aspirin 325 MG / citric acid 1000 MG / sodium bicarbonate 1916 MG Effervescent Oral Tablet [Bromo Seltzer Antacid Pain Reliever]

RxCUI: 1537012
RxNorm name: aspirin 325 MG / citric acid 1000 MG / sodium bicarbonate 1916 MG Effervescent Oral Tablet [Bromo Seltzer Antacid Pain Reliever]
Term type: SBD
Status: Active
Updated: 2026-09-25 04:21:58

RxNorm Status History#

Status: Active
Source: RXNORM
Current: YES
Release start: 062014
Active start: 062014
Multiple ingredient: YES
Branded: YES

Ingredients And Strength#

Ingredient, Strength, Base table
Ingredient	Strength	Base	Basis of strength
aspirin	325 MG / 1 EACH	aspirin	aspirin
citric acid	1000 MG / 1 EACH	citric acid	citric acid
sodium bicarbonate	1916 MG / 1 EACH	sodium bicarbonate	sodium bicarbonate

Dose Form Concepts#

Dose form, RxCUI table
Dose form	RxCUI
Effervescent Oral Tablet	1535727

Derived Ingredient Concepts#

Ingredient, RxCUI table
Ingredient	RxCUI
aspirin	1191
citric acid	21183
sodium bicarbonate	36676

Source Vocabulary Codes#

Code type, Values, Count table
Code type	Values	Count	Category
RXNAV_STR	ASA 325 MG / Citric Acid 1000 MG / NaHCO3 1916 MG Effervescent Oral Tablet [Bromo Seltzer Antacid Pain Reliever]	1	NAMES
RxNorm Name	aspirin 325 MG / citric acid 1000 MG / sodium bicarbonate 1916 MG Effervescent Oral Tablet [Bromo Seltzer Antacid Pain Reliever]	1	NAMES
RxNorm Synonym	2 linked values ASA 325 MG / Citric Acid 1000 MG / NaHCO3 1916 MG Effervescent Oral Tablet [Bromo Seltzer Antacid Pain Reliever] Bromo Seltzer Antacid Pain Reliever (aspirin 325 MG / citric acid 1000 MG / sodium bicarbonate 1916 MG) Effervescent Oral Tablet	2	NAMES
TTY	SBD	1	ATTRIBUTES
SPL_SET_ID	8ff88ee1-e33e-4051-992f-24e2720c48ce	1	CODES
RxCUI	1537012	1	CODES

FDA NDC Products And Packages#

Package NDC, Product NDC, Name table
Package NDC	Product NDC	Name	Labeler	Application
50201-0421-2	50201-0421	Bromo Seltzer ASPIRIN, SODIUM BICARBONATE, CITRIC ACID	Tower Laboratories Ltd	M013

Drugs@FDA Applications#

Application, NDC, Name table
Application	NDC	Name	Marketing category	Labeler
M013	50201-0421	Bromo Seltzer ASPIRIN, SODIUM BICARBONATE, CITRIC ACID	OTC MONOGRAPH DRUG	Tower Laboratories Ltd

RxNav Current And Historical NDCs#

RxNav current and historical NDC rows page 1 of 1 · 1 matching rows.

NDC11, Source, Active table
NDC11	Source	Active
50201042102	rxnav_ndcs	yes

UNII Substances#

UNII substance links page 1 of 1 · 0 matching rows.

No records found.

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 1 matching rows.

Brand, Generic, Manufacturer table
Brand	Generic	Manufacturer	SPL set ID	Effective date	Available safety fields	Join
Bromo Seltzer	ASPIRIN, SODIUM BICARBONATE, CITRIC ACID	Tower Laboratories Ltd	8ff88ee1-e33e-4051-992f-24e2720c48ce	2024-11-13	Warnings	Exact identifier ndc (package): 50201-0421-2 ndc (product): 50201-0421 ndc11 (package): 50201042102 rxcui: 1537012

Reported adverse events (FAERS/openFDA)#

Adverse event summaries are temporarily unavailable. Other product information remains available.

DailyMed RxNorm Mappings#

unique DailyMed labels mapped to this RxNorm concept page 1 of 1 · 1 matching rows.

