30 ML bupivacaine hydrochloride 2.5 MG/ML / epinephrine 0.005 MG/ML Injection [Marcaine with Epinephrine]

RxCUI: 1867614
RxNorm name: 30 ML bupivacaine hydrochloride 2.5 MG/ML / epinephrine 0.005 MG/ML Injection [Marcaine with Epinephrine]
Display name: MARCAINE WITH EPINEPHrine (Injectable)
Full name: 30 ML bupivacaine hydrochloride 2.5 MG/ML / epinephrine 0.005 MG/ML Injection [Marcaine with Epinephrine]
Term type: SBD
Status: Active
Strength: 2.5-0.005 mg/ml
Dose form: Injection 30 ml
Route: Injectable
Updated: 2026-10-27 17:49:53

RxNorm Status History#

Status: Active
Source: RXNORM
Current: YES
Release start: 032017
Active start: 032017
Multiple ingredient: YES
Branded: YES

Ingredients And Strength#

Ingredient, Strength, Base table
Ingredient	Strength	Base	Basis of strength
bupivacaine hydrochloride	2.5 MG / 1 ML	bupivacaine	bupivacaine hydrochloride
epinephrine bitartrate	5 MCG / 1 ML	epinephrine	epinephrine

Dose Form Concepts#

Dose form, RxCUI table
Dose form	RxCUI
Injection	1649574

Derived Ingredient Concepts#

Ingredient, RxCUI table
Ingredient	RxCUI
bupivacaine	1815
epinephrine	3992

Source Vocabulary Codes#

Code type, Values, Count table
Code type	Values	Count	Category
PRESCRIBABLE	Y	1	ATTRIBUTES
RXNAV_STR	Marcaine 0.25 % / EPINEPHrine (as EPINEPHrine bitartrate) 1:200,000 per 30 ML Injection	1	NAMES
RxNorm Name	30 ML bupivacaine hydrochloride 2.5 MG/ML / epinephrine 0.005 MG/ML Injection [Marcaine with Epinephrine]	1	NAMES
RxNorm Synonym	Marcaine 0.25 % / epinephrine (as epinephrine bitartrate) 1:200,000 per 30 ML Injection	1	NAMES
TTY	SBD	1	ATTRIBUTES
SPL_SET_ID	2 linked values 93cf0914-de08-4ec6-8f8c-d663243b9958 67578b56-7540-487e-1fba-481255620e78	2	CODES
RxCUI	1867614	1	CODES
MMSL_CODE	MTH_RXN_BD14937	1	CODES

FDA NDC Products And Packages#

Package NDC, Product NDC, Name table
Package NDC	Product NDC	Name	Labeler	Application
0409-1541-10	0409-1541	Marcaine with Epinephrine BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE	Hospira, Inc.	NDA016964
0409-1746-30	0409-1746	Marcaine with Epinephrine BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE BITARTRATE	Hospira, Inc.	NDA016964

Drugs@FDA Applications#

Application, NDC, Name table
Application	NDC	Name	Marketing category	Labeler
NDA016964	0409-1541	Marcaine with Epinephrine BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE	NDA	Hospira, Inc.

RxNav Current And Historical NDCs#

RxNav current and historical NDC rows page 1 of 1 · 4 matching rows.

NDC11, Source, Active table
NDC11	Source	Active
00409154101	rxnav_ndcs	yes
00409154110	rxnav_ndcs	yes
00409174630	rxnav_ndcs	yes
00409174671	rxnav_ndcs	yes

UNII Substances#

UNII substance links page 1 of 1 · 0 matching rows.

No records found.

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 1 matching rows.

Brand, Generic, Manufacturer table
Brand	Generic	Manufacturer	SPL set ID	Effective date	Available safety fields	Join
Marcaine with Epinephrine	BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE	Hospira, Inc.	93cf0914-de08-4ec6-8f8c-d663243b9958	2024-02-02	Boxed warning, Warnings, Adverse reactions	Exact identifier ndc (package): 0409-1541-10 ndc (product): 0409-1541 ndc11 (package): 00409154110 ndc11 (package): 00409154101 rxcui: 1867614

Reported adverse events (FAERS/openFDA)#

Adverse event summaries are temporarily unavailable. Other product information remains available.

