acetaminophen 650 MG / dextromethorphan hydrobromide 30 MG / doxylamine succinate 12.5 MG Powder for Oral Solution

RxCUI: 1805288
RxNorm name: acetaminophen 650 MG / dextromethorphan hydrobromide 30 MG / doxylamine succinate 12.5 MG Powder for Oral Solution
Term type: SCD
Status: Active
Updated: 2026-10-24 12:46:56

RxNorm Status History#

Status: Active
Source: RXNORM
Current: YES
Release start: 092016
Active start: 092016
Multiple ingredient: YES
Branded: NO

Ingredients And Strength#

Ingredient, Strength, Base table
Ingredient	Strength	Base	Basis of strength
acetaminophen	650 MG / 1 EACH	acetaminophen	acetaminophen
dextromethorphan hydrobromide	30 MG / 1 EACH	dextromethorphan	dextromethorphan hydrobromide
doxylamine succinate	12.5 MG / 1 EACH	doxylamine	doxylamine succinate

Dose Form Concepts#

Dose form, RxCUI table
Dose form	RxCUI
Powder for Oral Solution	1540455

Derived Ingredient Concepts#

Ingredient, RxCUI table
Ingredient	RxCUI
acetaminophen	161
dextromethorphan	3289
doxylamine	3642

Source Vocabulary Codes#

Code type, Values, Count table
Code type	Values	Count	Category
RXNAV_STR	acetaminophen 650 MG / dextromethorphan hydrobromide 30 MG / doxylamine succinate 12.5 MG Powder for Oral Solution	1	NAMES
RxNorm Name	acetaminophen 650 MG / dextromethorphan hydrobromide 30 MG / doxylamine succinate 12.5 MG Powder for Oral Solution	1	NAMES
RxNorm Synonym	2 linked values acetaminophen 650 MG / dextromethorphan hydrobromide 30 MG / doxylamine succinate 12.5 MG Granules for Oral Solution APAP 650 MG / Dextromethorphan Hydrobromide 30 MG / doxylamine succinate 12.5 MG Powder for Oral Solution	2	NAMES
TTY	SCD	1	ATTRIBUTES
SPL_SET_ID	90358b3c-63c9-4aef-a241-9a6e588535d5	1	CODES
RxCUI	1805288	1	CODES

RxNav Current And Historical NDCs#

RxNav current and historical NDC rows page 1 of 1 · 1 matching rows.

NDC11, Source, Active table
NDC11	Source	Active
59779069408	rxnav_historical

UNII Substances#

UNII substance links page 1 of 1 · 0 matching rows.

No records found.

Reported adverse events (FAERS/openFDA)#

Adverse event summaries are temporarily unavailable. Other product information remains available.

DailyMed RxNorm Mappings#

unique DailyMed labels mapped to this RxNorm concept page 1 of 1 · 1 matching rows.

Set ID, RxNorm mappings, Terms table
Set ID	RxNorm mappings	Terms	SPL version	Label	Effective
90358b3c-63c9-4aef-a241-9a6e588535d5	acetaminophen 650 MG / dextromethorphan HBr 30 MG / doxylamine succinate 12.5 MG Powder for Oral Solution [PSN] · acetaminophen 650 MG / dextromethorphan hydrobromide 30 MG / doxylamine succinate 12.5 MG Powder for Oral Solution [SCD] · acetaminophen 650 MG / dextromethorphan hydrobromide 30 MG / doxylamine succinate 12.5 MG Granules for Oral Solution [SY] · APAP 650 MG / Dextromethorphan Hydrobromide 30 MG / doxylamine succinate 12.5 MG Powder for Oral Solution [SY]	4	4	TopCare health ™ Day and Night Combination Pack Non-Drowsy Daytime Cold and Flu Relief Single Serve Cups Nighttime Cold and Flu Relief Single Serve Cups	20221130