Set ID, RxNorm mappings, Terms table
Set ID	RxNorm mappings	Terms	SPL version	Label	Effective
8ff88ee1-e33e-4051-992f-24e2720c48ce	BROMO SELTZER Antacid Pain Reliever 325 MG / 1000 MG / 1916 MG Effervescent Oral Tablet [PSN] · aspirin 325 MG / citric acid 1000 MG / sodium bicarbonate 1916 MG Effervescent Oral Tablet [Bromo Seltzer Antacid Pain Reliever] [SBD] · ASA 325 MG / Citric Acid 1000 MG / NaHCO3 1916 MG Effervescent Oral Tablet [Bromo Seltzer Antacid Pain Reliever] [SY] · Bromo Seltzer Antacid Pain Reliever (aspirin 325 MG / citric acid 1000 MG / sodium bicarbonate 1916 MG) Effervescent Oral Tablet [SY]	4	7	Bromo Seltzer	20241113

Recently Linked DailyMed Labels#

Set ID, Title, Manufacturer table
Set ID	Title	Manufacturer	Effective
8ff88ee1-e33e-4051-992f-24e2720c48ce	Bromo Seltzer	Tower Laboratories Ltd	20241113

Drug Classes#

Source, Class ID, Class table
Source	Class ID	Class	Type	Relationship	Drug concept
ATC	A09AB	Acid preparations	ATC1-4		citric acid
ATC	B05XA	Electrolyte solutions	ATC1-4		sodium bicarbonate
ATC	A01AD	Other agents for local oral treatment	ATC1-4		aspirin
ATC	B01AC	Platelet aggregation inhibitors excl. heparin	ATC1-4		aspirin
ATC	N02BA	Salicylic acid and derivatives	ATC1-4		aspirin
ATC	B05CB	Salt solutions	ATC1-4		sodium bicarbonate
FDASPL	N0000175722	Nonsteroidal Anti-inflammatory Drug	EPC	has_epc	aspirin
FDASPL	N0000175578	Platelet Aggregation Inhibitor	EPC	has_epc	aspirin
MEDRT	D001241	Aspirin	CHEM	has_ingredient	aspirin
MEDRT	D019343	Citric Acid	CHEM	has_ingredient	citric acid
MEDRT	D017693	Sodium Bicarbonate	CHEM	has_ingredient	sodium bicarbonate
MEDRT	D000141	Acidosis, Renal Tubular	DISEASE	may_treat	sodium bicarbonate
MEDRT	D000141	Acidosis, Renal Tubular	DISEASE	may_treat	citric acid
MEDRT	D000224	Addison Disease	DISEASE	ci_with	citric acid
MEDRT	D000471	Alkalosis	DISEASE	ci_with	sodium bicarbonate
MEDRT	D001002	Anuria	DISEASE	ci_with	citric acid
MEDRT	D001172	Arthritis, Rheumatoid	DISEASE	may_treat	aspirin
MEDRT	D001778	Blood Coagulation Disorders	DISEASE	ci_with	aspirin
MEDRT	D001791	Blood Platelet Disorders	DISEASE	ci_with	aspirin
MEDRT	D002544	Cerebral Infarction	DISEASE	may_prevent	aspirin
MEDRT	D002644	Chickenpox	DISEASE	ci_with	aspirin
MEDRT	D002675	Child, Preschool	DISEASE	ci_with	aspirin
MEDRT	D003681	Dehydration	DISEASE	ci_with	citric acid
MEDRT	D004342	Drug Hypersensitivity	DISEASE	ci_with	sodium bicarbonate
MEDRT	D004342	Drug Hypersensitivity	DISEASE	ci_with	aspirin
MEDRT	D004342	Drug Hypersensitivity	DISEASE	ci_with	citric acid
MEDRT	D062787	Drug Overdose	DISEASE	may_treat	sodium bicarbonate
MEDRT	D064420	Drug-Related Side Effects and Adverse Reactions	DISEASE	may_prevent	sodium bicarbonate
MEDRT	D004415	Dyspepsia	DISEASE	may_treat	sodium bicarbonate
MEDRT	D004487	Edema	DISEASE	ci_with	sodium bicarbonate
MEDRT	D005334	Fever	DISEASE	may_treat	aspirin
MEDRT	D005764	Gastroesophageal Reflux	DISEASE	may_treat	sodium bicarbonate
MEDRT	D006073	Gout	DISEASE	may_treat	aspirin
MEDRT	D006323	Heart Arrest	DISEASE	may_treat	sodium bicarbonate
MEDRT	D006356	Heartburn	DISEASE	may_treat	sodium bicarbonate
MEDRT	D006396	Hematemesis	DISEASE	ci_with	aspirin
MEDRT	D006474	Hemorrhagic Disorders	DISEASE	ci_with	aspirin
MEDRT	D006947	Hyperkalemia	DISEASE	may_treat	sodium bicarbonate
MEDRT	D006947	Hyperkalemia	DISEASE	ci_with	citric acid
MEDRT	D006955	Hypernatremia	DISEASE	ci_with	sodium bicarbonate
MEDRT	D006996	Hypocalcemia	DISEASE	ci_with	sodium bicarbonate
MEDRT	D007223	Infant	DISEASE	ci_with	aspirin
MEDRT	D007249	Inflammation	DISEASE	may_treat	aspirin
MEDRT	D002546	Ischemic Attack, Transient	DISEASE	may_prevent	aspirin
MEDRT	D008551	Melena	DISEASE	ci_with	aspirin
MEDRT	D009203	Myocardial Infarction	DISEASE	may_prevent	aspirin
MEDRT	D009298	Nasal Polyps	DISEASE	ci_with	aspirin
MEDRT	D010003	Osteoarthritis	DISEASE	may_treat	aspirin
MEDRT	D010146	Pain	DISEASE	may_prevent	aspirin
MEDRT	D010146	Pain	DISEASE	may_treat	aspirin
MEDRT	D011225	Pre-Eclampsia	DISEASE	may_prevent	aspirin
MEDRT	D011263	Pregnancy Trimester, Third	DISEASE	ci_with	aspirin
MEDRT	D011654	Pulmonary Edema	DISEASE	ci_with	sodium bicarbonate
MEDRT	D051437	Renal Insufficiency	DISEASE	ci_with	citric acid
MEDRT	D012213	Rheumatic Fever	DISEASE	may_treat	aspirin
MEDRT	D014555	Urination Disorders	DISEASE	may_treat	citric acid
MEDRT	N0000000226	Acid-Base Activity	MOA	has_moa	sodium bicarbonate
MEDRT	N0000000236	Alkylating Activity	MOA	has_moa	citric acid
MEDRT	N0000000160	Cyclooxygenase Inhibitors	MOA	has_moa	aspirin
MEDRT	N0000000220	Electrolyte Activity	MOA	has_moa	sodium bicarbonate
MEDRT	N0000008831	Decreased Platelet Activating Factor Production	PE	has_pe	aspirin
MEDRT	N0000008832	Decreased Platelet Aggregation	PE	has_pe	aspirin
MEDRT	N0000008836	Decreased Prostaglandin Production	PE	has_pe	aspirin
MEDRT	N0000009006	Decreased Thromboxane Production	PE	has_pe	aspirin
MEDRT	N0000009054	Gastric Acid Alteration	PE	has_pe	sodium bicarbonate
MEDRT	N0000009549	Increased Renal HCO3- Excretion	PE	has_pe	citric acid
MEDRT	N0000009549	Increased Renal HCO3- Excretion	PE	has_pe	sodium bicarbonate
MEDRT	N0000000026	Hepatic Metabolism	PK	has_pk	aspirin
MEDRT	N0000000042	Renal Excretion	PK	has_pk	aspirin