DailyMed RxNorm Mappings#

unique DailyMed labels mapped to this RxNorm concept page 1 of 1 · 2 matching rows.

Set ID, RxNorm mappings, Terms table
Set ID	RxNorm mappings	Terms	SPL version	Label	Effective
67578b56-7540-487e-1fba-481255620e78	Marcaine 0.25 % / EPINEPHrine 1:200,000 in 30 ML Injection [PSN] · 30 ML bupivacaine hydrochloride 2.5 MG/ML / epinephrine 0.005 MG/ML Injection [Marcaine with Epinephrine] [SBD] · Marcaine 0.25 % / epinephrine (as epinephrine bitartrate) 1:200,000 per 30 ML Injection [SY]	3	38	These highlights do not include all the information needed to use MARCAINE™ and MARCAINE™ WITH EPINEPHRINE safely and effectively. See full prescribing information for MARCAINE™ and MARCAINE™ WITH EPINEPHRINE. MARCAINE™ (bupivacaine hydrochloride) injection, for infiltration, perineural, caudal, epidural, or retrobulbar use MARCAINE™ WITH EPINEPHRINE (bupivacaine hydrochloride and epinephrine) injection, for infiltration, perineural, caudal, or epidural use Initial U.S. Approval: 1972	20260529
93cf0914-de08-4ec6-8f8c-d663243b9958	Marcaine 0.25 % / EPINEPHrine 1:200,000 in 30 ML Injection [PSN] · 30 ML bupivacaine hydrochloride 2.5 MG/ML / epinephrine 0.005 MG/ML Injection [Marcaine with Epinephrine] [SBD] · Marcaine 0.25 % / epinephrine (as epinephrine bitartrate) 1:200,000 per 30 ML Injection [SY]	3	5	These highlights do not include all the information needed to use MARCAINE™ and MARCAINE™ WITH EPINEPHRINE safely and effectively. See full prescribing information for MARCAINE™ and MARCAINE™ WITH EPINEPHRINE. MARCAINE™ (bupivacaine hydrochloride) injection, for infiltration, perineural, caudal, epidural, or retrobulbar use MARCAINE™ WITH EPINEPHRINE (bupivacaine hydrochloride and epinephrine) injection, for infiltration, perineural, caudal, or epidural use Initial U.S. Approval: 1972	20240202

