acetaminophen 250 MG / aspirin 250 MG / diphenhydramine citrate 38 MG Oral Tablet [Excedrin PM Triple Action]

RxCUI: 1593116
RxNorm name: acetaminophen 250 MG / aspirin 250 MG / diphenhydramine citrate 38 MG Oral Tablet [Excedrin PM Triple Action]
Display name: EXCEDRIN PM TRIPLE ACTION (Oral Pill)
Full name: acetaminophen 250 MG / aspirin 250 MG / diphenhydramine citrate 38 MG Oral Tablet [Excedrin PM Triple Action]
Term type: SBD
Status: Active
Strength: 250-250-38 mg
Dose form: Tab
Route: Oral Pill
Updated: 2026-10-15 14:49:37

RxNorm Status History#

Status: Active
Source: RXNORM
Current: YES
Release start: 122014
Active start: 122014
Multiple ingredient: YES
Branded: YES

Ingredients And Strength#

Ingredient, Strength, Base table
Ingredient	Strength	Base	Basis of strength
aspirin	250 MG / 1 EACH	aspirin	aspirin
acetaminophen	250 MG / 1 EACH	acetaminophen	acetaminophen
diphenhydramine citrate	38 MG / 1 EACH	diphenhydramine	diphenhydramine citrate

Dose Form Concepts#

Dose form, RxCUI table
Dose form	RxCUI
Oral Tablet	317541

Derived Ingredient Concepts#

Ingredient, RxCUI table
Ingredient	RxCUI
aspirin	1191
acetaminophen	161
diphenhydramine	3498

Source Vocabulary Codes#

Code type, Values, Count table
Code type	Values	Count	Category
PRESCRIBABLE	Y	1	ATTRIBUTES
RXNAV_STR	APAP 250 MG / ASA 250 MG / diphenhydrAMINE Citrate 38 MG Oral Tablet [Excedrin PM Triple Action]	1	NAMES
RxNorm Name	acetaminophen 250 MG / aspirin 250 MG / diphenhydramine citrate 38 MG Oral Tablet [Excedrin PM Triple Action]	1	NAMES
RxNorm Synonym	2 linked values APAP 250 MG / ASA 250 MG / Diphenhydramine Citrate 38 MG Oral Tablet [Excedrin PM Triple Action] Excedrin PM Triple Action (acetaminophen 250 MG / aspirin 250 MG / diphenhydramine citrate 38 MG) Oral Tablet	2	NAMES
TTY	SBD	1	ATTRIBUTES
SPL_SET_ID	3 linked values 444fa225-c204-45d1-b3b3-aa5650ee5d07 978a9d27-6d41-42cb-a193-11314923d2ac b3812d27-40af-40d7-864a-dfa4ae34cb9e	3	CODES
RxCUI	1593116	1	CODES
MMSL_CODE	BD29966	1	CODES

FDA NDC Products And Packages#

Package NDC, Product NDC, Name table
Package NDC	Product NDC	Name	Labeler	Application
0067-2056-24	0067-2056	Excedrin PM Triple Action Caplets Acetaminophen, Aspirin (NSAID) and Diphenhydramine Citrate	Haleon US Holdings LLC	M013
0067-2056-91	0067-2056	Excedrin PM Triple Action Caplets Acetaminophen, Aspirin (NSAID) and Diphenhydramine Citrate	Haleon US Holdings LLC	M013

Drugs@FDA Applications#

Application, NDC, Name table
Application	NDC	Name	Marketing category	Labeler
M013	0067-2056	Excedrin PM Triple Action Caplets Acetaminophen, Aspirin (NSAID) and Diphenhydramine Citrate	OTC MONOGRAPH DRUG	Haleon US Holdings LLC

RxNav Current And Historical NDCs#

RxNav current and historical NDC rows page 1 of 1 · 2 matching rows.

NDC11, Source, Active table
NDC11	Source	Active
00067205624	rxnav_ndcs	yes
00067205691	rxnav_ndcs	yes

UNII Substances#

UNII substance links page 1 of 1 · 0 matching rows.

No records found.

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 3 matching rows.

