Application 021164

Type
NDA
Sponsor
FABRE KRAMER

Application Products#

Product, Drug, Ingredient table
ProductDrugIngredientFormStrengthReference drugReference standard
001EXXUAGEPIRONE HYDROCHLORIDETABLET, EXTENDED RELEASE;ORALEQ 18.2MG BASEYesYes
002EXXUAGEPIRONE HYDROCHLORIDETABLET, EXTENDED RELEASE;ORALEQ 36.3MG BASEYesNo
003EXXUAGEPIRONE HYDROCHLORIDETABLET, EXTENDED RELEASE;ORALEQ 54.5MG BASE YesNo
004EXXUAGEPIRONE HYDROCHLORIDETABLET, EXTENDED RELEASE;ORALEQ 72.6MG BASEYesYes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 42.

Orange Book products#

Current product rows page 1 of 1 · 4 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
N021164-001EXXUAGEPIRONE HYDROCHLORIDEEQ 18.2MG BASETABLET, EXTENDED RELEASE / ORALRLD, RS2023-09-22
N021164-002EXXUAGEPIRONE HYDROCHLORIDEEQ 36.3MG BASETABLET, EXTENDED RELEASE / ORALRLD2023-09-22
N021164-003EXXUAGEPIRONE HYDROCHLORIDEEQ 54.5MG BASETABLET, EXTENDED RELEASE / ORALRLD2023-09-22
N021164-004EXXUAGEPIRONE HYDROCHLORIDEEQ 72.6MG BASETABLET, EXTENDED RELEASE / ORALRLD, RS2023-09-22

Orange Book patents#

Current patent rows page 1 of 1 · 4 matching rows.

Application-product, Patent, Expiration table
Application-productPatentExpirationUse codeCoverage / statusSubmission date
N021164-00175381162030-09-02U-36992023-10-18
N021164-00275381162030-09-02U-36992023-10-18
N021164-00375381162030-09-02U-36992023-10-18
N021164-00475381162030-09-02U-36992023-10-18

Orange Book exclusivity#

Current exclusivity rows page 1 of 1 · 4 matching rows.

Application-product, Exclusivity code, Expiration table
Application-productExclusivity codeExpiration
N021164-001NCE2028-09-22
N021164-002NCE2028-09-22
N021164-003NCE2028-09-22
N021164-004NCE2028-09-22

