aspirin 500 MG / caffeine 65 MG Effervescent Oral Tablet

RxCUI: 1536815
RxNorm name: aspirin 500 MG / caffeine 65 MG Effervescent Oral Tablet
Display name: Aspirin/Caffeine (Effervescent)
Full name: aspirin 500 MG / caffeine 65 MG Effervescent Oral Tablet
Term type: SCD
Status: Active
Strength: 500-65 mg
Dose form: Tab
Route: Effervescent
Updated: 2026-09-14 22:58:26

RxNorm Status History#

Status: Active
Source: RXNORM
Current: YES
Release start: 062014
Active start: 062014
Multiple ingredient: YES
Branded: NO

Ingredients And Strength#

Ingredient, Strength, Base table
Ingredient	Strength	Base	Basis of strength
aspirin	500 MG / 1 EACH	aspirin	aspirin
caffeine	65 MG / 1 EACH	caffeine	caffeine

Dose Form Concepts#

Dose form, RxCUI table
Dose form	RxCUI
Effervescent Oral Tablet	1535727

Derived Ingredient Concepts#

Ingredient, RxCUI table
Ingredient	RxCUI
aspirin	1191
caffeine	1886

Source Vocabulary Codes#

Code type, Values, Count table
Code type	Values	Count	Category
PRESCRIBABLE	Y	1	ATTRIBUTES
RXNAV_STR	aspirin 500 MG / caffeine 65 MG Effervescent Oral Tablet	1	NAMES
RxNorm Name	aspirin 500 MG / caffeine 65 MG Effervescent Oral Tablet	1	NAMES
RxNorm Synonym	ASA 500 MG / Caffeine 65 MG Effervescent Oral Tablet	1	NAMES
TTY	SCD	1	ATTRIBUTES
SPL_SET_ID	2 linked values 4a16b6e5-f0c6-e3a4-e063-6294a90a85ad dc235b06-999e-221d-e053-2a95a90a0ce1	2	CODES
RxCUI	1536815	1	CODES
MMSL_CODE	2 linked values BD8570 CD8570	2	CODES

FDA NDC Products And Packages#

Package NDC, Product NDC, Name table
Package NDC	Product NDC	Name	Labeler	Application
0280-0084-01	0280-0084	Alka-Seltzer Hangover Relief ANHYDROUS CITRIC ACID, ASPIRIN, and SODIUM BICARBONATE	Bayer HealthCare LLC.	M013
0280-0084-02	0280-0084	Alka-Seltzer Hangover Relief ANHYDROUS CITRIC ACID, ASPIRIN, and SODIUM BICARBONATE	Bayer HealthCare LLC.	M013
0280-0084-03	0280-0084	Alka-Seltzer Hangover Relief ANHYDROUS CITRIC ACID, ASPIRIN, and SODIUM BICARBONATE	Bayer HealthCare LLC.	M013
0280-0084-04	0280-0084	Alka-Seltzer Hangover Relief ANHYDROUS CITRIC ACID, ASPIRIN, and SODIUM BICARBONATE	Bayer HealthCare LLC.	M013
0280-0084-05	0280-0084	Alka-Seltzer Hangover Relief ANHYDROUS CITRIC ACID, ASPIRIN, and SODIUM BICARBONATE	Bayer HealthCare LLC.	M013
0280-0084-06	0280-0084	Alka-Seltzer Hangover Relief ANHYDROUS CITRIC ACID, ASPIRIN, and SODIUM BICARBONATE	Bayer HealthCare LLC.	M013
0280-8260-20	0280-8260	Alka-Seltzer Extra Strength Pain Relief ANHYDROUS CITRIC ACID, ASPIRIN	Bayer HealthCare LLC.	M013

Drugs@FDA Applications#

Application, NDC, Name table
Application	NDC	Name	Marketing category	Labeler
M013	0280-0084	Alka-Seltzer Hangover Relief ANHYDROUS CITRIC ACID, ASPIRIN, and SODIUM BICARBONATE	OTC MONOGRAPH DRUG	Bayer HealthCare LLC.

RxNav Current And Historical NDCs#

RxNav current and historical NDC rows page 1 of 1 · 11 matching rows.

NDC11, Source, Active table
NDC11	Source	Active
00280008401	rxnav_ndcs	yes
00280008402	rxnav_ndcs	yes
00280008403	rxnav_ndcs	yes
00280008404	rxnav_ndcs	yes
00280008405	rxnav_ndcs	yes
00280008406	rxnav_ndcs	yes
00280826020	rxnav_ndcs	yes
16500050338	rxnav_ndcs	yes
00280411016	rxnav_historical_indirect
16500050339	rxnav_historical_indirect
67751021801	rxnav_historical

UNII Substances#

UNII substance links page 1 of 1 · 0 matching rows.

No records found.

