acetaminophen 21.7 MG/ML / diphenhydramine hydrochloride 0.833 MG/ML / phenylephrine hydrochloride 0.333 MG/ML Oral Solution

RxCUI
1298348
RxNorm name
acetaminophen 21.7 MG/ML / diphenhydramine hydrochloride 0.833 MG/ML / phenylephrine hydrochloride 0.333 MG/ML Oral Solution
Display name
Acetaminophen/diphenhydrAMINE/Phenylephrine (Oral Liquid)
Full name
acetaminophen 21.7 MG/ML / diphenhydramine hydrochloride 0.833 MG/ML / phenylephrine hydrochloride 0.333 MG/ML Oral Solution
Term type
SCD
Status
Active
Strength
325-12.495-5 mg/15ml
Dose form
Sol
Route
Oral Liquid
Updated
2026-07-20 06:54:14

RxNorm Status History#

Status
Active
Source
RXNORM
Current
YES
Release start
072012
Active start
072012
Multiple ingredient
YES
Branded
NO

Ingredients And Strength#

Ingredient, Strength, Base table
IngredientStrengthBaseBasis of strength
acetaminophen21.7 MG / 1 MLacetaminophenacetaminophen
diphenhydramine hydrochloride0.833 MG / 1 MLdiphenhydraminediphenhydramine hydrochloride
phenylephrine hydrochloride0.333 MG / 1 MLphenylephrinephenylephrine hydrochloride

Dose Form Concepts#

Dose form, RxCUI table
Dose formRxCUI
Oral Solution316968

Derived Ingredient Concepts#

Ingredient, RxCUI table
IngredientRxCUI
acetaminophen161
diphenhydramine3498
phenylephrine8163

Source Vocabulary Codes#

FDA NDC Products And Packages#

Package NDC, Product NDC, Name table
Package NDCProduct NDCNameLabelerApplication
0067-8129-080067-8129Theraflu ExpressMax Acetaminophen, Diphenhydramine HCl, Phenylephrine HClHaleon US Holdings LLCM012
49580-0502-849580-0502Nighttime Severe Cold and Cough Acetaminophen, Diphenhydramine HCl, Phenylephrine HClP & L Development, LLCM012
68016-154-0868016-154Night Time Severe Cold and Cough Relief ACETAMINOPHEN, DIPHENHYDRAMINE HCL, PHENYLEPHRINE HCLChain Drug Consortium, LLCM013

Drugs@FDA Applications#

Application, NDC, Name table
ApplicationNDCNameMarketing categoryLabeler
M0120067-8129Theraflu ExpressMax Acetaminophen, Diphenhydramine HCl, Phenylephrine HClOTC MONOGRAPH DRUGHaleon US Holdings LLC
M01368016-154Night Time Severe Cold and Cough Relief ACETAMINOPHEN, DIPHENHYDRAMINE HCL, PHENYLEPHRINE HCLOTC MONOGRAPH DRUGChain Drug Consortium, LLC

RxNav Current And Historical NDCs#

NDC11, Source, Active table
NDC11SourceActive
00043046008rxnav_ndcsyes
00043626508rxnav_ndcsyes
00043640708rxnav_ndcsyes
00067812808rxnav_ndcsyes
00067812908rxnav_ndcsyes
46122001633rxnav_ndcsyes
49348090470rxnav_ndcsyes
49580050208rxnav_ndcsyes
59779069308rxnav_ndcsyes
59779093808rxnav_ndcsyes
68016015408rxnav_ndcsyes
00067640708rxnav_historical
00067812901rxnav_historical
00067813108rxnav_historical
00363200408rxnav_historical
11917008701rxnav_historical_indirect
15127086208rxnav_historical
15127092208rxnav_historical
24385015408rxnav_historical
30142015408rxnav_historical
30142025409rxnav_historical
30142031708rxnav_historical
36800015408rxnav_historical
36800031708rxnav_historical
37808001708rxnav_historical
42507031708rxnav_historical
46122031133rxnav_historical
49580200408rxnav_historical
50428455443rxnav_historical
53943053430rxnav_historical
55301031708rxnav_historical
55312031708rxnav_historical
55315000433rxnav_historical
55315031708rxnav_historical
55316015408rxnav_historical
55316031708rxnav_historical
55319020048rxnav_historical
55319031708rxnav_historical
55319060283rxnav_historical
55319097733rxnav_historical
55910015408rxnav_historical
55910061708rxnav_historical
58602012033rxnav_historical
58602014033rxnav_historical
58602016133rxnav_historical
59640015408rxnav_historical
59779015408rxnav_historical
59779020208rxnav_historical
59779093708rxnav_historical
63868006808rxnav_historical
63868095808rxnav_historical
68016022600rxnav_historical
68016029808rxnav_historical
69842065308rxnav_historical