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Product history page 1 of 3 · 84 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-08-18 06:07:402026-07N021164-001EXXUAEQ 18.2MG BASETABLET, EXTENDED RELEASE / ORALRLD, RS2023-09-22caaa826d4ba7…
2026-08-18 06:07:402026-07N021164-002EXXUAEQ 36.3MG BASETABLET, EXTENDED RELEASE / ORALRLD2023-09-22caaa826d4ba7…
2026-08-18 06:07:402026-07N021164-003EXXUAEQ 54.5MG BASETABLET, EXTENDED RELEASE / ORALRLD2023-09-22caaa826d4ba7…
2026-08-18 06:07:402026-07N021164-004EXXUAEQ 72.6MG BASETABLET, EXTENDED RELEASE / ORALRLD, RS2023-09-22caaa826d4ba7…
2026-02-19 14:30 UTC2026-02N021164-001EXXUAEQ 18.2MG BASETABLET, EXTENDED RELEASE / ORALRLD, RS2023-09-22011fe1cb6892…
2026-02-19 14:30 UTC2026-02N021164-002EXXUAEQ 36.3MG BASETABLET, EXTENDED RELEASE / ORALRLD2023-09-22011fe1cb6892…
2026-02-19 14:30 UTC2026-02N021164-003EXXUAEQ 54.5MG BASETABLET, EXTENDED RELEASE / ORALRLD2023-09-22011fe1cb6892…
2026-02-19 14:30 UTC2026-02N021164-004EXXUAEQ 72.6MG BASETABLET, EXTENDED RELEASE / ORALRLD, RS2023-09-22011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N021164-001EXXUAEQ 18.2MG BASETABLET, EXTENDED RELEASE / ORALRLD, RS2023-09-2231067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N021164-002EXXUAEQ 36.3MG BASETABLET, EXTENDED RELEASE / ORALRLD2023-09-2231067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N021164-003EXXUAEQ 54.5MG BASETABLET, EXTENDED RELEASE / ORALRLD2023-09-2231067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N021164-004EXXUAEQ 72.6MG BASETABLET, EXTENDED RELEASE / ORALRLD, RS2023-09-2231067a03dcf5…
2025-08-23 18:47 UTC2025-08N021164-001EXXUAEQ 18.2MG BASETABLET, EXTENDED RELEASE / ORALRLD2023-09-226a471c1ec25d…
2025-08-23 18:47 UTC2025-08N021164-002EXXUAEQ 36.3MG BASETABLET, EXTENDED RELEASE / ORALRLD2023-09-226a471c1ec25d…
2025-08-23 18:47 UTC2025-08N021164-003EXXUAEQ 54.5MG BASETABLET, EXTENDED RELEASE / ORALRLD2023-09-226a471c1ec25d…
2025-08-23 18:47 UTC2025-08N021164-004EXXUAEQ 72.6MG BASETABLET, EXTENDED RELEASE / ORALRLD2023-09-226a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N021164-001EXXUAEQ 18.2MG BASETABLET, EXTENDED RELEASE / ORALRLD2023-09-22fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N021164-002EXXUAEQ 36.3MG BASETABLET, EXTENDED RELEASE / ORALRLD2023-09-22fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N021164-003EXXUAEQ 54.5MG BASETABLET, EXTENDED RELEASE / ORALRLD2023-09-22fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N021164-004EXXUAEQ 72.6MG BASETABLET, EXTENDED RELEASE / ORALRLD2023-09-22fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N021164-001EXXUAEQ 18.2MG BASETABLET, EXTENDED RELEASE / ORALRLD2023-09-22b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N021164-002EXXUAEQ 36.3MG BASETABLET, EXTENDED RELEASE / ORALRLD2023-09-22b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N021164-003EXXUAEQ 54.5MG BASETABLET, EXTENDED RELEASE / ORALRLD2023-09-22b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N021164-004EXXUAEQ 72.6MG BASETABLET, EXTENDED RELEASE / ORALRLD2023-09-22b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N021164-001EXXUAEQ 18.2MG BASETABLET, EXTENDED RELEASE / ORALRLD2023-09-2203ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N021164-002EXXUAEQ 36.3MG BASETABLET, EXTENDED RELEASE / ORALRLD2023-09-2203ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N021164-003EXXUAEQ 54.5MG BASETABLET, EXTENDED RELEASE / ORALRLD2023-09-2203ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N021164-004EXXUAEQ 72.6MG BASETABLET, EXTENDED RELEASE / ORALRLD2023-09-2203ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N021164-001EXXUAEQ 18.2MG BASETABLET, EXTENDED RELEASE / ORALRLD2023-09-222680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N021164-002EXXUAEQ 36.3MG BASETABLET, EXTENDED RELEASE / ORALRLD2023-09-222680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N021164-003EXXUAEQ 54.5MG BASETABLET, EXTENDED RELEASE / ORALRLD2023-09-222680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N021164-004EXXUAEQ 72.6MG BASETABLET, EXTENDED RELEASE / ORALRLD2023-09-222680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N021164-001EXXUAEQ 18.2MG BASETABLET, EXTENDED RELEASE / ORALRLD2023-09-225bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N021164-002EXXUAEQ 36.3MG BASETABLET, EXTENDED RELEASE / ORALRLD2023-09-225bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N021164-003EXXUAEQ 54.5MG BASETABLET, EXTENDED RELEASE / ORALRLD2023-09-225bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N021164-004EXXUAEQ 72.6MG BASETABLET, EXTENDED RELEASE / ORALRLD2023-09-225bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N021164-001EXXUAEQ 18.2MG BASETABLET, EXTENDED RELEASE / ORALRLD2023-09-22d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N021164-002EXXUAEQ 36.3MG BASETABLET, EXTENDED RELEASE / ORALRLD2023-09-22d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N021164-003EXXUAEQ 54.5MG BASETABLET, EXTENDED RELEASE / ORALRLD2023-09-22d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N021164-004EXXUAEQ 72.6MG BASETABLET, EXTENDED RELEASE / ORALRLD2023-09-22d8e5a09893c0…