Brand, Generic, Manufacturer table
Brand	Generic	Manufacturer	SPL set ID	Effective date	Available safety fields	Join
Excedrin PM Triple Action Caplets and Excedrin Extra Strength Pain Reliever	ACETAMINOPHEN, ASPIRIN (NSAID), CAFFEINE, AND DIPHENHYDRAMINE CITRATE	Haleon US Holdings LLC	444fa225-c204-45d1-b3b3-aa5650ee5d07	2026-02-23	Warnings	Exact identifier ndc (package): 0067-2056-24 ndc11 (package): 00067205624 rxcui: 1593116
Excedrin PM Triple Action Caplets and Excedrin Tension Headache	ACETAMINOPHEN, ASPIRIN (NSAID), CAFFEINE, AND DIPHENHYDRAMINE CITRATE	Haleon US Holdings LLC	978a9d27-6d41-42cb-a193-11314923d2ac	2024-03-14	Warnings	Exact identifier ndc (package): 0067-2056-24 ndc11 (package): 00067205624 rxcui: 1593116
Excedrin PM Triple Action Caplets	ACETAMINOPHEN, ASPIRIN (NSAID) AND DIPHENHYDRAMINE CITRATE	Haleon US Holdings LLC	b3812d27-40af-40d7-864a-dfa4ae34cb9e	2024-03-14	Warnings	Exact identifier ndc (package): 0067-2056-91 ndc (package): 0067-2056-24 ndc (product): 0067-2056 ndc11 (package): 00067205691 ndc11 (package): 00067205624 rxcui: 1593116

Reported adverse events (FAERS/openFDA)#

Adverse event summaries are temporarily unavailable. Other product information remains available.

DailyMed RxNorm Mappings#

unique DailyMed labels mapped to this RxNorm concept page 1 of 1 · 3 matching rows.

Set ID, RxNorm mappings, Terms table
Set ID	RxNorm mappings	Terms	SPL version	Label	Effective
b3812d27-40af-40d7-864a-dfa4ae34cb9e	Excedrin PM Triple Action (250 MG / 250 MG / 38 MG) Oral Tablet [PSN] · acetaminophen 250 MG / aspirin 250 MG / diphenhydramine citrate 38 MG Oral Tablet [Excedrin PM Triple Action] [SBD] · APAP 250 MG / ASA 250 MG / Diphenhydramine Citrate 38 MG Oral Tablet [Excedrin PM Triple Action] [SY] · Excedrin PM Triple Action (acetaminophen 250 MG / aspirin 250 MG / diphenhydramine citrate 38 MG) Oral Tablet [SY]	4	9	Drug Facts	20240314
444fa225-c204-45d1-b3b3-aa5650ee5d07	Excedrin PM Triple Action (250 MG / 250 MG / 38 MG) Oral Tablet [PSN] · acetaminophen 250 MG / aspirin 250 MG / diphenhydramine citrate 38 MG Oral Tablet [Excedrin PM Triple Action] [SBD] · APAP 250 MG / ASA 250 MG / Diphenhydramine Citrate 38 MG Oral Tablet [Excedrin PM Triple Action] [SY] · Excedrin PM Triple Action (acetaminophen 250 MG / aspirin 250 MG / diphenhydramine citrate 38 MG) Oral Tablet [SY]	4	6	Drug Facts	20260223
978a9d27-6d41-42cb-a193-11314923d2ac	Excedrin PM Triple Action (250 MG / 250 MG / 38 MG) Oral Tablet [PSN] · acetaminophen 250 MG / aspirin 250 MG / diphenhydramine citrate 38 MG Oral Tablet [Excedrin PM Triple Action] [SBD] · APAP 250 MG / ASA 250 MG / Diphenhydramine Citrate 38 MG Oral Tablet [Excedrin PM Triple Action] [SY] · Excedrin PM Triple Action (acetaminophen 250 MG / aspirin 250 MG / diphenhydramine citrate 38 MG) Oral Tablet [SY]	4	5	Drug Facts	20240314

Recently Linked DailyMed Labels#

Set ID, Title, Manufacturer table
Set ID	Title	Manufacturer	Effective
444fa225-c204-45d1-b3b3-aa5650ee5d07	Drug Facts	Haleon US Holdings LLC	20260223
b3812d27-40af-40d7-864a-dfa4ae34cb9e	Drug Facts	Haleon US Holdings LLC	20240314
978a9d27-6d41-42cb-a193-11314923d2ac	Drug Facts	Haleon US Holdings LLC	20240314