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 2 matching rows.

Brand, Generic, Manufacturer table
Brand	Generic	Manufacturer	SPL set ID	Effective date	Available safety fields	Join
Alka-Seltzer Extra Strength Pain Relief	ANHYDROUS CITRIC ACID, ASPIRIN	Bayer HealthCare LLC.	4a16b6e5-f0c6-e3a4-e063-6294a90a85ad	2026-02-05	Warnings	Exact identifier ndc (package): 0280-8260-20 ndc (product): 0280-8260 ndc11 (package): 00280826020 rxcui: 1536815
Alka-Seltzer Hangover Relief	ANHYDROUS CITRIC ACID, ASPIRIN, AND SODIUM BICARBONATE	Bayer HealthCare LLC.	dc235b06-999e-221d-e053-2a95a90a0ce1	2025-10-16	Warnings	Exact identifier ndc (package): 0280-0084-05 ndc (package): 0280-0084-06 ndc (package): 0280-0084-02 ndc (package): 0280-0084-03 ndc (package): 0280-0084-01 ndc (package): 0280-0084-04 ndc (product): 0280-0084 ndc11 (package): 00280008403 ndc11 (package): 00280008404 ndc11 (package): 00280008402 ndc11 (package): 00280008406 ndc11 (package): 00280008405 ndc11 (package): 00280008401 rxcui: 1536815

DailyMed RxNorm Mappings#

unique DailyMed labels mapped to this RxNorm concept page 1 of 1 · 2 matching rows.

Set ID, RxNorm mappings, Terms table
Set ID	RxNorm mappings	Terms	SPL version	Label	Effective
dc235b06-999e-221d-e053-2a95a90a0ce1	aspirin 500 MG / caffeine 65 MG Effervescent Oral Tablet [PSN] · aspirin 500 MG / caffeine 65 MG Effervescent Oral Tablet [SCD] · ASA 500 MG / Caffeine 65 MG Effervescent Oral Tablet [SY]	3	16	Alka-Seltzer Hangover Relief	20251016
4a16b6e5-f0c6-e3a4-e063-6294a90a85ad	aspirin 500 MG / caffeine 65 MG Effervescent Oral Tablet [PSN] · aspirin 500 MG / caffeine 65 MG Effervescent Oral Tablet [SCD] · ASA 500 MG / Caffeine 65 MG Effervescent Oral Tablet [SY]	3	1	Alka-Seltzer Extra Strength Pain Relief UI1614788	20260205

Recently Linked DailyMed Labels#

Set ID, Title, Manufacturer table
Set ID	Title	Manufacturer	Effective
4a16b6e5-f0c6-e3a4-e063-6294a90a85ad	Alka-Seltzer Extra Strength Pain Relief UI1614788	Bayer HealthCare LLC.	20260205
dc235b06-999e-221d-e053-2a95a90a0ce1	Alka-Seltzer Hangover Relief	Bayer HealthCare LLC.	20251016
dc235b06-999e-221d-e053-2a95a90a0ce1	Alka-Seltzer Hangover Relief	Bayer HealthCare LLC.	20250811
f6f382e2-2241-bbdc-e053-6394a90ac996	Alka-Seltzer Hangover Relief	Navajo Manufacturing Company Inc.	20230317

