Application 020281

Type: NDA
Sponsor: JANSSEN PHARMS

Application Products#

Product, Drug, Ingredient table
Product	Drug	Ingredient	Form	Strength	Reference drug	Reference standard
001	ULTRAM	TRAMADOL HYDROCHLORIDE	TABLET;ORAL	100MG	No	No
002	ULTRAM	TRAMADOL HYDROCHLORIDE	TABLET;ORAL	50MG	Yes	Yes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 43.

Orange Book products#

Current product rows page 1 of 1 · 2 matching rows.

Application-product, Trade name, Ingredient table
Application-product	Trade name	Ingredient	Strength	Dosage form / route	TE codes	RLD / RS	Approval date
N020281-001	ULTRAM	TRAMADOL HYDROCHLORIDE	100MG Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	TABLET / ORAL		RLD	1995-03-03
N020281-002	ULTRAM	TRAMADOL HYDROCHLORIDE	50MG Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	TABLET / ORAL		RLD	1995-03-03

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Product history page 1 of 3 · 86 observed states.

Captured, Edition, Application-product table
Captured	Edition	Application-product	Trade name	Strength	Dosage form / route	Product TE source text	RLD / RS	Approval date	Source SHA-256
2026-09-14 22:38:34	2026-08	N020281-001	ULTRAM	100MG Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	TABLET / ORAL		RLD	1995-03-03	`84e616aacf4f…`
2026-09-14 22:38:34	2026-08	N020281-002	ULTRAM	50MG Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	TABLET / ORAL		RLD	1995-03-03	`84e616aacf4f…`
2026-08-18 06:07:40	2026-07	N020281-001	ULTRAM	100MG Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	TABLET / ORAL		RLD	1995-03-03	`caaa826d4ba7…`
2026-08-18 06:07:40	2026-07	N020281-002	ULTRAM	50MG Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	TABLET / ORAL		RLD	1995-03-03	`caaa826d4ba7…`
2026-02-19 14:30 UTC	2026-02	N020281-001	ULTRAM	100MG Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	TABLET / ORAL		RLD	1995-03-03	`011fe1cb6892…`
2026-02-19 14:30 UTC	2026-02	N020281-002	ULTRAM	50MG Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	TABLET / ORAL		RLD	1995-03-03	`011fe1cb6892…`
2025-12-14 10:44 UTC · 2 captures of this ZIP	2025-12	N020281-001	ULTRAM	100MG Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	TABLET / ORAL		RLD	1995-03-03	`31067a03dcf5…`
2025-12-14 10:44 UTC · 2 captures of this ZIP	2025-12	N020281-002	ULTRAM	50MG Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	TABLET / ORAL		RLD	1995-03-03	`31067a03dcf5…`
2025-08-23 18:47 UTC	2025-08	N020281-001	ULTRAM	100MG Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	TABLET / ORAL		RLD	1995-03-03	`6a471c1ec25d…`
2025-08-23 18:47 UTC	2025-08	N020281-002	ULTRAM	50MG Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	TABLET / ORAL		RLD	1995-03-03	`6a471c1ec25d…`
2025-03-22 03:13 UTC · 3 captures of this ZIP	2025-03	N020281-001	ULTRAM	100MG Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	TABLET / ORAL		RLD	1995-03-03	`fd3edfee7708…`
2025-03-22 03:13 UTC · 3 captures of this ZIP	2025-03	N020281-002	ULTRAM	50MG Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	TABLET / ORAL		RLD	1995-03-03	`fd3edfee7708…`
2025-02-26 10:13 UTC · 3 captures of this ZIP	2025-02	N020281-001	ULTRAM	100MG Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	TABLET / ORAL		RLD	1995-03-03	`b8a1b40f171c…`
2025-02-26 10:13 UTC · 3 captures of this ZIP	2025-02	N020281-002	ULTRAM	50MG Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	TABLET / ORAL		RLD	1995-03-03	`b8a1b40f171c…`
2025-01-19 17:59 UTC · 7 captures of this ZIP	2025-01	N020281-001	ULTRAM	100MG Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	TABLET / ORAL		RLD	1995-03-03	`03ed91905a0d…`
2025-01-19 17:59 UTC · 7 captures of this ZIP	2025-01	N020281-002	ULTRAM	50MG Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	TABLET / ORAL		RLD	1995-03-03	`03ed91905a0d…`