Drug Classes#

Source, Class ID, Class table
Source	Class ID	Class	Type	Relationship	Drug concept
ATC	R06AA	Aminoalkyl ethers	ATC1-4		doxylamine
ATC	N02BE	Anilides	ATC1-4		acetaminophen
ATC	R05DA	Opium alkaloids and derivatives	ATC1-4		dextromethorphan
FDASPL	N0000175750	Antihistamine	EPC	has_epc	doxylamine
FDASPL	N0000182149	Sigma-1 Agonist	EPC	has_epc	dextromethorphan
FDASPL	N0000181821	Uncompetitive N-methyl-D-aspartate Receptor Antagonist	EPC	has_epc	dextromethorphan
FDASPL	N0000000207	Histamine Receptor Antagonists	MOA	has_moa	doxylamine
FDASPL	N0000182147	Sigma-1 Receptor Agonists	MOA	has_moa	dextromethorphan
FDASPL	N0000181819	Uncompetitive NMDA Receptor Antagonists	MOA	has_moa	dextromethorphan
MEDRT	D000082	Acetaminophen	CHEM	has_ingredient	acetaminophen
MEDRT	D003915	Dextromethorphan	CHEM	has_ingredient	dextromethorphan hydrobromide
MEDRT	D003915	Dextromethorphan	CHEM	has_ingredient	dextromethorphan
MEDRT	D004319	Doxylamine	CHEM	has_ingredient	doxylamine
MEDRT	D004319	Doxylamine	CHEM	has_ingredient	doxylamine succinate
MEDRT	D003371	Cough	DISEASE	may_treat	dextromethorphan
MEDRT	D003371	Cough	DISEASE	may_prevent	dextromethorphan
MEDRT	D003371	Cough	DISEASE	may_treat	dextromethorphan hydrobromide
MEDRT	D003371	Cough	DISEASE	may_prevent	dextromethorphan hydrobromide
MEDRT	D004342	Drug Hypersensitivity	DISEASE	ci_with	acetaminophen
MEDRT	D004342	Drug Hypersensitivity	DISEASE	ci_with	doxylamine
MEDRT	D004342	Drug Hypersensitivity	DISEASE	ci_with	dextromethorphan
MEDRT	D004342	Drug Hypersensitivity	DISEASE	ci_with	doxylamine succinate
MEDRT	D004342	Drug Hypersensitivity	DISEASE	ci_with	dextromethorphan hydrobromide
MEDRT	D005334	Fever	DISEASE	may_prevent	acetaminophen
MEDRT	D005334	Fever	DISEASE	may_treat	acetaminophen
MEDRT	D005955	Glucosephosphate Dehydrogenase Deficiency	DISEASE	ci_with	acetaminophen
MEDRT	D006261	Headache	DISEASE	may_treat	doxylamine
MEDRT	D006261	Headache	DISEASE	may_treat	doxylamine succinate
MEDRT	D008107	Liver Diseases	DISEASE	ci_with	acetaminophen
MEDRT	D010146	Pain	DISEASE	may_treat	acetaminophen
MEDRT	D010146	Pain	DISEASE	may_prevent	acetaminophen
MEDRT	D012221	Rhinitis, Allergic, Perennial	DISEASE	may_treat	doxylamine
MEDRT	D012221	Rhinitis, Allergic, Perennial	DISEASE	may_treat	doxylamine succinate
MEDRT	D007319	Sleep Initiation and Maintenance Disorders	DISEASE	may_treat	doxylamine
MEDRT	D007319	Sleep Initiation and Maintenance Disorders	DISEASE	may_treat	doxylamine succinate
MEDRT	N0000000190	Histamine H1 Receptor Antagonists	MOA	has_moa	doxylamine succinate
MEDRT	N0000000190	Histamine H1 Receptor Antagonists	MOA	has_moa	doxylamine
MEDRT	N0000000184	Monoamine Oxidase Inhibitors	MOA	ci_moa	dextromethorphan
MEDRT	N0000000184	Monoamine Oxidase Inhibitors	MOA	ci_moa	dextromethorphan hydrobromide
MEDRT	N0000000108	Prostaglandin Receptor Antagonists	MOA	has_moa	acetaminophen
MEDRT	N0000000109	Serotonin Uptake Inhibitors	MOA	has_moa	dextromethorphan hydrobromide
MEDRT	N0000000109	Serotonin Uptake Inhibitors	MOA	has_moa	dextromethorphan
MEDRT	N0000182147	Sigma-1 Receptor Agonists	MOA	has_moa	dextromethorphan hydrobromide
MEDRT	N0000182147	Sigma-1 Receptor Agonists	MOA	has_moa	dextromethorphan
MEDRT	N0000181819	Uncompetitive NMDA Receptor Antagonists	MOA	has_moa	dextromethorphan hydrobromide
MEDRT	N0000181819	Uncompetitive NMDA Receptor Antagonists	MOA	has_moa	dextromethorphan
MEDRT	N0000175724	Central Nervous System Activity Alteration	PE	has_pe	acetaminophen
MEDRT	N0000008657	Decreased Histamine Activity	PE	has_pe	doxylamine succinate
MEDRT	N0000008657	Decreased Histamine Activity	PE	has_pe	doxylamine
MEDRT	N0000008701	Decreased Medullary Respiratory Drive	PE	has_pe	dextromethorphan hydrobromide
MEDRT	N0000008701	Decreased Medullary Respiratory Drive	PE	has_pe	dextromethorphan
MEDRT	N0000008836	Decreased Prostaglandin Production	PE	has_pe	acetaminophen
MEDRT	N0000009072	Hypothalamic Endocrine Activity Alteration	PE	has_pe	acetaminophen
MEDRT	N0000175725	Peripheral Nervous System Activity Alteration	PE	has_pe	acetaminophen
MEDRT	N0000000026	Hepatic Metabolism	PK	has_pk	acetaminophen
MEDRT	N0000000042	Renal Excretion	PK	has_pk	acetaminophen