Drug Classes#

Source, Class ID, Class table
Source	Class ID	Class	Type	Relationship	Drug concept
ATC	R06AA	Aminoalkyl ethers	ATC1-4		diphenhydramine
ATC	N02BE	Anilides	ATC1-4		acetaminophen
ATC	D04AA	Antihistamines for topical use	ATC1-4		diphenhydramine
ATC	A01AD	Other agents for local oral treatment	ATC1-4		aspirin
ATC	B01AC	Platelet aggregation inhibitors excl. heparin	ATC1-4		aspirin
ATC	N02BA	Salicylic acid and derivatives	ATC1-4		aspirin
FDASPL	N0000175587	Histamine-1 Receptor Antagonist	EPC	has_epc	diphenhydramine
FDASPL	N0000175722	Nonsteroidal Anti-inflammatory Drug	EPC	has_epc	aspirin
FDASPL	N0000175578	Platelet Aggregation Inhibitor	EPC	has_epc	aspirin
FDASPL	N0000000190	Histamine H1 Receptor Antagonists	MOA	has_moa	diphenhydramine
MEDRT	D000082	Acetaminophen	CHEM	has_ingredient	acetaminophen
MEDRT	D001241	Aspirin	CHEM	has_ingredient	aspirin
MEDRT	D004155	Diphenhydramine	CHEM	has_ingredient	diphenhydramine citrate
MEDRT	D004155	Diphenhydramine	CHEM	has_ingredient	diphenhydramine
MEDRT	D001008	Anxiety Disorders	DISEASE	may_treat	diphenhydramine citrate
MEDRT	D001008	Anxiety Disorders	DISEASE	may_treat	diphenhydramine
MEDRT	D001172	Arthritis, Rheumatoid	DISEASE	may_treat	aspirin
MEDRT	D001778	Blood Coagulation Disorders	DISEASE	ci_with	aspirin
MEDRT	D001791	Blood Platelet Disorders	DISEASE	ci_with	aspirin
MEDRT	D002544	Cerebral Infarction	DISEASE	may_prevent	aspirin
MEDRT	D002644	Chickenpox	DISEASE	ci_with	aspirin
MEDRT	D002675	Child, Preschool	DISEASE	ci_with	aspirin
MEDRT	D004342	Drug Hypersensitivity	DISEASE	ci_with	diphenhydramine
MEDRT	D004342	Drug Hypersensitivity	DISEASE	ci_with	acetaminophen
MEDRT	D004342	Drug Hypersensitivity	DISEASE	ci_with	aspirin
MEDRT	D004342	Drug Hypersensitivity	DISEASE	ci_with	diphenhydramine citrate
MEDRT	D005334	Fever	DISEASE	may_treat	acetaminophen
MEDRT	D005334	Fever	DISEASE	may_prevent	acetaminophen
MEDRT	D005334	Fever	DISEASE	may_treat	aspirin
MEDRT	D005955	Glucosephosphate Dehydrogenase Deficiency	DISEASE	ci_with	acetaminophen
MEDRT	D006073	Gout	DISEASE	may_treat	aspirin
MEDRT	D006396	Hematemesis	DISEASE	ci_with	aspirin
MEDRT	D006474	Hemorrhagic Disorders	DISEASE	ci_with	aspirin
MEDRT	D007223	Infant	DISEASE	ci_with	aspirin
MEDRT	D007231	Infant, Newborn	DISEASE	ci_with	diphenhydramine
MEDRT	D007231	Infant, Newborn	DISEASE	ci_with	diphenhydramine citrate
MEDRT	D007234	Infant, Premature	DISEASE	ci_with	diphenhydramine
MEDRT	D007234	Infant, Premature	DISEASE	ci_with	diphenhydramine citrate
MEDRT	D007249	Inflammation	DISEASE	may_treat	aspirin
MEDRT	D002546	Ischemic Attack, Transient	DISEASE	may_prevent	aspirin
MEDRT	D007774	Lactation	DISEASE	ci_with	diphenhydramine
MEDRT	D007774	Lactation	DISEASE	ci_with	diphenhydramine citrate
MEDRT	D008107	Liver Diseases	DISEASE	ci_with	acetaminophen
MEDRT	D008551	Melena	DISEASE	ci_with	aspirin
MEDRT	D009041	Motion Sickness	DISEASE	may_treat	diphenhydramine
MEDRT	D009041	Motion Sickness	DISEASE	may_treat	diphenhydramine citrate
MEDRT	D009203	Myocardial Infarction	DISEASE	may_prevent	aspirin
MEDRT	D009298	Nasal Polyps	DISEASE	ci_with	aspirin
MEDRT	D009325	Nausea	DISEASE	may_treat	diphenhydramine
MEDRT	D009325	Nausea	DISEASE	may_treat	diphenhydramine citrate
MEDRT	D010003	Osteoarthritis	DISEASE	may_treat	aspirin
MEDRT	D010146	Pain	DISEASE	may_prevent	acetaminophen
MEDRT	D010146	Pain	DISEASE	may_prevent	aspirin
MEDRT	D010146	Pain	DISEASE	may_treat	aspirin
MEDRT	D010146	Pain	DISEASE	may_treat	acetaminophen
MEDRT	D011225	Pre-Eclampsia	DISEASE	may_prevent	aspirin
MEDRT	D011263	Pregnancy Trimester, Third	DISEASE	ci_with	aspirin
MEDRT	D012213	Rheumatic Fever	DISEASE	may_treat	aspirin
MEDRT	D012221	Rhinitis, Allergic, Perennial	DISEASE	may_treat	diphenhydramine citrate
MEDRT	D012221	Rhinitis, Allergic, Perennial	DISEASE	may_treat	diphenhydramine
MEDRT	D007319	Sleep Initiation and Maintenance Disorders	DISEASE	may_treat	diphenhydramine citrate
MEDRT	D007319	Sleep Initiation and Maintenance Disorders	DISEASE	may_treat	diphenhydramine
MEDRT	D012912	Sneezing	DISEASE	may_treat	diphenhydramine citrate
MEDRT	D012912	Sneezing	DISEASE	may_treat	diphenhydramine
MEDRT	D013224	Status Asthmaticus	DISEASE	ci_with	diphenhydramine
MEDRT	D013224	Status Asthmaticus	DISEASE	ci_with	diphenhydramine citrate
MEDRT	D014581	Urticaria	DISEASE	may_treat	diphenhydramine citrate
MEDRT	D014581	Urticaria	DISEASE	may_treat	diphenhydramine
MEDRT	N0000000160	Cyclooxygenase Inhibitors	MOA	has_moa	aspirin
MEDRT	N0000000190	Histamine H1 Receptor Antagonists	MOA	has_moa	diphenhydramine
MEDRT	N0000000190	Histamine H1 Receptor Antagonists	MOA	has_moa	diphenhydramine citrate
MEDRT	N0000000108	Prostaglandin Receptor Antagonists	MOA	has_moa	acetaminophen
MEDRT	N0000175724	Central Nervous System Activity Alteration	PE	has_pe	acetaminophen
MEDRT	N0000008831	Decreased Platelet Activating Factor Production	PE	has_pe	aspirin
MEDRT	N0000008832	Decreased Platelet Aggregation	PE	has_pe	aspirin
MEDRT	N0000008836	Decreased Prostaglandin Production	PE	has_pe	acetaminophen
MEDRT	N0000008836	Decreased Prostaglandin Production	PE	has_pe	aspirin
MEDRT	N0000009006	Decreased Thromboxane Production	PE	has_pe	aspirin
MEDRT	N0000009072	Hypothalamic Endocrine Activity Alteration	PE	has_pe	acetaminophen
MEDRT	N0000175725	Peripheral Nervous System Activity Alteration	PE	has_pe	acetaminophen
MEDRT	N0000000026	Hepatic Metabolism	PK	has_pk	acetaminophen
MEDRT	N0000000026	Hepatic Metabolism	PK	has_pk	aspirin
MEDRT	N0000000042	Renal Excretion	PK	has_pk	acetaminophen
MEDRT	N0000000042	Renal Excretion	PK	has_pk	aspirin