2024-12-13 21:23 UTC · 2 captures of this ZIP	2024-12	N020281-001	ULTRAM	100MG Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	TABLET / ORAL		RLD	1995-03-03	`2680178bc6a6…`
2024-12-13 21:23 UTC · 2 captures of this ZIP	2024-12	N020281-002	ULTRAM	50MG Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	TABLET / ORAL		RLD	1995-03-03	`2680178bc6a6…`
2024-09-14 05:58 UTC · 2 captures of this ZIP	2024-09	N020281-001	ULTRAM	100MG Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	TABLET / ORAL		RLD	1995-03-03	`5bbf6a4d5a75…`
2024-09-14 05:58 UTC · 2 captures of this ZIP	2024-09	N020281-002	ULTRAM	50MG Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	TABLET / ORAL		RLD	1995-03-03	`5bbf6a4d5a75…`
2024-11-08 22:44 UTC · 3 captures of this ZIP	2024-11	N020281-001	ULTRAM	100MG Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	TABLET / ORAL		RLD	1995-03-03	`d8e5a09893c0…`
2024-11-08 22:44 UTC · 3 captures of this ZIP	2024-11	N020281-002	ULTRAM	50MG Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	TABLET / ORAL		RLD	1995-03-03	`d8e5a09893c0…`
2024-10-29 15:01 UTC	2024-10	N020281-001	ULTRAM	100MG Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	TABLET / ORAL		RLD	1995-03-03	`d06236e962d9…`
2024-10-29 15:01 UTC	2024-10	N020281-002	ULTRAM	50MG Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	TABLET / ORAL		RLD	1995-03-03	`d06236e962d9…`
2024-08-13 05:28 UTC · 3 captures of this ZIP	2024-08	N020281-001	ULTRAM	100MG Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	TABLET / ORAL		RLD	1995-03-03	`79d66fd596c7…`
2024-08-13 05:28 UTC · 3 captures of this ZIP	2024-08	N020281-002	ULTRAM	50MG Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	TABLET / ORAL		RLD	1995-03-03	`79d66fd596c7…`
2024-07-13 05:37 UTC · 2 captures of this ZIP	2024-07	N020281-001	ULTRAM	100MG Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	TABLET / ORAL		RLD	1995-03-03	`301d65b070ca…`
2024-07-13 05:37 UTC · 2 captures of this ZIP	2024-07	N020281-002	ULTRAM	50MG Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	TABLET / ORAL		RLD	1995-03-03	`301d65b070ca…`
2024-06-18 03:08 UTC · 5 captures of this ZIP	2024-06	N020281-001	ULTRAM	100MG Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	TABLET / ORAL		RLD	1995-03-03	`1e350fbaab3a…`
2024-06-18 03:08 UTC · 5 captures of this ZIP	2024-06	N020281-002	ULTRAM	50MG Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	TABLET / ORAL		RLD	1995-03-03	`1e350fbaab3a…`
2024-05-31 18:47 UTC	2024-05	N020281-001	ULTRAM	100MG Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	TABLET / ORAL		RLD	1995-03-03	`8072bd15b7f6…`
2024-05-31 18:47 UTC	2024-05	N020281-002	ULTRAM	50MG Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	TABLET / ORAL		RLD	1995-03-03	`8072bd15b7f6…`
2022-06-29 02:47 UTC · 2 captures of this ZIP	2022-06	N020281-001	ULTRAM	100MG Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	TABLET / ORAL			1995-03-03	`5c6f7cd8ea54…`
2022-06-29 02:47 UTC · 2 captures of this ZIP	2022-06	N020281-002	ULTRAM	50MG	TABLET / ORAL	AB	RLD, RS	1995-03-03	`5c6f7cd8ea54…`
2022-04-08 23:34 UTC	2022-04	N020281-001	ULTRAM	100MG	TABLET / ORAL			1995-03-03	`5d02ea3f76ae…`
2022-04-08 23:34 UTC	2022-04	N020281-002	ULTRAM	50MG	TABLET / ORAL	AB	RLD, RS	1995-03-03	`5d02ea3f76ae…`
2022-04-04 05:41 UTC	2022-04	N020281-001	ULTRAM	100MG	TABLET / ORAL			1995-03-03	`4b0b4de00fa7…`
2022-04-04 05:41 UTC	2022-04	N020281-002	ULTRAM	50MG	TABLET / ORAL	AB	RLD, RS	1995-03-03	`4b0b4de00fa7…`
2019-12-13 00:20 UTC	2019-12	N020281-001	ULTRAM	100MG	TABLET / ORAL			1995-03-03	`74a2ff9319b5…`
2019-12-13 00:20 UTC	2019-12	N020281-002	ULTRAM	50MG	TABLET / ORAL	AB	RLD, RS	1995-03-03	`74a2ff9319b5…`