Drug Classes#

Source, Class ID, Class table
Source	Class ID	Class	Type	Relationship	Drug concept
ATC	A01AD	Other agents for local oral treatment	ATC1-4		aspirin
ATC	D11AX	Other dermatologicals	ATC1-4		caffeine
ATC	B01AC	Platelet aggregation inhibitors excl. heparin	ATC1-4		aspirin
ATC	N02BA	Salicylic acid and derivatives	ATC1-4		aspirin
ATC	N06BC	Xanthine derivatives	ATC1-4		caffeine
FDASPL	D014970	Xanthines	CHEM	has_chemical_structure	caffeine
FDASPL	N0000175739	Central Nervous System Stimulant	EPC	has_epc	caffeine
FDASPL	N0000175790	Methylxanthine	EPC	has_epc	caffeine
FDASPL	N0000175722	Nonsteroidal Anti-inflammatory Drug	EPC	has_epc	aspirin
FDASPL	N0000175578	Platelet Aggregation Inhibitor	EPC	has_epc	aspirin
FDASPL	N0000175729	Central Nervous System Stimulation	PE	has_pe	caffeine
MEDRT	D001241	Aspirin	CHEM	has_ingredient	aspirin
MEDRT	D002110	Caffeine	CHEM	has_ingredient	caffeine
MEDRT	D001049	Apnea	DISEASE	may_treat	caffeine
MEDRT	D001172	Arthritis, Rheumatoid	DISEASE	may_treat	aspirin
MEDRT	D001778	Blood Coagulation Disorders	DISEASE	ci_with	aspirin
MEDRT	D001791	Blood Platelet Disorders	DISEASE	ci_with	aspirin
MEDRT	D002544	Cerebral Infarction	DISEASE	may_prevent	aspirin
MEDRT	D002644	Chickenpox	DISEASE	ci_with	aspirin
MEDRT	D002675	Child, Preschool	DISEASE	ci_with	aspirin
MEDRT	D004342	Drug Hypersensitivity	DISEASE	ci_with	aspirin
MEDRT	D004342	Drug Hypersensitivity	DISEASE	ci_with	caffeine
MEDRT	D005221	Fatigue	DISEASE	may_treat	caffeine
MEDRT	D005334	Fever	DISEASE	may_treat	aspirin
MEDRT	D006073	Gout	DISEASE	may_treat	aspirin
MEDRT	D006396	Hematemesis	DISEASE	ci_with	aspirin
MEDRT	D006474	Hemorrhagic Disorders	DISEASE	ci_with	aspirin
MEDRT	D007223	Infant	DISEASE	ci_with	aspirin
MEDRT	D007249	Inflammation	DISEASE	may_treat	aspirin
MEDRT	D002546	Ischemic Attack, Transient	DISEASE	may_prevent	aspirin
MEDRT	D008551	Melena	DISEASE	ci_with	aspirin
MEDRT	D009203	Myocardial Infarction	DISEASE	may_prevent	aspirin
MEDRT	D009298	Nasal Polyps	DISEASE	ci_with	aspirin
MEDRT	D010003	Osteoarthritis	DISEASE	may_treat	aspirin
MEDRT	D010146	Pain	DISEASE	may_prevent	aspirin
MEDRT	D010146	Pain	DISEASE	may_treat	aspirin
MEDRT	D011225	Pre-Eclampsia	DISEASE	may_prevent	aspirin
MEDRT	D011263	Pregnancy Trimester, Third	DISEASE	ci_with	aspirin
MEDRT	D012213	Rheumatic Fever	DISEASE	may_treat	aspirin
MEDRT	N0000000160	Cyclooxygenase Inhibitors	MOA	has_moa	aspirin
MEDRT	N0000000133	Enzyme Inhibitors	MOA	has_moa	caffeine
MEDRT	N0000008322	Bronchodilation	PE	has_pe	caffeine
MEDRT	N0000008331	Cardiovascular Activity Alteration	PE	has_pe	caffeine
MEDRT	N0000008567	Decreased Collecting Duct Water Permeability	PE	has_pe	caffeine
MEDRT	N0000008831	Decreased Platelet Activating Factor Production	PE	has_pe	aspirin
MEDRT	N0000008832	Decreased Platelet Aggregation	PE	has_pe	aspirin
MEDRT	N0000008836	Decreased Prostaglandin Production	PE	has_pe	aspirin
MEDRT	N0000009006	Decreased Thromboxane Production	PE	has_pe	aspirin
MEDRT	N0000009197	Increased Central Nervous System Organized Electrical Activity	PE	has_pe	caffeine
MEDRT	N0000000026	Hepatic Metabolism	PK	has_pk	aspirin
MEDRT	N0000000042	Renal Excretion	PK	has_pk	aspirin

Group, Type, Concept table
Group	Type	Concept	Source
DF	DF	Effervescent Oral Tablet	rxnav_allrelated
DFG	DFG	Oral Product	rxnav_allrelated
IN	IN	aspirin	rxnav_allrelated
IN	IN	caffeine	rxnav_allrelated
MIN	MIN	aspirin / caffeine	rxnav_allrelated
SCD	SCD	aspirin 500 MG / caffeine 65 MG Effervescent Oral Tablet	rxnav_allrelated
SCDC	SCDC	aspirin 500 MG	rxnav_allrelated
SCDC	SCDC	caffeine 65 MG	rxnav_allrelated
SCDF	SCDF	aspirin / caffeine Effervescent Oral Tablet	rxnav_allrelated
SCDG	SCDG	aspirin / caffeine Oral Product	rxnav_allrelated

Properties#

Category, Property, Value table
Category	Property	Value
ATTRIBUTES	AVAILABLE_STRENGTH	500 MG / 65 MG
ATTRIBUTES	GENERAL_CARDINALITY	MULTI
ATTRIBUTES	HUMAN_DRUG	US
ATTRIBUTES	RXNAV_HUMAN_DRUG	US
ATTRIBUTES	SCHEDULE	0
NAMES	Prescribable Synonym	aspirin 500 MG / caffeine 65 MG Effervescent Oral Tablet
SOURCES	Source	Gold Standard Alchemy
SOURCES	Source	Metathesaurus FDA Structured Product Labels
SOURCES	Source	Micromedex RED BOOK
SOURCES	Source	Multum MediSource Lexicon