source | Veterans Health Administration National Drug File |