Observed Orange Book normalized TE history#

Captured, Edition, Application-product table
Captured	Edition	Application-product	TE code	Order	Source SHA-256
2022-06-29 02:47 UTC · 2 captures of this ZIP	2022-06	N020281-002	AB	1	`5c6f7cd8ea54…`
2022-04-08 23:34 UTC	2022-04	N020281-002	AB	1	`5d02ea3f76ae…`
2022-04-04 05:41 UTC	2022-04	N020281-002	AB	1	`4b0b4de00fa7…`
2019-12-13 00:20 UTC	2019-12	N020281-002	AB	1	`74a2ff9319b5…`
2022-03-09 01:35 UTC	2022-03	N020281-002	AB	1	`bb7c543d1eb4…`
2021-12-28 21:50 UTC	2021-12	N020281-002	AB	1	`782e0a99824c…`
2021-05-05 16:15 UTC · 3 captures of this ZIP	2021-05	N020281-002	AB	1	`87673890dc5c…`
2021-03-12 10:30 UTC	2021-03	N020281-002	AB	1	`5aa47cf7b7d7…`
2020-12-22 03:56 UTC	2020-12	N020281-002	AB	1	`8869cabd3fbd…`
2020-11-12 02:37 UTC	2020-11	N020281-002	AB	1	`c0c555d07b60…`
2019-12-14 00:12 UTC	2019-12	N020281-002	AB	1	`3f01610625f2…`
2019-09-15 20:21 UTC	2019-09	N020281-002	AB	1	`b00525d2431f…`
2019-07-19 19:46 UTC	2019-07	N020281-002	AB	1	`ea99ee380514…`
2022-09-29 23:25 UTC	2022-09	N020281-002	AB	1	`e64feba35796…`
2022-07-09 03:26 UTC · 3 captures of this ZIP	2022-07	N020281-002	AB	1	`cb3db0bc1861…`