Recently Linked DailyMed Labels#

Set ID, Title, Manufacturer table
Set ID	Title	Manufacturer	Effective
67578b56-7540-487e-1fba-481255620e78	These highlights do not include all the information needed to use MARCAINE™ and MARCAINE™ WITH EPINEPHRINE safely and effectively. See full prescribing information for MARCAINE™ and MARCAINE™ WITH EPINEPHRINE. MARCAINE™ (bupivacaine hydrochloride) injection, for infiltration, perineural, caudal, epidural, or retrobulbar use MARCAINE™ WITH EPINEPHRINE (bupivacaine hydrochloride and epinephrine) injection, for infiltration, perineural, caudal, or epidural use Initial U.S. Approval: 1972	Hospira, Inc. \| Pfizer Healthcare India Private Limited	20261023
67578b56-7540-487e-1fba-481255620e78	These highlights do not include all the information needed to use MARCAINE™ and MARCAINE™ WITH EPINEPHRINE safely and effectively. See full prescribing information for MARCAINE™ and MARCAINE™ WITH EPINEPHRINE. MARCAINE™ (bupivacaine hydrochloride) injection, for infiltration, perineural, caudal, epidural, or retrobulbar use MARCAINE™ WITH EPINEPHRINE (bupivacaine hydrochloride and epinephrine) injection, for infiltration, perineural, caudal, or epidural use Initial U.S. Approval: 1972	Hospira, Inc. \| Pfizer Healthcare India Private Limited	20261014
67578b56-7540-487e-1fba-481255620e78	These highlights do not include all the information needed to use MARCAINE™ and MARCAINE™ WITH EPINEPHRINE safely and effectively. See full prescribing information for MARCAINE™ and MARCAINE™ WITH EPINEPHRINE. MARCAINE™ (bupivacaine hydrochloride) injection, for infiltration, perineural, caudal, epidural, or retrobulbar use MARCAINE™ WITH EPINEPHRINE (bupivacaine hydrochloride and epinephrine) injection, for infiltration, perineural, caudal, or epidural use Initial U.S. Approval: 1972	Hospira, Inc. \| Pfizer Healthcare India Private Limited	20260529
67578b56-7540-487e-1fba-481255620e78	These highlights do not include all the information needed to use MARCAINE™ and MARCAINE™ WITH EPINEPHRINE safely and effectively. See full prescribing information for MARCAINE™ and MARCAINE™ WITH EPINEPHRINE. MARCAINE™ (bupivacaine hydrochloride) injection, for infiltration, perineural, caudal, epidural, or retrobulbar use MARCAINE™ WITH EPINEPHRINE (bupivacaine hydrochloride and epinephrine) injection, for infiltration, perineural, caudal, or epidural use Initial U.S. Approval: 1972	Hospira, Inc. \| Pfizer Healthcare India Private Limited	20260423
67578b56-7540-487e-1fba-481255620e78	These highlights do not include all the information needed to use MARCAINE™ and MARCAINE™ WITH EPINEPHRINE safely and effectively. See full prescribing information for MARCAINE™ and MARCAINE™ WITH EPINEPHRINE. MARCAINE™ (bupivacaine hydrochloride) injection, for infiltration, perineural, caudal, epidural, or retrobulbar use MARCAINE™ WITH EPINEPHRINE (bupivacaine hydrochloride and epinephrine) injection, for infiltration, perineural, caudal, or epidural use Initial U.S. Approval: 1972	Hospira, Inc. \| Pfizer Healthcare India Private Limited	20251106
67578b56-7540-487e-1fba-481255620e78	These highlights do not include all the information needed to use MARCAINE™ and MARCAINE™ WITH EPINEPHRINE safely and effectively. See full prescribing information for MARCAINE™ and MARCAINE™ WITH EPINEPHRINE. MARCAINE™ (bupivacaine hydrochloride) injection, for infiltration, perineural, caudal, epidural, or retrobulbar use MARCAINE™ WITH EPINEPHRINE (bupivacaine hydrochloride and epinephrine) injection, for infiltration, perineural, caudal, or epidural use Initial U.S. Approval: 1972	Hospira, Inc. \| Pfizer Healthcare India Private Limited	20250828
67578b56-7540-487e-1fba-481255620e78	These highlights do not include all the information needed to use MARCAINE™ and MARCAINE™ WITH EPINEPHRINE safely and effectively. See full prescribing information for MARCAINE™ and MARCAINE™ WITH EPINEPHRINE. MARCAINE™ (bupivacaine hydrochloride) injection, for infiltration, perineural, caudal, epidural, or retrobulbar use MARCAINE™ WITH EPINEPHRINE (bupivacaine hydrochloride and epinephrine) injection, for infiltration, perineural, caudal, or epidural use Initial U.S. Approval: 1972	Hospira, Inc. \| Pfizer Healthcare India Private Limited	20250825
93cf0914-de08-4ec6-8f8c-d663243b9958	These highlights do not include all the information needed to use MARCAINE™ and MARCAINE™ WITH EPINEPHRINE safely and effectively. See full prescribing information for MARCAINE™ and MARCAINE™ WITH EPINEPHRINE. MARCAINE™ (bupivacaine hydrochloride) injection, for infiltration, perineural, caudal, epidural, or retrobulbar use MARCAINE™ WITH EPINEPHRINE (bupivacaine hydrochloride and epinephrine) injection, for infiltration, perineural, caudal, or epidural use Initial U.S. Approval: 1972	Hospira, Inc. \| Standard Chem. & Pharm. Co., Ltd. Plant II	20240202
b7f7b0dc-305d-4dc4-ba30-fe88b077d228		National Council for Prescription Drug Programs	20120724