Group, Type, Concept table
Group	Type	Concept	Source
BN	BN	Excedrin PM Triple Action	rxnav_allrelated
BPCK	BPCK	{100 (acetaminophen 250 MG / aspirin 250 MG / caffeine 65 MG Oral Tablet [Excedrin]) / 24 (acetaminophen 250 MG / aspirin 250 MG / diphenhydramine citrate 38 MG Oral Tablet [Excedrin PM Triple Action]) } Pack [Excedrin PM Triple Action Caplets and Excedrin Extra Strength Pain Reliever]	rxnav_allrelated
DF	DF	Oral Tablet	rxnav_allrelated
DFG	DFG	Oral Product	rxnav_allrelated
DFG	DFG	Pill	rxnav_allrelated
GPCK	GPCK	{100 (acetaminophen 250 MG / aspirin 250 MG / caffeine 65 MG Oral Tablet) / 24 (acetaminophen 250 MG / aspirin 250 MG / diphenhydramine citrate 38 MG Oral Tablet) } Pack	rxnav_allrelated
IN	IN	acetaminophen	rxnav_allrelated
IN	IN	aspirin	rxnav_allrelated
IN	IN	diphenhydramine	rxnav_allrelated
MIN	MIN	acetaminophen / aspirin / diphenhydramine	rxnav_allrelated
PIN	PIN	diphenhydramine citrate	rxnav_allrelated
SBD	SBD	acetaminophen 250 MG / aspirin 250 MG / diphenhydramine citrate 38 MG Oral Tablet [Excedrin PM Triple Action]	rxnav_allrelated
SBDC	SBDC	acetaminophen 250 MG / aspirin 250 MG / diphenhydramine citrate 38 MG [Excedrin PM Triple Action]	rxnav_allrelated
SBDF	SBDF	acetaminophen / aspirin / diphenhydramine Oral Tablet [Excedrin PM Triple Action]	rxnav_allrelated
SBDFP	SBDFP	acetaminophen / aspirin / diphenhydramine citrate Oral Tablet [Excedrin PM Triple Action]	rxnav_allrelated
SBDG	SBDG	Excedrin PM Triple Action Oral Product	rxnav_allrelated
SBDG	SBDG	Excedrin PM Triple Action Pill	rxnav_allrelated
SCD	SCD	acetaminophen 250 MG / aspirin 250 MG / diphenhydramine citrate 38 MG Oral Tablet	rxnav_allrelated
SCDC	SCDC	acetaminophen 250 MG	rxnav_allrelated
SCDC	SCDC	aspirin 250 MG	rxnav_allrelated
SCDC	SCDC	diphenhydramine citrate 38 MG	rxnav_allrelated
SCDF	SCDF	acetaminophen / aspirin / diphenhydramine Oral Tablet	rxnav_allrelated
SCDFP	SCDFP	acetaminophen / aspirin / diphenhydramine citrate Oral Tablet	rxnav_allrelated
SCDG	SCDG	acetaminophen / aspirin / diphenhydramine Oral Product	rxnav_allrelated
SCDG	SCDG	acetaminophen / aspirin / diphenhydramine Pill	rxnav_allrelated
SCDGP	SCDGP	acetaminophen / aspirin / diphenhydramine citrate Oral Product	rxnav_allrelated
SCDGP	SCDGP	acetaminophen / aspirin / diphenhydramine citrate Pill	rxnav_allrelated