Observed Orange Book patent history#

Captured, Edition, Application-product table
Captured	Edition	Application-product	Patent	Expiration	Use code	Coverage / status	Source SHA-256
2019-12-13 00:20 UTC	2019-12	N020281-001	6339105	2019-10-12	U-435		`74a2ff9319b5…`
2019-12-13 00:20 UTC	2019-12	N020281-001	6339105*PED	2020-04-12		Pediatric extension	`74a2ff9319b5…`
2019-12-13 00:20 UTC	2019-12	N020281-002	6339105	2019-10-12	U-435		`74a2ff9319b5…`
2019-12-13 00:20 UTC	2019-12	N020281-002	6339105*PED	2020-04-12		Pediatric extension	`74a2ff9319b5…`
2020-12-22 03:56 UTC	2020-12	N020281-001	6339105*PED	2020-04-12		Pediatric extension	`8869cabd3fbd…`
2020-12-22 03:56 UTC	2020-12	N020281-002	6339105*PED	2020-04-12		Pediatric extension	`8869cabd3fbd…`
2020-11-12 02:37 UTC	2020-11	N020281-001	6339105*PED	2020-04-12		Pediatric extension	`c0c555d07b60…`
2020-11-12 02:37 UTC	2020-11	N020281-002	6339105*PED	2020-04-12		Pediatric extension	`c0c555d07b60…`
2019-12-14 00:12 UTC	2019-12	N020281-001	6339105	2019-10-12	U-435		`3f01610625f2…`
2019-12-14 00:12 UTC	2019-12	N020281-001	6339105*PED	2020-04-12		Pediatric extension	`3f01610625f2…`
2019-12-14 00:12 UTC	2019-12	N020281-002	6339105	2019-10-12	U-435		`3f01610625f2…`
2019-12-14 00:12 UTC	2019-12	N020281-002	6339105*PED	2020-04-12		Pediatric extension	`3f01610625f2…`
2019-09-15 20:21 UTC	2019-09	N020281-001	6339105	2019-10-12	U-435		`b00525d2431f…`
2019-09-15 20:21 UTC	2019-09	N020281-001	6339105*PED	2020-04-12		Pediatric extension	`b00525d2431f…`
2019-09-15 20:21 UTC	2019-09	N020281-002	6339105	2019-10-12	U-435		`b00525d2431f…`
2019-09-15 20:21 UTC	2019-09	N020281-002	6339105*PED	2020-04-12		Pediatric extension	`b00525d2431f…`
2019-07-19 19:46 UTC	2019-07	N020281-001	6339105	2019-10-12	U-435		`ea99ee380514…`
2019-07-19 19:46 UTC	2019-07	N020281-001	6339105*PED	2020-04-12		Pediatric extension	`ea99ee380514…`
2019-07-19 19:46 UTC	2019-07	N020281-002	6339105	2019-10-12	U-435		`ea99ee380514…`
2019-07-19 19:46 UTC	2019-07	N020281-002	6339105*PED	2020-04-12		Pediatric extension	`ea99ee380514…`

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 3 of 5 · 91 matching rows.