Drug Classes#

Source, Class ID, Class table
Source	Class ID	Class	Type	Relationship	Drug concept
ATC	C01CA	Adrenergic and dopaminergic agents	ATC1-4		epinephrine
ATC	R03AA	Alpha- and beta-adrenoreceptor agonists	ATC1-4		epinephrine
ATC	N01BB	Amides	ATC1-4		bupivacaine
ATC	B02BC	Local hemostatics	ATC1-4		epinephrine
ATC	A01AD	Other agents for local oral treatment	ATC1-4		epinephrine
ATC	S01EA	Sympathomimetics in glaucoma therapy	ATC1-4		epinephrine
ATC	R01AA	Sympathomimetics, plain	ATC1-4		epinephrine
FDASPL	D000577	Amides	CHEM	has_chemical_structure	bupivacaine
FDASPL	D002395	Catecholamines	CHEM	has_chemical_structure	epinephrine
FDASPL	N0000175552	alpha-Adrenergic Agonist	EPC	has_epc	epinephrine
FDASPL	N0000175682	Amide Local Anesthetic	EPC	has_epc	bupivacaine
FDASPL	N0000175555	beta-Adrenergic Agonist	EPC	has_epc	epinephrine
FDASPL	N0000175570	Catecholamine	EPC	has_epc	epinephrine
FDASPL	N0000000209	Adrenergic alpha-Agonists	MOA	has_moa	epinephrine
FDASPL	N0000000245	Adrenergic beta-Agonists	MOA	has_moa	epinephrine
FDASPL	N0000175976	Local Anesthesia	PE	has_pe	bupivacaine
MEDRT	D002045	Bupivacaine	CHEM	has_ingredient	bupivacaine
MEDRT	D002045	Bupivacaine	CHEM	has_ingredient	bupivacaine hydrochloride
MEDRT	D004837	Epinephrine	CHEM	has_ingredient	epinephrine
MEDRT	D000402	Airway Obstruction	DISEASE	may_treat	epinephrine
MEDRT	D000707	Anaphylaxis	DISEASE	may_treat	epinephrine
MEDRT	D001145	Arrhythmias, Cardiac	DISEASE	ci_with	epinephrine
MEDRT	D001919	Bradycardia	DISEASE	may_treat	epinephrine
MEDRT	D001986	Bronchial Spasm	DISEASE	may_treat	epinephrine
MEDRT	D004342	Drug Hypersensitivity	DISEASE	ci_with	bupivacaine
MEDRT	D004342	Drug Hypersensitivity	DISEASE	ci_with	epinephrine
MEDRT	D004342	Drug Hypersensitivity	DISEASE	ci_with	bupivacaine hydrochloride
MEDRT	D015812	Glaucoma, Angle-Closure	DISEASE	ci_with	epinephrine
MEDRT	D005902	Glaucoma, Open-Angle	DISEASE	may_treat	epinephrine
MEDRT	D006323	Heart Arrest	DISEASE	may_treat	epinephrine
MEDRT	D006327	Heart Block	DISEASE	may_treat	epinephrine
MEDRT	D007022	Hypotension	DISEASE	may_treat	epinephrine
MEDRT	D010146	Pain	DISEASE	may_prevent	bupivacaine hydrochloride
MEDRT	D010146	Pain	DISEASE	may_prevent	bupivacaine
MEDRT	D010149	Postoperative Pain	DISEASE	may_treat	bupivacaine hydrochloride
MEDRT	D010149	Postoperative Pain	DISEASE	may_treat	bupivacaine
MEDRT	D012772	Shock, Septic	DISEASE	may_treat	epinephrine
MEDRT	D017180	Tachycardia, Ventricular	DISEASE	may_treat	epinephrine
MEDRT	D014693	Ventricular Fibrillation	DISEASE	may_treat	epinephrine
MEDRT	N0000000209	Adrenergic alpha-Agonists	MOA	has_moa	epinephrine
MEDRT	N0000009921	Adrenergic beta1-Agonists	MOA	has_moa	epinephrine
MEDRT	N0000009922	Adrenergic beta2-Agonists	MOA	has_moa	epinephrine
MEDRT	N0000000108	Prostaglandin Receptor Antagonists	MOA	has_moa	bupivacaine hydrochloride
MEDRT	N0000000108	Prostaglandin Receptor Antagonists	MOA	has_moa	bupivacaine
MEDRT	N0000000180	Sodium Channel Interactions	MOA	has_moa	bupivacaine hydrochloride
MEDRT	N0000000180	Sodium Channel Interactions	MOA	has_moa	bupivacaine
MEDRT	N0000008298	Arterial Vasoconstriction	PE	has_pe	epinephrine
MEDRT	N0000008322	Bronchodilation	PE	has_pe	epinephrine
MEDRT	N0000009944	Decreased Intraocular Aqueous Secretion	PE	has_pe	epinephrine
MEDRT	N0000008768	Decreased Organized Electrical Activity	PE	has_pe	bupivacaine hydrochloride
MEDRT	N0000008768	Decreased Organized Electrical Activity	PE	has_pe	bupivacaine
MEDRT	N0000009014	Decreased Uterine Smooth Muscle Contraction or Tone	PE	has_pe	epinephrine
MEDRT	N0000009070	Hemostasis Alteration	PE	has_pe	epinephrine
MEDRT	N0000178478	Increased Blood Pressure	PE	has_pe	epinephrine
MEDRT	N0000175976	Local Anesthesia	PE	has_pe	bupivacaine hydrochloride
MEDRT	N0000175976	Local Anesthesia	PE	has_pe	bupivacaine
MEDRT	N0000009808	Positive Chronotropy	PE	has_pe	epinephrine
MEDRT	N0000009809	Positive Inotropy	PE	has_pe	epinephrine
MEDRT	N0000009820	Pupillary Dilation	PE	has_pe	epinephrine