DailyMed RxNorm Mappings#

Set ID, RxNorm string, TTY table
Set IDRxNorm stringTTYSPL versionLabelEffective
f5a66541-1b15-4dfe-91e0-d8d5f8fdc7fbAPAP 21.7 MG/ML / Diphenhydramine Hydrochloride 0.833 MG/ML / Phenylephrine Hydrochloride 0.333 MG/ML Oral SolutionSY7Drug Facts20240307
f5a66541-1b15-4dfe-91e0-d8d5f8fdc7fbacetaminophen 325 MG / diphenhydrAMINE HCl 12.5 MG / phenylephrine HCl 5 MG in 15 mL Oral SolutionPSN7Drug Facts20240307
f5a66541-1b15-4dfe-91e0-d8d5f8fdc7fbacetaminophen 650 MG / diphenhydramine HCl 25 MG / phenylephrine HCl 10 MG per 30 ML Oral SolutionSY7Drug Facts20240307
f5a66541-1b15-4dfe-91e0-d8d5f8fdc7fbacetaminophen 21.7 MG/ML / diphenhydramine hydrochloride 0.833 MG/ML / phenylephrine hydrochloride 0.333 MG/ML Oral SolutionSCD7Drug Facts20240307
f5a66541-1b15-4dfe-91e0-d8d5f8fdc7fbacetaminophen 325 MG / diphenhydramine HCl 12.5 MG / phenylephrine HCl 5 MG per 15 ML Oral SolutionSY7Drug Facts20240307
c8e9b57b-83e9-46c5-9791-02c4c2b94004APAP 21.7 MG/ML / Diphenhydramine Hydrochloride 0.833 MG/ML / Phenylephrine Hydrochloride 0.333 MG/ML Oral SolutionSY520241229
c8e9b57b-83e9-46c5-9791-02c4c2b94004acetaminophen 325 MG / diphenhydrAMINE HCl 12.5 MG / phenylephrine HCl 5 MG in 15 mL Oral SolutionPSN520241229
c8e9b57b-83e9-46c5-9791-02c4c2b94004acetaminophen 325 MG / diphenhydramine HCl 12.5 MG / phenylephrine HCl 5 MG per 15 ML Oral SolutionSY520241229
c8e9b57b-83e9-46c5-9791-02c4c2b94004acetaminophen 21.7 MG/ML / diphenhydramine hydrochloride 0.833 MG/ML / phenylephrine hydrochloride 0.333 MG/ML Oral SolutionSCD520241229
c8e9b57b-83e9-46c5-9791-02c4c2b94004acetaminophen 650 MG / diphenhydramine HCl 25 MG / phenylephrine HCl 10 MG per 30 ML Oral SolutionSY520241229
9736ad4c-8c2e-421f-b023-f91b72d2828bacetaminophen 650 MG / diphenhydramine HCl 25 MG / phenylephrine HCl 10 MG per 30 ML Oral SolutionSY5Drug Facts20240410
9736ad4c-8c2e-421f-b023-f91b72d2828bAPAP 21.7 MG/ML / Diphenhydramine Hydrochloride 0.833 MG/ML / Phenylephrine Hydrochloride 0.333 MG/ML Oral SolutionSY5Drug Facts20240410
9736ad4c-8c2e-421f-b023-f91b72d2828bacetaminophen 325 MG / diphenhydrAMINE HCl 12.5 MG / phenylephrine HCl 5 MG in 15 mL Oral SolutionPSN5Drug Facts20240410
9736ad4c-8c2e-421f-b023-f91b72d2828bacetaminophen 21.7 MG/ML / diphenhydramine hydrochloride 0.833 MG/ML / phenylephrine hydrochloride 0.333 MG/ML Oral SolutionSCD5Drug Facts20240410
9736ad4c-8c2e-421f-b023-f91b72d2828bacetaminophen 325 MG / diphenhydramine HCl 12.5 MG / phenylephrine HCl 5 MG per 15 ML Oral SolutionSY5Drug Facts20240410
8d27b94d-23a1-4e6c-a064-79e2580f7e2eAPAP 21.7 MG/ML / Diphenhydramine Hydrochloride 0.833 MG/ML / Phenylephrine Hydrochloride 0.333 MG/ML Oral SolutionSY3Drug Facts20240415
8d27b94d-23a1-4e6c-a064-79e2580f7e2eacetaminophen 650 MG / diphenhydramine HCl 25 MG / phenylephrine HCl 10 MG per 30 ML Oral SolutionSY3Drug Facts20240415
8d27b94d-23a1-4e6c-a064-79e2580f7e2eacetaminophen 21.7 MG/ML / diphenhydramine hydrochloride 0.833 MG/ML / phenylephrine hydrochloride 0.333 MG/ML Oral SolutionSCD3Drug Facts20240415
8d27b94d-23a1-4e6c-a064-79e2580f7e2eacetaminophen 325 MG / diphenhydrAMINE HCl 12.5 MG / phenylephrine HCl 5 MG in 15 mL Oral SolutionPSN3Drug Facts20240415
8d27b94d-23a1-4e6c-a064-79e2580f7e2eacetaminophen 325 MG / diphenhydramine HCl 12.5 MG / phenylephrine HCl 5 MG per 15 ML Oral SolutionSY3Drug Facts20240415