Brand, Generic, Manufacturer table
Brand	Generic	Manufacturer	SPL set ID	Effective date	Available safety fields	Join
Tramadol Hydrochloride	TRAMADOL HYDROCHLORIDE	RedPharm Drug Inc	f4c148f3-845a-61e3-e053-2a95a90a326e	2025-11-14	Boxed warning, Warnings, Adverse reactions	Name fallback generic name: TRAMADOL HYDROCHLORIDE
Tramadol Hydrochloride	TRAMADOL HYDROCHLORIDE	Preferred Pharmaceuticals Inc.	f558c59c-cbd4-4b17-9a3d-b014ad09bbb1	2025-10-13	Boxed warning, Warnings, Adverse reactions	Name fallback generic name: TRAMADOL HYDROCHLORIDE
TRAMADOL HYDROCHLORIDE	TRAMADOL HYDROCHLORIDE	Preferred Pharmaceuticals, Inc.	83367367-5654-4078-831a-69ade48bc795	2025-10-01	Boxed warning, Warnings, Adverse reactions	Name fallback generic name: TRAMADOL HYDROCHLORIDE
tramadol hydrochloride	TRAMADOL HYDROCHLORIDE	Preferred Pharmaceuticals Inc.	05f8e06b-f3eb-4cb2-aee5-bd0b03884178	2025-10-01	Boxed warning, Warnings, Adverse reactions	Name fallback generic name: TRAMADOL HYDROCHLORIDE
TRAMADOL HYDROCHLORIDE	TRAMADOL HYDROCHLORIDE	Preferred Pharmaceuticals, Inc.	c30f6e9e-8014-40fc-9615-a6b8654137c1	2025-10-01	Boxed warning, Warnings, Adverse reactions	Name fallback generic name: TRAMADOL HYDROCHLORIDE
Tramadol Hydrochloride	TRAMADOL HYDROCHLORIDE	Preferred Pharmaceuticals Inc.	84b12129-cf10-4a3e-889c-990ebabdece6	2025-10-01	Boxed warning, Warnings, Adverse reactions	Name fallback generic name: TRAMADOL HYDROCHLORIDE
Tramadol Hydrochloride	TRAMADOL HYDROCHLORIDE	Preferred Pharmaceuticals Inc.	e6e275c3-1e16-4a00-b7fd-608ae6cbd515	2025-09-29	Boxed warning, Warnings, Adverse reactions	Name fallback generic name: TRAMADOL HYDROCHLORIDE
Tramadol Hydrochloride	TRAMADOL HYDROCHLORIDE	Bryant Ranch Prepack	2bf66203-8b45-475d-9a70-4d7c8bdfe6b3	2025-09-26	Boxed warning, Warnings, Adverse reactions	Name fallback generic name: TRAMADOL HYDROCHLORIDE
TRAMADOL HYDROCHLORIDE	TRAMADOL HYDROCHLORIDE	A-S Medication Solutions	c28c98ac-7e07-46a5-8f34-57c008308fba	2025-09-05	Boxed warning, Warnings, Adverse reactions	Name fallback generic name: TRAMADOL HYDROCHLORIDE
Tramadol Hydrochloride	TRAMADOL HYDROCHLORIDE	American Health Packaging	f6f6069b-cc75-4b87-afa5-b83001b543e0	2025-08-27	Boxed warning, Warnings, Adverse reactions	Name fallback generic name: TRAMADOL HYDROCHLORIDE
Tramadol Hydrochloride	TRAMADOL HYDROCHLORIDE	Asclemed USA, Inc.	6a60bd36-7dcc-49c3-b6de-b263fdaa312c	2025-08-14	Boxed warning, Warnings, Adverse reactions	Name fallback generic name: TRAMADOL HYDROCHLORIDE
Tramadol Hydrochloride	TRAMADOL HYDROCHLORIDE	Coupler LLC	3135a131-5f2d-3775-e063-6394a90a4322	2025-03-25	Boxed warning, Warnings, Adverse reactions	Name fallback generic name: TRAMADOL HYDROCHLORIDE
TRAMADOL HYDROCHLORIDE	TRAMADOL HYDROCHLORIDE	Coupler LLC	2f23ba6c-89d2-cc42-e063-6394a90aee0a	2025-02-27	Boxed warning, Warnings, Adverse reactions	Name fallback generic name: TRAMADOL HYDROCHLORIDE
Tramadol Hydrochloride	TRAMADOL HYDROCHLORIDE	Advanced Rx of Tennessee, LLC	2e738ced-9cde-e776-e063-6294a90a7e33	2025-02-13	Boxed warning, Warnings, Adverse reactions	Name fallback generic name: TRAMADOL HYDROCHLORIDE
Tramadol Hydrochloride	TRAMADOL HYDROCHLORIDE	Clinical Solutions Wholesale, LLC	728157e2-d153-4ea0-81eb-36599dc7dfda	2025-02-06	Boxed warning, Warnings, Adverse reactions	Name fallback generic name: TRAMADOL HYDROCHLORIDE
Tramadol Hydrochloride	TRAMADOL HYDROCHLORIDE	NuCare Pharmaceuticals,Inc.	5babcfcf-331b-5db9-e053-2a91aa0aaf89	2025-02-03	Boxed warning, Warnings, Adverse reactions	Name fallback generic name: TRAMADOL HYDROCHLORIDE
TRAMADOL HYDROCHLORIDE	TRAMADOL HYDROCHLORIDE	DirectRx	d5685c80-c84d-d0a1-e053-2995a90afc54	2025-01-21	Warnings, Adverse reactions	Name fallback generic name: TRAMADOL HYDROCHLORIDE
TRAMADOL HYDROCHLORIDE	TRAMADOL HYDROCHLORIDE	DIRECT RX	b3c702f7-0a8c-a52b-e053-2995a90a6df3	2025-01-17	Boxed warning, Warnings, Adverse reactions	Name fallback generic name: TRAMADOL HYDROCHLORIDE
tramadol hydrochloride	TRAMADOL HYDROCHLORIDE	NuCare Pharmaceuticals,Inc.	1e79e1fa-3473-f4a7-e063-6294a90a9576	2025-01-14	Boxed warning, Warnings, Adverse reactions	Name fallback generic name: TRAMADOL HYDROCHLORIDE
Tramadol Hydrochloride	TRAMADOL HYDROCHLORIDE	Proficient Rx LP	d7e75fd3-18d1-4370-bb63-c9dd8a2c1719	2025-01-01	Boxed warning, Warnings, Adverse reactions	Name fallback generic name: TRAMADOL HYDROCHLORIDE