Group, Type, Concept table
Group	Type	Concept	Source
BN	BN	Marcaine with Epinephrine	rxnav_allrelated
DF	DF	Injection	rxnav_allrelated
DFG	DFG	Injectable Product	rxnav_allrelated
IN	IN	bupivacaine	rxnav_allrelated
IN	IN	epinephrine	rxnav_allrelated
MIN	MIN	bupivacaine / epinephrine	rxnav_allrelated
PIN	PIN	bupivacaine hydrochloride	rxnav_allrelated
SBD	SBD	30 ML bupivacaine hydrochloride 2.5 MG/ML / epinephrine 0.005 MG/ML Injection [Marcaine with Epinephrine]	rxnav_allrelated
SBDC	SBDC	bupivacaine hydrochloride 2.5 MG/ML / epinephrine 0.005 MG/ML [Marcaine with Epinephrine]	rxnav_allrelated
SBDF	SBDF	bupivacaine / epinephrine Injection [Marcaine with Epinephrine]	rxnav_allrelated
SBDFP	SBDFP	bupivacaine hydrochloride / epinephrine Injection [Marcaine with Epinephrine]	rxnav_allrelated
SBDG	SBDG	Marcaine with Epinephrine Injectable Product	rxnav_allrelated
SCD	SCD	30 ML bupivacaine hydrochloride 2.5 MG/ML / epinephrine 0.005 MG/ML Injection	rxnav_allrelated
SCDC	SCDC	bupivacaine hydrochloride 2.5 MG/ML	rxnav_allrelated
SCDC	SCDC	epinephrine 0.005 MG/ML	rxnav_allrelated
SCDF	SCDF	bupivacaine / epinephrine Injection	rxnav_allrelated
SCDFP	SCDFP	bupivacaine hydrochloride / epinephrine Injection	rxnav_allrelated
SCDG	SCDG	bupivacaine / epinephrine Injectable Product	rxnav_allrelated
SCDGP	SCDGP	bupivacaine hydrochloride / epinephrine Injectable Product	rxnav_allrelated

Properties#

Category, Property, Value table
Category	Property	Value
ATTRIBUTES	AVAILABLE_STRENGTH	2.5 MG/ML / 0.005 MG/ML
ATTRIBUTES	GENERAL_CARDINALITY	MULTI
ATTRIBUTES	HUMAN_DRUG	US
ATTRIBUTES	QUANTITY	30 ML
ATTRIBUTES	RXNAV_HUMAN_DRUG	US
ATTRIBUTES	SCHEDULE	0
CODES	NDA	NDA016964
NAMES	Prescribable Synonym	Marcaine 0.25 % / EPINEPHrine 1:200,000 in 30 ML Injection
NAMES	Tallman Synonym	30 ML BUPivacaine hydrochloride 2.5 MG/ML / EPINEPHrine 0.005 MG/ML Injection [Marcaine with EPINEPHrine]
NAMES	Tallman Synonym	Marcaine 0.25 % / EPINEPHrine (as EPINEPHrine bitartrate) 1:200,000 per 30 ML Injection
SOURCES	Source	Gold Standard Alchemy
SOURCES	Source	Metathesaurus FDA Structured Product Labels
SOURCES	Source	Micromedex RED BOOK
SOURCES	Source	Multum MediSource Lexicon