DailyMed Labels#

Set ID, Title, Manufacturer table
Set IDTitleManufacturerEffective
c8e9b57b-83e9-46c5-9791-02c4c2b94004Chain Drug Consortium, LLC | AptaPharma Inc.20241229
8d27b94d-23a1-4e6c-a064-79e2580f7e2eDrug FactsP & L Development, LLC20240415
9736ad4c-8c2e-421f-b023-f91b72d2828bDrug FactsHaleon US Holdings LLC20240410
f5a66541-1b15-4dfe-91e0-d8d5f8fdc7fbDrug FactsHaleon US Holdings LLC20240307
ed063755-6bdc-479a-92ab-04120350434dDrug FactsTOP CARE (Topco Associates LLC)20231013
fcb23436-7a62-4338-83b1-7b3755b58616Drug FactsH E B20230211

Drug Classes#

Source, Class ID, Class table
SourceClass IDClassTypeRelationshipDrug concept
ATCC01CAAdrenergic and dopaminergic agentsATC1-4phenylephrine
ATCR06AAAminoalkyl ethersATC1-4diphenhydramine
ATCN02BEAnilidesATC1-4acetaminophen
ATCD04AAAntihistamines for topical useATC1-4diphenhydramine
ATCC05AXOther agents for treatment of hemorrhoids and anal fissures for topical useATC1-4phenylephrine
ATCR01BASympathomimeticsATC1-4phenylephrine
ATCS01FBSympathomimetics excl. antiglaucoma preparationsATC1-4phenylephrine
ATCS01GASympathomimetics used as decongestantsATC1-4phenylephrine
ATCR01ABSympathomimetics, combinations excl. corticosteroidsATC1-4phenylephrine
ATCR01AASympathomimetics, plainATC1-4phenylephrine
FDASPLN0000186105alpha-1 Adrenergic AgonistEPChas_epcphenylephrine
FDASPLN0000175587Histamine-1 Receptor AntagonistEPChas_epcdiphenhydramine
FDASPLN0000000190Histamine H1 Receptor AntagonistsMOAhas_moadiphenhydramine
MEDRTD000082AcetaminophenCHEMhas_ingredientacetaminophen
MEDRTD004155DiphenhydramineCHEMhas_ingredientdiphenhydramine hydrochloride
MEDRTD004155DiphenhydramineCHEMhas_ingredientdiphenhydramine
MEDRTD010656PhenylephrineCHEMhas_ingredientphenylephrine
MEDRTD010656PhenylephrineCHEMhas_ingredientphenylephrine hydrochloride
MEDRTD013447SulfitesCHEMci_chemclassphenylephrine
MEDRTD013447SulfitesCHEMci_chemclassphenylephrine hydrochloride
MEDRTD001008Anxiety DisordersDISEASEmay_treatdiphenhydramine hydrochloride
MEDRTD001008Anxiety DisordersDISEASEmay_treatdiphenhydramine
MEDRTD004342Drug HypersensitivityDISEASEci_withdiphenhydramine
MEDRTD004342Drug HypersensitivityDISEASEci_withdiphenhydramine hydrochloride
MEDRTD004342Drug HypersensitivityDISEASEci_withphenylephrine hydrochloride
MEDRTD004342Drug HypersensitivityDISEASEci_withacetaminophen
MEDRTD004342Drug HypersensitivityDISEASEci_withphenylephrine
MEDRTD005334FeverDISEASEmay_treatacetaminophen
MEDRTD005334FeverDISEASEmay_preventacetaminophen
MEDRTD005401Fissure in AnoDISEASEmay_treatphenylephrine
MEDRTD005401Fissure in AnoDISEASEmay_treatphenylephrine hydrochloride
MEDRTD005902Glaucoma, Open-AngleDISEASEmay_treatphenylephrine hydrochloride
MEDRTD005902Glaucoma, Open-AngleDISEASEmay_treatphenylephrine
MEDRTD005955Glucosephosphate Dehydrogenase DeficiencyDISEASEci_withacetaminophen
MEDRTD006484HemorrhoidsDISEASEmay_treatphenylephrine hydrochloride
MEDRTD006484HemorrhoidsDISEASEmay_treatphenylephrine
MEDRTD006973HypertensionDISEASEci_withphenylephrine
MEDRTD006973HypertensionDISEASEci_withphenylephrine hydrochloride
MEDRTD007022HypotensionDISEASEmay_treatphenylephrine hydrochloride
MEDRTD007022HypotensionDISEASEmay_treatphenylephrine
MEDRTD007231Infant, NewbornDISEASEci_withdiphenhydramine hydrochloride
MEDRTD007231Infant, NewbornDISEASEci_withdiphenhydramine