Group, Type, Concept table
Group	Type	Concept	Source
BN	BN	Bromo Seltzer Antacid Pain Reliever	rxnav_allrelated
DF	DF	Effervescent Oral Tablet	rxnav_allrelated
DFG	DFG	Oral Product	rxnav_allrelated
IN	IN	aspirin	rxnav_allrelated
IN	IN	citric acid	rxnav_allrelated
IN	IN	sodium bicarbonate	rxnav_allrelated
MIN	MIN	aspirin / citric acid / sodium bicarbonate	rxnav_allrelated
SBD	SBD	aspirin 325 MG / citric acid 1000 MG / sodium bicarbonate 1916 MG Effervescent Oral Tablet [Bromo Seltzer Antacid Pain Reliever]	rxnav_allrelated
SBDC	SBDC	aspirin 325 MG / citric acid 1000 MG / sodium bicarbonate 1916 MG [Bromo Seltzer Antacid Pain Reliever]	rxnav_allrelated
SBDF	SBDF	aspirin / citric acid / sodium bicarbonate Effervescent Oral Tablet [Bromo Seltzer Antacid Pain Reliever]	rxnav_allrelated
SBDG	SBDG	Bromo Seltzer Antacid Pain Reliever Oral Product	rxnav_allrelated
SCD	SCD	aspirin 325 MG / citric acid 1000 MG / sodium bicarbonate 1916 MG Effervescent Oral Tablet	rxnav_allrelated
SCDC	SCDC	aspirin 325 MG	rxnav_allrelated
SCDC	SCDC	citric acid 1000 MG	rxnav_allrelated
SCDC	SCDC	sodium bicarbonate 1916 MG	rxnav_allrelated
SCDF	SCDF	aspirin / citric acid / sodium bicarbonate Effervescent Oral Tablet	rxnav_allrelated
SCDG	SCDG	aspirin / citric acid / sodium bicarbonate Oral Product	rxnav_allrelated

Properties#

Category, Property, Value table
Category	Property	Value
ATTRIBUTES	AVAILABLE_STRENGTH	325 MG / 1000 MG / 1916 MG
ATTRIBUTES	GENERAL_CARDINALITY	MULTI
ATTRIBUTES	HUMAN_DRUG	US
ATTRIBUTES	RXNAV_HUMAN_DRUG	US
NAMES	Prescribable Synonym	BROMO SELTZER Antacid Pain Reliever 325 MG / 1000 MG / 1916 MG Effervescent Oral Tablet
SOURCES	Source	Metathesaurus FDA Structured Product Labels