Reported adverse events (FAERS/openFDA)#

Adverse event summaries are temporarily unavailable. Other product information remains available.

NDC Listings For This Application#

NDC listings for this application page 1 of 1 · 7 matching rows.

NDC, Name, Nonproprietary name table
NDC	Name	Nonproprietary name	Labeler	Marketing category	Status
50458-659	ULTRAM	tramadol hydrochloride	Janssen Pharmaceuticals, Inc.	NDA	Current
50458-659	ULTRAM	tramadol hydrochloride	Janssen Pharmaceuticals, Inc.	NDA	Current
50458-659	ULTRAM	tramadol hydrochloride	Janssen Pharmaceuticals, Inc.	NDA	Current
50458-659	ULTRAM	tramadol hydrochloride	Janssen Pharmaceuticals,	NDA	Current
50458-659	ULTRAM	tramadol hydrochloride	Janssen Pharmaceuticals, Inc.	NDA	Current
50458-659	ULTRAM	tramadol hydrochloride	Janssen Pharmaceuticals, Inc.	NDA	Current
50458-659	ULTRAM	tramadol hydrochloride	Janssen Pharmaceuticals, Inc.	NDA	Current

Documents#

Document, Submission type, Date table
Document	Submission type	Date
76230	ORIG	2023-11-03
73501	SUPPL	2023-02-14
73500	SUPPL	2023-02-14
73491	SUPPL	2023-02-14
68609	SUPPL	2021-09-14
68608	SUPPL	2021-09-13
68607	SUPPL	2021-09-13
66585	SUPPL	2021-03-08
66584	SUPPL	2021-03-08
66506	SUPPL	2021-03-05
60342	SUPPL	2019-10-08
60327	SUPPL	2019-10-08
60326	SUPPL	2019-10-08
58278	SUPPL	2019-04-10
58263	SUPPL	2019-04-09
57644	ORIG	2019-02-15
55875	SUPPL	2018-10-11
55874	SUPPL	2018-10-11
55679	SUPPL	2018-10-01
55678	SUPPL	2018-10-01
49625	SUPPL	2017-08-30
49595	SUPPL	2017-08-30
46386	SUPPL	2016-12-21
46385	SUPPL	2016-12-21
46252	SUPPL	2016-12-20
46251	SUPPL	2016-12-20
24731	SUPPL	2009-11-12
24730	SUPPL	2009-11-12
34472	SUPPL	2009-10-06
12419	SUPPL	2009-10-06
24728	SUPPL	2004-06-29
24727	SUPPL	2004-06-29
34471	SUPPL	2004-05-03
2293	SUPPL	2004-04-20
20585	SUPPL	2003-08-07
20584	SUPPL	2003-08-07
34470	SUPPL	2003-04-22
34469	SUPPL	1999-12-23
24729	SUPPL	1999-12-23