MEDRTD007234Infant, PrematureDISEASEci_withdiphenhydramine hydrochloride
MEDRTD007234Infant, PrematureDISEASEci_withdiphenhydramine
MEDRTD007774LactationDISEASEci_withdiphenhydramine
MEDRTD007774LactationDISEASEci_withdiphenhydramine hydrochloride
MEDRTD008107Liver DiseasesDISEASEci_withacetaminophen
MEDRTD009041Motion SicknessDISEASEmay_treatdiphenhydramine hydrochloride
MEDRTD009041Motion SicknessDISEASEmay_treatdiphenhydramine
MEDRTD015878MydriasisDISEASEinducesphenylephrine
MEDRTD015878MydriasisDISEASEinducesphenylephrine hydrochloride
MEDRTD009325NauseaDISEASEmay_treatdiphenhydramine hydrochloride
MEDRTD009325NauseaDISEASEmay_treatdiphenhydramine
MEDRTD010146PainDISEASEmay_treatacetaminophen
MEDRTD010146PainDISEASEmay_preventacetaminophen
MEDRTD011538Pruritus AniDISEASEmay_treatphenylephrine
MEDRTD011538Pruritus AniDISEASEmay_treatphenylephrine hydrochloride
MEDRTD012221Rhinitis, Allergic, PerennialDISEASEmay_treatdiphenhydramine
MEDRTD012221Rhinitis, Allergic, PerennialDISEASEmay_treatdiphenhydramine hydrochloride
MEDRTD012223Rhinitis, VasomotorDISEASEmay_treatphenylephrine
MEDRTD012223Rhinitis, VasomotorDISEASEmay_treatphenylephrine hydrochloride
MEDRTD012772Shock, SepticDISEASEmay_treatphenylephrine hydrochloride
MEDRTD012772Shock, SepticDISEASEmay_treatphenylephrine
MEDRTD007319Sleep Initiation and Maintenance DisordersDISEASEmay_treatdiphenhydramine hydrochloride
MEDRTD007319Sleep Initiation and Maintenance DisordersDISEASEmay_treatdiphenhydramine
MEDRTD012912SneezingDISEASEmay_treatdiphenhydramine
MEDRTD012912SneezingDISEASEmay_treatdiphenhydramine hydrochloride
MEDRTD013224Status AsthmaticusDISEASEci_withdiphenhydramine
MEDRTD013224Status AsthmaticusDISEASEci_withdiphenhydramine hydrochloride
MEDRTD013617Tachycardia, SupraventricularDISEASEmay_treatphenylephrine
MEDRTD013617Tachycardia, SupraventricularDISEASEmay_treatphenylephrine hydrochloride
MEDRTD017180Tachycardia, VentricularDISEASEci_withphenylephrine hydrochloride
MEDRTD017180Tachycardia, VentricularDISEASEci_withphenylephrine
MEDRTD014581UrticariaDISEASEmay_treatdiphenhydramine
MEDRTD014581UrticariaDISEASEmay_treatdiphenhydramine hydrochloride
MEDRTN0000000209Adrenergic alpha-AgonistsMOAhas_moaphenylephrine
MEDRTN0000000209Adrenergic alpha-AgonistsMOAhas_moaphenylephrine hydrochloride
MEDRTN0000000190Histamine H1 Receptor AntagonistsMOAhas_moadiphenhydramine hydrochloride
MEDRTN0000000190Histamine H1 Receptor AntagonistsMOAhas_moadiphenhydramine
MEDRTN0000000108Prostaglandin Receptor AntagonistsMOAhas_moaacetaminophen
MEDRTN0000175724Central Nervous System Activity AlterationPEhas_peacetaminophen
MEDRTN0000008371Conjunctival Arterial VasoconstrictionPEhas_pephenylephrine
MEDRTN0000008371Conjunctival Arterial VasoconstrictionPEhas_pephenylephrine hydrochloride
MEDRTN0000008896Decreased Nasal and Sinus SecretionsPEhas_pephenylephrine hydrochloride
MEDRTN0000008896Decreased Nasal and Sinus SecretionsPEhas_pephenylephrine
MEDRTN0000008836Decreased Prostaglandin ProductionPEhas_peacetaminophen
MEDRTN0000009072Hypothalamic Endocrine Activity AlterationPEhas_peacetaminophen
MEDRTN0000175725Peripheral Nervous System Activity AlterationPEhas_peacetaminophen
MEDRTN0000000026Hepatic MetabolismPKhas_pkacetaminophen
MEDRTN0000000042Renal ExcretionPKhas_pkacetaminophen