Group, Type, Concept table
Group	Type	Concept	Source
DF	DF	Powder for Oral Solution	rxnav_allrelated
DFG	DFG	Oral Powder Product	rxnav_allrelated
DFG	DFG	Oral Product	rxnav_allrelated
IN	IN	acetaminophen	rxnav_allrelated
IN	IN	dextromethorphan	rxnav_allrelated
IN	IN	doxylamine	rxnav_allrelated
MIN	MIN	acetaminophen / dextromethorphan / doxylamine	rxnav_allrelated
PIN	PIN	dextromethorphan hydrobromide	rxnav_allrelated
PIN	PIN	doxylamine succinate	rxnav_allrelated
SCD	SCD	acetaminophen 650 MG / dextromethorphan hydrobromide 30 MG / doxylamine succinate 12.5 MG Powder for Oral Solution	rxnav_allrelated
SCDC	SCDC	acetaminophen 650 MG	rxnav_allrelated
SCDC	SCDC	dextromethorphan hydrobromide 30 MG	rxnav_allrelated
SCDC	SCDC	doxylamine succinate 12.5 MG	rxnav_allrelated
SCDF	SCDF	acetaminophen / dextromethorphan / doxylamine Powder for Oral Solution	rxnav_allrelated
SCDFP	SCDFP	acetaminophen / dextromethorphan hydrobromide / doxylamine succinate Powder for Oral Solution	rxnav_allrelated
SCDG	SCDG	acetaminophen / dextromethorphan / doxylamine Oral Powder Product	rxnav_allrelated
SCDG	SCDG	acetaminophen / dextromethorphan / doxylamine Oral Product	rxnav_allrelated
SCDGP	SCDGP	acetaminophen / dextromethorphan hydrobromide / doxylamine succinate Oral Powder Product	rxnav_allrelated
SCDGP	SCDGP	acetaminophen / dextromethorphan hydrobromide / doxylamine succinate Oral Product	rxnav_allrelated

Properties#

Category, Property, Value table
Category	Property	Value
ATTRIBUTES	AVAILABLE_STRENGTH	650 MG / 30 MG / 12.5 MG (expressed as doxylamine succinate)
ATTRIBUTES	GENERAL_CARDINALITY	MULTI
ATTRIBUTES	HUMAN_DRUG	US
ATTRIBUTES	RXNAV_HUMAN_DRUG	US
NAMES	Prescribable Synonym	acetaminophen 650 MG / dextromethorphan HBr 30 MG / doxylamine succinate 12.5 MG Powder for Oral Solution
SOURCES	Source	Metathesaurus FDA Structured Product Labels