Observed Orange Book patent history#

Patent history page 1 of 2 · 80 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productPatentExpirationUse codeCoverage / statusSubmission dateSource SHA-256
2026-08-18 06:07:402026-07N021164-00175381162030-09-02U-36992023-10-18caaa826d4ba7…
2026-08-18 06:07:402026-07N021164-00275381162030-09-02U-36992023-10-18caaa826d4ba7…
2026-08-18 06:07:402026-07N021164-00375381162030-09-02U-36992023-10-18caaa826d4ba7…
2026-08-18 06:07:402026-07N021164-00475381162030-09-02U-36992023-10-18caaa826d4ba7…
2026-02-19 14:30 UTC2026-02N021164-00175381162030-09-02U-36992023-10-18011fe1cb6892…
2026-02-19 14:30 UTC2026-02N021164-00275381162030-09-02U-36992023-10-18011fe1cb6892…
2026-02-19 14:30 UTC2026-02N021164-00375381162030-09-02U-36992023-10-18011fe1cb6892…
2026-02-19 14:30 UTC2026-02N021164-00475381162030-09-02U-36992023-10-18011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N021164-00175381162030-09-02U-36992023-10-1831067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N021164-00275381162030-09-02U-36992023-10-1831067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N021164-00375381162030-09-02U-36992023-10-1831067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N021164-00475381162030-09-02U-36992023-10-1831067a03dcf5…
2025-08-23 18:47 UTC2025-08N021164-00175381162025-09-02U-36992023-10-186a471c1ec25d…
2025-08-23 18:47 UTC2025-08N021164-00275381162025-09-02U-36992023-10-186a471c1ec25d…
2025-08-23 18:47 UTC2025-08N021164-00375381162025-09-02U-36992023-10-186a471c1ec25d…
2025-08-23 18:47 UTC2025-08N021164-00475381162025-09-02U-36992023-10-186a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N021164-00175381162025-09-02U-36992023-10-18fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N021164-00275381162025-09-02U-36992023-10-18fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N021164-00375381162025-09-02U-36992023-10-18fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N021164-00475381162025-09-02U-36992023-10-18fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N021164-00175381162025-09-02U-36992023-10-18b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N021164-00275381162025-09-02U-36992023-10-18b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N021164-00375381162025-09-02U-36992023-10-18b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N021164-00475381162025-09-02U-36992023-10-18b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N021164-00175381162025-09-02U-36992023-10-1803ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N021164-00275381162025-09-02U-36992023-10-1803ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N021164-00375381162025-09-02U-36992023-10-1803ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N021164-00475381162025-09-02U-36992023-10-1803ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N021164-00175381162025-09-02U-36992023-10-182680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N021164-00275381162025-09-02U-36992023-10-182680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N021164-00375381162025-09-02U-36992023-10-182680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N021164-00475381162025-09-02U-36992023-10-182680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N021164-00175381162025-09-02U-36992023-10-185bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N021164-00275381162025-09-02U-36992023-10-185bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N021164-00375381162025-09-02U-36992023-10-185bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N021164-00475381162025-09-02U-36992023-10-185bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N021164-00175381162025-09-02U-36992023-10-18d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N021164-00275381162025-09-02U-36992023-10-18d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N021164-00375381162025-09-02U-36992023-10-18d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N021164-00475381162025-09-02U-36992023-10-18d8e5a09893c0…

Observed Orange Book exclusivity history#

Exclusivity history page 1 of 2 · 80 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productExclusivity codeExpirationSource SHA-256
2026-08-18 06:07:402026-07N021164-001NCE2028-09-22caaa826d4ba7…
2026-08-18 06:07:402026-07N021164-002NCE2028-09-22caaa826d4ba7…
2026-08-18 06:07:402026-07N021164-003NCE2028-09-22caaa826d4ba7…
2026-08-18 06:07:402026-07N021164-004NCE2028-09-22caaa826d4ba7…
2026-02-19 14:30 UTC2026-02N021164-001NCE2028-09-22011fe1cb6892…
2026-02-19 14:30 UTC2026-02N021164-002NCE2028-09-22011fe1cb6892…
2026-02-19 14:30 UTC2026-02N021164-003NCE2028-09-22011fe1cb6892…
2026-02-19 14:30 UTC2026-02N021164-004NCE2028-09-22011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N021164-001NCE2028-09-2231067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N021164-002NCE2028-09-2231067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N021164-003NCE2028-09-2231067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N021164-004NCE2028-09-2231067a03dcf5…
2025-08-23 18:47 UTC2025-08N021164-001NCE2028-09-226a471c1ec25d…
2025-08-23 18:47 UTC2025-08N021164-002NCE2028-09-226a471c1ec25d…
2025-08-23 18:47 UTC2025-08N021164-003NCE2028-09-226a471c1ec25d…
2025-08-23 18:47 UTC2025-08N021164-004NCE2028-09-226a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N021164-001NCE2028-09-22fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N021164-002NCE2028-09-22fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N021164-003NCE2028-09-22fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N021164-004NCE2028-09-22fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N021164-001NCE2028-09-22b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N021164-002NCE2028-09-22b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N021164-003NCE2028-09-22b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N021164-004NCE2028-09-22b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N021164-001NCE2028-09-2203ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N021164-002NCE2028-09-2203ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N021164-003NCE2028-09-2203ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N021164-004NCE2028-09-2203ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N021164-001NCE2028-09-222680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N021164-002NCE2028-09-222680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N021164-003NCE2028-09-222680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N021164-004NCE2028-09-222680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N021164-001NCE2028-09-225bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N021164-002NCE2028-09-225bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N021164-003NCE2028-09-225bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N021164-004NCE2028-09-225bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N021164-001NCE2028-09-22d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N021164-002NCE2028-09-22d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N021164-003NCE2028-09-22d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N021164-004NCE2028-09-22d8e5a09893c0…

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 1 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
EXXUAGEPIRONEAytu Therapeutics, LLC0c78edd8-6acb-433c-9d34-2527da8d64e12026-07-14Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (NDA): 021164
application number: NDA021164

Documents#

Document, Submission type, Date table
DocumentSubmission typeDate
82531SUPPL 2025-06-10
82501SUPPL 2025-06-09
76672ORIG 2023-11-28
75557ORIG 2023-09-25
75552ORIG 2023-09-25