Properties#

Category, Property, Value table
CategoryPropertyValue
ATTRIBUTESAVAILABLE_STRENGTH21.7 MG/ML / 0.833 MG/ML / 0.333 MG/ML
ATTRIBUTESGENERAL_CARDINALITYMULTI
ATTRIBUTESHUMAN_DRUGUS
ATTRIBUTESPRESCRIBABLEY
ATTRIBUTESRXNAV_HUMAN_DRUGUS
ATTRIBUTESSCHEDULE0
ATTRIBUTESTTYSCD
CODESMMSL_CODEBD17167
CODESMMSL_CODEBD19702
CODESMMSL_CODECD17167
CODESMMSL_CODECD19702
CODESRxCUI1298348
CODESSPL_SET_ID8d27b94d-23a1-4e6c-a064-79e2580f7e2e
CODESSPL_SET_ID9736ad4c-8c2e-421f-b023-f91b72d2828b
CODESSPL_SET_IDc8e9b57b-83e9-46c5-9791-02c4c2b94004
CODESSPL_SET_IDf5a66541-1b15-4dfe-91e0-d8d5f8fdc7fb
CODESVUID4035417
NAMESPrescribable Synonymacetaminophen 325 MG / diphenhydrAMINE HCl 12.5 MG / phenylephrine HCl 5 MG in 15 mL Oral Solution
NAMESRXNAV_STRacetaminophen 21.7 MG/ML / diphenhydrAMINE hydrochloride 0.833 MG/ML / phenylephrine hydrochloride 0.333 MG/ML Oral Solution
NAMESRxNorm Nameacetaminophen 21.7 MG/ML / diphenhydramine hydrochloride 0.833 MG/ML / phenylephrine hydrochloride 0.333 MG/ML Oral Solution
NAMESRxNorm Synonymacetaminophen 325 MG / diphenhydramine HCl 12.5 MG / phenylephrine HCl 5 MG per 15 ML Oral Solution
NAMESRxNorm Synonymacetaminophen 650 MG / diphenhydramine HCl 25 MG / phenylephrine HCl 10 MG per 30 ML Oral Solution
NAMESRxNorm SynonymAPAP 21.7 MG/ML / Diphenhydramine Hydrochloride 0.833 MG/ML / Phenylephrine Hydrochloride 0.333 MG/ML Oral Solution
NAMESTallman Synonymacetaminophen 21.7 MG/ML / diphenhydrAMINE hydrochloride 0.833 MG/ML / phenylephrine hydrochloride 0.333 MG/ML Oral Solution
NAMESTallman Synonymacetaminophen 325 MG / diphenhydrAMINE HCl 12.5 MG / phenylephrine HCl 5 MG per 15 ML Oral Solution
NAMESTallman Synonymacetaminophen 650 MG / diphenhydrAMINE HCl 25 MG / phenylephrine HCl 10 MG per 30 ML Oral Solution
NAMESTallman SynonymAPAP 21.7 MG/ML / diphenhydrAMINE Hydrochloride 0.833 MG/ML / Phenylephrine Hydrochloride 0.333 MG/ML Oral Solution
SOURCESSourceGold Standard Alchemy
SOURCESSourceMetathesaurus FDA Structured Product Labels
SOURCESSourceMicromedex RED BOOK
SOURCESSourceMultum MediSource Lexicon
SOURCESSourceNational Drug Data File Plus Source Vocabulary
SOURCESSourceVeterans Health Administration National Drug File