Properties#

Category, Property, Value table
Category	Property	Value
ATTRIBUTES	AVAILABLE_STRENGTH	250 MG / 250 MG / 38 MG
ATTRIBUTES	GENERAL_CARDINALITY	MULTI
ATTRIBUTES	HUMAN_DRUG	US
ATTRIBUTES	RXNAV_HUMAN_DRUG	US
ATTRIBUTES	SCHEDULE	0
NAMES	Prescribable Synonym	Excedrin PM Triple Action (250 MG / 250 MG / 38 MG) Oral Tablet
NAMES	Tallman Synonym	acetaminophen 250 MG / aspirin 250 MG / diphenhydrAMINE citrate 38 MG Oral Tablet [Excedrin PM Triple Action]
NAMES	Tallman Synonym	APAP 250 MG / ASA 250 MG / diphenhydrAMINE Citrate 38 MG Oral Tablet [Excedrin PM Triple Action]
NAMES	Tallman Synonym	Excedrin PM Triple Action (acetaminophen 250 MG / aspirin 250 MG / diphenhydrAMINE citrate 38 MG) Oral Tablet
SOURCES	Source	Gold Standard Alchemy
SOURCES	Source	Metathesaurus FDA Structured Product Labels
SOURCES	Source	Micromedex RED BOOK
SOURCES	Source	Multum MediSource Lexicon